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Conserved domains on  [gi|1099520071|ref|NP_001333791|]
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tuftelin-interacting protein 11 isoform 2 [Homo sapiens]

Protein Classification

G-patch and GCFC domain-containing protein( domain architecture ID 10323083)

protein containing domains TIP_N, G-patch, and GCFC

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
 366-635 6.34e-133

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


:

Pssm-ID: 400273  Cd Length: 275  Bit Score: 396.05  E-value: 6.34e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 366 LDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADA 445
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDILSRWRKLLEPDVSSDDTGGRESMDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 446 FHRLIWEVWMPFVRN-IVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTV-----PIHS 519
Cdd:pfam07842  81 YETMLWEGWLPSYRSsIISTWDPRDPDPMLALLEAWAPLLPSWILDNILEQLILPKLTAAVEEWDPLSDTVtrnlvPIHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 520 WIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSsAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQ 599
Cdd:pfam07842 161 WIHPWLPLLGARLEPLYPDIRRKLRQALDAWHPSRS-ALAGLKPWKDVFSPGEWDKFLRRHILPKLALALQEFVINPRQQ 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1099520071 600 HMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVL 635
Cdd:pfam07842 240 SLELFRNVLKWKDLLPPSVLADLLEKEFFPKWLQVL 275
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 118-162 5.87e-18

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 77.93  E-value: 5.87e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1099520071 118 TKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 162
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
TIP_N super family cl13843
Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is ...
 39-73 2.98e-05

Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with pfam08697, pfam01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralization of enamel - tuftelin.


The actual alignment was detected with superfamily member pfam12457:

Pssm-ID: 463593  Cd Length: 94  Bit Score: 43.51  E-value: 2.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1099520071  39 GARDYSAPVNFISAGLKKGAAEEAELEDSDDEEKP 73
Cdd:pfam12457  60 GRKDYTKPVAFVSGGIQQPGKKDKEIDDDSDDEEE 94
 
Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
 366-635 6.34e-133

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


Pssm-ID: 400273  Cd Length: 275  Bit Score: 396.05  E-value: 6.34e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 366 LDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADA 445
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDILSRWRKLLEPDVSSDDTGGRESMDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 446 FHRLIWEVWMPFVRN-IVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTV-----PIHS 519
Cdd:pfam07842  81 YETMLWEGWLPSYRSsIISTWDPRDPDPMLALLEAWAPLLPSWILDNILEQLILPKLTAAVEEWDPLSDTVtrnlvPIHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 520 WIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSsAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQ 599
Cdd:pfam07842 161 WIHPWLPLLGARLEPLYPDIRRKLRQALDAWHPSRS-ALAGLKPWKDVFSPGEWDKFLRRHILPKLALALQEFVINPRQQ 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1099520071 600 HMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVL 635
Cdd:pfam07842 240 SLELFRNVLKWKDLLPPSVLADLLEKEFFPKWLQVL 275
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 118-162 5.87e-18

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 77.93  E-value: 5.87e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1099520071 118 TKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 162
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 117-162 9.26e-16

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 71.81  E-value: 9.26e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1099520071  117 HTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 162
Cdd:smart00443   2 STSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47
TIP_N pfam12457
Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is ...
 39-73 2.98e-05

Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with pfam08697, pfam01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralization of enamel - tuftelin.


Pssm-ID: 463593  Cd Length: 94  Bit Score: 43.51  E-value: 2.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1099520071  39 GARDYSAPVNFISAGLKKGAAEEAELEDSDDEEKP 73
Cdd:pfam12457  60 GRKDYTKPVAFVSGGIQQPGKKDKEIDDDSDDEEE 94
 
Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
 366-635 6.34e-133

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


Pssm-ID: 400273  Cd Length: 275  Bit Score: 396.05  E-value: 6.34e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 366 LDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADA 445
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDILSRWRKLLEPDVSSDDTGGRESMDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 446 FHRLIWEVWMPFVRN-IVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTV-----PIHS 519
Cdd:pfam07842  81 YETMLWEGWLPSYRSsIISTWDPRDPDPMLALLEAWAPLLPSWILDNILEQLILPKLTAAVEEWDPLSDTVtrnlvPIHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1099520071 520 WIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSsAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQ 599
Cdd:pfam07842 161 WIHPWLPLLGARLEPLYPDIRRKLRQALDAWHPSRS-ALAGLKPWKDVFSPGEWDKFLRRHILPKLALALQEFVINPRQQ 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1099520071 600 HMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVL 635
Cdd:pfam07842 240 SLELFRNVLKWKDLLPPSVLADLLEKEFFPKWLQVL 275
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 118-162 5.87e-18

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 77.93  E-value: 5.87e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1099520071 118 TKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 162
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 117-162 9.26e-16

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 71.81  E-value: 9.26e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1099520071  117 HTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 162
Cdd:smart00443   2 STSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 120-161 4.27e-06

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 44.58  E-value: 4.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1099520071 120 GIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGA 161
Cdd:pfam12656  16 EFGAAMLRGMGWKPGQGIGKNKKGDVKPKEYKRRPGGLGLGA 57
TIP_N pfam12457
Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is ...
 39-73 2.98e-05

Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with pfam08697, pfam01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralization of enamel - tuftelin.


Pssm-ID: 463593  Cd Length: 94  Bit Score: 43.51  E-value: 2.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1099520071  39 GARDYSAPVNFISAGLKKGAAEEAELEDSDDEEKP 73
Cdd:pfam12457  60 GRKDYTKPVAFVSGGIQQPGKKDKEIDDDSDDEEE 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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