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Conserved domains on  [gi|1815547647|ref|NP_001365582|]
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uncharacterized protein LOC102642386 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 2.82e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.59  E-value: 2.82e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1815547647   4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLDTYRNLTTIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-421 1.87e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 241 KPYECNQCGKTFAQINHLRTHK--VVHTGE--KPYKC--NQCDKAFSQQSHLRIHERTHTGEKPYKCnqcgksfvshsHL 314
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-----------KL 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 315 QSHGRIHTGEKpykcNQCDKAFAQHNSlqIHKRTHTGEKPYkcNQCDKAFAQSSSLQYHKRTHTGEKPYECD--QCGKAF 392
Cdd:COG5048   357 LNSSSKFSPLL----NNEPPQSLQQYK--DLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|....*....
gi 1815547647 393 THPSTVVLHKRTHTGEKPYECDQCGKAFA 421
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 5.16e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 145 HLRTHERTHTGKKPYECDQCGKAFAY 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 1.78e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 173 ALVLHKRTHTGEKPYECDQCGKAFAH 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-226 3.75e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|..
gi 1815547647 205 HKRTHTGEKPYECDQCGKAFAY 226
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 2.82e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.59  E-value: 2.82e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1815547647   4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLDTYRNLTTIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 1.79e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.79  E-value: 1.79e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1815547647    4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLDTYRNLTTIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 3.98e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 3.98e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1815547647   4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLDTYRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-421 1.87e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 241 KPYECNQCGKTFAQINHLRTHK--VVHTGE--KPYKC--NQCDKAFSQQSHLRIHERTHTGEKPYKCnqcgksfvshsHL 314
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-----------KL 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 315 QSHGRIHTGEKpykcNQCDKAFAQHNSlqIHKRTHTGEKPYkcNQCDKAFAQSSSLQYHKRTHTGEKPYECD--QCGKAF 392
Cdd:COG5048   357 LNSSSKFSPLL----NNEPPQSLQQYK--DLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|....*....
gi 1815547647 393 THPSTVVLHKRTHTGEKPYECDQCGKAFA 421
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 4.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 369 SLQYHKRTHTGEKPYECDQCGKAFTH 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 5.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 145 HLRTHERTHTGKKPYECDQCGKAFAY 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 173 ALVLHKRTHTGEKPYECDQCGKAFAH 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-226 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|..
gi 1815547647 205 HKRTHTGEKPYECDQCGKAFAY 226
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 2.82e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.59  E-value: 2.82e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1815547647   4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLDTYRNLTTIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 1.79e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.79  E-value: 1.79e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1815547647    4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLDTYRNLTTIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 3.98e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 3.98e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1815547647   4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLDTYRNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-421 1.87e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 241 KPYECNQCGKTFAQINHLRTHK--VVHTGE--KPYKC--NQCDKAFSQQSHLRIHERTHTGEKPYKCnqcgksfvshsHL 314
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE-----------KL 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 315 QSHGRIHTGEKpykcNQCDKAFAQHNSlqIHKRTHTGEKPYkcNQCDKAFAQSSSLQYHKRTHTGEKPYECD--QCGKAF 392
Cdd:COG5048   357 LNSSSKFSPLL----NNEPPQSLQQYK--DLKNDKKSETLS--NSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|....*....
gi 1815547647 393 THPSTVVLHKRTHTGEKPYECDQCGKAFA 421
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
128-413 6.04e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 6.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 128 KKPYKCNQCDKVFSQQRHLRTHERTHTGKKPYECDQCGKAFAYQ--SALVLHKRTHTGEKPYECDQCGKAFahHFTVVLH 205
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLS--NSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 206 KRTHTGEKPYECDQC-----GKAFAYQSALVLHKRTHTGEKPYE-CNQCGKTFAQINHLR-------------------T 260
Cdd:COG5048   109 SLSSSSSNSNDNNLLsshslPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 261 HKVVHTGEKPYKCNQCDKAFSQQSHLRIHERTHTGEKPYKCNQCG----KSFVSHSHLQSHGRIHTGEKP--YKCNQCDK 334
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSSDSSSSASesPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 335 AFAQHNSLQIHKRTHTG-EKPYKCNQCDKAFAQSSSLQYHKRT--HTGE--KPYECD--QCGKAFTHPSTVVLHKRTHTG 407
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348


                  ....*.
gi 1815547647 408 EKPYEC 413
Cdd:COG5048   349 ISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 351-434 1.33e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 351 GEKPYKCN--QCDKAFAQSSSLQYHKRThtgekpyecDQCGKAFTHPSTVVLHKRTHTGEKPYECDQCGKAFAHHSTLQY 428
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1815547647 429 HKKNHT 434
Cdd:COG5189   417 HRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-374 3.93e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 213 KPYECDQCGKAFAYQSALVLHKRT--HTGE--KPYEC--NQCGKTFAQINHLRTHKVVHTGEKPYKC--NQCDKAFSQQS 284
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 285 HLRIHERTH-----TGEKPYKC--NQCGKSFVSHSHLQSHGRIHTGEKP--YKCNQCDKAFAQHNSLQIHKRTHTGEKPY 355
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1815547647 356 KCNQCDKAFAQSSSLQYHK 374
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 267-350 1.98e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 267 GEKPYKCN--QCDKAFSQQSHLRIHeRTHtgekpykcNQCGKSFVSHSHLQSHGRIHTGEKPYKCNQCDKAFAQHNSLQI 344
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1815547647 345 HkRTHT 350
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 4.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 369 SLQYHKRTHTGEKPYECDQCGKAFTH 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 5.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 145 HLRTHERTHTGKKPYECDQCGKAFAY 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 6.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 285 HLRIHERTHTGEKPYKCNQCGKSFVS 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 6.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 341 SLQIHKRTHTGEKPYKCNQCDKAFAQ 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 173 ALVLHKRTHTGEKPYECDQCGKAFAH 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 3.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 313 HLQSHGRIHTGEKPYKCNQCDKAFAQ 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 3.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 257 HLRTHKVVHTGEKPYKCNQCDKAFSQ 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 3.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 1815547647 229 ALVLHKRTHTGEKPYECNQCGKTFAQ 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-422 3.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.50e-03
                          10        20
                  ....*....|....*....|..
gi 1815547647 401 HKRTHTGEKPYECDQCGKAFAH 422
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-226 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|..
gi 1815547647 205 HKRTHTGEKPYECDQCGKAFAY 226
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-418 9.39e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 9.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815547647 338 QHNSLQIHKRTHTGE----KPYKCNQCDKAFAQSSSLQYHKRTHTGEKPYEC--DQCGKAFTHPSTVVLHKRTHTGEKPY 411
Cdd:COG5048    13 NSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD 92


                  ....*..
gi 1815547647 412 ECDQCGK 418
Cdd:COG5048    93 LNSKSLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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