|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
47-452 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 717.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 47 VYHAAFVIFLEFFAWGLLTTPMLTVLHETFPQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPI 126
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 127 PLMRINPWWYFGMISVSGVFSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATL 206
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 207 VALLDICFILIAVPESLSEKIRPASWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 286
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 287 FGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAVSA 366
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 367 LISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHVELSELGP----KLNSDDDPLQGAFIPGPPFLFGACIVL 442
Cdd:cd17387 321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPvqssKQRMQNPSLEGAIIPGPPFLFGAISVL 400
|
410
....*....|
gi 142370886 443 MSFLVALFIP 452
Cdd:cd17387 401 LAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
53-450 |
8.62e-71 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 229.39 E-value: 8.62e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 53 VIFLEFFAWGLLTTPMLTVLHET-FPQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI 131
Cdd:cd17330 4 VVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 132 --NPWWYFGMISVSGVFSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVAL 209
Cdd:cd17330 84 srNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 210 LDICFILIAVPeslsekirpaswgaqiswkqadpfaslkkvgkdsTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGS 289
Cdd:cd17330 164 LNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 290 VKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGS-QAWMMWAAGTVAAMSSITFPAVSALI 368
Cdd:cd17330 210 SQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSALL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 369 SRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFymfhvelselgpklnsdddplqGAFIPGPPFLFGACIVLMSFLVA 448
Cdd:cd17330 290 SKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY----------------------SFLGPGVPFLLAAGLLLIALFLL 347
|
..
gi 142370886 449 LF 450
Cdd:cd17330 348 SL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
84-450 |
1.81e-42 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 155.49 E-value: 1.81e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 84 NGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRINP--WWYFGMISVSGVFSVTFSVIFAYVADFT 161
Cdd:cd17388 40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVT 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 162 QEHERSTAYGWVSATFAASLVSSPAIGTYLsANYGDSLVVLVATLVALLDICFILIAVPESLSEKIRPASwgaqiSWKQA 241
Cdd:cd17388 120 PPEQRARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF-----RWRRA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 242 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNK 321
Cdd:cd17388 194 NPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEK 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 322 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGF 401
Cdd:cd17388 274 RAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTG 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 142370886 402 IFYMFhvelselgpklnsdddplqGAFIPGPPFLFGACIVLMSFLVALF 450
Cdd:cd17388 354 IFAAS-------------------PATWPGLAWIIGAALYLICLVLAYR 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-451 |
3.58e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 126.92 E-value: 3.58e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 51 AFVIFLEFFAWGLLTtPMLTVLHETFPQHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFPIPLM 129
Cdd:cd17325 2 SLALFLDMLGYGIII-PILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLlGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 130 RINPWWYFGMISV-SGVFS-VTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLV 207
Cdd:cd17325 80 FATSYWQLLLARFlQGLASaAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 208 ALLDICFILIAVPESLSEKIRPASwgaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF 287
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAV-------SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 288 GSVKIVAFIAMVGILSIVAQtVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVA-AMSSITFPAVSA 366
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 367 LISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHvelselgpklnsdddplqgafiPGPPFLFGACIVLMSFL 446
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG----------------------FATPFLAAAALLLLAAV 369
|
....*
gi 142370886 447 VALFI 451
Cdd:cd17325 370 LFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
51-394 |
1.56e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.84 E-value: 1.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 51 AFVIFLEFFAWGLLTtPMLTVLHETFpQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMR 130
Cdd:COG2814 16 ALGAFLSGLGIGIVL-PALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 131 I--NPWWYFGMISVSGVFS-VTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLV 207
Cdd:COG2814 94 LapSLWLLLAARFLQGLGAgALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 208 ALLDICFILIAVPESLSEkirpaswgaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF 287
Cdd:COG2814 174 ALLALLLLLRLLPESRPA-------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 288 GSVKIVAFIAMVGILSIVAQTVFlSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAVSA 366
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGALLA-GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQA 319
|
330 340
....*....|....*....|....*...
gi 142370886 367 LISRNAESDQQGVAQGIVTGIRGLCNGL 394
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
50-407 |
9.67e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.89 E-value: 9.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHETfpQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLM 129
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 130 RINP---WWYFGMISVSGVFSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDS--LVVLVA 204
Cdd:cd06174 79 AFAPsfwLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 205 TLVALLDICFILIAVPESLSEKIRPASWGaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQV 284
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEA-----SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 285 IGFGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGT-VAAMSSITFPA 363
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPL 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 142370886 364 VSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFH 407
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
51-396 |
1.41e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 101.73 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 51 AFVIFLEFFAWGLLTTPMLTVLHETFpQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFP--IPL 128
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 129 MRINPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLV 207
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 208 ALldICFILIAVPESLSEKIRPASWGAqiswKQADPFASLKKVGKDstVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF 287
Cdd:pfam07690 161 SL--LAAVLLLLPRPPPESKRPKPAEE----ARLSLIVAWKALLRD--PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 288 GSVKIVAFIAMVGILSIVAQtVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGF----GSQAWMMWAAGTVAAMSSITFPA 363
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILAALGLLLlsltLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|...
gi 142370886 364 VSALISRNAESDQQGVAQGIVTGIRGLCNGLGP 396
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
85-406 |
5.88e-23 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 100.38 E-value: 5.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--NPWWYFGMISVSGVF-SVTFSVIFAYVADFT 161
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 162 QEHERSTAYGWVSATFAASLVSSPAIGTYLsANYGDSLVVLVATLVALLDICFILIAVPESLSEKIRPaswgaqiswKQA 241
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 242 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVAQtVFLSKLMRSLGNK 321
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ-FPVARLVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 322 NTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYG 400
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
....*.
gi 142370886 401 FIFYMF 406
Cdd:cd17329 347 LLLDLL 352
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
85-445 |
5.42e-19 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 89.19 E-value: 5.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKPFLLGTVFFTCFPIPLMRINP--------WWYFGMISVSGVFSVTFS 151
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILIGAIPLALSFVLLFTAPdlsptgklIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 152 VIF-AYVADFTQE-HERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSL---VVLVATLVALLDICFILIAVPeSLSEK 226
Cdd:COG2211 129 IPYsALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAalgYRLTALIFAVLGLLAFLLTFF-GTKER 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 227 IRPASwgaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFgSVKIVAFIAMVGILSIVA 306
Cdd:COG2211 208 PVPEE-------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGL-SAALVGLLLALYFLAALL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 307 QTVFLSKLMRSLGNKNTVLLGLGFQ---MLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAVSALISRNAESDQQ------ 377
Cdd:COG2211 280 GAPLWPRLAKRFGKKKAFIIGLLLAalgLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrr 359
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 142370886 378 -GVAQGIVTGIRGLCNGLGPALYGFIfymfhVELSELGPKLNSDDDPLQG---AFIPGPPFLFGACIVLMSF 445
Cdd:COG2211 360 eGLYFGIFTFAIKLGQALAGALAGLL-----LALFGYVAGAAQSPSALTGirlLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-403 |
3.30e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 86.06 E-value: 3.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHETFPQhtflmNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLM 129
Cdd:cd17324 7 AAFAIGTTEYVIQGLLPDIARDFGVSVAQ-----AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 130 RINPWWYFGMIS--VSGVF-SVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATL 206
Cdd:cd17324 82 ALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 207 VALLDICFILIAVPESLSEKIRPASwgaqiswkqadPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIG 286
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLG-----------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 287 FGSVKIVAFIAMVGILSIVAqTVFLSKLMRSLGNKnTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTV--AAMSSITFPAV 364
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVG-SPLAGRLADRGGRR-ALLIALLLLAAALLLLTLLGPSPLLLLVGLVlwGLGFFAAHSAL 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 142370886 365 SALISRNAEsDQQGVAQGIVTGIRGLCNGLGPALYGFIF 403
Cdd:cd17324 309 QTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVL 346
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
82-406 |
9.14e-18 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 85.02 E-value: 9.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 82 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLmrinpWWY---FGM--IS--VSGVFSVTFSVIF 154
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYAL-----WAVsrsFTIflLSriVGGISKGNVSLST 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 155 AYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVV------LVATLVALLDICFILIAVPESLSEKIR 228
Cdd:cd17389 139 AIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVffsmpaLFALVLALADLLFIFFFLPETLPSNLR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 229 PASWGaqiswkqadpfaslkkvgkdstvllicitVFLSYLPEAG-QYSSFFLyLRQVIGFGSVKIVAFIAMVGILSIVAQ 307
Cdd:cd17389 219 RLGLV-----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 308 TVFLSKLmRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAVSALISRNAESDQQGVAQGIVTG 386
Cdd:cd17389 269 GGYVRRI-KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGIFRS 347
|
330 340
....*....|....*....|
gi 142370886 387 IRGLCNGLGPALYGFIFYMF 406
Cdd:cd17389 348 LGALARALGPIVACTVYWLA 367
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
83-403 |
6.25e-17 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 82.65 E-value: 6.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 83 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRI-NPWWYFgmIS-VSGVFSVTFSVIFAYVAD 159
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGpRAALVLSFLSSALSYLLLAFAsSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 160 FTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICfILIAVPESLSEKIRPASWGAQISWK 239
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV-LVILLIPSNTKSKREKEAKESASPP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 240 QADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLG 319
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 320 NKNTVLLGLGFQMLQLAWYGF-GSQAWMMWAAGTVAAMSSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPAL 398
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352
|
....*
gi 142370886 399 YGFIF 403
Cdd:cd17331 353 GGALL 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
85-408 |
7.20e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.20 E-value: 7.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGT-------VFFTCFPIPLMRINPWWYFGMISVSGVFSVTFSVIF-AY 156
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 157 VADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSEKIRPASWGAQI 236
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 237 SWkqadpfASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVAqTVFLSKLMR 316
Cdd:cd06173 197 LR------EGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 317 SLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITF-PAVSALISRNAESDQQGVAQGIVTGIRGLCNGLG 395
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|...
gi 142370886 396 PALYGFIFYMFHV 408
Cdd:cd06173 350 ALLAGLLADALGL 362
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
53-447 |
2.39e-15 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 77.32 E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 53 VIFLEFFAWGLLTTPMLtvlHETFPQHTFLMNGLIQGVKGLLSflsAPLIGALSDVWGRKP--------FLLGTVFFTCF 124
Cdd:cd17386 7 IVFLYMFASVLSGPVTQ---NFVYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPpllmslvgLLLSSLILVLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 125 PIPLMRINPWWYFG---MISVSGVFSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVV 201
Cdd:cd17386 81 VYFTTVPSVWWFYLsaiPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 202 LVATLVALLDICFILIAVpeslsekirpaswgaqiswkqadpfaslkkvgkdSTVLLICITVFLSYLPEAGQYSSFFLYL 281
Cdd:cd17386 161 SISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYLFV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 282 RQVIGFGSVKIVAFIAmVGILSIVAQTVFLSKLMRSLGNKNTV---LLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSS 358
Cdd:cd17386 207 LEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSDStlaMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 359 ITFPAVSALISRNAESDQQGVaqgiVTGIRGLCNGLGPALYGFIFYMFHvelselgpklnsdddPLQGAFIPGPPFLFGA 438
Cdd:cd17386 286 IVGPMIRSILSKLVPKSEQGK----IFSLLSVLESLSPLVASPIYNNIY---------------KATLTTFPGFFFLLSA 346
|
....*....
gi 142370886 439 CIVLMSFLV 447
Cdd:cd17386 347 GLLLIPVIL 355
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
45-402 |
3.76e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 77.20 E-value: 3.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 45 PSVYHAAFVIFLEFFAWGLLTT---PMLTVLHETFpQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFF 121
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 122 T---CFPIPLMRINPWWYFGMISVSGVFSVTFSVIFAYVADFTQEHeRSTAYGWVSATFAASLVSSPAIGTYLSANYGDS 198
Cdd:COG0738 83 MalgLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 199 LVVLVATLVALLDICFILIAVPESLSEKIRPASwgaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFF 278
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 279 LYLRQVIGFgSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWM-MWAAGTVAAMS 357
Cdd:COG0738 235 LYLKDVLGL-SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLGL 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 142370886 358 SITFPAVSALISRNAESDQQGVAqGIVTGIRGLCNGLGPALYGFI 402
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
97-452 |
3.75e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 73.77 E-value: 3.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 97 LSAPLIGALSDVWGRKPFLLGTVFFT---CFPIPLMRINPWWYFGMIsVSGVFSVTFSVIFAYVADFTQEHERSTAYGWV 173
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYtagSLLAAFAPNLPVLIAGRA-LQGIGGAVFPLAFALVREEFPPERVPVAQGIL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 174 SATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSekiRPASWGAQIswkqadpfaslkkvgkd 253
Cdd:cd17504 125 SATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLRLLR---RRNVLLANI----------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 254 sTVLLICITVFLSYlpeagQYSSFFLYLRQVIGFGSVKIVAFIAMV-GILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQM 332
Cdd:cd17504 185 -TALLAGFGMFMVF-----QLLPQLLQLPTPTGFGLGITEAGLLLLpGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 333 LQLAWYGF-GSQAWMMWAAGTVAAM-SSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHVEL 410
Cdd:cd17504 259 VGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSI 338
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 142370886 411 SELGPklnsdddPLQGAFIPGppFLFGACIVLMSFLVALFIP 452
Cdd:cd17504 339 TSGGV-------PTEGAYVLA--FLIGAALALAALLLSLLIP 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-450 |
5.14e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.40 E-value: 5.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 52 FVIFLEFFAWGLLTTPMLTVLHETFPQHTflMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI 131
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEA--VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 132 --NPWWYFGMISVSGV-FSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVA 208
Cdd:cd17489 81 atSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 209 LLDICFILIaVPESLSEKIrpaswgaqiswKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVigfG 288
Cdd:cd17489 161 LLALLLVFL-VKDPPPVAA-----------EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER---G 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 289 SVKIVAFIAMVGILSIVAQtVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAVSAL 367
Cdd:cd17489 226 ISNAGLFFTVYAIALLLSR-PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQAL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 368 ISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFymfhvelselgpklnsdddplqGAFIPGPPFLFGACIVLMSFLV 447
Cdd:cd17489 305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA----------------------ELFGYRAMFLLAAVVVLLALVL 362
|
...
gi 142370886 448 ALF 450
Cdd:cd17489 363 YIF 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
100-452 |
1.98e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 71.82 E-value: 1.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 100 PLIGALSDVWGRKP-FLLGTVFFT-----CFpiplMRINPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGW 172
Cdd:cd17321 49 LLAGRLGDRFGRKRvFLIGLALFGlasllCA----LAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 173 VSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALldICFILIavpeslsekirpaswgaqiswkqadpfaslkkvgk 252
Cdd:cd17321 125 WGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL--VALLLA----------------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 253 dSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKI-VAFIAMVGILSIVAQTVflSKLMRSLGNKNTVLLGLGFQ 331
Cdd:cd17321 168 -RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAgLALLPLALAMLVAAPLA--GRLADRFGPRLVLVAGLLLT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 332 MLQLAWYGFGSQAWMMW--AAGTVAAM--SSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYM-F 406
Cdd:cd17321 245 AVGLLLLALLGADSSVWllLPGLVLLGlgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAgL 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 142370886 407 HVELSELGPKLNSDDDPLQGAFIPGPPFLFGACIVLMSFLVALFIP 452
Cdd:cd17321 325 SANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
50-457 |
2.31e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 71.45 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHETFPQhtflmNGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTcfpIPL 128
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQ-----LGLLFAIPVLVGALLRIPLGFLVDRFGpRRVLLIGLLLLG---IGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 129 M----RINPWWYFGMISVSGVFS-VTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLV 203
Cdd:COG2223 85 LllalAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 204 ATLVALLDICFILIAVPESLSEKIRPAswgaqiswkqADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQ 283
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAAA----------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 284 VIGFGSVKIVAFIAMVGILSIVAqTVFLSKLMRSLGNKNTVLLGLGFQMLQLAW--YGFGSQAWMMWAAGTVAAMSSITF 361
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGGN 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 362 PAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFhvelselgpklnsdddplqGAFIPGppFLFGACIV 441
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT-------------------GSYTAA--FLVFAVLA 372
|
410
....*....|....*.
gi 142370886 442 LMSFLVALFIPEYRKT 457
Cdd:COG2223 373 LVALVLTLLLYRRPRR 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
50-456 |
9.68e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 69.51 E-value: 9.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHETFPQHtflmnGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFT---CFPI 126
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWglaTLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 127 PLMRiNPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVAT 205
Cdd:COG2271 93 GFAT-SFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 206 LVAlldicfILIAVPeslsekirpaswgaqiswkqadpfaslkkvgkdsTVLLICITVFLSYLPEAGQYSSFFLYLRQVI 285
Cdd:COG2271 172 LPG------LLLALL----------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 286 GFGSVKIVAFIAMVGILSIVAQTV--FLSKLMRSlGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSI-TFP 362
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVGSLLggWLSDRLGR-RRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 363 AVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHvelselgpklnsdddpLQGAFIpgppfLFGACIVL 442
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG----------------YQAAFL-----LLAALALL 349
|
410
....*....|....
gi 142370886 443 MSFLVALFIPEYRK 456
Cdd:COG2271 350 AALLALLLLRETRK 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
62-385 |
2.04e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 62 GLLTTPMLTVLHETFPQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCF-PIPLMRINPWWYFGM 139
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIaGLLLYGIGgVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 140 -----ISVSGVFSVTFSVIfayvADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLsANYGDSLVVLVaTLVALLDICF 214
Cdd:cd17473 95 rallgIGVAGIMTLATALI----GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLV-YLLALPVLIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 215 ILIAVPESLSEKIRPASWGAQisWKQADPFASlkkvgkdstVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIVA 294
Cdd:cd17473 169 VLLFLPEPARKSKSAASPGAA--TAAALPWKR---------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 295 FIAMVGILSIVAQTVFlSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM-SSITFPAVSALISRNAE 373
Cdd:cd17473 238 ALAIASLAGAIGALLF-GRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVP 316
|
330
....*....|..
gi 142370886 374 SDQQGVAQGIVT 385
Cdd:cd17473 317 PELRGRAMGIVT 328
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
52-415 |
2.61e-12 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 68.02 E-value: 2.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 52 FVIFLEFFAWGLLTTPMLTVLHETFPQHTflMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI 131
Cdd:cd17390 3 LVGFLDLFGVSMILPLLSTHIRSLGASPT--VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 132 NPWWYFGMIS--VSGVFSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSA-NYGDSLVVLVATLVA 208
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 209 LLDICFILIAVPESLSekirpaswgaqiswkqadpFASLKkvgkdstvLLICITVFLSylpeagqYSSFFLYLRQVIGFG 288
Cdd:cd17390 161 ILNAGLVWFLLSKLWD-------------------LLLVR--------FLMGFSVLLF-------RSNFSLYLEERFDLS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 289 SVKIVAFIAMVGILSIVAQtvFLSKLMRSLGNKNTVLLGLGFQMLQ---LAWYGFGSQAWMMWAAGT-VAAMSSITFPAV 364
Cdd:cd17390 207 PKTIGYLISYSGVLGALSG--FLVGRILKLYKNNEYLLLLHSFILLalsLLGLALAPSIWLLVLCLTpLSISSAVLRTCS 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 142370886 365 SALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIfymfhVELSELGP 415
Cdd:cd17390 285 TSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLL-----QEFSVSGP 330
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
85-402 |
3.28e-12 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 67.99 E-value: 3.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTC---FPIPLMRINPWWYFGMISVSGVFSVTFSVIFAYVAdF 160
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVlffLSLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSIT-L 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 161 TQEHERSTAYG----WVSATF-AASLVSSPAIG-TYLSANYGDSLVVLVAtlvalldicFILIAVPESLSEKIRPASWGA 234
Cdd:cd17335 114 QYLGEERERYGkqrlWGSIGFgIAALLVGILIDrSSTYKNYTIAFYVFAV---------LMLLALLLALKFPFRPKHPEP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 235 QISWKQadpfasLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQvIGfGSVKIVAFIAMVGILSIVAQTVFLSKL 314
Cdd:cd17335 185 NENTGG------LLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LG-GSKTLIGLLWTVGVVSEIPFFFFSSRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 315 MRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMwaaGTVAAMSSITFPAV----SALISRNAESDQQGVAQGIVTgirGL 390
Cdd:cd17335 257 IQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALVwaaaVSYASAAAPPGLRATAQGLLQ---GL 330
|
330
....*....|..
gi 142370886 391 CNGLGPALYGFI 402
Cdd:cd17335 331 YFGLGGGLGSLI 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-219 |
1.61e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.68 E-value: 1.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 19 PKASTMPEKRGSAQAASGSWLQGFGHPSVYHAAFVIFLEFFAWGLLTTPMLTVLHETFpQHTFLMNGLIQGVKGLLSFLS 98
Cdd:cd17325 173 EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALS 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 99 APLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--NPWWYFGMISVSGV-FSVTFSVIFAYVADFTQEHERSTAYGWVSA 175
Cdd:cd17325 252 QPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLatSFWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNT 331
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 142370886 176 TFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAV 219
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-403 |
5.03e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 64.16 E-value: 5.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 51 AFVIFLEFFawGL-LTTPMLTVLHETFPQHTFLMNGLIQGVKGLL-SFLSAPLiGALSDVWGRKP-FLLGTVFFTC-FPI 126
Cdd:cd17472 2 SLIFSLRML--GMfLVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPvILFGLLLFIAgSLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 127 PLMRINPWWYFGMISVSGVFSVTfSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATL 206
Cdd:cd17472 79 AAYATSIYGLILGRALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 207 VALLDICFILIAVPESLSEKirpaswgaQISWKQAdpfASLKKVGKDSTVLLICITVFLSYLpeagQYSSFF----LYLR 282
Cdd:cd17472 158 LSLVSLLILLFFVPDPPKIV--------QISEKEK---KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFyilpLLLT 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 283 QVIG--------FGSVKIVAFIAMVgILSIVAQTVFLSKLMRSLGnknTVLLGLGFQMLqlawyGFGSQAWMMWAAGTVA 354
Cdd:cd17472 223 QLGGgkgqlwkvYLPAILIGFILMV-PFVIYAEKKGKMKQVFVSS---ILLIAVGFLLL-----LFAATSLWLLIIGLII 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 142370886 355 AMSSITF--PAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIF 403
Cdd:cd17472 294 FFIGFNLleALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
90-407 |
7.22e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.83 E-value: 7.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 90 VKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFT--CFPIPLMRINPWWYFGMISVSGVFSVTFS-VIFAYVADFTQEHE 165
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGpRRVMLLGLLLLAagLVLLALATSLWQLYLLWGLLGGGGAGTLAaVAFATVAAWWFERR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 166 RSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSEKIRPASWGAqiswKQADPFA 245
Cdd:cd17355 126 RGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDA----SPASPGS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 246 SLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQvIGFGSVKIVAFIAMVGILSIVAqTVFLSKLMRSLGNKNTVL 325
Cdd:cd17355 202 TLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLLA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 326 LGLGFQMLQLAWYGFG-SQAWMMWAAGTVAAMSSI-TFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIF 403
Cdd:cd17355 280 ASYALRALGLALLLLLpFPPLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
|
....
gi 142370886 404 YMFH 407
Cdd:cd17355 360 DRTG 363
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
85-406 |
2.82e-10 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 61.88 E-value: 2.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWGR--KPFLLGTVFFTCFPIPLMRINP----WWYFGMISVSGVFSVTFSVIFAyVA 158
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGKrkAVVRLASILAAVLFLSVLFIPIsltfWWLALLVVLFSFFWNAILPQFE-VA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 159 DFTQEHERSTAYG----WVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDicfilIAVPESLSEKirpaSWGA 234
Cdd:pfam12832 116 TLQHLGEKRKDYGrqrlWGSVGFALSVFGLGALFDHYSVGLLPSVLFYLFAALMLLS-----LLLPLAPPEM----EYES 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 235 QISwkqadPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQViGFGSVKIVAFIAmVGILSIVAQTVFLSKL 314
Cdd:pfam12832 187 KGG-----SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENL-GASNTLLGALWA-LGVVAEIPLFFYAHRL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 315 MRSLGNKNTVLLGLGFQMLQLAWYGFG-SQAWMMWAAGTVAAMSSITFPAVSA-LISRNAESDQQGVAQGIVTGIR-GLC 391
Cdd:pfam12832 260 LRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAISFGLTHAAAIeYVRRIFPGSLQGTGQALYSGLYfGLG 339
|
330
....*....|....*
gi 142370886 392 NGLGPALYGFIFYMF 406
Cdd:pfam12832 340 GALGSLIGGQLWDLF 354
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
47-451 |
6.78e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 6.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 47 VYHAAFVIFLEFFAWGLLTtPMLTVLHETFPQHTFlMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFP 125
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVD-PILPAIAEALGASPA-QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLpGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 126 -IPLMRINPWWYFGMISVSGVFSVTFSVI-FAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSAN--YGDSLVV 201
Cdd:cd17474 79 lLCGLSDSFALLLAGRALQGIGAAGLGPLaLTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIswRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 202 LVATLVALLDICFIliaVPESLSEKIRPASWgaqiswKQADPFASLKKVGKDSTVLLICITVF-----LSYLPeagqyss 276
Cdd:cd17474 159 AALIPVAFLAILFL---LPEPKEKAKSSSAT------KLRDLKKALRGRGLLTFLVSAFLYFFlyfafLTYLP------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 277 ffLYLRQVIGFGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAM 356
Cdd:cd17474 223 --FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 357 SS-ITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFymfhvelselgpklnsdddplqGAFIPGPPFL 435
Cdd:cd17474 301 GLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL----------------------EIFGLSAPFL 358
|
410
....*....|....*.
gi 142370886 436 FGACIVLMSFLVALFI 451
Cdd:cd17474 359 VGAAIALAAAVLLALL 374
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
85-407 |
7.49e-09 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 57.86 E-value: 7.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLM---RINPWWYFGMISVSGVFSVTFSVIF--AYVA 158
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGrKKPFLAFFTLLGVLATAALffvAPGGLWLGLLLFVLANIGFEGSLVFynAFLP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 159 DFTQEHERST--AYGW--------VSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSEKIR 228
Cdd:COG2270 135 DIATPEEIGRvsGLGWalgylggvLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 229 PASWGAQISWKQAdpFASLKKVGKDSTVL--LICITVFLSYLpeAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVA 306
Cdd:COG2270 215 PPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALG 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 307 qTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAVS-ALISRNAESDQQGVAQGI-- 383
Cdd:COG2270 291 -ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEFFGLya 369
|
330 340
....*....|....*....|....*...
gi 142370886 384 ----VTGIrglcngLGPALYGFIFYMFH 407
Cdd:COG2270 370 lsgkAASF------LGPLLFGLVTQLTG 391
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
101-403 |
7.47e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 54.50 E-value: 7.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 101 LIGALSDVWGRKPFLL-GTVFF--TCFpIPLMRINPWWYFGMISVSGVFSVTFSVI-FAYVADFTQEHERSTAYGWVSAT 176
Cdd:cd17320 53 LYGPLSDRFGRRPVLLaGLLLFilASL-LCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMI 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 177 FAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSEKIRPASWGAQiswkqadpFASLKKVGKDSTV 256
Cdd:cd17320 132 LAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSL--------LRAYKRVLKNRRF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 257 LLICITVFLSYLPEAGQYS-SFFLYLrQVIGFGSVKIVAFIAMVGILSIVAqTVFLSKLMRSLGNKNTVLLGLGFQ---- 331
Cdd:cd17320 204 LGYALALGLSFAGLFAYLAaAPFIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLlaaa 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 142370886 332 --MLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAVSALISRnAESDQQGVAQGIVTGIRGLCNGLGPALYGFIF 403
Cdd:cd17320 282 lvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
46-221 |
1.10e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.72 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 46 SVYHAAFVIFLEFFAWGLLTTPMLTVLHETFpQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFP 125
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 126 IPLMRI----NPWWYFGMISVSGVFS-VTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLV 200
Cdd:COG2271 260 LALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|.
gi 142370886 201 VLVATLVALLDICFILIAVPE 221
Cdd:COG2271 340 FLLLAALALLAALLALLLLRE 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-177 |
1.26e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 23 TMPE-KRGSAQAASGSWLQGFGHPSVYHAAFVIFLEFFAWGLLTTPMLTVLHETFpQHTFLMNGLIQGVKGLLSFLSAPL 101
Cdd:COG2814 184 LLPEsRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALL 262
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 142370886 102 IGALSDVWGRKPFLLGTVFFTCFPIPLMRI--NPWWYFGMISVSGV-FSVTFSVIFAYVADFTQEHERSTAYGWVSATF 177
Cdd:COG2814 263 AGRLADRFGRRRLLLIGLLLLALGLLLLALagSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
64-449 |
1.41e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.70 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 64 LTTPMLTVLHETfpqhTFLMnGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRINPWWyfgmISV 142
Cdd:cd17370 21 ILPLFLVVLGAS----AAAV-GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSW----QLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 143 SGVFSV--TFSVIF-----AYVADFTQEHERSTAYGWVSA--TFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDIC 213
Cdd:cd17370 92 LLLRILerLGKGIRtpprdALLADATPPSGRGKAFGLHRAldTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 214 FILIAVPEslseKIRPASWGAQISWKqadpfaSLKKVGKDSTVLLICITVFlsylpEAGQYS-SFFLYLRQVIGFGSVKI 292
Cdd:cd17370 172 ILLFVVKE----YPRPPKLRKKSKKT------SLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 293 VAFIAMVGILSIVAQTVFlSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAA----GTVAAMSSITFPAVSALI 368
Cdd:cd17370 237 PLLYALFNLVYALAAYPA-GRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGfilwGLYMGAQESIERAAVADL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 369 srnAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHVELselgpklnsdddplqgafipgpPFLFGACIVLMSFLVA 448
Cdd:cd17370 316 ---VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA----------------------AFLFSAVLALIALLLL 370
|
.
gi 142370886 449 L 449
Cdd:cd17370 371 L 371
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
85-402 |
1.42e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.42 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--NPWWYFGMISVSGVFSVTFSVIFAYVAdfTQ 162
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFvtNVWQLLILRLLQGVFSGYVPNATALIA--SQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 163 EHERSTayGWVSATFAASLVS----SPAIGTYLSANYGDSLVVLVATlvALLDICFILIAVpeSLSEKIRPASWGAQISW 238
Cdd:cd17391 117 TPKEKS--GWALGTLSTGVVAgtliGPLLGGFLADLFGIRNVFFITG--GLLFLAFLLTLF--FVKEDFKPVEKKKMVST 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 239 KQAdpfasLKKVGKDSTVLLICITVFLSylpeagQYSSFF------LYLRQVIGFGSVkiVAFIA-MV----GILSIVAq 307
Cdd:cd17391 191 KEV-----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLMGDASN--LAFISgLVfsatGVSSLLS- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 308 TVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAW-MMWAAGTVAAMSSITFPAVSALISRNAESDQQGVAQGIVTG 386
Cdd:cd17391 257 APRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQS 336
|
330
....*....|....*.
gi 142370886 387 IRGLCNGLGPALYGFI 402
Cdd:cd17391 337 FQYLGNVAGPLLGSAI 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
50-319 |
1.90e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.89 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHETFPQHtflmnGLIQGVKGLLSFLSAPLIGALSDVWGRKP-FLLGTVFFT--CFPI 126
Cdd:COG0477 22 GTFLEGLDFTIVNVALPSIAADLGASSAQL-----GWIVSAYLLGRAIGLLLFGRLGDRYGRKRvLLIGLLLFGlaSLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 127 PLMrINPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVAT 205
Cdd:COG0477 97 GLA-PSPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 206 LVALLDIcFILIAVPESLSEKIRPASWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVI 285
Cdd:COG0477 176 PLGLLAL-VLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270
....*....|....*....|....*....|....
gi 142370886 286 GFGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLG 319
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
97-403 |
2.04e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 53.38 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 97 LSAPLIGALSDV----WGR-KPFLL------GTVFFTCF--PIPLMRINPWWYFGMISVSGVFSVTFSVIF-AYVADFTQ 162
Cdd:cd17332 50 INDPLMGYLIDRtrsrWGRfRPWLLwgaiplALLFVLLFttPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 163 E-HERSTAYGW--VSATFAASLVSS--PAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPEslsekIRPASWGAQIS 237
Cdd:cd17332 130 DpEERTSLTSWrmFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFG-----TRERVVPPEEE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 238 WKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGfGSVKIVAFIAMVGILSIVAQTVFLSKLMRs 317
Cdd:cd17332 205 KSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKR- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 318 LGNKNTVLLGLGFQMLQLAWYGFGS--QAWMMWAAGTVAAM-SSITFPAVSALISRNAESDQ--QGV-AQGIVTGIRGLC 391
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFF 362
|
330
....*....|..
gi 142370886 392 NGLGPALYGFIF 403
Cdd:cd17332 363 RKLGLALAGALV 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
83-402 |
9.52e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.07 E-value: 9.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 83 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRINP--WWYFGMISVSGVFSVTFSVIFAYVAD 159
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPspWGLLIARFLSGIAAATWVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 160 FTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSEKIRPASWgaqiswk 239
Cdd:cd17490 112 YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTEL------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 240 qadpfASLKKVGKDSTVLLICITVFLS-YLPEAGQYSSFFLYLRQvIGFGSVKIVAFIAMVGILSIVAQTVFLSKLMRSL 318
Cdd:cd17490 185 -----KELLSVLKDKKLLFFSLLAILQqMITFSTTFGFTPLIAKQ-LGASSFQLGLLSIIYLLPNALASLLSGTLFYKKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 319 GNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSS-ITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPA 397
Cdd:cd17490 259 GERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPV 338
|
....*
gi 142370886 398 LYGFI 402
Cdd:cd17490 339 LVGII 343
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
50-215 |
1.26e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 50.60 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHET--FPQHTFLMNGLIQGVkglLSFLSAPLIGALSDVWGRKP-FLLGTVFFTCFPI 126
Cdd:cd17369 233 AIGLRLAENVLFYLFTTFALSYATQTlgVDRSTVLLAVLIASV---VAAITIPLFGWLSDRVGRRPvYLAGALLAALFAF 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 127 PLM-----RINPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGwVSATFAASLVSS--PAIGTYLSANYGDS 198
Cdd:cd17369 310 PFFwlldtGSTWLIVLAAVVVLGVLhGMMYGPQAAFLAELFPTRVRYTGAS-LGYQLGAILGGGfaPLIATALVAATGSW 388
|
170
....*....|....*..
gi 142370886 199 LVVlVATLVALLDICFI 215
Cdd:cd17369 389 WPV-ALYLAALAVISLV 404
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
50-210 |
7.61e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 7.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHETF---PQHTFLMNGLIqgvkGLLSFLSAPLIGALSDVWGRKPFLL-GTVFFTCFP 125
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLglsPATSSLYLLLI----SLGALVGALIAGLLSDRIGRKKTLViGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 126 IPL---MRINPWWYFGMISVSGVFSVTFSVIF-AYVADFTQEHERSTAYGWVSAT-FAASLVSSPAIGTYLSANYGDSLV 200
Cdd:cd17316 258 LPLfylLSGSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVP 337
|
170
....*....|
gi 142370886 201 VLVATLVALL 210
Cdd:cd17316 338 ALILALLAIV 347
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
59-450 |
2.06e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 46.85 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 59 FAWGLLTTPMLTVLHETFPQHTFLmnGLIQGVKGLLSFLSAPLIGALSDV----WG-RKPFLLGTVFFTCFPIPLMRINP 133
Cdd:cd17313 13 FGWALENSYVPPILQTLGLSHALI--GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 134 WWYFGMISVSGVFSVTFSVIF----------------AYVADFTQEHERSTAYGW------VSATFAASLVSSP----AI 187
Cdd:cd17313 91 DIGLALGDGPRTWALVLFVLGivlldfamnvcqgpvrALLPDLVPPEQRSKANGIinfmggLGGVLGYLLGAILwdhnWF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 188 GTYLSANYgdSLVVLVATLVALLDICFILIAVPEslsEKIRPASWGAQISWKQADPFASLKKV--GKDSTVLLICITVFL 265
Cdd:cd17313 171 GFALGGNL--KVPFYIGAIILLVCVLVTLFFVKE---PPLSPEAGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLVIFF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 266 SYLpeAGQYSSFF--LYLRQVIGFG----------SVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQML 333
Cdd:cd17313 246 WWI--AFFPFELFftDYMGEEVYHGtsaasshygaGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 334 QLAWYGFGSQAW----MMWAAG-TVAAMSSITFPAVSALISRNAESdqQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHV 408
Cdd:cd17313 324 GMALMALVHNVTvalvLFALGGiGWATININPYPLVSDYHSESGRG--QGTDTGLLNLAISLAQILVSLLAGPIIDVKGY 401
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 142370886 409 elselgpklnsdddplqgafipGPPFLFGACIVLMSFLVALF 450
Cdd:cd17313 402 ----------------------GTVFPVAAVASFLSLVGALF 421
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
52-217 |
2.53e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.45 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 52 FVIFLEFF---AWGLLTTPMLTVLHETFPQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKP-----FLLGTVFftC 123
Cdd:cd17353 216 WLLWLMFFlnaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNtlsiaFLIQGVA--M 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 124 FPIPLMRINPWWYFGMISVSGV-FSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVL 202
Cdd:cd17353 294 FLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFI 373
|
170
....*....|....*
gi 142370886 203 VATLVALLDICFILI 217
Cdd:cd17353 374 IAAALSLVALALALL 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
259-474 |
3.10e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.27 E-value: 3.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 259 ICITVFLSYLPEAGqYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVAQtVFLSKLMRSLGNKNTVLLGLGFQMLQLAWY 338
Cdd:cd06174 1 LLLGFFLTGLARGL-ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 339 GFGSQAWMMWAAGTVAAM-SSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHVELSELgpkl 417
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAV---- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 142370886 418 nsdddplqgafipgppFLFGACIVLMSFLVALFIPEYRKTSGVQKHNNSTSGSLSTP 474
Cdd:cd06174 155 ----------------FLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
82-445 |
5.96e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 45.38 E-value: 5.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 82 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPlmrinpwwYFGMISVSGVFSVTFSVIFAYVADFt 161
Cdd:pfam13347 72 LLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIP--------YWSLGPELTRDYDERTSLTSYRSFF- 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 162 qehersTAYGWVSATFAASLVSSPaIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSEKIRPASWGAqiswKQA 241
Cdd:pfam13347 143 ------SVGGGLLAAALAFPLVLI-LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQK----EAG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 242 DPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVkiVAFIAMVGILSIVAQTVFLSKLMRSLGNK 321
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFA--ASAFPLVFTIGALLGIPLWPPLAKRIGKK 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 322 NTVLLGLGFQM--LQLAWYGFGSQAWMMWAAGTVAAMSSIT-FPAVSALISRNAESDQ---QGVAQGIVTGIRGLCN--- 392
Cdd:pfam13347 290 NTYILGALITIagFALALLLGPNNTLLFLVLYIIIGFGYGSsFFLPWSMLADVVDYGElrtGKRREGTFFAMWSFISkla 369
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 393 -GLGPALYGFIfymfhveLSELGPKLNSDDDPLQG------AFIPGPPFLFGACIVLMSF 445
Cdd:pfam13347 370 tGVGLGVSGLL-------LSAFGYNAGDSVQSPQAvtairlLYAVLPAVLFLVALLLLYF 422
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
50-449 |
6.10e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 6.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 50 AAFVIFLEFFAWGLLTTPMLTVLHETFPQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLM 129
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 130 RI--NPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLvvlvatl 206
Cdd:cd17316 84 GLlpTPILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 207 vaLLDICFILIAVPESLSEKIRPASWGAQISWkqadpfaslkkvgkdsTVLLICITVFLSYLPEagqyssfflYLRQVIG 286
Cdd:cd17316 157 --GWRILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLPT---------YLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 287 FGSVKIVAFIAMVGILSIVAQTVFLSkLMRSLGNKNTVLLG--LGFQMLQLAWYGFGSQAWMMWAAG-TVAAMSSITFPA 363
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGL-LSDRIGRKKTLVIGliLSGILALPLFYLLSGSPTLLLLLLfILSFFVGGVWGA 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 364 VSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIfymfhvelselgpklnsdddpLQGAFIPGPPFLFGACIVLM 443
Cdd:cd17316 289 LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL---------------------LASTGGTGVPALILALLAIV 347
|
....*.
gi 142370886 444 SFLVAL 449
Cdd:cd17316 348 ALIVAL 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
259-406 |
6.58e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 259 ICITVFLSYLPEAGQYSSFFLYLRQVIGFgSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWY 338
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGI-SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 142370886 339 GFGSQAWMMWAAGTVAAM-SSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMF 406
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
246-358 |
7.01e-05 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 44.99 E-value: 7.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 246 SLKKVGKDSTVLLICITVFLSYLPeAGQYSSFFLYLRQVIGFGSVKIVAFIAmVGILSIVAQTVFLSKLMRSLGNKNTVL 325
Cdd:cd17479 195 GLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIA-LALLSEILMSFFGNWLLRKLGHAGCVV 272
|
90 100 110
....*....|....*....|....*....|...
gi 142370886 326 LGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSS 358
Cdd:cd17479 273 LGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSN 305
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
66-409 |
9.98e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 9.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 66 TPMLTVLHETFpQHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--NPWWYFGMISVS 143
Cdd:cd17478 16 PALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFapNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 144 GVFSVTFSVIFAYVADFTQEHERSTAYGWVSA--TFAASLvsSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPE 221
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 222 SLSEKIRPASWGAQISWKQADPFAslkkvgkdstVLLICITVFLSYLPEAGqYSSFF-LYLRQVigFGSVKIVAFIAMVG 300
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRA----------LLLLLIIVFLRSWVLSS-LTTFLpFYLVQR--GYSLVFAGLLLSLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 301 ILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPaVSALISRNAESDQQGVA 380
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP-VTVVLAQELLPGNVGLA 318
|
330 340
....*....|....*....|....*....
gi 142370886 381 QGIVTGIRGLCNGLGPALYGFIFYMFHVE 409
Cdd:cd17478 319 SGLMMGLSFGLGGIGAPVLGALADAFGLE 347
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
82-401 |
1.03e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 44.53 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 82 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRI--NPWWYFGMISVSGVFSVTFSVIFAYVAD 159
Cdd:PRK09874 54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLaqNIWQFLILRALLGLLGGFVPNANALIAT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 160 FTQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATlvALLDICFILIAVpeSLSEKIRPASWGAQISWK 239
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITA--SVLFLCFLVTLF--CIRENFQPVSKKEMLHMR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 240 QAdpFASLKkvgKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIgfGSVKIVAFIA-MVGILSIVAQTVF---LSKLM 315
Cdd:PRK09874 210 EV--VTSLK---NPKLVLSLFVTTLIIQVATGSIAPILTLYVRELA--GNVSNIAFISgMIASVPGVAALLSaprLGKLG 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 316 RSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAG-TVAAMSSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGL 394
Cdd:PRK09874 283 DRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRfLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVT 362
|
330
....*....|....
gi 142370886 395 GP-------ALYGF 401
Cdd:PRK09874 363 GPlmgaaisANYGF 376
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
52-401 |
1.22e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 52 FVIFLEFFAWGLLTtPMLTVLHETFPQHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFT-CFPIPLM 129
Cdd:cd17477 3 LSVALLGLGSGLLL-PLLSLRLEREGVSTALI-GLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAvSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 130 RINPWWYFGMISVSGV-FSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIGTYLSaNYGDSLVVLVA--TL 206
Cdd:cd17477 81 TDSPWVWFLLRFVMGIgLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPFLIAAvlLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 207 VALLDICFILIAVPESLSEKIRPASWGAQISWkqadpfaslkkvgkdstvlLICITVFLSYLPEAGQYSSFFLYLRQViG 286
Cdd:cd17477 160 LALVPLLLTRRAAPEIEEAESISLRRLLRIAP-------------------LALLGAFVAGFLEGAFYSLLPLYGLRL-G 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 287 FGSVKIVAFIAMVGILSIVAQtVFLSKLMRSLGnKNTVLLGLGF--QMLQLAWYGFGSQAWMMWAAGTVAAMSSIT-FPA 363
Cdd:cd17477 220 LSVAQAALLLAAFVLGGLLLQ-WPLGWLADRFD-RRRVLLGCALlgALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTL 297
|
330 340 350
....*....|....*....|....*....|....*...
gi 142370886 364 VSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGF 401
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGA 335
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
255-402 |
4.21e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 255 TVLLICITVFLSYLpEAGQYSSFFLYLRQVIGFGSVKIVAFIAMVGILSIVAQtVFLSKLMRSLGNKNTVLLGLGFQMLQ 334
Cdd:COG2814 11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 142370886 335 LAWYGFGSQAWMMWAAGTVAAM-SSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFI 402
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
24-210 |
4.79e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.54 E-value: 4.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 24 MPEKRGSAQAASGSWLQGFGHPSVYHAAFVIFLEFFAWGLLTTPMLTVLHETFPQHTFLMNGLIqGVKGLLSFLSAPLIG 103
Cdd:cd17324 177 LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL-LLFGVAGVVGSPLAG 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 104 ALSDVWGRKPFLLGTVFFTCFPIPLMRINPWWYF---GMISVSGVFSVTFSVIFAYVADFTQEHeRSTAYGWVSATFAAS 180
Cdd:cd17324 256 RLADRGGRRALLIALLLLAAALLLLTLLGPSPLLllvGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLG 334
|
170 180 190
....*....|....*....|....*....|
gi 142370886 181 LVSSPAIGTYLSANYGDSLVVLVATLVALL 210
Cdd:cd17324 335 GALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
101-347 |
6.03e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 101 LIGALSDVWG-RKPFLLGTVFF---TCFPIPLMRiNPWWYFGM-ISVSGVFSVTFSVIFAYVADFTQEH---ERSTAYGW 172
Cdd:cd17471 51 WLGRLSDRGGdRKPLILLALLAgalGYLLFAFLR-NYWVLLLVgVVLLSLGAAAFPQLFALAREYADRSsgrDATLFNSV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 173 VSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESLSEKIrpaswgaqiswkQADPFASLKKVGK 252
Cdd:cd17471 130 LRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQ------------KATPASSLVKAPV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 253 DSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGfGSVKIVAFIAMVGILSIVAQTVFLSKLMRSLGNKNTVLLGLGFQM 332
Cdd:cd17471 198 NRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELG-GSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGV 276
|
250
....*....|....*
gi 142370886 333 LQLAWYGFGSQAWMM 347
Cdd:cd17471 277 LFYLGLALATSLWQL 291
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
259-453 |
7.16e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 7.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 259 ICITVFLSYLPEAGQYSSFFLYLRQvIGFGSVKIVAFIAMVGILSIVAQTVFlSKLMRSLGNKNTVLLGLGFQMLQLAWY 338
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPA-GRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 339 GFGSQAWMMWAAGTVA-AMSSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHVELselgpkl 417
Cdd:cd17325 79 AFATSYWQLLLARFLQgLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA------- 151
|
170 180 190
....*....|....*....|....*....|....*.
gi 142370886 418 nsdddplqgafipgpPFLFGACIVLMSFLVALFIPE 453
Cdd:cd17325 152 ---------------PFLVCAALALLALVLALLLLP 172
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
42-217 |
8.08e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 8.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 42 FGHPSVYHAAFVIFLEFFAWGLLTTPMLTVLHETFpQHTFLMNGLIQGVKGLLSFLSAPLIGALSD---VWGRKPFLLGT 118
Cdd:cd17319 176 FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 119 VFFTCFPIPLMRI--NPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGWVSATFA-ASLVSSPAIGTYLSAN 194
Cdd:cd17319 255 LLLAAVGLLLAYLttSPVVAVILLSLAGFGiGAASPVFWSLPADLLPGEAAATAGGLINSGGNlGGFVAPLLIGYLVDAT 334
|
170 180
....*....|....*....|...
gi 142370886 195 YGDSLVVLVATLVALLDICFILI 217
Cdd:cd17319 335 GSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
100-452 |
1.01e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.41 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 100 PLIGALSDVWGRKP-FLLGTVFFTCFPIpLMRINPWWYFGMIS--VSGVFS-VTFSVIFAYVADFTQEHERSTAYGWVSA 175
Cdd:cd17503 49 PLSGWLADRFGTRRlFLTALALFTLGSL-LCGLAPNLASLIIFriLQGFGGgVLIPLAQTILLRIYPPEKRGAAMGLVGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 176 TFAASLVSSPAIGTYLSANYGDSLVVLVATLVALldICFILIavpeslsekirpaswgaqiswkqadPFASLKkVGKDST 255
Cdd:cd17503 128 VILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI--LALLLA-------------------------PLLDLR-LFKDRN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 256 VLLICITVFLSYLpeaGQYSSFF---LYLRQVIGFGSVKIVAFIAMVGILSIVAQtVFLSKLMRSLGNKNTVLLGL---G 329
Cdd:cd17503 180 FTLGLLLSFLLGL---GLFGAMFllpLYLQNVLGYSAFESGLVLAPGGLASAILS-PLVGRLLDKFGPRLLLLAGLlllA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 330 FQMLQLAWYGFGSQAWMMWAAGTVAAMS-SITFPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFY---- 404
Cdd:cd17503 256 LGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTnrtq 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 142370886 405 MFHVELSELGPKLNSDDDPLQGAFIPgppFLFGACIVLMSFLVALFIP 452
Cdd:cd17503 336 FHHSRLSELLAQQVQKQALIIAFNDA---FLVSAILLLVGLLLALFLR 380
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
92-210 |
1.08e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 41.51 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 92 GLLSFLSAPLIGALSDVWGRKPFLLGT-VFFTCFPIPLMRI-----NPWWYFGMISVSGVFSVTFSVIFAYV-ADFTQEH 164
Cdd:cd17367 269 LLVFMLLQPLGGRLSDRIGRRPLLLFFgIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 142370886 165 ERST----AYGWVSATFAAslvSSPAIGTYLSANYGDSLVVLVATLVALL 210
Cdd:cd17367 349 VRALgvglPYALAVAIFGG---TAPYVALWLKSIGHEWVFFWYVAGLIAI 395
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
85-400 |
3.53e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.79 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWG-RKPFLLGTVFFTCFPIPLMRI-----NPWWYFGMISVSGV----FSVTFSVIF 154
Cdd:cd17337 35 ALLFTVYGLTVAIASWLSGVLAELFGpRRVMLIGLIIWLVFEVLFLAFglpshNYPLMLLTYGLRGFgyplFAYSFLVWI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 155 AYVADftqEHERSTAYGWVSATFAASLvssPAIGTYLSA----NYGD------SLV-VLVATLVALLDI--CFILIAVPE 221
Cdd:cd17337 115 TYRTP---AERLGSAVGWFWFAFTGGL---PVLGSYLASftipVIGEigtlwlSLVfVALGGLIALFLVrdRTGEQPLAN 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 222 SLSEKIRPASWGAQISWKQadpfaslKKVGKDSTVLLICITV---FLSYLPeagqyssffLYLRQVIGFGSVKIVAFIAM 298
Cdd:cd17337 189 PSEEPLKELLSGITILFRN-------PKIAIGGIVRIINTLSqfgFPVFMP---------LYFTDTGGFSTSQWLQIWGI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 299 VGILSIVAQTVFlSKLMRSLGNKNTVL----LGLGFQMLqLAWYG---FGSQAWMMWAAGTVAAMSSITFPAVSALISRN 371
Cdd:cd17337 253 IFLVNIFFNLIF-GILGDKIGWRRTVRwfggVGCAISTL-LFYYVpqlFGHNYWAALIAAILFGIGLAGFVPLSALMPSL 330
|
330 340
....*....|....*....|....*....
gi 142370886 372 AEsDQQGVAQGIVTGIRGLCNGLGPALYG 400
Cdd:cd17337 331 AP-EHKGAAMSILNLGAGLSNFVGPAIVT 358
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
53-210 |
3.99e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.49 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 53 VIFLEFFAWGLLTTPMLTVLHET-FPQHTFLMNGLIQGVKGLLSFLsapLIGALSDVWGRKPFLLGTVFFTC---FPIPL 128
Cdd:cd17365 179 TFFMGLLLVYLLNSWLPKLMVEAgYSLSQALTITLLLNIGGVIGSL---LLGWLADRFGPKRVLALFFALGAvslALLGV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 129 MRINPWWYFGMISVSGVF-SVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAI-GTYLSANYGDSLVVLVATL 206
Cdd:cd17365 256 SPASLVLLYVLVFLAGACvNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLgGLLLAAGLGPESVFLALAI 335
|
....
gi 142370886 207 VALL 210
Cdd:cd17365 336 PAAL 339
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
93-443 |
4.91e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 39.41 E-value: 4.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 93 LLSFLSAPLIGALSDVWGRKPFL----LGTVFFTCFPIPLMRIN---PWWYFGMI--SVSGVFSVTFSVIFAYVADFTQE 163
Cdd:cd17449 76 LVGLFSVTLLGPWSDSVGRRPVLilpsLGLALQAAVYLLVMYLQlhvAYFLIGRIlsGLLGDFNGILAGCFAYVADVSDR 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 164 HERSTAYGWVSATFA-ASLVSSPAIGTYLSAN-YGDSLVVLVATLVALldICFILIAVPESLSEK--IRPASWGAQISWK 239
Cdd:cd17449 156 RSRTFRVAVLEACLGlAGMLASIIGGQWRKAQgYINPFWLVLALNLAA--ALYAAFCVGESVKEPksARLFTTRHHQSVV 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 240 Q----ADPFASLKKVGKDSTVLLICITVFL--SYLPEAGQYSSFFLYLRQVIGFGSV-KIVAFIAMVGILSIVAQTvfls 312
Cdd:cd17449 234 RlyvaPAPNGSRRKLALYSLALFVVVTVHFgaKDLLVLYELSSPLCWDSDLIGYGSAaEHLTYLSSLLGLRLLQLC---- 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 313 klmrsLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAVSALISRNAESDQQGVAQGIVTGIRGLCN 392
Cdd:cd17449 310 -----LEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCS 384
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 142370886 393 GLGPALYGFIFymfhvelselgpklnsdddPLQGAFIPGPPFLFGACIVLM 443
Cdd:cd17449 385 LVATGIFNSLY-------------------PATLHFMKGFPFLFGAALLLI 416
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
85-402 |
6.92e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.78 E-value: 6.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFFTCFPIPLMRINPWWYFGMISVsGVFSVTFSVIfaYVADFTQEH 164
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALAL-FLFGAANGAL--DVAMNAQGV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 165 ERSTAYG----------WVSATFAASLVSSPAIGTYLSANygdsLVVLVATLVALLDICFILIAVPESLSEKIRPASWGA 234
Cdd:cd17393 114 AVERAYGrpimsslhamWSLGGLAGALLGAAAIGAGVSPG----VHLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 235 qiswkqadpfASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGF----GSVKIVAFIAMVGILSIVAQtvf 310
Cdd:cd17393 190 ----------GKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGAsaalAALGYAVFSLAMTVGRLFGD--- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 311 lsKLMRSLGNKNTVLLG-----LGFQMLQLA-WYGFGSQAWMMWAAGtVAAMSSITFPAVSALISRNAESdqqGVAQGIV 384
Cdd:cd17393 257 --RLVDRFGDVAVLRAGallaaLGLLLALLApSVWVALAGFALMGLG-LSVVVPLAFSAAGALPGLAAGI---AVARVAT 330
|
330
....*....|....*...
gi 142370886 385 TGIRGLCngLGPALYGFI 402
Cdd:cd17393 331 LGYLGFL--VGPPLIGFL 346
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
53-210 |
7.81e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 7.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 53 VIFLEFFAWGLLTTPMLTVLHETFPQHTFLMNGLIqGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVFF------TCFPI 126
Cdd:cd17314 214 AIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLM-SIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTilglglCAFLF 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 127 PLMRInPWWYFGMISVSG-VFSVTFSVIFAYVADFTQEHERSTAYGWVSATFAASLVSSPAIG--------TYLSANYGD 197
Cdd:cd17314 293 LLKMT-PVGLVLTGSLLGfSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGakfydrtpSYISAVYIY 371
|
170
....*....|...
gi 142370886 198 SLVVLVATLVALL 210
Cdd:cd17314 372 AVIVFLASAILLA 384
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
85-357 |
8.24e-03 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 38.36 E-value: 8.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWGRKP-----FLLGTVFFTCFpipLMRINP--WWYFGMISVSGVFSVTFSVIF--A 155
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKKrflafFCLIGVVSTAL---LFFVTPgqWLLALLLFILANIGFSGANVFydA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 156 YVADFTQEHE--RSTAYGWVSATFAASLVSSPAIGTYLsanYGDSLVVLVATLVallDICFILIAVpeslsekirpaSWG 233
Cdd:cd17482 119 FLPDVASPERmdRVSSLGYALGYIGGGLLFAVNLVLIL---GPDAFGLDTAEAV---RLSFLSVAL-----------WWA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 234 AqiswkqadpFASLKKvgkdstVLLICITVFLSYLPEAGQYSSF-FLYLRQVIGFGSVKIVAFIAMVGILSIVAqTVFLS 312
Cdd:cd17482 182 L---------FSIPLK------QLLLFLIAYFFYIDGVQTIIRMaTIYGAEEGKLGSSALILALLLTQFVAFPG-ALLFG 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 142370886 313 KLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMS 357
Cdd:cd17482 246 WLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLV 290
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
85-215 |
8.56e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.31 E-value: 8.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 142370886 85 GLIQGVKGLLSFLSAPLIGALSDVWGRKPFLLGTVF---FTCFPIPLMRINPWWYFGMISVSGVFSVT-FSVIFAYVADF 160
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALlgaLAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 142370886 161 TQEHERSTAYGWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFI 215
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| |
