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Conserved domains on  [gi|304376292|ref|NP_001182067|]
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GTPase IMAP family member GIMD1 [Homo sapiens]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 9-211 2.61e-25

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd01852:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 201  Bit Score: 97.61  E-value: 2.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292   9 INLALFGMTQSGKSSAGNILLGSTDFHSSFAPCSVTtccslgRSCHLHSFMRRGglevaLQVQVLDTPGYPHSRLSKKYV 88
Cdd:cd01852    1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVT------KTCQKESAVWDG-----RRVNVIDTPGLFDTSVSPEQL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292  89 KQEVKEALAHHFgqGGLHLALLVqradVPFCG--QEVTDPVQMIQELLGHAWMNYTAILFTHAEKIEeaGLTEDKYLHEA 166
Cdd:cd01852   70 SKEIIRCLSLSA--PGPHAFLLV----VPLGRftEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLE--GGSLEDYLEDS 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 304376292 167 SDTLKTLLNSIQHKYV-FQYK-KGKSLNEQRMKILERIMEFIKEN---CY 211
Cdd:cd01852  142 CEALKRLLEKCGGRYVaFNNKaKGREQEQQVKELLAKVEEMVRENggkPY 191
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 9-211 2.61e-25

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 97.61  E-value: 2.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292   9 INLALFGMTQSGKSSAGNILLGSTDFHSSFAPCSVTtccslgRSCHLHSFMRRGglevaLQVQVLDTPGYPHSRLSKKYV 88
Cdd:cd01852    1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVT------KTCQKESAVWDG-----RRVNVIDTPGLFDTSVSPEQL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292  89 KQEVKEALAHHFgqGGLHLALLVqradVPFCG--QEVTDPVQMIQELLGHAWMNYTAILFTHAEKIEeaGLTEDKYLHEA 166
Cdd:cd01852   70 SKEIIRCLSLSA--PGPHAFLLV----VPLGRftEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLE--GGSLEDYLEDS 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 304376292 167 SDTLKTLLNSIQHKYV-FQYK-KGKSLNEQRMKILERIMEFIKEN---CY 211
Cdd:cd01852  142 CEALKRLLEKCGGRYVaFNNKaKGREQEQQVKELLAKVEEMVRENggkPY 191
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 10-210 1.70e-18

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 79.96  E-value: 1.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292   10 NLALFGMTQSGKSSAGNILLGSTDFHSSFAPCSVTtccslgRSCHLHSFMRRGglevaLQVQVLDTPGYPHSRLSKKYVK 89
Cdd:pfam04548   2 RIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVT------KTCQLVSRTWDG-----RIINVIDTPGLFDLSVSNDFIS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292   90 QEVKEALahHFGQGGLHLALLVqrADVPFCGQEVTDPVQMIQELLGHAWMNYTAILFTHAEKIEEAGLteDKYLHEAS-D 168
Cdd:pfam04548  71 KEIIRCL--LLAEPGPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCpE 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 304376292  169 TLKTLLnsiqhkyvfQYKKGKSLNEQRMKILERIMEFIKENC 210
Cdd:pfam04548 145 FLKEVL---------RTADGEEKEEQVQQLLALVEAIVKENG 177
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 9-211 2.61e-25

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 97.61  E-value: 2.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292   9 INLALFGMTQSGKSSAGNILLGSTDFHSSFAPCSVTtccslgRSCHLHSFMRRGglevaLQVQVLDTPGYPHSRLSKKYV 88
Cdd:cd01852    1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVT------KTCQKESAVWDG-----RRVNVIDTPGLFDTSVSPEQL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292  89 KQEVKEALAHHFgqGGLHLALLVqradVPFCG--QEVTDPVQMIQELLGHAWMNYTAILFTHAEKIEeaGLTEDKYLHEA 166
Cdd:cd01852   70 SKEIIRCLSLSA--PGPHAFLLV----VPLGRftEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLE--GGSLEDYLEDS 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 304376292 167 SDTLKTLLNSIQHKYV-FQYK-KGKSLNEQRMKILERIMEFIKEN---CY 211
Cdd:cd01852  142 CEALKRLLEKCGGRYVaFNNKaKGREQEQQVKELLAKVEEMVRENggkPY 191
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 10-210 1.70e-18

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 79.96  E-value: 1.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292   10 NLALFGMTQSGKSSAGNILLGSTDFHSSFAPCSVTtccslgRSCHLHSFMRRGglevaLQVQVLDTPGYPHSRLSKKYVK 89
Cdd:pfam04548   2 RIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVT------KTCQLVSRTWDG-----RIINVIDTPGLFDLSVSNDFIS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304376292   90 QEVKEALahHFGQGGLHLALLVqrADVPFCGQEVTDPVQMIQELLGHAWMNYTAILFTHAEKIEEAGLteDKYLHEAS-D 168
Cdd:pfam04548  71 KEIIRCL--LLAEPGPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCpE 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 304376292  169 TLKTLLnsiqhkyvfQYKKGKSLNEQRMKILERIMEFIKENC 210
Cdd:pfam04548 145 FLKEVL---------RTADGEEKEEQVQQLLALVEAIVKENG 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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