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Conserved domains on  [gi|1130619702|ref|NP_001335086|]
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zinc finger protein 525 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 231-282 8.55e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.55e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130619702 231 GEKPYKCN--ECGKSFSQMSSLTYHhRLH--------------------TGEKPYKCEECDKAFRHNSALQRHR 282
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-302 1.24e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 277 ALQRHRRIHTGEKPHKCNECGKTFSQ 302
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-357 2.01e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702  94 HAGNKPIKYQLGSSFHsHLSELHIFQPKGKINNQVEKSINDASSVSTAQRISC-RPKTHISNNYGDNFLNYSLLTQRQEV 172
Cdd:COG5048   203 SPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSsSASESPRSSLPTASSQSSSPNESDSS 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 173 --RMREKSFQCIESGKAFNYSSLLRKHQ--IIHLGE--KQYKCDV--CDKVFIRKRYLARHRRCHTGEKPYKCNECGKSF 244
Cdd:COG5048   282 seKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 245 SQMSSLTYHHRLHTgekpykceecdkafrhnsalqRHRRIHTGEKPHKC--NECGKTFSQKSYLACHRSIHTGKKPYECE 322
Cdd:COG5048   362 KFSPLLNNEPPQSL---------------------QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1130619702 323 --ECDKAFSFKSNLESHRITHTGEKPYKCNDCGKTFS 357
Cdd:COG5048   421 npPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
389-414 9.64e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 389 SLERHRRIHNGEKLYKCNECGKTFSQ 414
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 231-282 8.55e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.55e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130619702 231 GEKPYKCN--ECGKSFSQMSSLTYHhRLH--------------------TGEKPYKCEECDKAFRHNSALQRHR 282
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-302 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 277 ALQRHRRIHTGEKPHKCNECGKTFSQ 302
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-357 2.01e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702  94 HAGNKPIKYQLGSSFHsHLSELHIFQPKGKINNQVEKSINDASSVSTAQRISC-RPKTHISNNYGDNFLNYSLLTQRQEV 172
Cdd:COG5048   203 SPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSsSASESPRSSLPTASSQSSSPNESDSS 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 173 --RMREKSFQCIESGKAFNYSSLLRKHQ--IIHLGE--KQYKCDV--CDKVFIRKRYLARHRRCHTGEKPYKCNECGKSF 244
Cdd:COG5048   282 seKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 245 SQMSSLTYHHRLHTgekpykceecdkafrhnsalqRHRRIHTGEKPHKC--NECGKTFSQKSYLACHRSIHTGKKPYECE 322
Cdd:COG5048   362 KFSPLLNNEPPQSL---------------------QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1130619702 323 --ECDKAFSFKSNLESHRITHTGEKPYKCNDCGKTFS 357
Cdd:COG5048   421 npPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
221-246 3.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 221 YLARHRRCHTGEKPYKCNECGKSFSQ 246
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-358 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 333 NLESHRITHTGEKPYKCNDCGKTFSH 358
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
389-414 9.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 389 SLERHRRIHNGEKLYKCNECGKTFSQ 414
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 231-282 8.55e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 8.55e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130619702 231 GEKPYKCN--ECGKSFSQMSSLTYHhRLH--------------------TGEKPYKCEECDKAFRHNSALQRHR 282
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-302 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 277 ALQRHRRIHTGEKPHKCNECGKTFSQ 302
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-357 2.01e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702  94 HAGNKPIKYQLGSSFHsHLSELHIFQPKGKINNQVEKSINDASSVSTAQRISC-RPKTHISNNYGDNFLNYSLLTQRQEV 172
Cdd:COG5048   203 SPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSsSASESPRSSLPTASSQSSSPNESDSS 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 173 --RMREKSFQCIESGKAFNYSSLLRKHQ--IIHLGE--KQYKCDV--CDKVFIRKRYLARHRRCHTGEKPYKCNECGKSF 244
Cdd:COG5048   282 seKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 245 SQMSSLTYHHRLHTgekpykceecdkafrhnsalqRHRRIHTGEKPHKC--NECGKTFSQKSYLACHRSIHTGKKPYECE 322
Cdd:COG5048   362 KFSPLLNNEPPQSL---------------------QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1130619702 323 --ECDKAFSFKSNLESHRITHTGEKPYKCNDCGKTFS 357
Cdd:COG5048   421 npPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
221-246 3.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 221 YLARHRRCHTGEKPYKCNECGKSFSQ 246
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-358 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 333 NLESHRITHTGEKPYKCNDCGKTFSH 358
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 260-366 1.86e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 260 EKPYKCEECDKAFRHNSALQ---RHRRIHT-GEKPHKCN--ECGKTFSQKSYLACHRsIHTGKKPYECEECDKafsfksn 333
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNidtPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP------- 386

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1130619702 334 lESHRITHTGEKPYKCNDCGKTFSHMSTLTCHR 366
Cdd:COG5189   387 -EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
233-313 2.95e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130619702 233 KPYKCNECGKSFSQMSSLTYHHRLHTGEKPYKC--EECDKAFRHNSALQRHRRIHTGEKPHKCNecgKTFSQKSYLACHR 310
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108


                  ...
gi 1130619702 311 SIH 313
Cdd:COG5048   109 SLS 111
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-274 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 249 SLTYHHRLHTGEKPYKCEECDKAFRH 274
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 263-285 6.54e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.54e-03
                          10        20
                  ....*....|....*....|...
gi 1130619702 263 YKCEECDKAFRHNSALQRHRRIH 285
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
389-414 9.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1130619702 389 SLERHRRIHNGEKLYKCNECGKTFSQ 414
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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