NCBI Conserved Domain Search

Conserved domains on [gi|53933280|ref|NP_001005513|]

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olfactory receptor 4C45 [Homo sapiens]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

20-286

4.07e-150

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 421.62 E-value: 4.07e-150

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 53933280 260 FPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

20-286

4.07e-150

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 421.62 E-value: 4.07e-150

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 53933280 260 FPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

26-296

1.59e-35

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 129.16 E-value: 1.59e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280    26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   186 DthtlgplIAANSGSLCFLIFSILD-------ASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPL 257
Cdd:pfam13853 161 D-------IKVNNIYGLFVVTSTFGidsllivLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHR 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 53933280   258 TSFPTDKAVTVFCT----LFTPMLNPLIYTVKNKAVKNVIKKL 296
Cdd:pfam13853 234 FGHNVPPLLQIMMAnaylFFPPVLNPIVYSVKTKQIRDCVKRM 276

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

20-286

4.07e-150

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 421.62 E-value: 4.07e-150

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 53933280 260 FPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

21-286

6.03e-114

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 329.93 E-value: 6.03e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15226 162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                       250       260
                ....*....|....*....|....*.
gi 53933280 261 PTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15226 242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

21-286

1.08e-101

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 298.63 E-value: 1.08e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP--L 257
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPssS 241

                       250       260
                ....*....|....*....|....*....
gi 53933280 258 TSFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

21-286

4.75e-101

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 296.94 E-value: 4.75e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15936 162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                       250       260
                ....*....|....*....|....*.
gi 53933280 261 PTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15936 242 PMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

21-286

6.02e-101

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 296.73 E-value: 6.02e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 53933280 260 FP--TDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15230 242 YSldQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

21-290

3.04e-98

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 290.13 E-value: 3.04e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 53933280 260 F--PTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15225 242 YspETDKLLSLFYTVVTPMLNPIIYSLRNKEVK 274

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

6-296

5.03e-98

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 290.42 E-value: 5.03e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   6 EFILLGLTHNPELQKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENN 85
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  86 TISFNGCMTQLFTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCG 165
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 166 PNVIDHFMCDLVPLLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVIL 244
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53933280 245 FFVPCSYLYLRPLTSFP--TDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKKL 296
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSldQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

22-286

3.64e-96

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 284.72 E-value: 3.64e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15940   3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15940  83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSFP 261
Cdd:cd15940 163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFS 242

                       250       260
                ....*....|....*....|....*
gi 53933280 262 TDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15940 243 EDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

7-290

1.65e-95

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 283.83 E-value: 1.65e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   7 FILLGLTHNPELQKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNT 86
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  87 ISFNGCMTQLFTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGP 166
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 167 NVIDHFMCDLVPLLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILF 245
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53933280 246 FVPCSYLYLRPLT--SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15408 241 YGSLAFMYLRPSSrySLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

7-296

2.18e-94

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 281.08 E-value: 2.18e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   7 FILLGLTHNPELQKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNT 86
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  87 ISFNGCMTQLFTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGP 166
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 167 NVIDHFMCDLVPLLELACTDTHTLGPLIAANSGSLCFLIFSILDASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILF 245
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVfIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 53933280 246 FVPCSYLYLRPLTSFP--TDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKKL 296
Cdd:cd15410 241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

21-290

1.60e-91

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 273.32 E-value: 1.60e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15229   2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15229  82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP--L 257
Cdd:cd15229 162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIhIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPnsA 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 53933280 258 TSFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15229 242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVK 274

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

21-295

1.56e-88

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 265.66 E-value: 1.56e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDT---HTLGPLIAANSGSLCFLIFSIldaSYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP 256
Cdd:cd15417 162 SLSCSDTfisQVVLFLVAVLFGVFSVLVVLI---SYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRP 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53933280 257 LT--SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15417 239 SSshSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

21-286

8.72e-88

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 263.58 E-value: 8.72e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLgPLIAANSGSLCFLIFSILD-ASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15911 162 KLSCSDTSLV-ELVTFILSSIVTLPPFLLTlTSYIcIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 259 SFPTD--KAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15911 241 NTSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

19-290

5.14e-87

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 261.77 E-value: 5.14e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  19 QKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFT 98
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  99 EHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVP 178
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 179 LLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPL 257
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 53933280 258 TSFPTDKA--VTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15235 241 SSYSADKDrvATVMYTVVTPMLNPFIYSLRNKDVK 275

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

22-295

1.80e-86

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 260.33 E-value: 1.80e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15411   3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15411  83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15411 163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53933280 261 PT--DKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15411 243 SLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

11-296

3.95e-86

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 259.99 E-value: 3.95e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  11 GLTHNPELQKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFN 90
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  91 GCMTQLFTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVID 170
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 171 HFMCDLVPLLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPC 249
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 53933280 250 SYLYLRPLTSFPTD--KAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKKL 296
Cdd:cd15406 241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

21-286

4.48e-86

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 258.95 E-value: 4.48e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPL--IAANSGSLCFLIFSILdaSYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPL 257
Cdd:cd15912 162 KLSCSDTRLIELLdfILASVVLLGSLLLTIV--SYIyIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPS 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933280 258 T--SFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15912 240 QssSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

22-295

1.65e-85

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 258.07 E-value: 1.65e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15416   3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15416  83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15416 163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53933280 261 PTD--KAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15416 243 SMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

21-286

2.28e-85

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 257.39 E-value: 2.28e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPAL-GSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                       250       260
                ....*....|....*....|....*..
gi 53933280 260 FPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15935 242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

22-286

2.63e-85

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 257.11 E-value: 2.63e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRshSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSFP 261
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFP 240

                       250       260
                ....*....|....*....|....*
gi 53933280 262 TDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15938 241 VDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

21-293

6.26e-85

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 256.42 E-value: 6.26e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15231   2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15231  82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15231 162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933280 260 FP--TDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVI 293
Cdd:cd15231 242 YSldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

21-295

1.86e-84

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 255.31 E-value: 1.86e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP-LT 258
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933280 259 SFP-TDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15419 242 SSPeQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

21-286

3.55e-84

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 254.15 E-value: 3.55e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15915   2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15915  82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSL--RSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15915 162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 259 --SFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15915 242 gdSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

20-286

6.74e-84

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 253.74 E-value: 6.74e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 259 SFPT--DKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15237 241 THSPdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

21-286

9.48e-84

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 253.12 E-value: 9.48e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                       250       260
                ....*....|....*....|....*.
gi 53933280 261 PTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15937 242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

20-286

1.63e-83

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 252.53 E-value: 1.63e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 259 SFPT--DKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15918 241 SHSAskDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

7-295

4.36e-83

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 252.36 E-value: 4.36e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   7 FILLGLTHNPELQKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNT 86
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  87 ISFNGCMTQLFTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGP 166
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 167 NVIDHFMCDLVPLLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILF 245
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 53933280 246 FVPCSYLYLRPLTSFP--TDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15945 241 YGTLLFMYLRPSSSYSldTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

21-290

5.09e-83

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 251.70 E-value: 5.09e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAAnSGSLCFLI-FSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPlT 258
Cdd:cd15421 162 KLSCADTSAYETVVYV-SGVLFLLIpFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRP-G 239

                       250       260       270
                ....*....|....*....|....*....|....*
gi 53933280 259 SFPT---DKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15421 240 SYHSpeqDKVVSVFYTILTPMLNPLIYSLRNKEVL 274

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

22-295

2.25e-82

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 249.93 E-value: 2.25e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGslCFLIFSILDA--SYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15413 163 LSCSDTHEKELIILIFAG--FNLISSLLIVlvSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933280 259 --SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15413 241 shSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

22-295

1.37e-81

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 248.08 E-value: 1.37e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15412   3 LFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15412  83 LVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSG-SLCFLIFSILdASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT- 258
Cdd:cd15412 163 LSCSDTYVKETAMFIVAGfNLSSSLLIIL-ISYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSe 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933280 259 -SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15412 242 eSVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

21-295

1.74e-81

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 247.71 E-value: 1.74e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15415   2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15415  82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15415 162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933280 260 FPTD--KAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15415 242 YSLEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

21-286

1.93e-81

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 247.14 E-value: 1.93e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIaQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNVINHFFCEVQALL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP--L 257
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIrIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPqsK 240

                       250       260
                ....*....|....*....|....*....
gi 53933280 258 TSFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

22-290

2.42e-81

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 247.34 E-value: 2.42e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 261 PTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15228 243 VLVTPVQIFNNVVTPMLNPLIYTLRNKEVK 272

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

22-295

3.55e-81

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 246.95 E-value: 3.55e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15407   3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT-- 258
Cdd:cd15407 163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSsh 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53933280 259 SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15407 243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

21-295

1.24e-80

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 245.78 E-value: 1.24e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15409  82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP--L 257
Cdd:cd15409 162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPssL 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933280 258 TSFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15409 242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

22-291

5.06e-80

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 243.85 E-value: 5.06e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT-- 258
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSgs 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 53933280 259 SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKN 291
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKG 275

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

23-286

4.11e-79

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 241.20 E-value: 4.11e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  23 FVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFF 102
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 103 AAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLEL 182
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 183 ACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSFP 261
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                       250       260
                ....*....|....*....|....*..
gi 53933280 262 T--DKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15227 244 SllDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

22-290

6.22e-79

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 241.20 E-value: 6.22e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISEN-NTISFNGCMTQLFTEH 100
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933280 260 FPTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15916 243 EALDGVIAVFYTVVTPLLNPLIYTLRNKEVK 273

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

21-286

4.43e-78

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 238.70 E-value: 4.43e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT- 258
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSs 241

                       250       260
                ....*....|....*....|....*....
gi 53933280 259 -SFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15232 242 ySPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

21-290

1.92e-77

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 237.23 E-value: 1.92e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAAnsGSLCFLI--FSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPL 257
Cdd:cd15420 162 KLACADTWINEILIFA--GCVFILLgpFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPG 239

                       250       260       270
                ....*....|....*....|....*....|....*
gi 53933280 258 TSFPT--DKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15420 240 SSNSAeqEKILSLFYSLFNPMLNPLIYSLRNKQVK 274

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

21-295

2.89e-76

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 234.63 E-value: 2.89e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53933280 260 FP--TDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKK 295
Cdd:cd15414 242 SSldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRR 279

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

22-286

4.59e-76

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 233.71 E-value: 4.59e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHT--LGPLIAAnsgsLCFLIFSIL--DASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP 256
Cdd:cd15224 163 LSCTDMSLaeLVDFILA----LIILLVPLLvtVASYIcIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARP 238

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933280 257 --LTSFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15224 239 kaISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

7-296

2.03e-75

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 232.75 E-value: 2.03e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   7 FILLGLTHNPELQKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNT 86
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  87 ISFNGCMTQLFTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGP 166
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 167 NVIDHFMCDLVPLLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILF 245
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 53933280 246 FVPCSYLYLRPLT--SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKKL 296
Cdd:cd15944 241 YGTVIFMYLRPTSvySLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

20-286

1.16e-73

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 227.51 E-value: 1.16e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAvLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 259 SFPTD--KAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15947 241 SYSQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

22-290

1.37e-72

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 224.99 E-value: 1.37e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNiLHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933280 261 PTD--KAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15405 243 SVNqgKVSSVFYTNVVPMLNPLIYSLRNKDVK 274

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

22-293

3.04e-72

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 223.85 E-value: 3.04e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVyIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 53933280 261 PTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVI 293
Cdd:cd15942 243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

22-290

4.57e-71

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 221.15 E-value: 4.57e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15424  83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15424 163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933280 261 PT--DKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15424 243 TPdrDKQIAVFYIVITPLLNPIIYTLRNKDVH 274

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

19-296

5.64e-71

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 221.19 E-value: 5.64e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  19 QKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFT 98
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  99 EHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVP 178
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 179 LLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPL 257
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53933280 258 TS--FPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVIKKL 296
Cdd:cd15418 241 SShtPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

21-286

3.33e-69

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 216.08 E-value: 3.33e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVvLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                       250       260
                ....*....|....*....|....*....
gi 53933280 260 FPT--DKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15914 242 YSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

21-286

8.35e-68

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 212.56 E-value: 8.35e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASY-VIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTS 259
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYtLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*....
gi 53933280 260 FPTD--KAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15913 242 NSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

22-290

8.95e-68

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 212.72 E-value: 8.95e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15432   3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15432  83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15432 163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAvLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933280 261 PTD--KAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15432 243 SHDrgKMVALFYGIITPMLNPLIYTLRNKDVK 274

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

21-293

1.13e-67

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 212.44 E-value: 1.13e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP-LT 258
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSaVT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933280 259 SFPTDKAVT-VFCTLFTPMLNPLIYTVKNKAVKNVI 293
Cdd:cd15234 242 HSSRKTAVAsVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

20-286

3.15e-67

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 211.08 E-value: 3.15e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15430 161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 259 --SFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15430 241 knAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

21-290

4.16e-67

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 210.80 E-value: 4.16e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDTHTLGPLIAANSGSLCFLIFSILDASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP--L 257
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTrIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksS 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 53933280 258 TSFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15428 242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVK 274

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

21-293

4.49e-67

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 210.86 E-value: 4.49e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPAL-GSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISEN-NTISFNGCMTQLFT 98
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLhGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  99 EHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVP 178
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 179 LLELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPL 257
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933280 258 TSFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVKNVI 293
Cdd:cd15941 242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

20-293

9.12e-64

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 202.22 E-value: 9.12e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAAnsgsLCFLIFS-----ILDASYVIILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYL 254
Cdd:cd15434 161 IKLACVDTTAYEATIFA----LGVFILLfplslILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYL 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53933280 255 RPLTSFPTD--KAVTVFCTLFTPMLNPLIYTVKNKAVKNVI 293
Cdd:cd15434 237 QPKNSVSQDqgKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

23-290

9.72e-64

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 202.31 E-value: 9.72e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  23 FVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFF 102
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 103 AAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLEL 182
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 183 ACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSFP 261
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933280 262 TDK--AVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15236 244 SDKdiVASVMYTVVTPMLNPFIYSLRNRDIK 274

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

22-286

4.67e-62

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 197.70 E-value: 4.67e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSF 260
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                       250       260
                ....*....|....*....|....*...
gi 53933280 261 P--TDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd15946 243 SpeRDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

20-290

1.23e-60

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 194.24 E-value: 1.23e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  20 KFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTE 99
Cdd:cd15433   1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 100 HFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLT 258
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAvLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 53933280 259 SFPTD--KAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15433 241 RYSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVK 274

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

22-290

2.91e-60

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 193.47 E-value: 2.91e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTLGPLIAANSGSLCFLIFSILDASYV-IILCSLRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRP--LT 258
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLgsVY 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933280 259 SFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVK 274

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

21-291

5.87e-57

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 184.80 E-value: 5.87e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDT---HTLGPLIA-ANSGSLCFLIFsildASYVIILCS-LRSHSSEGHLKALSSCASHiFTVILFF---VPCSYL 252
Cdd:cd15223 162 SLACGDTtinSIYGLAVAwLIVGSDIILIF----FSYALILRAvLRLASGEARSKALNTCGSH-LIVILFFytaVLVSSL 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53933280 253 YLRPLTSFPTDKAV--TVFCTLFTPMLNPLIYTVKNKAVKN 291
Cdd:cd15223 237 TYRFGKTIPPDVHVllSVLYILIPPALNPIIYGVRTKEIRQ 277

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

26-287

7.40e-54

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 176.71 E-value: 7.40e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 186 DT--HTLGPLIAANSGSLCFLIFSILdaSYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSFPT 262
Cdd:cd15917 167 DTrvNSIYGLFVALLIVGFDLLFIAL--SYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                       250       260
                ....*....|....*....|....*....
gi 53933280 263 DKAVTVFCT----LFTPMLNPLIYTVKNK 287
Cdd:cd15917 245 PPHVHILLAnlylLLPPMLNPIVYGVRTK 273

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

26-287

4.99e-49

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 164.39 E-value: 4.99e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 186 DthtlgplIAANS--GSLCFLIFSILDA-----SYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPC--SYLYLR 255
Cdd:cd15221 167 D-------ITVNIwyGLTVALLTVGLDVvliavSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAffSFLTHR 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53933280 256 PLTSFPtdKAVTVF----CTLFTPMLNPLIYTVKNK 287
Cdd:cd15221 240 FGRHIP--RHVHILlanlYVLVPPMLNPIVYGVKTK 273

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

26-289

1.31e-47

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 160.66 E-value: 1.31e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 186 DTH------TLGPLIAANSGSLCflifsiLDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVP--CSYLYLRP 256
Cdd:cd15950 167 DPRpsslysITGSTLVVGTDSAF------IAVSYGLILRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPglLSIYTQRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 53933280 257 LTSFPTDKAVTV--FCTLFTPMLNPLIYTVKNKAV 289
Cdd:cd15950 241 GQGVPPHTQVLLadLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

26-287

5.55e-47

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 159.05 E-value: 5.55e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 186 DTHtlgpLIAANSGSLCFLI----FSILDASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPC--SYLYLRPLT 258
Cdd:cd15951 167 DTR----VSRAYGLSVAFLVggldVIFIAVSYIQILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPAlfSFLTHRFGH 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 53933280 259 SFPTDKAVTV--FCTLFTPMLNPLIYTVKNK 287
Cdd:cd15951 243 NVPPHVHILIanVYLLVPPMLNPIIYGVRTK 273

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

26-287

2.52e-46

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 157.16 E-value: 2.52e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQ------SMCGFLMVVAGILGFVhggiqtLFIAQLPFCGPNVIDHFMCDLVPL 179
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNkvisviALGIVLRPLLLVLPFV------FLILRLPFCGHNIIPHTYCEHMGI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 180 LELACTDthtlgplIAANS----GSLCFLIFSIL--DASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPC--S 250
Cdd:cd15952 161 AKLACAS-------IRINIiyglFAISVLVLDVIliALSYVLILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPAlfS 233

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933280 251 YLYLRPLTSFP--TDKAVTVFCTLFTPMLNPLIYTVKNK 287
Cdd:cd15952 234 FLTHRFGHNIPryIHILLANLYVVLPPMLNPVIYGVRTK 272

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

22-287

8.03e-46

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 156.12 E-value: 8.03e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15222  83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHTlgpliaaNSGSLCFLIFSI--LDA-----SYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVP----- 248
Cdd:cd15222 163 LACSDTRV-------NSIYGLFVVLSTmgLDSllillSYVLILKTvLGIASREERLKALNTCVSHICAVLIFYVPmigls 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53933280 249 ----------------CSYLYLrpltsfptdkavtvfctLFTPMLNPLIYTVKNK 287
Cdd:cd15222 236 mvhrfgkhasplvhvlMANVYL-----------------LVPPVLNPIIYSVKTK 273

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

5-290

5.59e-43

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 149.16 E-value: 5.59e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   5 TEFILLGLTHNPELQKFLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISEN 84
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  85 NTISFNGCMTQLFTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFC 164
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 165 GPNVIDHFMCDLVPLLELACTDThTLGPLIAANSGSLCFLIFSI-LDASYVIIL-CSLRSHSSEGHLKALSSCASHIFTV 242
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDV-SINNHYGLTIGFLVLIMDSLfIVLSYIMILrVVQRLATSEARLKTFGTCVSHVCAI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 53933280 243 ILFFVP--CSYLYLR--PLTSFPTDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15949 241 LAFYVPiaVSSLIHRfgQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

26-289

6.40e-43

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 148.57 E-value: 6.40e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 186 DThtlgpLIAANSGSLCFLIFSILD-----ASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPC--SYLYLRPL 257
Cdd:cd15953 167 DT-----TINRIYGLVVALLVVGLDllliaLSYALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPAlfSFLTHRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 53933280 258 TSFPTDKAVTV--FCTLFTPMLNPLIYTVKNKAV 289
Cdd:cd15953 242 QGIAPHIHIILanLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

26-290

1.12e-38

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 137.73 E-value: 1.12e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 186 DT--HTLGPLIAANSGSLCFLIFSILdaSYVIILCSLRSHSS-EGHLKALSSCASHIFTVILFFVPC---SYLYLRPLTS 259
Cdd:cd15948 168 DTrfNNIYGIAVALFIVGLDLMFIIL--SYVFILRAVLSLASkEEQLKAFGTCGSHICAILVFYTPVvlsSTMHRFARHV 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 53933280 260 FP-TDKAVTVFCTLFTPMLNPLIYTVKNKAVK 290
Cdd:cd15948 246 APhVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

21-289

1.72e-37

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 134.22 E-value: 1.72e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd15956   2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLL 180
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 181 ELACTDT-----HTLGPLIAANSGSLCFLIFsildaSYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYL 254
Cdd:cd15956 162 KLACGATtvdslYGLALALFIGGGDVLFIAY-----SYGLIVKTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVL 236

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53933280 255 RPLTSFPTDKAVTVFCT----LFTPMLNPLIYTVKNKAV 289
Cdd:cd15956 237 MHRFGHSVPSAAHVLLSnlylLLPPALNPIVYGIRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

26-296

1.59e-35

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 129.16 E-value: 1.59e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280    26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFMCDLVPLLELACT 185
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   186 DthtlgplIAANSGSLCFLIFSILD-------ASYVIILCS-LRSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPL 257
Cdd:pfam13853 161 D-------IKVNNIYGLFVVTSTFGidsllivLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHR 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 53933280   258 TSFPTDKAVTVFCT----LFTPMLNPLIYTVKNKAVKNVIKKL 296
Cdd:pfam13853 234 FGHNVPPLLQIMMAnaylFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

26-289

4.45e-32

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 120.31 E-value: 4.45e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSmcgfLMVVAGILGFVHGGIQ----TLFIAQLPFCGPNVIDHFMCDLVPLLE 181
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNP----VITKAGLATFLRGVMLiipfPLLTKRLPYCRGNFIPHTYCDHMSVVK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 LACTDTHT---LGPLIAANSGSLCFLIFSIldaSYVIILCSLRSHSS-EGHLKALSSCASHIFTVILFFVPCSYLYL--R 255
Cdd:cd15954 163 LACANIRVdaiYGLMVALLIGGFDILCISV---SYAMILRAVVSLSSkEARSKAFSTCTAHICAIVITYTPAFFTFFahR 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53933280 256 PLTSFPTDKAVTVFCTLF---TPMLNPLIYTVKNKAV 289
Cdd:cd15954 240 FGGHHITPHIHIIMANLYlllPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

26-289

2.39e-28

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 110.24 E-value: 2.39e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  26 FLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAA 105
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIA-QLPFCGPNVIDHFMCDLVPLLELAC 184
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 185 TDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSL-RSHSSEGHLKALSSCASHIFTVILFFVPCSYLYLRPLTSFPTD 263
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVA 246

                       250       260       270
                ....*....|....*....|....*....|
gi 53933280 264 KAVTVFCT----LFTPMLNPLIYTVKNKAV 289
Cdd:cd15955 247 PYVHILLSnlylLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

36-282

7.29e-18

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 81.19 E-value: 7.29e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280    36 GNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENN-TISFNGCMTQLFTEHFFAAAETILLSVMA 114
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   115 YDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNvidHFMCDLVPLLELACTDTHTLGPLI 194
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280   195 aansgsLCFLI-FSILDASYVIILCSLRSHSSEGH--------LKALSSCASHIFTVILFFVPCSYLYLRPL-------- 257
Cdd:pfam00001 158 ------LGFLLpLLVILVCYTLIIRTLRKSASKQKssertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSlaldcels 231

                         250       260
                  ....*....|....*....|....*
gi 53933280   258 TSFPTDKAVTVFCTLFTPMLNPLIY 282
Cdd:pfam00001 232 RLLDKALSVTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

22-286

1.01e-16

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 78.48 E-value: 1.01e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHF 101
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 102 FAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVIDHFmcdlvplle 181
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLC--------- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 182 laCTDTHTLGPLIAANSGSLCFLIFSILDASYVIILCSLRSHSSEGHLKALSSCASH-----------IFTVILFFVPC- 249
Cdd:cd00637 152 --WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktLLIVVVVFLLCw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53933280 250 ---------SYLYLRPLTSFPTDKAVTVFCTLFTPMLNPLIYTVKN 286
Cdd:cd00637 230 lpyfillllDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

21-178

1.55e-05

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 45.63 E-value: 1.55e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  21 FLFVMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEH 100
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVhggIQTLFIAQLPFCGPNVIDHFMCDLVP 178
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL---ISLPPLVGWRDETQPSVVDCECEFTP 155

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

31-170

2.32e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 44.92 E-value: 2.32e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  31 LITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYS-SSIAPKMIFDLisennTISFNG----CMTQLFTEHFFAAA 105
Cdd:cd15196  12 VLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDI-----TYRFYGgdllCRLVKYLQVVGMYA 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 53933280 106 ETILLSVMAYDCYVAICKPLHYATIMTQSMcgFLMV-VAGILGFVHGGIQtLFIAQLPFCGPNVID 170
Cdd:cd15196  87 SSYVLVATAIDRYIAICHPLSSHRWTSRRV--HLMVaIAWVLSLLLSIPQ-LFIFSYQEVGSGVYD 149

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

22-146

4.41e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 44.36 E-value: 4.41e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITYLITLAGNLLisVIIFIS--PALGSPMYLFLSYLSIIDIFYSSSIAPkmiFDLISENNTISFNG---CMTQL 96
Cdd:cd15317   3 IYIVLVLAMLITVSGNLV--VIISIShfKQLHSPTNMLVLSLATADFLLGLCVMP---FSMIRTVETCWYFGdlfCKFHT 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 53933280  97 FTEHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGIL 146
Cdd:cd15317  78 GLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

22-149

2.08e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 42.34 E-value: 2.08e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITylITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIapkMIFDLISENNTISFNG---CMTQLFT 98
Cdd:cd15065   4 IFLSLIIV--LAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLV---MTFAVVNDLLGYWLFGetfCNIWISF 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 53933280  99 EHFFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFV 149
Cdd:cd15065  79 DVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129

7tmA_GPR6

cd15962

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...

24-293

2.64e-04

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320628 [Multi-domain] Cd Length: 268 Bit Score: 41.84 E-value: 2.64e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  24 VMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFngcMTQLFTEHFFA 103
Cdd:cd15962   5 IMLCISGTVIACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISL---ITVGFLVASFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 104 AAETILLSVMAyDCYVAICKPLHYATimTQSMCGFLMVVAGILGFvhggiqTLFIAQLPFCGPNVIDHFMcdlvpllelA 183
Cdd:cd15962  82 ASVSSLLAITV-DRYLSLYNALTYYS--EKTVLGVHLMLAATWGV------SLCLGLLPVLGWNCLEERA---------S 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 184 CTdthTLGPLIAANSGSLC---FLIFSILDASYVIILCSLRSHSSEGHLKALSSCASHI---------FTVILFFVPCSY 251
Cdd:cd15962 144 CS---IVRPLTKSNVTLLSasfFFIFILMLHLYIKICKIVCRHAHQIALQQHFLTASHYvatkkgvstLAIILGTFGASW 220

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53933280 252 L--YLRPLTSFPTDKAVTVFCTL----FTPMLNPLIYTVKNKAVKNVI 293
Cdd:cd15962 221 LpfAIYCVVGDHEYPAVYTYATLlpatYNSMINPIIYAYRNQEIQRSM 268

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

24-150

2.69e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 41.85 E-value: 2.69e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  24 VMFLITYLITLAGNLLiSVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQL--FTEHF 101
Cdd:cd14978   5 YVLPVICIFGIIGNIL-NLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpYIYPL 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 53933280 102 FAAAETI---LLSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVH 150
Cdd:cd14978  84 ANTFQTAsvwLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLL 135

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

22-143

1.35e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 39.75 E-value: 1.35e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  22 LFVMFLITyLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTI-SFNGCMTQLFTEH 100
Cdd:cd15005   4 LTTLGLIL-CVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAV 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 53933280 101 FFAAAETILLSVMAYDCYVAICKPLHYATIMTQSMCgfLMVVA 143
Cdd:cd15005  83 LFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTC--LAVIC 123

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-159

1.39e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 39.78 E-value: 1.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  25 MFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFA- 103
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIDNVIDSm 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 53933280 104 -----AAETILLSVMAYDCYVAICKPLHYATIMTQSMCGflMVVAGILGFVhGGIQTLFIA 159
Cdd:cd15103  86 icsslLASICSLLAIAVDRYITIFYALRYHSIMTVRRAG--VIITAIWVFC-TVCGILFII 143

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

24-151

2.16e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 39.15 E-value: 2.16e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  24 VMFLITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIfdLISENNTISFNGCMtqlftehFFA 103
Cdd:cd15069   5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--TISLGFCTDFHSCL-------FLA 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53933280 104 AAETIL-------LSVMAYDCYVAICKPLHYATIMTQSMCGFLMVVAGILGFVHG 151
Cdd:cd15069  76 CFVLVLtqssifsLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIG 130

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

28-140

3.00e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 38.65 E-value: 3.00e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  28 ITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSS-SIAPKMIFDLisennTISFNG----CMTQLFTEHFF 102
Cdd:cd15385   9 VIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDI-----TYRFYGpdflCRIVKHLQVLG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 53933280 103 AAAETILLSVMAYDCYVAICKPLH---------YATIMTQSMCGFLM 140
Cdd:cd15385  84 MFASTYMLVMMTADRYIAICHPLKtlqqptkrsYLMIGSAWALSFIL 130

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

24-125

3.17e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 38.64 E-value: 3.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  24 VMFLITYLiTLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSS-SIAPKMIFDLisennTISFNG----CMTQLFT 98
Cdd:cd15387   6 VLALILFL-ALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDI-----TFRFYGpdflCRLVKYL 79

                        90       100
                ....*....|....*....|....*..
gi 53933280  99 EHFFAAAETILLSVMAYDCYVAICKPL 125
Cdd:cd15387  80 QVVGMFASTYMLLLMSIDRCLAICQPL 106

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

28-133

4.97e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 37.96 E-value: 4.97e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  28 ITYLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFAAAET 107
Cdd:cd15959   9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88

                        90       100
                ....*....|....*....|....*.
gi 53933280 108 ILLSVMAYDCYVAICKPLHYATIMTQ 133
Cdd:cd15959  89 ETLCAIAVDRYLAITNPLRYEALVTK 114

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

23-149

5.87e-03

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 37.57 E-value: 5.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  23 FVMFLITyLITLAGNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFF 102
Cdd:cd14969   5 VYLSLIG-VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 53933280 103 AAAETILLSVMAYDCYVAICKPLhYATIMTQSMCGFLMVVAGILGFV 149
Cdd:cd14969  84 GLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLF 129

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

29-293

9.41e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 37.02 E-value: 9.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280  29 TYLITLA-----GNLLISVIIFISPALGSPMYLFLSYLSIIDIFYSSSIAPKMIFDLISENNTISFNGCMTQLFTEHFFA 103
Cdd:cd15073   5 AYLIVAGiistiSNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 104 AAETILLSVMAYDCYVAICKPLHYATiMTQSMCGFLMVVAGILGFvhggiqtlFIAQLPFCGPNVIDHFMCDLVPLLELA 183
Cdd:cd15073  85 MASIGLLTVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAF--------FWAAMPLVGWASYALDPTGATCTINWR 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53933280 184 CTDTHTLGPLIAANsgSLCFLI-FSILDASYVIILCSLRSHSSEGHLKALSSCASH--------IFTVILFFV---PCSY 251
Cdd:cd15073 156 KNDSSFVSYTMSVI--VVNFIVpLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDqndvtkmsVIMIVMFLVawsPYSI 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 53933280 252 LYLrpLTSFPTDKAVTVFCTLFTPML-------NPLIYTVKNKAVKNVI 293
Cdd:cd15073 234 VCL--WASFGEPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01