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Conserved domains on  [gi|266456217|ref|NP_001161046|]
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uroplakin-3a isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UP_III_II super family cl06408
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 17-107 6.93e-36

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


The actual alignment was detected with superfamily member cd09970:

Pssm-ID: 471435  Cd Length: 212  Bit Score: 123.55  E-value: 6.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217  17 SAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDS--------------------------- 69
Cdd:cd09970    1 SAVNLQPQLASVTFATNNPTLTTITLEKPFCMFDSKEALTGTHEVYLYVLVDSaisrnasvqdstntplgstflqteggr 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217     --------------------------------------------------------------------------------
Cdd:cd09970   81 tgpykaaafdlppcsdlpsldaigdvskasqilnaylvrvgangtclwdpnfkglcnpplsaateyrfkyvlvnmstglv 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 266456217  70 --------------VTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 107
Cdd:cd09970  161 edqtlwsdpirtnqLTPYSTIDTWPGRRSGGMIVITSILSTLPFFLLVGFAG 212
 
Name Accession Description Interval E-value
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 17-107 6.93e-36

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197379  Cd Length: 212  Bit Score: 123.55  E-value: 6.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217  17 SAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDS--------------------------- 69
Cdd:cd09970    1 SAVNLQPQLASVTFATNNPTLTTITLEKPFCMFDSKEALTGTHEVYLYVLVDSaisrnasvqdstntplgstflqteggr 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217     --------------------------------------------------------------------------------
Cdd:cd09970   81 tgpykaaafdlppcsdlpsldaigdvskasqilnaylvrvgangtclwdpnfkglcnpplsaateyrfkyvlvnmstglv 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 266456217  70 --------------VTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 107
Cdd:cd09970  161 edqtlwsdpirtnqLTPYSTIDTWPGRRSGGMIVITSILSTLPFFLLVGFAG 212
 
Name Accession Description Interval E-value
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 17-107 6.93e-36

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197379  Cd Length: 212  Bit Score: 123.55  E-value: 6.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217  17 SAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDS--------------------------- 69
Cdd:cd09970    1 SAVNLQPQLASVTFATNNPTLTTITLEKPFCMFDSKEALTGTHEVYLYVLVDSaisrnasvqdstntplgstflqteggr 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217     --------------------------------------------------------------------------------
Cdd:cd09970   81 tgpykaaafdlppcsdlpsldaigdvskasqilnaylvrvgangtclwdpnfkglcnpplsaateyrfkyvlvnmstglv 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 266456217  70 --------------VTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 107
Cdd:cd09970  161 edqtlwsdpirtnqLTPYSTIDTWPGRRSGGMIVITSILSTLPFFLLVGFAG 212
UP_III cd09968
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ...
 17-107 2.39e-24

Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197377  Cd Length: 187  Bit Score: 93.21  E-value: 2.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217  17 SAVNLQPQLASvTFATNNPTLTTVALEKPLCMFDSKEalTGTHEVYLYVLVDSVT------------------------- 71
Cdd:cd09968    1 EAVSYVPQLAS-TFLEGNPTSTTFTLEQPRCVFDSSA--SDTDDVWLVVAVSNATnnfnapqnstdpistysqfsggqyy 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217  72 --------------------------------------------------------------------------PYSTID 77
Cdd:cd09968   78 ltlrasrdlypcgnpslnayvlrvgadgnctdngncngplpgpgpyrvkylvmngsgvvaqtnwsdpirlnqakSYQTID 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 266456217  78 TWPGRRSGGMIVITSILGSLPFFLLVGFAG 107
Cdd:cd09968  158 TWPGRRSGGMIVITSILSVLLALLLLALLA 187
UP_III_II cd09966
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 19-107 3.80e-14

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197375  Cd Length: 181  Bit Score: 66.29  E-value: 3.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217  19 VNLQPQLASVTFAtNNPTLTTVALEKPLCMFDSkealTGTHEVYLYVLVDSV---------------------------- 70
Cdd:cd09966    1 LSYVPQLTASTGA-GNPTLSTFTLEQPPCMFDS----SSTDDVWLVVALPNAtlafqnvtlstdistyltfttgnyyktl 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 266456217  71 -----------------------------------------TPY----------------------------STIDTWPG 81
Cdd:cd09966   76 rasfdlppcrnrrdivsayvlrvgntttclsgycntplpgpGPYrvkylvmngsgpsaqtewstpirlnqnkIYSTTWPG 155

                        170       180
                 ....*....|....*....|....*.
gi 266456217  82 RRSGGMIVITSILGSLPFFLLVGFAG 107
Cdd:cd09966  156 ARSGGMIVITVILSVLMFLLLVALIA 181
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 73-105 1.95e-08

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 51.24  E-value: 1.95e-08
                         10        20        30
                 ....*....|....*....|....*....|...
gi 266456217  73 YSTIDTWPGRRSGGMIVITSILGSLPFFLLVGF 105
Cdd:cd09969  150 PQTIDTWPGRRSGGMIVITTILSVLLALLLLAL 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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