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Conserved domains on  [gi|1269208329|ref|NP_001344139|]
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potassium voltage-gated channel subfamily G member 4 isoform 2 [Mus musculus]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 1000312)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
58-167 9.62e-71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18423:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 112  Bit Score: 213.14  E-value: 9.62e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18423     2 REIIINVGGIKYLMPWSTLDEFPLTRLGKLKFCSSYEEIVQICDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREM 81
                          90       100       110
                  ....*....|....*....|....*....|
gi 1269208329 138 CALSFREELSYWGIEETNLERCCLRKLLKK 167
Cdd:cd18423    82 CALSFQEELTYWGIEEANLERCCLRKLFQK 111
 
Name Accession Description Interval E-value
BTB_POZ_KCNG4 cd18423
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-167 9.62e-71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349730 [Multi-domain]  Cd Length: 112  Bit Score: 213.14  E-value: 9.62e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18423     2 REIIINVGGIKYLMPWSTLDEFPLTRLGKLKFCSSYEEIVQICDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREM 81
                          90       100       110
                  ....*....|....*....|....*....|
gi 1269208329 138 CALSFREELSYWGIEETNLERCCLRKLLKK 167
Cdd:cd18423    82 CALSFQEELTYWGIEEANLERCCLRKLFQK 111
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
60-159 3.09e-30

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 108.83  E-value: 3.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRsheeitqlCDDYDEDSQEFFFDRNPSAFGVIVSFL-AAGKLVLLREMC 138
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE--------CDDYDDDTNEYFFDRSPKHFETILNFYrTGGKLHRPEEVC 72
                          90       100
                  ....*....|....*....|.
gi 1269208329 139 ALSFREELSYWGIEETNLERC 159
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
60-167 3.68e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.08  E-value: 3.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329   60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLrlcrsheeitQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREmCA 139
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALF----------SSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NV 70
                           90       100
                   ....*....|....*....|....*...
gi 1269208329  140 LSFREELSYWGIEEtnLERCCLRKLLKK 167
Cdd:smart00225  71 EELLELADYLQIPG--LVELCEEFLLKL 96
 
Name Accession Description Interval E-value
BTB_POZ_KCNG4 cd18423
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-167 9.62e-71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349730 [Multi-domain]  Cd Length: 112  Bit Score: 213.14  E-value: 9.62e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18423     2 REIIINVGGIKYLMPWSTLDEFPLTRLGKLKFCSSYEEIVQICDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREM 81
                          90       100       110
                  ....*....|....*....|....*....|
gi 1269208329 138 CALSFREELSYWGIEETNLERCCLRKLLKK 167
Cdd:cd18423    82 CALSFQEELTYWGIEEANLERCCLRKLFQK 111
BTB_POZ_Kv6_KCNG cd18382
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-167 2.18e-63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349691 [Multi-domain]  Cd Length: 109  Bit Score: 194.57  E-value: 2.18e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18382     1 VIINVGGARYSLPWSTLDRFPLTRLSRLKACRSEDDILRVCDDYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCA 80
                          90       100
                  ....*....|....*....|....*...
gi 1269208329 140 LSFREELSYWGIEETNLERCCLRKLLKK 167
Cdd:cd18382    81 LSFQEELAYWGIEEAHLERCCKRRLLRR 108
BTB_POZ_KCNG1_2 cd18421
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-167 3.06e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349728 [Multi-domain]  Cd Length: 114  Bit Score: 181.49  E-value: 3.06e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18421     6 VIINVGGIKYRIPWTTLEEFPLTRLGQLKSCNNFDEIMDICDDYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREMCA 85
                          90       100
                  ....*....|....*....|....*...
gi 1269208329 140 LSFREELSYWGIEETNLERCCLRKLLKK 167
Cdd:cd18421    86 LSFQEELLYWGIEEENLEWCCRRRLLQK 113
BTB_POZ_Kv2_KCNB cd18378
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-160 5.02e-41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349687 [Multi-domain]  Cd Length: 109  Bit Score: 137.52  E-value: 5.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18378     2 RRVLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNTHESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEM 81
                          90       100
                  ....*....|....*....|...
gi 1269208329 138 CALSFREELSYWGIEETNLERCC 160
Cdd:cd18378    82 CVLSFSQELEYWGIDEIYLESCC 104
BTB_POZ_Shab-like cd18413
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-163 1.06e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349720 [Multi-domain]  Cd Length: 109  Bit Score: 126.15  E-value: 1.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18413     2 RRVVINVGGVKHEVLWRTLDRMPHTRLGKLRDSNTHEAIVELCDDYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEEM 81
                          90       100
                  ....*....|....*....|....*.
gi 1269208329 138 CALSFREELSYWGIEETNLERCCLRK 163
Cdd:cd18413    82 CVLAFSDDLEYWGVDELYLESCCQHK 107
BTB_POZ_KCNG3 cd18422
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-164 1.70e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349729  Cd Length: 111  Bit Score: 123.05  E-value: 1.70e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18422     1 VTLNVGGTRYSFSREVIKDFPLRRVSRLHGCLSEQDVLEVCDDYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMCE 80
                          90       100
                  ....*....|....*....|....*
gi 1269208329 140 LSFREELSYWGIEETNLERCCLRKL 164
Cdd:cd18422    81 LSFYNEMIYWGLERSHLEYCCQRRL 105
BTB_POZ_KCNB1 cd18411
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-160 3.27e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349718 [Multi-domain]  Cd Length: 117  Bit Score: 117.41  E-value: 3.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18411    10 RRVKLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHESLMEICDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEM 89
                          90       100
                  ....*....|....*....|...
gi 1269208329 138 CALSFREELSYWGIEETNLERCC 160
Cdd:cd18411    90 CALSFSQELDYWGIDEIYLESCC 112
BTB_POZ_KCNS1 cd18426
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 3.97e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349733 [Multi-domain]  Cd Length: 106  Bit Score: 116.91  E-value: 3.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18426     1 ININVGGLKRRLSSSTLSKFPDTRLGRLLSCDSEESILQICDDYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCV 80
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18426    81 FSFSQEIEYWGINEFFLDSCC 101
BTB_POZ_KCNB2 cd18412
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-167 9.46e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349719 [Multi-domain]  Cd Length: 127  Bit Score: 116.65  E-value: 9.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18412    17 RRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEM 96
                          90       100       110
                  ....*....|....*....|....*....|
gi 1269208329 138 CALSFREELSYWGIEETNLERCCLRKLLKK 167
Cdd:cd18412    97 CALSFGQELDYWGIDEIYLESCCQARYHQK 126
BTB_POZ_KCNS2 cd18427
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-160 5.81e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349734  Cd Length: 107  Bit Score: 113.79  E-value: 5.81e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  59 EILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMC 138
Cdd:cd18427     1 EISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELC 80
                          90       100
                  ....*....|....*....|..
gi 1269208329 139 ALSFREELSYWGIEETNLERCC 160
Cdd:cd18427    81 VFSFSQEIEYWGINEFFIDSCC 102
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
60-159 3.09e-30

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 108.83  E-value: 3.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRsheeitqlCDDYDEDSQEFFFDRNPSAFGVIVSFL-AAGKLVLLREMC 138
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE--------CDDYDDDTNEYFFDRSPKHFETILNFYrTGGKLHRPEEVC 72
                          90       100
                  ....*....|....*....|.
gi 1269208329 139 ALSFREELSYWGIEETNLERC 159
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93
BTB_POZ_Kv9_KCNS cd18384
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 4.63e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349692  Cd Length: 106  Bit Score: 106.45  E-value: 4.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18384     1 IRINVGGFRRRLSASALLRFPGTRLGRLLACHSEEAILELCDDYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18384    81 FSFSQEIEYWGINEFFLDSCC 101
BTB_POZ_KCNS3 cd18428
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 7.80e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349735  Cd Length: 108  Bit Score: 105.69  E-value: 7.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18428     3 INLNVGGFKQSVDQSTLLRFPHTRLGKLLNCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 82
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18428    83 FSFCQEIEYWGINELFIDSCC 103
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
62-167 3.66e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 104.13  E-value: 3.66e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  62 VNVGGQRYLLPWSTLDAFPLSRLSRLRLCrSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCALS 141
Cdd:cd18424     3 INVGGSRFVLSQQVLSSHPETRLGKLAVS-VRDSVLELCDDANFVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAIS 81
                          90       100
                  ....*....|....*....|....*.
gi 1269208329 142 FREELSYWGIEETNLERCCLRKLLKK 167
Cdd:cd18424    82 FLQEIEYWGIDELSIDSCCRERYYRR 107
BTB_POZ_KCNV2 cd18425
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
62-160 1.88e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349732  Cd Length: 108  Bit Score: 99.84  E-value: 1.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  62 VNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCALS 141
Cdd:cd18425     3 INVGGTSYQISYRVAASYPKTRIGRLATYTDRSRKLDLCDDYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCPRN 82
                          90
                  ....*....|....*....
gi 1269208329 142 FREELSYWGIEETNLERCC 160
Cdd:cd18425    83 FLEEINYWGVRIKNTPRCC 101
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-150 9.44e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 94.21  E-value: 9.44e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSheeitqlcdDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18317     1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESH---------AYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCP 71
                          90
                  ....*....|.
gi 1269208329 140 LSFREELSYWG 150
Cdd:cd18317    72 ASFKEELEFWG 82
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 5.53e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 93.23  E-value: 5.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLrlcrshEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18379     1 IVINVGGVRHETYKSTLRNLPDTRLAWL------TETEASAFDYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCG 74
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18379    75 PLFEEELAFWGIDETQIEPCC 95
BTB_POZ_Kv5_KCNF1 cd18381
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-160 5.74e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349690  Cd Length: 116  Bit Score: 93.29  E-value: 5.74e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  59 EILVNVGGQRYLLPWSTLDAFPLSRLSRL--RLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLRE 136
Cdd:cd18381     2 EIVVNVGGVRQVLYGDVLNRYPETRLAELlnCLSGGYDAIFSLCDDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKKG 81
                          90       100
                  ....*....|....*....|....
gi 1269208329 137 MCALSFREELSYWGIEETNLERCC 160
Cdd:cd18381    82 ICPICFKNEMDFWRVDLDFLDECC 105
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-160 2.33e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 89.24  E-value: 2.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  59 EILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEItqlcdDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMC 138
Cdd:cd18414     4 RIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVC 78
                          90       100
                  ....*....|....*....|..
gi 1269208329 139 ALSFREELSYWGIEETNLERCC 160
Cdd:cd18414    79 GPLYEEELAFWGIDETDVEPCC 100
BTB_Shaw-like cd18416
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 5.09e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349723 [Multi-domain]  Cd Length: 112  Bit Score: 80.39  E-value: 5.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLrlcrsheeiTQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18416     4 VVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCG 74
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18416    75 PLFEEELEFWGLDANQVEPCC 95
BTB_KCNC2_4 cd18415
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 4.41e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349722 [Multi-domain]  Cd Length: 124  Bit Score: 75.20  E-value: 4.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLR------LCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVL 133
Cdd:cd18415     4 IILNVGGTRHETYRSTLKTLPGTRLALLAssdpqgDCLTQCSQVGGSDGSPGGGNEFFFDRHPGVFAYVLNYYRTGKLHC 83
                          90       100
                  ....*....|....*....|....*..
gi 1269208329 134 LREMCALSFREELSYWGIEETNLERCC 160
Cdd:cd18415    84 PADVCGPLFEEELAFWGIDETDVEPCC 110
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 8.28e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 71.24  E-value: 8.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRlrlcrSHEEITqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18380     2 IVINVSGRRFETWKNTLEKYPDTLLGS-----TEKEFF-----YDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECI 71
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18380    72 SAYDDELAFFGILPEIIGDCC 92
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-163 1.72e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 71.52  E-value: 1.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  59 EIL-VNVGGQRYLLPWSTLDAFPLSRLSRlrlcrSHEEITqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18417    35 EILvVNVSGRRFQTWKNTLDRYPDTLLGS-----SEKEFF-----YNEDTQEYFFDRDPEMFRHILNFYRTGRLHYPRHE 104
                          90       100
                  ....*....|....*....|....*.
gi 1269208329 138 CALSFREELSYWGIEETNLERCCLRK 163
Cdd:cd18417   105 CIQAFDEELSFYGIIPEIIGDCCLEE 130
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 3.76e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 64.99  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRlrlcrSHEEITqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18419    37 IVLNVSGRRFQTWRTTLERYPDTLLGS-----TEKEFF-----FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECI 106
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18419   107 SAYDEELAFYGILPEIIGDCC 127
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-149 8.63e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 62.49  E-value: 8.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLrlCRSHEEITqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLTRHPDTLLGRM--FKPGREFT-----FPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISI 73
                          90
                  ....*....|
gi 1269208329 140 LSFREELSYW 149
Cdd:cd18187    74 PDLREECDFY 83
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-160 5.00e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 61.13  E-value: 5.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRlrlcrSHEEITqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCA 139
Cdd:cd18418     2 IVLNVSGTRFQTWRNTLERYPDTLLGS-----SERDFF-----YHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECI 71
                          90       100
                  ....*....|....*....|.
gi 1269208329 140 LSFREELSYWGIEETNLERCC 160
Cdd:cd18418    72 SAYDEELAFFGIIPEIIGDCC 92
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-160 2.22e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 60.25  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSrlrlcrSHEEITQlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18420    36 EKLIINVSGRRFETWRNTLEKYPDTLLG------SNEREFF----YDEETKEYFFDRDPDIFRHILNYYRTGKLHYPKHE 105
                          90       100
                  ....*....|....*....|...
gi 1269208329 138 CALSFREELSYWGIEETNLERCC 160
Cdd:cd18420   106 CLTAYDEELAFFGIMPDIIGDCC 128
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
62-136 4.93e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 57.57  E-value: 4.93e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208329  62 VNVGGQRYLLPWSTLDAFPLSRLSRLrlCRSHEEITQlcddyDEDsQEFFFDRNPSAFGVIVSFLAAGKLVLLRE 136
Cdd:cd18316     3 LNVGGTLFTTSRSTLLKDPDSLLAAL--FSGRWPLPR-----DED-GSIFIDRDPELFRHILNFLRTGKLPLPSD 69
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
60-167 3.68e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.08  E-value: 3.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329   60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLrlcrsheeitQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREmCA 139
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALF----------SSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NV 70
                           90       100
                   ....*....|....*....|....*...
gi 1269208329  140 LSFREELSYWGIEEtnLERCCLRKLLKK 167
Cdd:smart00225  71 EELLELADYLQIPG--LVELCEEFLLKL 96
BTB_POZ_KCTD17 cd18391
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-167 6.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.


Pssm-ID: 349699  Cd Length: 101  Bit Score: 49.61  E-value: 6.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLsrLRLCRSHEeitqLCDDYDEdSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18391     1 KWVRLNVGGTVFLTTRQTLCREQKSFL--SRLCQGEE----LQSDRDE-TGAYLIDRDPTYFGPILNFLRHGKLVLDKDM 73
                          90       100       110
                  ....*....|....*....|....*....|
gi 1269208329 138 CALSFREELSYWGIeeTNLERCCLRKLLKK 167
Cdd:cd18391    74 AEEGVLEEAEFYNI--GPLIRIIKDRMEEK 101
BTB_POZ_KCTD2 cd18389
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-151 1.53e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.


Pssm-ID: 349697 [Multi-domain]  Cd Length: 105  Bit Score: 48.83  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSRLrlCrshEEITQLCDDYDEdSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18389     1 KWVRLNVGGTYFVSTKQTLCRDPKSFLYRL--C---QEDPDLDSDKDE-TGAYLIDRDPTYFGPILNYLRHGKLIINKEL 74
                          90
                  ....*....|....
gi 1269208329 138 CALSFREELSYWGI 151
Cdd:cd18389    75 AEEGVLEEAEFYNI 88
BTB_POZ_KCTD5 cd18390
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-151 1.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.


Pssm-ID: 349698 [Multi-domain]  Cd Length: 112  Bit Score: 48.83  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLsrLRLCRSHEEItqlcdDYDED-SQEFFFDRNPSAFGVIVSFLAAGKLVLLRE 136
Cdd:cd18390     5 KWVRLNVGGTYFLTTRQTLCRDPKSFL--YRLCQADPDL-----DSDKDeTGAYLIDRDPTYFGPVLNYLRHGKLVINKD 77
                          90
                  ....*....|....*
gi 1269208329 137 MCALSFREELSYWGI 151
Cdd:cd18390    78 LAEEGVLEEAEFYNI 92
BTB_POZ_KCTD2-like cd18362
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-137 5.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.


Pssm-ID: 349671 [Multi-domain]  Cd Length: 85  Bit Score: 43.90  E-value: 5.06e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLrlCRSHEEitqLCDDYDEdSQEFFFDRNPSAFGVIVSFLAAGKLVLLREM 137
Cdd:cd18362     2 VKLNVGGTYFLTTRTTLCRDPKSFLCRL--CQEDPD---LPSDKDE-TGAYLIDRDPTYFGPILNYLRHGKLIIDKDL 73
BTB_POZ_KCTD1-like cd18361
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
62-153 1.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349670  Cd Length: 94  Bit Score: 42.36  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  62 VNVGGQRYLLPWSTLDAFPLSRLSrlRLCRSHEEITqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVL---LREMC 138
Cdd:cd18361     3 IDVGGHIYTSSLETLTKYPESRLG--KLFNGSIPIV-----LDSLKQHYFIDRDGKMFRHILNFLRTSKLLLpddFTEFD 75
                          90
                  ....*....|....*
gi 1269208329 139 ALsfREELSYWGIEE 153
Cdd:cd18361    76 LL--YEEARYYELQP 88
BTB_POZ_KCNRG cd18375
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-133 5.32e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349684  Cd Length: 97  Bit Score: 41.25  E-value: 5.32e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRlrlcrsheeitqLCDDYDED----SQEFFFDRNPSAFGVIVSFLAAGKLVL 133
Cdd:cd18375     3 VTLNVGGKKFTTRPSTLRRFPDSRLAR------------MLDGKDQDfkvvNGQFFVDRDGSLFSYILDYLRTGQLTL 68
BTB_POZ_KCTD15 cd18388
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
62-158 5.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.


Pssm-ID: 349696  Cd Length: 99  Bit Score: 41.13  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  62 VNVGGQRYLLPWSTLDAFPLSRLSRLrlCRSHEEITqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCALS 141
Cdd:cd18388     6 IDVGGHMYTSSLATLTKYPDSRISRL--FNGTEPIV-----LDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFN 78
                          90       100
                  ....*....|....*....|
gi 1269208329 142 -FREELSYWGIEET--NLER 158
Cdd:cd18388    79 lLYEEAKYYQLQPMvkELER 98
BTB_POZ_KCTD3-like cd18363
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-151 1.39e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349672  Cd Length: 86  Bit Score: 39.66  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRsheeITQLCDDYDEdsqeFFFDRNPSAFGVIVSFLAAgKLVLLREMCA 139
Cdd:cd18363     4 INLNVGGKRFSTSRQTLTWIPDSFFTSLLSGR----ISSLKDETGA----IFIDRDPKLFSIILNYLRT-KEIDLRNVDI 74
                          90
                  ....*....|..
gi 1269208329 140 LSFREELSYWGI 151
Cdd:cd18363    75 SSLRHEAEFYGI 86
BTB_POZ_KCTD9 cd18368
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-153 1.82e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.


Pssm-ID: 349677 [Multi-domain]  Cd Length: 100  Bit Score: 39.94  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDA-FPLSRLSRLRLCRSHEEITQlcddydEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMC 138
Cdd:cd18368     3 IKLNVGGRIFTTTRSTLVKkEPDSMLARMFSDDSTWPSSR------DENGAYLIDRSPEYFEPILNYLRHGQLILNDGLN 76
                          90
                  ....*....|....*
gi 1269208329 139 ALSFREELSYWGIEE 153
Cdd:cd18368    77 PLGVLEEAKFFGIQS 91
BTB_POZ_KCNA5 cd18406
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-158 1.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 5 (KCNA5); KCNA5, also called HPCN1, voltage-gated potassium channel HK2, or voltage-gated potassium channel subunit Kv1.5, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA5 may play a role in regulating the secretion of insulin in normal pancreatic islets. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA5 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349713  Cd Length: 97  Bit Score: 39.85  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRL----SRLRLcrsheeitqlcddYDEDSQEFFFDRN-PSAFGVIVSFLAAGKLV 132
Cdd:cd18406     1 ERVIINIAGLRFETQLGTLNQFPDTLLgdpdKRMRY-------------FDPLRNEYFFDRNrPSFDGILYFYQSGGKIR 67
                          90       100
                  ....*....|....*....|....*.
gi 1269208329 133 LLREMCALSFREELSYWGIEETNLER 158
Cdd:cd18406    68 RPVNVSIDVFADEIRFYQLGEEAMER 93
BTB_POZ_KCTD3 cd18392
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-151 4.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349700  Cd Length: 88  Bit Score: 38.31  E-value: 4.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRsheeITQLCDDydedSQEFFFDRNPSAFGVIVSFLAAGKLVlLREMCA 139
Cdd:cd18392     4 IQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR----ISSLKDE----TGAIFIDRDPTAFVPILNFLRTKELD-LRGVNI 74
                          90
                  ....*....|..
gi 1269208329 140 LSFREELSYWGI 151
Cdd:cd18392    75 NVLRHEAEFYGI 86
BTB_POZ_KCNA7 cd18408
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
53-158 4.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349715  Cd Length: 115  Bit Score: 39.14  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  53 PEANLKEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHeeitqlcddYDEDSQEFFFDRNPSAFGVIVSFL-AAGKL 131
Cdd:cd18408     1 PCGCCERVVLNVAGLRFETRARTLGRFPDTLLGDPARRGRF---------YDDRRREYFFDRHRPSFDAVLYYYqSGGRL 71
                          90       100
                  ....*....|....*....|....*..
gi 1269208329 132 VLLREMCALSFREELSYWGIEETNLER 158
Cdd:cd18408    72 RRPAHVPLDVFLEEVAFYGLGAAALAR 98
BTB_POZ_KCTD7 cd18366
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
56-152 5.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349675  Cd Length: 92  Bit Score: 38.44  E-value: 5.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  56 NLKEIL-VNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHeeitqlcddYDEDSQ-EFFFDRNPSAFGVIVSFLAAGKLVl 133
Cdd:cd18366     1 QFPEVVpLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRHH---------IPKDSEgRYFIDRDGSYFGYILNFLRDGDLP- 70
                          90
                  ....*....|....*....
gi 1269208329 134 LREMCALSFREELsYWGIE 152
Cdd:cd18366    71 PRERARAVYKEAQ-YYGIG 88
BTB_POZ_Shaker-like cd18410
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-158 6.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shaker and similar proteins; Shaker, also termed protein minisleep, represents a family of putative potassium channel proteins in the nervous system of Drosophila. It is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Shaker plays a role in the regulation of sleep need or efficiency. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaker is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349717  Cd Length: 100  Bit Score: 38.37  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLS----RLRLcrsheeitqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVL 133
Cdd:cd18410     1 ERVVINVSGLRFETQLKTLNQFPDTLLGdpqrRNRY-------------YDPLRNEYFFDRNRPSFDAILYYYQSGGRLR 67
                          90       100
                  ....*....|....*....|....*.
gi 1269208329 134 LREMCALS-FREELSYWGIEETNLER 158
Cdd:cd18410    68 RPVNVPLDvFSEEIKFYELGENAFEK 93
BTB_POZ_KCTD6_like cd18365
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-133 1.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349674 [Multi-domain]  Cd Length: 94  Bit Score: 36.99  E-value: 1.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLSrlrlcrsheeiTQLCDDYD---EDSQEFFFDRNPSAFGVIVSFLAAGKLVL 133
Cdd:cd18365     3 VNLNVGGVHYTTTLATLTRFPDSMLG-----------AMFSGSMPttrDDQGNYFIDRDGTLFRYILNFLRSSQLSL 68
BTB_POZ_KCNA2_KCNA3 cd18403
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-157 2.57e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349711  Cd Length: 99  Bit Score: 36.49  E-value: 2.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLS----RLRLcrsheeitqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVL 133
Cdd:cd18403     1 ERVVINISGLRFETQLKTLAQFPETLLGdpkkRMRY-------------FDPLRNEYFFDRNRPSFDAILYYYQSGGRLR 67
                          90       100
                  ....*....|....*....|....*
gi 1269208329 134 LREMCALS-FREELSYWGIEETNLE 157
Cdd:cd18403    68 RPVNVPLDiFSEEIRFYELGEEAME 92
BTB_POZ_KCTD8-like cd18367
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
63-133 3.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349676  Cd Length: 100  Bit Score: 36.12  E-value: 3.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1269208329  63 NVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQlcddydeDSQ-EFFFDRNPSAFGVIVSFLAAGKLVL 133
Cdd:cd18367     8 NVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQELAR-------DSKgRYFLDRDGVLFRYILDYLRNQKLVL 72
BTB_POZ_KCNA10 cd18409
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-131 3.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349716  Cd Length: 87  Bit Score: 35.97  E-value: 3.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1269208329  58 KEILVNVGGQRYLLPWSTLDAFPLSRLSrlrlcrsheEITQLCDDYDEDSQEFFFDRN-PSAFGVIVSFLAAGKL 131
Cdd:cd18409     1 QKVIINIAGLRFETQLKTLDQFPDTLLG---------DPEKRMKYFDSMRNEYFFDRNrPSFDGILYYYQSGGKI 66
BTB_POZ_Kv1_KCNA cd18377
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
60-129 6.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349686  Cd Length: 85  Bit Score: 34.96  E-value: 6.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1269208329  60 ILVNVGGQRYLLPWSTLDAFPLSRLS----RLRLcrsheeitqlcddYDEDSQEFFFDRNPSAFGVIVSFLAAG 129
Cdd:cd18377     3 VVINVSGLRFETQLKTLAQFPNTLLGdpnkRMRF-------------FDPLRNEYFFDRNRPSFDAILYYYQSG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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