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Conserved domains on  [gi|407339777|ref|NP_001258400|]
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leucine-rich repeat-containing protein 51 isoform LRTOMT1d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.11e-06

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  52 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  116 ESLDLSGNQLTDL-------PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                         90
                 ....*....|
gi 407339777 132 LTLHGNPMEE 141
Cdd:COG4886  187 LDLSNNQITD 196
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.11e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  52 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  116 ESLDLSGNQLTDL-------PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                         90
                 ....*....|
gi 407339777 132 LTLHGNPMEE 141
Cdd:COG4886  187 LDLSNNQITD 196
LRR_8 pfam13855
Leucine rich repeat;
80-139 1.60e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 407339777   80 NLAWIDLSFNDLTSIDPvlTTFFNLS---VLYLHGNSIQRLGEvNKLAVLPRLRSLTLHGNPM 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD--GAFKGLSnlkVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-146 7.45e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 7.45e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 407339777  85 DLSFNDLTSIDPvLTTFFNLSVLYLHGNSIQRLGEVNK-LAVLPRLRSLTLHGNPMEEEKGYR 146
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYR 187
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.11e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  52 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  116 ESLDLSGNQLTDL-------PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKE 186

                         90
                 ....*....|
gi 407339777 132 LTLHGNPMEE 141
Cdd:COG4886  187 LDLSNNQITD 196
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-137 5.22e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 5.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  52 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEvnkLAVLPRLRS 131
Cdd:COG4886  185 KELDLSNNQITDL-------PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEE 254


                 ....*.
gi 407339777 132 LTLHGN 137
Cdd:COG4886  255 LDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.55e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  52 QSLWLNNNVLNDLRDFnqvasqlLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  139 KELDLSNNQLTDLPEP-------LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEE 209

                         90
                 ....*....|
gi 407339777 132 LTLHGNPMEE 141
Cdd:COG4886  210 LDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.76e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  52 QSLWLNNNVLNDLRDFnqvasqlLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAVLPRLRS 131
Cdd:COG4886  162 KSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLET 232

                         90
                 ....*....|
gi 407339777 132 LTLHGNPMEE 141
Cdd:COG4886  233 LDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 2.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  52 QSLWLNNNVLNDLrdfnqvaSQLLEHPENLAWIDLSFNDLTSIdPVLTTFFNLSVLYLHGNSIQRLGEvnkLAVLPRLRS 131
Cdd:COG4886  208 EELDLSGNQLTDL-------PEPLANLTNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPP---LANLTNLKT 276

                         90
                 ....*....|
gi 407339777 132 LTLHGNPMEE 141
Cdd:COG4886  277 LDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-141 6.02e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 6.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407339777  22 SIHVIQDLVNEEPRTGLRPLKRSKSGKSLTQSLWLNNNVLNDLRDFNQVASQLLEHPENLAWIDLSFNDLTSIDPVLTTF 101
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 407339777 102 FNLSVLYLHGNSIQRLGEVnkLAVLPRLRSLTLHGNPMEE 141
Cdd:COG4886  136 TNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTD 173
LRR_8 pfam13855
Leucine rich repeat;
80-139 1.60e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 407339777   80 NLAWIDLSFNDLTSIDPvlTTFFNLS---VLYLHGNSIQRLGEvNKLAVLPRLRSLTLHGNPM 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD--GAFKGLSnlkVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
89-146 3.01e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 3.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 407339777   89 NDLTSIDPVLTTFF-NLSVLYLHGNSIQRLGEVNKLAVLPRLRSLTLHGNPMEEEKGYR 146
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYR 132
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-146 7.45e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 7.45e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 407339777  85 DLSFNDLTSIDPvLTTFFNLSVLYLHGNSIQRLGEVNK-LAVLPRLRSLTLHGNPMEEEKGYR 146
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYR 187
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-137 3.43e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 35.92  E-value: 3.43e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 407339777  86 LSFND--LTSIDpVLTTFFNLSVLYLHGNSIQRLgevNKLAVLPRLRSLTLHGN 137
Cdd:cd21340    7 LYLNDknITKID-NLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNN 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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