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Conserved domains on  [gi|542133052|ref|NP_001269422|]
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golgin subfamily A member 8K [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GOLGA2L5 super family cl25923
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 226-509 1.77e-38

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


The actual alignment was detected with superfamily member pfam15070:

Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 149.06  E-value: 1.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  226 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVP-- 303
Cdd:pfam15070   1 QLMESLKQLQTERDQYAENLKEEGAVWQQKMQQLSEQVRTLREEKERSVSQVQELETSLAELKNQAAVPPAEEEQPPAgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  304 SEVE------LQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSL------------- 364
Cdd:pfam15070  81 SEEEqrlqeeAEQLQKELEALAGQLQAQVQDNEQLSRLNQEQEQRLLELERAAERWGEQAEDRKQILedmqsdratisra 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  365 --------QQLAKPQSVFEEPNNEN---KNALQLEQQVK--------ELQEKLGE------------------------- 400
Cdd:pfam15070 161 lsqnrelkEQLAELQNGFVKLTNENmelTSALQSEQHVKkelakklgQLQEELGElketlelksqeaqslqeqrdqylah 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  401 ------------------------------------------------------EHLEAASQQNQQLTAQLSLMALPGEG 426
Cdd:pfam15070 241 lqqyvaayqqlasekeelhkqyllqtqlmdrlqheevqgkvaaemarqelqetqERLEALTQQNQQLQAQLSLLANPGEG 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  427 HGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHL-----KEKADLSELVKKElcfihhwrDRRHQKTHHLLS----EP 497
Cdd:pfam15070 321 DGLESEEEEEEAPRPSLSIPEDFESREAMVAFFNSAlaqaeEERAELRRQLKEQ--------KRRCRRLAQQAApaqeEP 392

                         410
                  ....*....|..
gi 542133052  498 GGCAKDAALGGG 509
Cdd:pfam15070 393 EHEAHAPGTGGD 404
GM130_C pfam19046
GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 ...
 591-630 4.14e-14

GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 protein that is bound by the GRASP65 PDZ domain pfam04495.


:

Pssm-ID: 465957  Cd Length: 46  Bit Score: 66.64  E-value: 4.14e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 542133052  591 PLLDKPTAQPIV------QDHKEHPGLGSNCCVPLFCWAWLPRRRR 630
Cdd:pfam19046   1 SPPENPTAQQIMqllpeiQNPQEHPGLGSNPCIPFFYRADENDEVK 46
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 86-290 2.39e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  86 LDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLryfEEKSKD 165
Cdd:COG4942   29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL---EAQKEE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 166 LA--VRLQHSLQRKGELESVLSNVMATQKKKA----NQLSSRSKARTEwKLEQSMREEALLKVQLTQLKESFQQVQLERD 239
Cdd:COG4942  106 LAelLRALYRLGRQPPLALLLSPEDFLDAVRRlqylKYLAPARREQAE-ELRADLAELAALRAELEAERAELEALLAELE 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 542133052 240 EYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQ 290
Cdd:COG4942  185 EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
 
Name Accession Description Interval E-value
GOLGA2L5 pfam15070
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 226-509 1.77e-38

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 149.06  E-value: 1.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  226 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVP-- 303
Cdd:pfam15070   1 QLMESLKQLQTERDQYAENLKEEGAVWQQKMQQLSEQVRTLREEKERSVSQVQELETSLAELKNQAAVPPAEEEQPPAgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  304 SEVE------LQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSL------------- 364
Cdd:pfam15070  81 SEEEqrlqeeAEQLQKELEALAGQLQAQVQDNEQLSRLNQEQEQRLLELERAAERWGEQAEDRKQILedmqsdratisra 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  365 --------QQLAKPQSVFEEPNNEN---KNALQLEQQVK--------ELQEKLGE------------------------- 400
Cdd:pfam15070 161 lsqnrelkEQLAELQNGFVKLTNENmelTSALQSEQHVKkelakklgQLQEELGElketlelksqeaqslqeqrdqylah 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  401 ------------------------------------------------------EHLEAASQQNQQLTAQLSLMALPGEG 426
Cdd:pfam15070 241 lqqyvaayqqlasekeelhkqyllqtqlmdrlqheevqgkvaaemarqelqetqERLEALTQQNQQLQAQLSLLANPGEG 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  427 HGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHL-----KEKADLSELVKKElcfihhwrDRRHQKTHHLLS----EP 497
Cdd:pfam15070 321 DGLESEEEEEEAPRPSLSIPEDFESREAMVAFFNSAlaqaeEERAELRRQLKEQ--------KRRCRRLAQQAApaqeEP 392

                         410
                  ....*....|..
gi 542133052  498 GGCAKDAALGGG 509
Cdd:pfam15070 393 EHEAHAPGTGGD 404
GM130_C pfam19046
GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 ...
 591-630 4.14e-14

GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 protein that is bound by the GRASP65 PDZ domain pfam04495.


Pssm-ID: 465957  Cd Length: 46  Bit Score: 66.64  E-value: 4.14e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 542133052  591 PLLDKPTAQPIV------QDHKEHPGLGSNCCVPLFCWAWLPRRRR 630
Cdd:pfam19046   1 SPPENPTAQQIMqllpeiQNPQEHPGLGSNPCIPFFYRADENDEVK 46
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 80-416 1.99e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.27  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  80 QERAVVLD--SRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLR 157
Cdd:COG1196  219 KEELKELEaeLLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELA 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 158 YFEEKSKDLAVRLQHSLQRKGELEsvlsnvmATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLtQLKESFQQVQLE 237
Cdd:COG1196  299 RLEQDIARLEERRRELEERLEELE-------EELAELEEELEELEEELEELEEELEEAEEELEEAEA-ELAEAEEALLEA 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 238 RDEYSEHLKGERARWQQRMRKMSQEIcTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELER 317
Cdd:COG1196  371 EAELAEAEEELEELAEELLEALRAAA-ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 318 VAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAK-----PQSVFEEPNNENKN----ALQLE 388
Cdd:COG1196  450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAdyegfLEGVKAALLLAGLRglagAVAVL 529

                        330       340
                 ....*....|....*....|....*...
gi 542133052 389 QQVKELQEKLGEEHLEAASQQNQQLTAQ 416
Cdd:COG1196  530 IGVEAAYEAALEAALAAALQNIVVEDDE 557
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 80-374 1.99e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.84  E-value: 1.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052    80 QERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYF 159
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   160 EEKSKDLAVRLQHSLQRKGELESVLSNVMAtQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQlERD 239
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELES-KLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE-ELE 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   240 EYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKL-----KNQMAEPLPPEPPAVPSEVELQHLRKE 314
Cdd:TIGR02168  379 EQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELlkkleEAELKELQAELEELEEELEELQEELER 458

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   315 LERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVF 374
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGL 518
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 86-290 2.39e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  86 LDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLryfEEKSKD 165
Cdd:COG4942   29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL---EAQKEE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 166 LA--VRLQHSLQRKGELESVLSNVMATQKKKA----NQLSSRSKARTEwKLEQSMREEALLKVQLTQLKESFQQVQLERD 239
Cdd:COG4942  106 LAelLRALYRLGRQPPLALLLSPEDFLDAVRRlqylKYLAPARREQAE-ELRADLAELAALRAELEAERAELEALLAELE 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 542133052 240 EYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQ 290
Cdd:COG4942  185 EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
PRK11281 PRK11281
mechanosensitive channel MscK;
216-416 1.38e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.82  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  216 EEALLKVQLTQLKESFQQVQLERDEySEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRR------VEKLERSLSKLKN 289
Cdd:PRK11281   57 EDKLVQQDLEQTLALLDKIDRQKEE-TEQLKQQLAQAPAKLRQAQAELEALKDDNDEETREtlstlsLRQLESRLAQTLD 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  290 QMAEPLPPEPPAVPSEVELQhlrKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQ--------EERIQEQH 361
Cdd:PRK11281  136 QLQNAQNDLAEYNSQLVSLQ---TQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRPSQRVLlqaeqallNAQNDLQR 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 542133052  362 KSLQQLAKPQSVFEEPNNE-NKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQ 416
Cdd:PRK11281  213 KSLEGNTQLQDLLQKQRDYlTARIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQ 268
 
Name Accession Description Interval E-value
GOLGA2L5 pfam15070
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 226-509 1.77e-38

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 149.06  E-value: 1.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  226 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVP-- 303
Cdd:pfam15070   1 QLMESLKQLQTERDQYAENLKEEGAVWQQKMQQLSEQVRTLREEKERSVSQVQELETSLAELKNQAAVPPAEEEQPPAgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  304 SEVE------LQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSL------------- 364
Cdd:pfam15070  81 SEEEqrlqeeAEQLQKELEALAGQLQAQVQDNEQLSRLNQEQEQRLLELERAAERWGEQAEDRKQILedmqsdratisra 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  365 --------QQLAKPQSVFEEPNNEN---KNALQLEQQVK--------ELQEKLGE------------------------- 400
Cdd:pfam15070 161 lsqnrelkEQLAELQNGFVKLTNENmelTSALQSEQHVKkelakklgQLQEELGElketlelksqeaqslqeqrdqylah 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  401 ------------------------------------------------------EHLEAASQQNQQLTAQLSLMALPGEG 426
Cdd:pfam15070 241 lqqyvaayqqlasekeelhkqyllqtqlmdrlqheevqgkvaaemarqelqetqERLEALTQQNQQLQAQLSLLANPGEG 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  427 HGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHL-----KEKADLSELVKKElcfihhwrDRRHQKTHHLLS----EP 497
Cdd:pfam15070 321 DGLESEEEEEEAPRPSLSIPEDFESREAMVAFFNSAlaqaeEERAELRRQLKEQ--------KRRCRRLAQQAApaqeEP 392

                         410
                  ....*....|..
gi 542133052  498 GGCAKDAALGGG 509
Cdd:pfam15070 393 EHEAHAPGTGGD 404
GM130_C pfam19046
GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 ...
 591-630 4.14e-14

GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 protein that is bound by the GRASP65 PDZ domain pfam04495.


Pssm-ID: 465957  Cd Length: 46  Bit Score: 66.64  E-value: 4.14e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 542133052  591 PLLDKPTAQPIV------QDHKEHPGLGSNCCVPLFCWAWLPRRRR 630
Cdd:pfam19046   1 SPPENPTAQQIMqllpeiQNPQEHPGLGSNPCIPFFYRADENDEVK 46
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 80-416 1.99e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.27  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  80 QERAVVLD--SRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLR 157
Cdd:COG1196  219 KEELKELEaeLLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELA 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 158 YFEEKSKDLAVRLQHSLQRKGELEsvlsnvmATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLtQLKESFQQVQLE 237
Cdd:COG1196  299 RLEQDIARLEERRRELEERLEELE-------EELAELEEELEELEEELEELEEELEEAEEELEEAEA-ELAEAEEALLEA 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 238 RDEYSEHLKGERARWQQRMRKMSQEIcTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELER 317
Cdd:COG1196  371 EAELAEAEEELEELAEELLEALRAAA-ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 318 VAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAK-----PQSVFEEPNNENKN----ALQLE 388
Cdd:COG1196  450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAdyegfLEGVKAALLLAGLRglagAVAVL 529

                        330       340
                 ....*....|....*....|....*...
gi 542133052 389 QQVKELQEKLGEEHLEAASQQNQQLTAQ 416
Cdd:COG1196  530 IGVEAAYEAALEAALAAALQNIVVEDDE 557
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 80-374 1.99e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.84  E-value: 1.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052    80 QERAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYF 159
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   160 EEKSKDLAVRLQHSLQRKGELESVLSNVMAtQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQlERD 239
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELES-KLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE-ELE 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   240 EYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKL-----KNQMAEPLPPEPPAVPSEVELQHLRKE 314
Cdd:TIGR02168  379 EQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELlkkleEAELKELQAELEELEEELEELQEELER 458

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   315 LERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVF 374
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGL 518
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 93-413 4.18e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.95  E-value: 4.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  93 ISQLKNTIKSLKQQKKQVE--HQLEEEKKANNKK---------QKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEE 161
Cdd:COG1196  195 LGELERQLEPLERQAEKAEryRELKEELKELEAEllllklrelEAELEELEAELEELEAELEELEAELAELEAELEELRL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 162 KSKDLAVRLQHSLQRKGELES---VLSNVMATQKKKANQLSSRsKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLER 238
Cdd:COG1196  275 ELEELELELEEAQAEEYELLAelaRLEQDIARLEERRRELEER-LEELEEELAELEEELEELEEELEELEEELEEAEEEL 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 239 DEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERV 318
Cdd:COG1196  354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 319 AGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLakpqsvfEEPNNENKNALQLEQQVKELQEKL 398
Cdd:COG1196  434 EEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAEL-------LEELAEAAARLLLLLEAEADYEGF 506

                        330
                 ....*....|....*
gi 542133052 399 GEEHLEAASQQNQQL 413
Cdd:COG1196  507 LEGVKAALLLAGLRG 521
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 97-454 2.57e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.37  E-value: 2.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052    97 KNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQR 176
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   177 KGELESvlsnvmatqkkkanqlssrSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQQrm 256
Cdd:TIGR02168  756 LTELEA-------------------EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTL-- 814

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   257 rkmsqeictLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKKNQrislln 336
Cdd:TIGR02168  815 ---------LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALL------ 879

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   337 qrqeeriqeqeERLRKQEERIQEQHKSLQQLAkpqsvfEEPNNENKNALQLEQQVKELQEKLG--EEHLEAASQQNQQLT 414
Cdd:TIGR02168  880 -----------NERASLEEALALLRSELEELS------EELRELESKRSELRRELEELREKLAqlELRLEGLEVRIDNLQ 942

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 542133052   415 AQLSlmalpgeghgEHLDSEGEEAPQPMPSVPEDLESREA 454
Cdd:TIGR02168  943 ERLS----------EEYSLTLEEAEALENKIEDDEEEARR 972
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 86-290 2.39e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  86 LDSRSVEISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLryfEEKSKD 165
Cdd:COG4942   29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL---EAQKEE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 166 LA--VRLQHSLQRKGELESVLSNVMATQKKKA----NQLSSRSKARTEwKLEQSMREEALLKVQLTQLKESFQQVQLERD 239
Cdd:COG4942  106 LAelLRALYRLGRQPPLALLLSPEDFLDAVRRlqylKYLAPARREQAE-ELRADLAELAALRAELEAERAELEALLAELE 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 542133052 240 EYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQ 290
Cdd:COG4942  185 EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 100-425 1.61e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.60  E-value: 1.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   100 IKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEElnTDLYHMKRSlryfEEKSKDLAVRLQHSLQRKGE 179
Cdd:TIGR02168  167 ISKYKERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEK--AERYKELKA----ELRELELALLVLRLEELREE 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   180 LESVLSNVMATQKKKaNQLSSRSKARTEwKLEQSMREEALLKVQLTQLKESFQQVQLERDEysehLKGERARWQQRMRKM 259
Cdd:TIGR02168  241 LEELQEELKEAEEEL-EELTAELQELEE-KLEELRLEVSELEEEIEELQKELYALANEISR----LEQQKQILRERLANL 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   260 SQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQV-KKNQRISLLnqr 338
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLeTLRSKVAQL--- 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   339 qeeriqeqEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQlEQQVKELQEKLGEEHLEAASQQNQQLTAQLS 418
Cdd:TIGR02168  392 --------ELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLE-EAELKELQAELEELEEELEELQEELERLEEA 462


                   ....*..
gi 542133052   419 LMALPGE 425
Cdd:TIGR02168  463 LEELREE 469
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 98-291 7.80e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 7.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  98 NTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRK 177
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 178 GELESVLSNVMATQKKKANQ------LSSRSKARTEWKLE------QSMREEAL-LKVQLTQLKESFQQVQLERDEYSEH 244
Cdd:COG4942  100 EAQKEELAELLRALYRLGRQpplallLSPEDFLDAVRRLQylkylaPARREQAEeLRADLAELAALRAELEAERAELEAL 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 542133052 245 LKG---ERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQM 291
Cdd:COG4942  180 LAEleeERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI 229
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 113-401 1.30e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   113 QLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSNVMATQK 192
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   193 KKANQlsSRSKARTEWKLEQSMREEALLKVQLTQLKESF--QQVQLERDEYSEhLKGERARWQQRMRKMSQEICTLKKEK 270
Cdd:TIGR02169  752 EIENV--KSELKELEARIEELEEDLHKLEEALNDLEARLshSRIPEIQAELSK-LEEEVSRIEARLREIEQKLNRLTLEK 828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   271 QQDMRRVEKLERSLSKLKNQMAEPLPpeppavpsEVELQHLRK-ELERVAGELQAQVKK--NQRISLlnqrqEERIQEQE 347
Cdd:TIGR02169  829 EYLEKEIQELQEQRIDLKEQIKSIEK--------EIENLNGKKeELEEELEELEAALRDleSRLGDL-----KKERDELE 895

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 542133052   348 ERLRKQEERIQEQHKSLQQLAKPQSVFEEpnnenknALQ-LEQQVKELQEKLGEE 401
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKKRKRLSELKA-------KLEaLEEELSEIEDPKGED 943
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 209-419 1.35e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 209 KLEQSMREEALLKVQLTQLKESFQQVQLERDEYsehlkgerarwQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLK 288
Cdd:COG1196  254 ELEELEAELAELEAELEELRLELEELELELEEA-----------QAEEYELLAELARLEQDIARLEERRRELEERLEELE 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 289 NQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKKNQRisllnqrqeeRIQEQEERLRKQEERIQEQHKSLQQLA 368
Cdd:COG1196  323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEE----------ALLEAEAELAEAEEELEELAEELLEAL 392

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 542133052 369 KPQSVFEepnNENKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSL 419
Cdd:COG1196  393 RAAAELA---AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEE 440
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 93-413 1.61e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.63  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   93 ISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLA---VR 169
Cdd:TIGR04523 119 KNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKnklLK 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  170 LQHSL-------QRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEAL--LKVQLTQLKESFQQVQLERDE 240
Cdd:TIGR04523 199 LELLLsnlkkkiQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLnqLKDEQNKIKKQLSEKQKELEQ 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  241 YSEHLKGERARWQQrmrkMSQEICTLKKEKQQDMRRVEKlerslSKLKNQmaeplppeppavpsEVELQHLRKELervag 320
Cdd:TIGR04523 279 NNKKIKELEKQLNQ----LKSEISDLNNQKEQDWNKELK-----SELKNQ--------------EKKLEEIQNQI----- 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  321 elqaqVKKNQRISLLNQR----QEERIQEQEERLRKQEErIQEQHKSLQQLAKP-QSVFEEPNN--ENKNALQLEQQVKE 393
Cdd:TIGR04523 331 -----SQNNKIISQLNEQisqlKKELTNSESENSEKQRE-LEEKQNEIEKLKKEnQSYKQEIKNleSQINDLESKIQNQE 404

                         330       340
                  ....*....|....*....|
gi 542133052  394 LQEKLGEEHLEAASQQNQQL 413
Cdd:TIGR04523 405 KLNQQKDEQIKKLQQEKELL 424
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 220-419 1.94e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 220 LKVQLTQLK------ESFQQVQLERDEYSEHLKGERARW-QQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMA 292
Cdd:COG1196  198 LERQLEPLErqaekaERYRELKEELKELEAELLLLKLRElEAELEELEAELEELEAELEELEAELAELEAELEELRLELE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 293 EPLPPEPPAVPsevELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKpqs 372
Cdd:COG1196  278 ELELELEEAQA---EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE--- 351

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 542133052 373 VFEEPNNENKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSL 419
Cdd:COG1196  352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 103-467 2.85e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 43.94  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  103 LKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELES 182
Cdd:pfam05483 217 LKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTK 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  183 VLSNVMATqkkkanqlssrskartewkLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQE 262
Cdd:pfam05483 297 ELEDIKMS-------------------LQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEAT 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  263 ICTLKKEKQQDMRRVEKLERSLS----KLKNQMAEPLPPEPPAVPSEVELQhlrkELERVAGELQAQVKKNQRISLLNQR 338
Cdd:pfam05483 358 TCSLEELLRTEQQRLEKNEDQLKiitmELQKKSSELEEMTKFKNNKEVELE----ELKKILAEDEKLLDEKKQFEKIAEE 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  339 QEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQqvkeLQEKLGEEHLEAASQQNQQLTAQLS 418
Cdd:pfam05483 434 LKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK----LKNIELTAHCDKLLLENKELTQEAS 509

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 542133052  419 LMALPGEGHGEHLDSEGEEAPQPMPSVpEDLESREA-----MSSFMDHLKEKAD 467
Cdd:pfam05483 510 DMTLELKKHQEDIINCKKQEERMLKQI-ENLEEKEMnlrdeLESVREEFIQKGD 562
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
113-424 3.31e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 3.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 113 QLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTDLYHMKRSLRyfeekSKDLAVRLQHSLQRKGELESVLSNVMAtqk 192
Cdd:COG4717   75 ELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELE-----KLEKLLQLLPLYQELEALEAELAELPE--- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 193 kKANQLSSRSKARTEWKLEQSMREEALLKVQlTQLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQ 272
Cdd:COG4717  147 -RLEELEERLEELRELEEELEELEAELAELQ-EELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEE 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 273 DMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEV-----ELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQE 347
Cdd:COG4717  225 LEEELEQLENELEAAALEERLKEARLLLLIAAALlallgLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEA 304

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542133052 348 ERLRKQEERIQEQHKSLQQLAKPQSVfeEPNNENKNALQLEQQVKELQEKLGE-EHLEAASQQNQQLTAQLSLMALPG 424
Cdd:COG4717  305 EELQALPALEELEEEELEELLAALGL--PPDLSPEELLELLDRIEELQELLREaEELEEELQLEELEQEIAALLAEAG 380
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 92-417 3.83e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052   92 EISQLKNTIKSLKQQKKQVEHQLEEEKKANNKKQKAKRVLEVQIQTLNIQKEELNTD-----LYHMKRSLRYFEEKSKDL 166
Cdd:TIGR04523 247 EISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQkeqdwNKELKSELKNQEKKLEEI 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  167 AVRLQHSLQRKGELESVLSNVmatQKKKANQLSSRSKARTEwkLEQSMREEALLKVQLTQLKESFQQVQLERDEysehLK 246
Cdd:TIGR04523 327 QNQISQNNKIISQLNEQISQL---KKELTNSESENSEKQRE--LEEKQNEIEKLKKENQSYKQEIKNLESQIND----LE 397

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  247 GERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQV 326
Cdd:TIGR04523 398 SKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSI 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  327 KKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQlaKPQSVFEEPNNENKNALQLEQQVKELQEKLGE------ 400
Cdd:TIGR04523 478 NKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTK--KISSLKEKIEKLESEKKEKESKISDLEDELNKddfelk 555

                         330
                  ....*....|....*...
gi 542133052  401 -EHLEAASQQNQQLTAQL 417
Cdd:TIGR04523 556 kENLEKEIDEKNKEIEEL 573
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
192-422 5.64e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 5.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 192 KKKANQLSSRSKARTEWKLEQSMREEALLKvQLTQLKESFQQVQLERDEYS---EHLKGERARWQQRMRKMSQEIctlkk 268
Cdd:COG4717   52 EKEADELFKPQGRKPELNLKELKELEEELK-EAEEKEEEYAELQEELEELEeelEELEAELEELREELEKLEKLL----- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 269 EKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVkknQRISLLNQRQEERIQEQEE 348
Cdd:COG4717  126 QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELL---EQLSLATEEELQDLAEELE 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 542133052 349 RLRKQEERIQEQHKSLQQLAKpqsvfeepnnenknalQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMAL 422
Cdd:COG4717  203 ELQQRLAELEEELEEAQEELE----------------ELEEELEQLENELEAAALEERLKEARLLLLIAAALLA 260
PRK11281 PRK11281
mechanosensitive channel MscK;
216-416 1.38e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.82  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  216 EEALLKVQLTQLKESFQQVQLERDEySEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRR------VEKLERSLSKLKN 289
Cdd:PRK11281   57 EDKLVQQDLEQTLALLDKIDRQKEE-TEQLKQQLAQAPAKLRQAQAELEALKDDNDEETREtlstlsLRQLESRLAQTLD 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  290 QMAEPLPPEPPAVPSEVELQhlrKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQ--------EERIQEQH 361
Cdd:PRK11281  136 QLQNAQNDLAEYNSQLVSLQ---TQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRPSQRVLlqaeqallNAQNDLQR 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 542133052  362 KSLQQLAKPQSVFEEPNNE-NKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQ 416
Cdd:PRK11281  213 KSLEGNTQLQDLLQKQRDYlTARIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQ 268
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
169-404 3.74e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.43  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 169 RLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEALLKvqLTQLKESFQQVQLERDEYSEHLKGE 248
Cdd:PRK03918 180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKE--LEELKEEIEELEKELESLEGSKRKL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 249 RARWQQRMRKMsqeictlkKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKK 328
Cdd:PRK03918 258 EEKIRELEERI--------EELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER 329

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 542133052 329 NQRISllnqrqeeriqeqeerlrKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQVKELQEKLGEEHLE 404
Cdd:PRK03918 330 IKELE------------------EKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPE 387
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 161-419 4.27e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.75  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 161 EKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKANQLSSRSK--ARTEWKLEQSMREEALLKVQLTQLKESFQQVQLER 238
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERriAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 239 DEYSEHLKgERARWQQRMRKMSQEICTLKKEKQQDM-RRVEKLERSLSKLKNQMAeplppeppavpsevELQHLRKELER 317
Cdd:COG4942  100 EAQKEELA-ELLRALYRLGRQPPLALLLSPEDFLDAvRRLQYLKYLAPARREQAE--------------ELRADLAELAA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052 318 VAGELQAQVKKNQRIsllnqrqeerIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNE-NKNALQLEQQVKELQE 396
Cdd:COG4942  165 LRAELEAERAELEAL----------LAELEEERAALEALKAERQKLLARLEKELAELAAELAElQQEAEELEALIARLEA 234

                        250       260
                 ....*....|....*....|...
gi 542133052 397 KLGEEHLEAASQQNQQLTAQLSL 419
Cdd:COG4942  235 EAAAAAERTPAAGFAALKGKLPW 257
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 174-416 7.33e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  174 LQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQ 253
Cdd:pfam17380 312 VERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKN 391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  254 QRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVElqhlrKELERVAGELQAQVKKNQRIs 333
Cdd:pfam17380 392 ERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERA-----REMERVRLEEQERQQQVERL- 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  334 llnqrqeerIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQVKELQEKLGEEHLEAASQQNQQL 413
Cdd:pfam17380 466 ---------RQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRR 536


                  ...
gi 542133052  414 TAQ 416
Cdd:pfam17380 537 EAE 539
PTZ00121 PTZ00121
MAEBL; Provisional
 160-475 9.37e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  160 EEKSKDLAVRLQHSLQRKGELESVLSNVM--ATQKKKANQLSSRSKARTEWKLEQSMREEALLKVQLTQLKESFQQVQLE 237
Cdd:PTZ00121 1435 EAKKKAEEAKKADEAKKKAEEAKKAEEAKkkAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADE 1514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  238 RDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQmaeplppeppavpsEVELQHLRKELER 317
Cdd:PTZ00121 1515 AKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAE--------------EAKKAEEDKNMAL 1580

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133052  318 VAGELQAQVKKnQRISLLNQRQEERIQEQEERLRKQEEriqEQHKSlQQLAKPQSvfeepnnENKNALQLEQqvKELQEK 397
Cdd:PTZ00121 1581 RKAEEAKKAEE-ARIEEVMKLYEEEKKMKAEEAKKAEE---AKIKA-EELKKAEE-------EKKKVEQLKK--KEAEEK 1646

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 542133052  398 LGEEHLEAASQQNQQLTAQLSLMALPGEGHGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHLKEKADLSELVKKE 475
Cdd:PTZ00121 1647 KKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA 1724
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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