NCBI Conserved Domain Search

Conserved domains on [gi|47577595|ref|NP_001000925|]

View

olfactory receptor Olr661 [Rattus norvegicus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-288

4.24e-139

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 393.50 E-value: 4.24e-139

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAH 102
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 103 FFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLL 182
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 183 KLACTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSV 262
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-288

4.24e-139

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 393.50 E-value: 4.24e-139

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAH 102
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 103 FFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLL 182
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 183 KLACTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSV 262
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

28-300

2.31e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 136.86 E-value: 2.31e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595    28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLACT 187
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   188 ETRLLVI----VIITTTGVMSILTFVALVisyIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP--MGDS 261
Cdd:pfam13853 161 DIKVNNIyglfVVTSTFGIDSLLIVLSYG---LILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVhrFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 47577595   262 VGD--DKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKVWC 300
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-288

4.24e-139

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 393.50 E-value: 4.24e-139

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAH 102
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 103 FFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLL 182
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 183 KLACTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSV 262
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

22-288

3.28e-103

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 302.87 E-value: 3.28e-103

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPL 181
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 182 LKLACTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PM 258
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLtLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVrpSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577595 259 GDSVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd13954 241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-288

4.85e-102

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 299.50 E-value: 4.85e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15226   5 VFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15226  85 GSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGDD 265
Cdd:cd15226 165 CTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVD 244

                       250       260
                ....*....|....*....|...
gi 47577595 266 KVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15226 245 KFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-288

1.14e-99

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 293.65 E-value: 1.14e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15230   5 VLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15230  85 TTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15230 165 CSDTHINELVLFAFSGFIGLSTLLIiLISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLrpSSSYSL 244

                       250       260
                ....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15230 245 DQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-295

1.56e-98

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 291.28 E-value: 1.56e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15225   5 VVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15225  85 GTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFV-ALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP--MGDSV 262
Cdd:cd15225 165 CADTSLNEIAIFVASVLVILVPFLlILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRpkSSYSP 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15225 245 ETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

8-298

3.05e-97

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 288.49 E-value: 3.05e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   8 EFILLGLFHDEDVKAICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCN 87
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  88 TISYNACIAQMFYAHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCG 167
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 168 TNEIDHYFCDIFPLLKLACTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFM 246
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEiLVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577595 247 FFLPLIFTYV-PMGD-SVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKV 298
Cdd:cd15943 241 FYGTTLFMYLrPSSSySLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

26-295

7.02e-91

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 271.79 E-value: 7.02e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15235   6 LLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15235  86 NTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLS 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIItTTGVMSILTFVALVIS--YIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDS 261
Cdd:cd15235 166 CSDTSLNELLIF-TEGAVVVLGPFLLIVLsyARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFqpSSSYS 244

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577595 262 VGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15235 245 ADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

9-292

3.54e-90

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 270.35 E-value: 3.54e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   9 FILLGLFHDEDVKAICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNT 88
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  89 ISYNACIAQMFYAHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGT 168
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 169 NEIDHYFCDIFPLLKLACTETRLLVIVIITTTG-VMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMF 247
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGfNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47577595 248 FLPLIFTYVPMGD--SVGDDKVFALFYTMIAPLFNPLIYTLRNTDMK 292
Cdd:cd15408 241 YGSLAFMYLRPSSrySLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-288

1.46e-89

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 268.05 E-value: 1.46e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15936   5 LVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15936  85 GAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGDD 265
Cdd:cd15936 165 CTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPMD 244

                       250       260
                ....*....|....*....|...
gi 47577595 266 KVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15936 245 KAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-295

7.23e-89

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 266.38 E-value: 7.23e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15229   5 LVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15229  85 GTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFV-ALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15229 165 CSDTFANKMVLLTSSVIFGLGSFLlTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLrpNSASSS 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15229 245 VLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-288

7.20e-88

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 263.58 E-value: 7.20e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15912   5 LLLLLTYLLTLLGNlLIITITLVDHRL-HTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15912  84 GTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRL--LVIVIITTTGVMSILTFVaLVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGD 260
Cdd:cd15912 164 SCSDTRLieLLDFILASVVLLGSLLLT-IVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVrpSQSS 242

                       250       260
                ....*....|....*....|....*...
gi 47577595 261 SVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15912 243 SLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-288

7.38e-88

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 263.53 E-value: 7.38e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15940   5 MLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15940  85 CTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGDD 265
Cdd:cd15940 165 CTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSED 244

                       250       260
                ....*....|....*....|...
gi 47577595 266 KVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15940 245 KVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

9-298

2.29e-87

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 263.37 E-value: 2.29e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   9 FILLGLFHDEDVKAICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNT 88
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  89 ISYNACIAQMFYAHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGT 168
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 169 NEIDHYFCDIFPLLKLACTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMF 247
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLlIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577595 248 FLPLIFTYV--PMGDSVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKV 298
Cdd:cd15410 241 HGTILFMYCrpSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-297

2.59e-87

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 262.63 E-value: 2.59e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15419   5 LLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15419  85 TTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGD--SV 262
Cdd:cd15419 165 CSDTFINELVMFVLCGLIIVSTIlVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAvsSP 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15419 245 EQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

26-288

1.26e-86

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 260.62 E-value: 1.26e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15918   5 GLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15918  85 DLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15918 165 CSDTHLNELVILVLGGLVGLVPFLCiLVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLspPSSHSA 244

                       250       260
                ....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15918 245 SKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

23-288

1.47e-86

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 260.46 E-value: 1.47e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGN-LIVLLTIKGSQLSeQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd15227   2 LHFVLFLLIYLAALTGNlLIITVVTLDHHLH-TPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPL 181
Cdd:cd15227  81 IFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 182 LKLACTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PM 258
Cdd:cd15227 161 LKLSCSDTYLNEIGVLVLSVCLGLGCFVFiIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLkpPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577595 259 GDSVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15227 241 DSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

26-288

5.14e-85

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 256.43 E-value: 5.14e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15237   5 ILFLLIYLLTLLGNgLIILLIWLDSRL-HTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15237  84 GVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDS 261
Cdd:cd15237 164 ACADTSLNEAVIFVTSVLVLLIPFsLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMrpHSTHS 243

                       250       260
                ....*....|....*....|....*..
gi 47577595 262 VGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15237 244 PDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-288

8.88e-85

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 255.82 E-value: 8.88e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15937   5 VLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15937  85 AAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGDD 265
Cdd:cd15937 165 CTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFPMD 244

                       250       260
                ....*....|....*....|...
gi 47577595 266 KVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15937 245 KVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

9-297

1.37e-84

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 256.21 E-value: 1.37e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   9 FILLGLFHDEDVKAICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNT 88
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  89 ISYNACIAQMFYAHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGT 168
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 169 NEIDHYFCDIFPLLKLACTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMF 247
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAiIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577595 248 FLPLIFTYV-PMGD-SVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15945 241 YGTLLFMYLrPSSSySLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

26-295

1.91e-84

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 255.27 E-value: 1.91e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15231   5 LIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15231  85 GTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFV-ALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15231 165 CSDTSLNEVLLLVASVFIGLTPFLfIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNrpSSGYSL 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15231 245 DKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-288

2.22e-84

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 254.84 E-value: 2.22e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15431   5 VLLLIVYLVTLLGNgLIILLIRVDSQL-HTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLViIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15431  84 GITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT-MPLHFCGPNVINHFFCEVQALLKL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIITTtgvmSILTFVA-----LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV-PM 258
Cdd:cd15431 163 ACSDTSLNEILMFAT----SIFTLLLpfsfiLVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLrPQ 238

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577595 259 GDSVGD-DKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15431 239 SKSSSDqDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-297

2.64e-84

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 255.02 E-value: 2.64e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNL-IVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15409   5 LVFLAIYLITLVGNLgLIALIWKDSHL-HTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15409  84 ATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKI 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVG 263
Cdd:cd15409 164 SCTDPSINELVLFIFSGSIQVFTILTvLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577595 264 D--DKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15409 244 LdqDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

22-297

5.26e-84

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 254.17 E-value: 5.26e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLCYLAILCGNL-IVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFY 100
Cdd:cd15413   1 IPLFGLFLVIYLTTVMGNLgMIILTRLDSRL-QTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 101 AHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFP 180
Cdd:cd15413  80 FLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 181 LLKLACTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--P 257
Cdd:cd15413 160 LLALSCSDTHEKELIILIFAGFNLISSLlIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLqpK 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47577595 258 MGDSVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15413 240 SSHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

27-298

1.26e-83

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 253.83 E-value: 1.26e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  27 LFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGA 106
Cdd:cd15406  15 LFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 107 TEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLAC 186
Cdd:cd15406  95 AECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSC 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 187 TETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSVG 263
Cdd:cd15406 175 SSTYINELLLFIVGGFNVLATTLAiLISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLkpSSSSSMT 254

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577595 264 DDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKV 298
Cdd:cd15406 255 QEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

26-297

1.27e-83

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 253.11 E-value: 1.27e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15415   5 MLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15415  85 TTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGD--SV 262
Cdd:cd15415 165 CSDTHINELLLLTFSGVIAMSTLlTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSqySL 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15415 245 EQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

22-297

1.36e-83

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 253.06 E-value: 1.36e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPL 181
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 182 LKLACTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PM 258
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVlTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVmpNS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577595 259 GDSVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

26-288

3.99e-83

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 251.84 E-value: 3.99e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNL-IVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15915   5 VLFLLLYLASLLGNGaILAVVIAEPRL-HSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15915  84 GSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIITTTGVMSILTF--VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGD 260
Cdd:cd15915 164 ACGDTSLNLWLLNIVTGSIALGTFilTLLSYIYIISFLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIrpSSGD 243

                       250       260
                ....*....|....*....|....*...
gi 47577595 261 SVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15915 244 SLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-295

6.49e-83

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 251.55 E-value: 6.49e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15429   5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15429  85 GTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIViITTTGVMSILT--FVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV-PMGD-S 261
Cdd:cd15429 165 CVDTSLNEVA-ILVSSVVVLLTpcFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMrPRSGsS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577595 262 VGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15429 244 ALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

26-297

7.09e-83

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 251.47 E-value: 7.09e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15411   5 VLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15411  85 TTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTG---VMSILTFvaLVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGD-- 260
Cdd:cd15411 165 CSDTHVNEMLIFILAGltlVGSLLII--LVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSsy 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577595 261 SVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15411 243 SLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-297

2.85e-82

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 249.87 E-value: 2.85e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15417   5 VLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15417  85 LTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTT---GVMSILtfVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGD 260
Cdd:cd15417 165 CSDTFISQVVLFLVAvlfGVFSVL--VVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLrpSSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577595 261 SVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15417 243 SQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-288

1.18e-81

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 247.76 E-value: 1.18e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKG-SQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15935   5 VLVLACYAAILLGNLLIVVTVHAdPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15935  85 GGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGD 264
Cdd:cd15935 165 ACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSSV 244

                       250       260
                ....*....|....*....|....
gi 47577595 265 DKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15935 245 DKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-288

2.16e-81

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 247.40 E-value: 2.16e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15911   5 LLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15911  85 ATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFV-ALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV-PMGDSVG 263
Cdd:cd15911 165 CSDTSLVELVTFILSSIVTLPPFLlTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVvPSTNTSR 244

                       250       260
                ....*....|....*....|....*.
gi 47577595 264 D-DKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15911 245 DlNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-288

3.40e-81

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 246.71 E-value: 3.40e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15938   5 ALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15938  85 AAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVALVisYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGDD 265
Cdd:cd15938 165 CTDTCVTELLMVSNSGLISTVCFVVLV--TSYTTILVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPVD 242

                       250       260
                ....*....|....*....|...
gi 47577595 266 KVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15938 243 KHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-298

1.58e-80

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 245.80 E-value: 1.58e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15414   5 LLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15414  85 AAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILT-FVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15414 165 CADTQINKWVLFIMAGALGVLSgLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVrpSSSSSL 244

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKV 298
Cdd:cd15414 245 DLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRT 280

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

27-295

1.69e-80

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 245.15 E-value: 1.69e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  27 LFLLCYLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15421   6 LILLIFLVALTGNaLLILLIWLDSRL-HTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15421  85 GAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMG--DSV 262
Cdd:cd15421 165 CADTSAYETVVYVSGVLFLLIPFsLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGsyHSP 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15421 245 EQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-288

3.38e-80

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 244.09 E-value: 3.38e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15232   5 WLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15232  85 GSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15232 165 CSDTSLNEIMAFVADVFFGVGNFlLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIrpSSSYSP 244

                       250       260
                ....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15232 245 EKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-297

4.00e-78

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 239.22 E-value: 4.00e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15412   5 VLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15412  85 ITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGV-MSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15412 165 CSDTYVKETAMFIVAGFnLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLrpPSEESV 244

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15412 245 EQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

26-288

1.64e-77

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 237.52 E-value: 1.64e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNL-IVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15947   5 VVVLIFYLLTLLGNTaIILLSLLDPRL-HTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15947  84 GSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRL--LVIVIITTTGVMSILTFVaLVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSV 262
Cdd:cd15947 164 ACVDTTFneLELFVASVFFLLVPLSLI-LVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 47577595 263 GDD--KVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15947 243 SQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-295

3.44e-77

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 236.56 E-value: 3.44e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15228   5 VLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15228  85 STECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGD 264
Cdd:cd15228 165 CADTSIAETVSFTNVGLVPLTCFLLiLASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPVL 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577595 265 DKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15228 245 VTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

27-295

8.92e-77

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 235.81 E-value: 8.92e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  27 LFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLL-VQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15916   6 IFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHFLG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15916  86 STECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVALVI-SYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGD 264
Cdd:cd15916 166 CADTTINELVIFASIGVVALGCFILILLsYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEAL 245

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577595 265 DKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15916 246 DGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-295

1.31e-76

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 235.30 E-value: 1.31e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15420   5 GLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15420  85 HTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIItTTGVMSILT--FVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTY-VPM-GDS 261
Cdd:cd15420 165 CADTWINEILIF-AGCVFILLGpfSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYmVPGsSNS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577595 262 VGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15420 244 AEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-297

1.49e-75

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 232.70 E-value: 1.49e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15407   5 IIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15407  85 TVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRL--LVIVIITTTGVMSILTfVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDS 261
Cdd:cd15407 165 CSDIHIseIVLFFLASFNVFFALL-VILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLqpSSSHS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577595 262 VGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRK 297
Cdd:cd15407 244 MDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

22-295

1.57e-74

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 230.04 E-value: 1.57e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd15236   1 GVFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPL 181
Cdd:cd15236  81 IFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 182 LKLACTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PM 258
Cdd:cd15236 161 LKLSCSSTSLNELVIFTEGGLLFVLPLLLiLGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFfpSS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577595 259 GDSVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15236 241 NNSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

27-295

1.86e-73

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 227.07 E-value: 1.86e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  27 LFLLCYLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15234   6 LFLSMYLVTVLGNlLIILAVSSDSHL-HTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15234  85 GLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVA-LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMG--DSV 262
Cdd:cd15234 165 CSDTLINNILIYLATVIFGGIPLSGiIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAvtHSS 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15234 245 RKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

23-295

3.56e-73

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 226.49 E-value: 3.56e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGNL-IVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd15434   2 ILSVVVLIFYLLTLVGNTtIILVSCLDSRL-HTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPL 181
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 182 LKLACTETRLLVIViITTTGVMSILT--FVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMG 259
Cdd:cd15434 161 IKLACVDTTAYEAT-IFALGVFILLFplSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPK 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577595 260 DSVGDD--KVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15434 240 NSVSQDqgKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-295

1.44e-72

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 224.99 E-value: 1.44e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15405   5 FLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15405  85 ISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSIL-TFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGD--SV 262
Cdd:cd15405 165 CTSTYVNELVVFVVVGINIIVpSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSvgSV 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15405 245 NQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

23-288

6.01e-72

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 223.02 E-value: 6.01e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAH 102
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 103 FFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLL 182
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 183 KLACTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGD- 260
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFlLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKs 241

                       250       260
                ....*....|....*....|....*....
gi 47577595 261 -SVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15914 242 ySLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-288

2.64e-71

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 221.39 E-value: 2.64e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15224   5 LLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15224  85 CTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRL-------LVIVIITTTGVMSILTFVALVisyiiiLSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV-P 257
Cdd:cd15224 165 CTDMSLaelvdfiLALIILLVPLLVTVASYICII------STVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYArP 238

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577595 258 MGDSVGD-DKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15224 239 KAISSFDsNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

9-298

5.68e-71

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 221.58 E-value: 5.68e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   9 FILLGLFHDEDVKAICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNT 88
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  89 ISYNACIAQMFYAHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGT 168
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 169 NEIDHYFCDIFPLLKLACTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMF 247
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLsIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577595 248 FLPLIFTYVPMGD--SVGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKV 298
Cdd:cd15944 241 YGTVIFMYLRPTSvySLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

28-295

5.59e-70

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 218.46 E-value: 5.59e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:cd15942   7 FLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLACT 187
Cdd:cd15942  87 ECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 188 ETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGDDK 266
Cdd:cd15942 167 DTAFNELVTFIDIGLVAMTCFlLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPLDG 246

                       250       260
                ....*....|....*....|....*....
gi 47577595 267 VFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15942 247 VVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-288

6.85e-70

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 218.01 E-value: 6.85e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLC---YLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd15430   2 LLFVLClimYLVILLGNgVLIIITILDSHL-HTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPL 181
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 182 LKLACTETRLLVIvIITTTGVMSILTFVALVIS--YIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP-- 257
Cdd:cd15430 161 LKLACVDISLNEI-IMLVGNIIFLVIPLLLICIsyIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKpk 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577595 258 MGDSVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15430 240 SKNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-295

2.84e-69

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 216.53 E-value: 2.84e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15424   5 VVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15424  85 STECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRlLVIVIITTTGVMSILT--FVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTY-VPMGDSV 262
Cdd:cd15424 165 CADTH-ITEAIVFGAGVLILLVplSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYmRPRSGST 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577595 263 GD-DKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15424 244 PDrDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-295

6.66e-69

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 215.48 E-value: 6.66e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKG-SQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQC-NTISYNACIAQMFYAHF 103
Cdd:cd15941   5 LLFLLIYLLTVLGNLLILLTIGSdPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAFHF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 104 FGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLK 183
Cdd:cd15941  85 LASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLK 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 184 LACTETRLLVIVIITTTGVMSILTFVALVI-SYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSV 262
Cdd:cd15941 165 LACADTTINELVILANIGIVAAGCFLLIVIsYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQ 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15941 245 AGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-288

2.87e-67

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 211.02 E-value: 2.87e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15913   5 SFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15913  85 TTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFV-ALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDSV 262
Cdd:cd15913 165 CVPAPGTELICYTLSSLIIFGTFLfILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVspGSGNST 244

                       250       260
                ....*....|....*....|....*.
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15913 245 GMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-288

2.99e-67

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 211.18 E-value: 2.99e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15946   5 AVFLLIYLSILLGNgLIITLICLDSRL-HTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15946  84 GITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLL-VIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVG 263
Cdd:cd15946 164 ACADTSLNeMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYS 243

                       250       260
                ....*....|....*....|....*..
gi 47577595 264 D--DKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15946 244 PerDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

21-298

3.34e-66

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 208.87 E-value: 3.34e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  21 KAICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFY 100
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 101 AHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFP 180
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 181 LLKLACTETRL--LVIVIITTTGVMSIlTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPM 258
Cdd:cd15418 161 LVKLACDDTRVyeLILYFILGFNVIAP-TALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRP 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577595 259 GDS--VGDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKV 298
Cdd:cd15418 240 SSShtPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

26-295

1.36e-65

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 207.33 E-value: 1.36e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15432   5 VVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15432  85 STECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTET-----RLLVIVIITTTGVMSILtfvaLVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGD 260
Cdd:cd15432 165 CVDTtaneaELFVISVLLLLIPLGLI----LISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577595 261 SVGDD--KVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15432 241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-295

4.53e-64

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 203.10 E-value: 4.53e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15233   5 VTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15233  85 GADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTFVALVISYI-IILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMG--DSV 262
Cdd:cd15233 165 CSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGsvYSS 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 263 GDDKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15233 245 DKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

26-295

3.44e-61

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 195.78 E-value: 3.44e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15433   5 VVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15433  85 SAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRLLVIVIITTTGVMSILTF-VALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMGDSVGD 264
Cdd:cd15433 165 CGDDETTEVQMFVARVVILLLPAaLILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQ 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 265 D--KVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15433 245 AhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-295

7.75e-61

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 195.01 E-value: 7.75e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGN-LIVLLTIKGSQLsEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15428   5 ILFLIIYLMTVLGNlLLVLLVIVDSHL-HTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15428  84 GITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIItttgVMSILTFVA-----LVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPMG 259
Cdd:cd15428 164 ASTDTHQAEMAMF----IMCVFTLVLpvlliLASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPK 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577595 260 DSVGD--DKVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15428 240 SSTSKeyDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-295

1.49e-53

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 176.33 E-value: 1.49e-53

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFG 105
Cdd:cd15223   5 LPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLA 185
Cdd:cd15223  85 AMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 186 CTETRL--LVIVIITTTGVMSILTFVALvISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP--MGDS 261
Cdd:cd15223 165 CGDTTInsIYGLAVAWLIVGSDIILIFF-SYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTyrFGKT 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577595 262 VGDD--KVFALFYTMIAPLFNPLIYTLRNTDMKNAM 295
Cdd:cd15223 244 IPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

25-287

1.73e-49

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 165.63 E-value: 1.73e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15952   4 GFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15952  84 TGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRllvIVIITTTGVMSILTFVALVISYIIILS---ILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYvpMGDS 261
Cdd:cd15952 164 ACASIR---INIIYGLFAISVLVLDVILIALSYVLIlraVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSF--LTHR 238

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577595 262 VGDDK------VFALFYTMIAPLFNPLIYTLR 287
Cdd:cd15952 239 FGHNIpryihiLLANLYVVLPPMLNPVIYGVR 270

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

28-287

8.28e-48

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 161.30 E-value: 8.28e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLACT 187
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 188 ETRLLVIVIITTTGVMSILTFVAL-VISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFT--------YVPM 258
Cdd:cd15221 167 DITVNIWYGLTVALLTVGLDVVLIaVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSflthrfgrHIPR 246

                       250       260
                ....*....|....*....|....*....
gi 47577595 259 GDSVgddkVFALFYTMIAPLFNPLIYTLR 287
Cdd:cd15221 247 HVHI----LLANLYVLVPPMLNPIVYGVK 271

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

25-287

3.51e-47

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 159.50 E-value: 3.51e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15950   4 AIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15950  84 TAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRL--LVIVIITTTGVMSILTFVAlVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTY------- 255
Cdd:cd15950 164 ACADPRPssLYSITGSTLVVGTDSAFIA-VSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIytqrfgq 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 256 -VPMGDSVgddkVFALFYTMIAPLFNPLIYTLR 287
Cdd:cd15950 243 gVPPHTQV----LLADLYLLVPPMLNPIIYGMR 271

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

25-288

3.78e-47

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 159.38 E-value: 3.78e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15917   4 SIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15917  84 TAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVI----VIITTTGVMSILTFVALVisyIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPmgD 260
Cdd:cd15917 164 ACGDTRVNSIyglfVALLIVGFDLLFIALSYV---LILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLT--H 238

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577595 261 SVGDDK------VFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15917 239 RFGHHVpphvhiLLANLYLLLPPMLNPIVYGVRT 272

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-287

4.60e-44

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 151.50 E-value: 4.60e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15222   4 SIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYM-ITMSRQVCYILVIGSVFGAFIHsLVHVLVIIRLPFCGTNEIDHYFCDIFPLLK 183
Cdd:cd15222  84 SFMESSVLLAMAFDRFVAICNPLRYAsILTNSRIAKIGLAIVLRSVLLL-LPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 184 LACTETRLLVI----VIITTTGVMSILTFVALVisyIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLI------- 252
Cdd:cd15222 163 LACSDTRVNSIyglfVVLSTMGLDSLLILLSYV---LILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIglsmvhr 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577595 253 -------FTYVPMGDSvgddkvfalfYTMIAPLFNPLIYTLR 287
Cdd:cd15222 240 fgkhaspLVHVLMANV----------YLLVPPVLNPIIYSVK 271

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

28-288

4.28e-43

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 148.95 E-value: 4.28e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLACT 187
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 188 ETRL-----LVIVIITttgVMSILTFVALvISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP----M 258
Cdd:cd15953 167 DTTInriygLVVALLV---VGLDLLLIAL-SYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLThrfgQ 242

                       250       260       270
                ....*....|....*....|....*....|
gi 47577595 259 GDSVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15953 243 GIAPHIHIILANLYLLVPPMLNPIIYGVKT 272

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

25-288

1.58e-42

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 147.49 E-value: 1.58e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15951   4 SIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15951  84 STMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETR------LLVIVIITTTGVMSIltfvaLVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP- 257
Cdd:cd15951 164 ACADTRvsraygLSVAFLVGGLDVIFI-----AVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTh 238

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577595 258 -MGDSVGD--DKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15951 239 rFGHNVPPhvHILIANVYLLVPPMLNPIIYGVRT 272

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

28-300

2.31e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 136.86 E-value: 2.31e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595    28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLACT 187
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   188 ETRLLVI----VIITTTGVMSILTFVALVisyIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP--MGDS 261
Cdd:pfam13853 161 DIKVNNIyglfVVTSTFGIDSLLIVLSYG---LILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVhrFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 47577595   262 VGD--DKVFALFYTMIAPLFNPLIYTLRNTDMKNAMRKVWC 300
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

7-292

6.22e-36

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 130.67 E-value: 6.22e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   7 TEFILLGLFHDEDVKAICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQC 86
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  87 NTISYNACIAQMFYAHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFC 166
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 167 GTNEIDHYFCDIFPLLKLACTETRLLVIVIITTTGVMSILTFVALVISYIIIL-SILRTRSSEGRRKALSTCGSHITVVF 245
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILrVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577595 246 MFFLPLIFTYV--PMGDSVGDDK--VFALFYTMIAPLFNPLIYTLRNTDMK 292
Cdd:cd15949 242 AFYVPIAVSSLihRFGQNVPPPThiLLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

25-292

3.17e-34

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 125.79 E-value: 3.17e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd15948   5 SIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd15948  85 SIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIITTTGVMSILTFV-ALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYV--PMGDS 261
Cdd:cd15948 165 ACGDTRFNNIYGIAVALFIVGLDLMfIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARH 244

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577595 262 VGDDK--VFALFYTMIAPLFNPLIYTLRNTDMK 292
Cdd:cd15948 245 VAPHVhiLLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

28-287

5.15e-34

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 125.36 E-value: 5.15e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:cd15956   7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLAC- 186
Cdd:cd15956  87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACg 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 187 --TETRLLVIVIITTTGVMSILTFVAlvISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP--MGDSV 262
Cdd:cd15956 167 atTVDSLYGLALALFIGGGDVLFIAY--SYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMhrFGHSV 244

                       250       260
                ....*....|....*....|....*..
gi 47577595 263 GDDK--VFALFYTMIAPLFNPLIYTLR 287
Cdd:cd15956 245 PSAAhvLLSNLYLLLPPALNPIVYGIR 271

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

28-287

1.84e-30

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 116.08 E-value: 1.84e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLACT 187
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 188 ETRLLVIVIITTTGVMSILTFVAL-VISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP---MGDSVG 263
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCIsVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfGGHHIT 246

                       250       260
                ....*....|....*....|....*.
gi 47577595 264 DDK--VFALFYTMIAPLFNPLIYTLR 287
Cdd:cd15954 247 PHIhiIMANLYLLLPPMMNPIVYGVK 272

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

28-288

2.14e-28

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 110.24 E-value: 2.14e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCY-ILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLAC 186
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLgIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 187 TETR------LLVIVIITTTGVMSILTFVALVisyiiILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVP--M 258
Cdd:cd15955 167 DDVRvnkiygLFVAFSILGFDIIFITTSYALI-----FRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAhrF 241

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577595 259 GDSVGD--DKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd15955 242 GHHVAPyvHILLSNLYLLVPPVLNPIVYGVKT 273

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

38-284

1.04e-23

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 97.37 E-value: 1.04e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595    38 GNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCN-TISYNACIAQMFYAHFFGATEIFILVVMA 116
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   117 YDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRlpfCGTNEIDHYFCDIFPLLKLACTETRLLVIVI 196
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595   197 ITT---TGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLPLIFTYVPM------GDSVGDDKV 267
Cdd:pfam00001 158 LGFllpLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDslaldcELSRLLDKA 237

                         250
                  ....*....|....*....
gi 47577595   268 FAL--FYTMIAPLFNPLIY 284
Cdd:pfam00001 238 LSVtlWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

25-288

5.83e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 79.25 E-value: 5.83e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKL 184
Cdd:cd00637  82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 185 ACTETRLLVIVIITTTGVMSILTFVAL----VISYIIILSILRTRSSEGRRKALSTCGSHITVVFMFFLP-----LIFTY 255
Cdd:cd00637 162 TIFLFVLLFLLPLLVIIVCYVRIFRKLrrhrRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPyfillLLDVF 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577595 256 VPMGDSVGDD-KVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd00637 242 GPDPSPLPRIlYFLALLLAYLNSAINPIIYAFFN 275

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

25-154

1.79e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 54.55 E-value: 1.79e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILcGNLIVLLTIKGSQLSEQPMYFFLSYLSFMD--VCFTStVAPKFIIGLLVQ-------CNTISYnaci 95
Cdd:cd15196   5 AVLATILVLALF-GNSCVLLVLYRRRRKLSRMHLFILHLSVADllVALFN-VLPQLIWDITYRfyggdllCRLVKY---- 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47577595  96 AQMF--YAhffgatEIFILVVMAYDRYVAICRPLYYMiTMSRQVCYILVIGSVFGAFIHSL 154
Cdd:cd15196  79 LQVVgmYA------SSYVLVATAIDRYIAICHPLSSH-RWTSRRVHLMVAIAWVLSLLLSI 132

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

25-155

1.35e-05

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 45.63 E-value: 1.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFF 104
Cdd:cd14967   3 AVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLC 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577595 105 GATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLV 155
Cdd:cd14967  83 CTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP 133

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

22-295

1.54e-05

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 45.66 E-value: 1.54e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLCYLAILcGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd14969   2 VLAVYLSLIGVLGVV-LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLvhvlviirlPFCGTN----EIDHYFCD 177
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALP---------PLFGWSsyvpEGGGTSCS 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 178 IFPLLKLACTETRLLVI---------VIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTcgsHITVVFMFF 248
Cdd:cd14969 152 VDWYSKDPNSLSYIVSLfvfcfflplAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAEKKVAK---MVLVMIVAF 228

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577595 249 LpliFTYVP-----MGDSVGDDKVFALFYTMIAPLF-------NPLIYTLRNTDMKNAM 295
Cdd:cd14969 229 L---IAWTPyavvsLYVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

55-212

2.18e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 45.32 E-value: 2.18e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  55 PMYFFLSYLSFMDVCFTSTVAPKFII-GLLVQCNTISYNACIAQMFYAHFFG----ATEIFILVVMAYDRYVAICRPLYY 129
Cdd:cd14978  33 STNVYLAALAVSDILVLLSALPLFLLpYIADYSSSFLSYFYAYFLPYIYPLAntfqTASVWLTVALTVERYIAVCHPLKA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 130 MITMSRQVCYILVIGSVFGAFIHSLVHVLVIIRLPFCGTNEIDHYFCDIFPLLKLACTetrLLVIVIITTTGVMSILTFV 209
Cdd:cd14978 113 RTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETY---LLKYYFWLYAIFVVLLPFI 189


                ...
gi 47577595 210 ALV 212
Cdd:cd14978 190 LLL 192

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

109-286

5.87e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 43.70 E-value: 5.87e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 109 IFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLvhVLVIIRLPFCGTNEIDHYFCD-IFPLLKLAct 187
Cdd:cd15055  88 IFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSS--VLLYDNLNQPGLIRYNSCYGEcVVVVNFIW-- 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 188 ETRLLVIVIITTTGVMSILT----FVAL----------VISYIIILSILRTRSSEgrRKALSTCGSHITVVFMFFLPLIF 253
Cdd:cd15055 164 GVVDLVLTFILPCTVMIVLYmrifVVARsqarairshtAQVSLEGSSKKVSKKSE--RKAAKTLGIVVGVFLLCWLPYYI 241

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 47577595 254 TYVPMGDSVGDDKVFA----LFYTMIAplFNPLIYTL 286
Cdd:cd15055 242 VSLVDPYISTPSSVFDvliwLGYFNSC--LNPLIYAL 276

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

103-254

7.72e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 43.39 E-value: 7.72e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 103 FFGATEIFILVVMAYDRYVAICRPLYYMITMS-RQVCYILVIGSVFGAFIHSlvhvlviirLPFCGTNEIDHYFCDIFPL 181
Cdd:cd14981  85 FFGLSSLLIVCAMAVERFLAITHPFFYNSHVKkRRARLMLGAVWAFALLIAS---------LPLLGLGSYVLQYPGTWCF 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 182 LKLACTETR---------LLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKAlstcgSHI-TVVFMFFLPL 251
Cdd:cd14981 156 LDFYSKNTGdaayaylysILGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKR-----NEIqMVVLLLAITV 230


                ...
gi 47577595 252 IFT 254
Cdd:cd14981 231 VFS 233

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

29-142

9.83e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 43.21 E-value: 9.83e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  29 LLCYLAI-LCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPkFIIGLLVQCNTISYNA--CIAQMFYAHFFG 105
Cdd:cd15005   7 LGLILCVsLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFP-FVMASVRHGSGWIYGAlsCKVIAFLAVLFC 85

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47577595 106 ATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILV 142
Cdd:cd15005  86 FHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVI 122

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

25-127

1.62e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 42.50 E-value: 1.62e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLCYLAiLCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMD-VCFTSTVAPKFIIGLLVQ-------CNTISYNACIA 96
Cdd:cd15387   5 TVLALILFLA-LTGNICVLLAIHTTRHKHSRMYFFMKHLSIADlVVAVFQVLPQLIWDITFRfygpdflCRLVKYLQVVG 83

                        90       100       110
                ....*....|....*....|....*....|.
gi 47577595  97 qmfyahFFGATeiFILVVMAYDRYVAICRPL 127
Cdd:cd15387  84 ------MFAST--YMLLLMSIDRCLAICQPL 106

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

26-129

2.07e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 42.15 E-value: 2.07e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLC---YLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAH 102
Cdd:cd15318   2 VIYLACaigMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDT 81

                        90       100
                ....*....|....*....|....*..
gi 47577595 103 FFGATEIFILVVMAYDRYVAICRPLYY 129
Cdd:cd15318  82 LFCLTSIFHLCFISIDRHCAICDPLLY 108

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

23-127

2.88e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 41.66 E-value: 2.88e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAH 102
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                        90       100
                ....*....|....*....|....*
gi 47577595 103 FFGATEIFILVVMAYDRYVAICRPL 127
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPL 105

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

38-143

4.37e-04

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 41.24 E-value: 4.37e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  38 GNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGATEIFILVVMAY 117
Cdd:cd15336  17 GNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAISL 96

                        90       100
                ....*....|....*....|....*..
gi 47577595 118 DRYVAICRPLYYMITMSRQ-VCYILVI 143
Cdd:cd15336  97 DRYLVITKPLASIRWVSKKrAMIIILL 123

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

21-127

7.13e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 40.55 E-value: 7.13e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  21 KAICAVLFLLCYLAILCGNLIVLLTIKGSQLsEQPMYFFLSYLSFMD---------VCFTSTVAPKFIIGLLvqcntisy 91
Cdd:cd15082  14 TVLAALMFVVTSLSLAENFAVMLVTFRFKQL-RQPLNYIIVNLSVADflvsltggtISFLTNARGYFFLGVW-------- 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47577595  92 nACIAQMFYAHFFGATEIFILVVMAYDRYVAICRPL 127
Cdd:cd15082  85 -ACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPL 119

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

26-151

1.60e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 39.50 E-value: 1.60e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMD-----VCFTSTVAPKFIIGLL---VQCNTISYNACIAQ 97
Cdd:cd14993   5 VLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADllvslFCMPLTLLENVYRPWVfgeVLCKAVPYLQGVSV 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577595  98 mfyahffgATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFI 151
Cdd:cd14993  85 --------SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAII 130

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

26-150

1.71e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 39.45 E-value: 1.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  26 VLFLLCYLAILCGNLIVLLTIKGSQLsEQPMYFFLSYLSFMDV----CFTSTVAPKFIIGLLVqcntISYNACIAQMFYA 101
Cdd:cd15085   6 LMFLNATFSIFNNVLVIAVTLKNPQL-RNPINIFILNLSFSDLmmalCGTTIVTVTNYEGYFY----LGDAFCIFQGFAV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAF 150
Cdd:cd15085  81 NYFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLF 129

7tmA_GPBAR1

cd15905

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...

35-129

2.01e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.

Pssm-ID: 320571 [Multi-domain] Cd Length: 272 Bit Score: 38.97 E-value: 2.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  35 ILCGNLIVLLTIKGS-QLSEQPMYFFLSYLsFMDvCFTSTVAPkFIIGLLVQCNtISYNACIAQMFYAHFFGATEIFILV 113
Cdd:cd15905  12 IIFANLFIILGIACNrKLHNTANYFFLSLL-LAD-LLTGVALP-FIPGMSNESR-RGYHSCLFVYVAPNFLFLSFLANLL 87

                        90
                ....*....|....*.
gi 47577595 114 VMAYDRYVAICRPLYY 129
Cdd:cd15905  88 MVHYERYLCIVYPLQY 103

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

24-288

2.39e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 38.95 E-value: 2.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  24 CAVLFLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCftSTVAPKFIIGLLVQCNTISYNACIAQMFYAHF 103
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLL--ASLVVLVLFFLLGLTEASSRPQALCYLIYLLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 104 FGAT--EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAFIHSLVHVLVI-IRLPFCGTNEIDHYFCDIFP 180
Cdd:cd14964  79 YGANlaSIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKgAIPRYNTLTGSCYLICTTIY 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595 181 LLKLACTETRLLVIVIITTTGVMSILTFVALVISYIIILSILRTRSSEGRRKALSTCGSHITV-VFMFFLPLIFTYVPMG 259
Cdd:cd14964 159 LTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCwLPFSIVFILHALVAAG 238

                       250       260
                ....*....|....*....|....*....
gi 47577595 260 DSVGDDKVFALFYTMIAPLFNPLIYTLRN 288
Cdd:cd14964 239 QGLNLLSILANLLAVLASTLNPFIYCLGN 267

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

22-154

3.05e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 38.56 E-value: 3.05e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLcylaILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTstvapkfIIGLLVQCN---TISYNA----C 94
Cdd:cd15197   5 ATLWVLFVF----IVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVG-------LINVLTDIIwriTVEWRAgdfaC 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  95 IAQMFYAHFFGATEIFILVVMAYDRYVAICRPLYYMitMSRQVCYILVIGSVFGAFIHSL 154
Cdd:cd15197  74 KVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSI 131

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

22-153

3.25e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 38.65 E-value: 3.25e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLCYLailcGNLIVLLTIKGSQLSEQPMYFFLSYLSFMD--VCFTStVAPKFIIGLLVQCNTISYNACIA--- 96
Cdd:cd15385   5 AVLAVIFAVAVI----GNSSVLLALYKTKKKASRMHLFIKHLSLADlvVAFFQ-VLPQLCWDITYRFYGPDFLCRIVkhl 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577595  97 QMFyaHFFGATeiFILVVMAYDRYVAICRPLyYMITMSRQVCYILVIGSVFGAFIHS 153
Cdd:cd15385  80 QVL--GMFAST--YMLVMMTADRYIAICHPL-KTLQQPTKRSYLMIGSAWALSFILS 131

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

28-142

3.76e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 38.20 E-value: 3.76e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  28 FLLCYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYAHFFGAT 107
Cdd:cd15317   7 LVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTT 86

                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577595 108 EIFILVVMAYDRYVAICRPLYYMITMSRQVCYILV 142
Cdd:cd15317  87 SIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFI 121

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

22-154

4.25e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 38.15 E-value: 4.25e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  22 AICAVLFLLCylaiLCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFYA 101
Cdd:cd15195   5 LVTWVLFVIS----AAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577595 102 HFFGATEIFILVVMAYDRYVAICRPLyyMITMSRQVCYILVIGSVFGAFIHSL 154
Cdd:cd15195  81 QFGMYLSSFMLVVIALDRVFAILSPL--SANQARKRVKIMLTVAWVLSALCSI 131

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

25-143

6.32e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 37.74 E-value: 6.32e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  25 AVLFLLcYLAILCGNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFT-STVAPKFIIGLLVQ-------CNTISYNACIA 96
Cdd:cd14986   5 AVLGVL-FVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEwvagdvlCRIVKYLQVVG 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577595  97 qmfyahFFGATeiFILVVMAYDRYVAICRPL---------YYMITMSRQVCYILVI 143
Cdd:cd14986  84 ------LFAST--YILVSMSLDRYQAIVKPMsslkprkraRLMIVVAWVLSFLFSI 131

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

38-138

7.41e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 37.47 E-value: 7.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  38 GNLIVLLTIKGSQLSEQPMYFFLSYLSFMDVCFTS-TVAPKFI-------IGLLVQCNTISYNACIAqmfyahFFGATei 109
Cdd:cd15386  17 GNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIweityrfQGPDLLCRAVKYLQVLS------MFAST-- 88

                        90       100
                ....*....|....*....|....*....
gi 47577595 110 FILVVMAYDRYVAICRPLYYMITMSRQVC 138
Cdd:cd15386  89 YMLIMMTVDRYIAVCHPLRTLQQPSRQAY 117

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

23-150

8.17e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 37.25 E-value: 8.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577595  23 ICAVLFLLCYLAILCGNLIVLLTI--KGSQLseQPMYFFLSYLSFMDVCFTSTVAPKFIIGLLVQCNTISYNACIAQMFY 100
Cdd:cd15074   2 IIGIYLTVIGILSTLGNGTVLFVLyrRRSKL--KPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFC 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577595 101 AHFFGATEIFILVVMAYDRYVAICRPLYYMITMSRQVCYILVIGSVFGAF 150
Cdd:cd15074  80 GFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALF 129

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01