NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4505731|ref|NP_000279|]
View 

peroxisomal biogenesis factor 7 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-317 9.37e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 9.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   46 GTLLILDPDeAGLRLFRSFDWNDGLFDVTWSENNEHvLITCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSqtRGE 125
Cdd:COG2319 100 GTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFS--PDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  126 QLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHipGCF-ASASGDQTLRIWDVKAAGVRIVIPAHQAEILSC 204
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKLlASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  205 DWCKyNENLLVTGAVDCSLRGWDLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPdSLLETVEH 284
Cdd:COG2319 253 AFSP-DGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-KLLRTLTG 328

                       250       260       270
                ....*....|....*....|....*....|...
gi 4505731  285 HTEFTCGLDFSlQSPTQVADCSWDETIKIYDPA 317
Cdd:COG2319 329 HTGAVRSVAFS-PDGKTLASGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-317 9.37e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 9.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   46 GTLLILDPDeAGLRLFRSFDWNDGLFDVTWSENNEHvLITCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSqtRGE 125
Cdd:COG2319 100 GTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFS--PDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  126 QLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHipGCF-ASASGDQTLRIWDVKAAGVRIVIPAHQAEILSC 204
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKLlASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  205 DWCKyNENLLVTGAVDCSLRGWDLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPdSLLETVEH 284
Cdd:COG2319 253 AFSP-DGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-KLLRTLTG 328

                       250       260       270
                ....*....|....*....|....*....|...
gi 4505731  285 HTEFTCGLDFSlQSPTQVADCSWDETIKIYDPA 317
Cdd:COG2319 329 HTGAVRSVAFS-PDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 68-315 6.36e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 6.36e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   68 DGLFDVTWSeNNEHVLITCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSQTRgeQLVVSGSWDQTVKLWDPTVGKS 147
Cdd:cd00200  52 GPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGE-CVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  148 LCTFRGHESIIYSTIWSPhiPGCF-ASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKyNENLLVTGAVDCSLRGW 226
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  227 DLRNVRQpVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNfSKPDSLLETVEHHTEFTCGLDFSlQSPTQVADCS 306
Cdd:cd00200 205 DLSTGKC-LGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWS-PDGKRLASGS 280


                ....*....
gi 4505731  307 WDETIKIYD 315
Cdd:cd00200 281 ADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 116-273 1.38e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.57  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   116 SVDWSQTRGEQlVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKaAGVRIVIP 195
Cdd:PLN00181 537 GICWNSYIKSQ-VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSIN-QGVSIGTI 614

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4505731   196 AHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFspFHASVLASCSYDFTVRFWNFS 273
Cdd:PLN00181 615 KTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-141 4.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4505731     103 PLQVYKEHAQEVYSVDWSQTrgEQLVVSGSWDQTVKLWD 141
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-141 6.33e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 6.33e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4505731    103 PLQVYKEHAQEVYSVDWSQTrgEQLVVSGSWDQTVKLWD 141
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-317 9.37e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 9.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   46 GTLLILDPDeAGLRLFRSFDWNDGLFDVTWSENNEHvLITCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSqtRGE 125
Cdd:COG2319 100 GTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFS--PDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  126 QLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHipGCF-ASASGDQTLRIWDVKAAGVRIVIPAHQAEILSC 204
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKLlASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  205 DWCKyNENLLVTGAVDCSLRGWDLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPdSLLETVEH 284
Cdd:COG2319 253 AFSP-DGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-KLLRTLTG 328

                       250       260       270
                ....*....|....*....|....*....|...
gi 4505731  285 HTEFTCGLDFSlQSPTQVADCSWDETIKIYDPA 317
Cdd:COG2319 329 HTGAVRSVAFS-PDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 68-315 6.36e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 6.36e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   68 DGLFDVTWSeNNEHVLITCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSQTRgeQLVVSGSWDQTVKLWDPTVGKS 147
Cdd:cd00200  52 GPVRDVAAS-ADGTYLASGSSDKTIRLWDLETGE-CVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  148 LCTFRGHESIIYSTIWSPhiPGCF-ASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKyNENLLVTGAVDCSLRGW 226
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  227 DLRNVRQpVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNfSKPDSLLETVEHHTEFTCGLDFSlQSPTQVADCS 306
Cdd:cd00200 205 DLSTGKC-LGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWS-PDGKRLASGS 280


                ....*....
gi 4505731  307 WDETIKIYD 315
Cdd:cd00200 281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-317 8.16e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 8.16e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731    8 AARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCS 87
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   88 GDGSLQLWDTAkAAGPLQVYKEHAQEVYSVDWSqtRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSP-- 165
Cdd:COG2319  98 ADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFS--PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdg 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  166 -HIpgcfASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKyNENLLVTGAVDCSLRGWDLRNvRQPVFELLGHTYA 244
Cdd:COG2319 175 kLL----ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGS 248

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4505731  245 IRRVKFSPfHASVLASCSYDFTVRFWNFSkPDSLLETVEHHTEFTCGLDFSLQSpTQVADCSWDETIKIYDPA 317
Cdd:COG2319 249 VRSVAFSP-DGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
67-317 2.00e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 2.00e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   67 NDGLFDVTWSENNEHvLITCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSqtRGEQLVVSGSWDQTVKLWDPTVGK 146
Cdd:COG2319 162 SGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFS--PDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  147 SLCTFRGHESIIYSTIWSP---HIpgcfASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKyNENLLVTGAVDCSL 223
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPdgrLL----ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTV 312

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  224 RGWDLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPdSLLETVEHHTEFTCGLDFSLQSPTqVA 303
Cdd:COG2319 313 RLWDLAT-GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRT-LA 388

                       250
                ....*....|....
gi 4505731  304 DCSWDETIKIYDPA 317
Cdd:COG2319 389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-271 4.42e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.79  E-value: 4.42e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   67 NDGLFDVTWSeNNEHVLITCSGDGSLQLWDTAKAaGPLQVYKEHAQEVYSVDWSQTrgEQLVVSGSWDQTVKLWDPTVGK 146
Cdd:cd00200  93 TSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLRTGK 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  147 SLCTFRGHESIIYSTIWSPhIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKyNENLLVTGAVDCSLRGW 226
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVW 246

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 4505731  227 DLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWN 271
Cdd:cd00200 247 DLRT-GECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-315 2.56e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.47  E-value: 2.56e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   67 NDGLFDVTWSENNEHvLITCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSQTRgeQLVVSGSWDQTVKLWDPTVGK 146
Cdd:cd00200   9 TGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADG--TYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  147 SLCTFRGHESIIYSTIWSPHIPgCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNeNLLVTGAVDCSLRGW 226
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  227 DLRNVRqPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKpDSLLETVEHHTEFTCGLDFSlQSPTQVADCS 306
Cdd:cd00200 163 DLRTGK-CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFS-PDGYLLASGS 238


                ....*....
gi 4505731  307 WDETIKIYD 315
Cdd:cd00200 239 EDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
10-271 1.43e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 1.43e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   10 RMLRTPGRHG---YAAEFSPylPGRLAcATAQHYGiagcgTLLILDPDEAglRLFRSFD-WNDGLFDVTWSENNeHVLIT 85
Cdd:COG2319 153 KLLRTLTGHSgavTSVAFSP--DGKLL-ASGSDDG-----TVRLWDLATG--KLLRTLTgHTGAVRSVAFSPDG-KLLAS 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   86 CSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSqtRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSP 165
Cdd:COG2319 222 GSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFS--PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  166 ---HIpgcfASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKyNENLLVTGAVDCSLRGWDLRNvRQPVFELLGHT 242
Cdd:COG2319 299 dgkLL----ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT-GELLRTLTGHT 372

                       250       260
                ....*....|....*....|....*....
gi 4505731  243 YAIRRVKFSPfHASVLASCSYDFTVRFWN 271
Cdd:COG2319 373 GAVTSVAFSP-DGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 103-317 4.92e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 4.92e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  103 PLQVYKEHAQEVYSVDWSqtRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPgCFASASGDQTLRI 182
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFS--PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731  183 WDVKAAGVRIVIPAHQAEILSCDWCKYNEnLLVTGAVDCSLRGWDLRNvRQPVFELLGHTYAIRRVKFSPFHaSVLASCS 262
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDG-TFVASSS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4505731  263 YDFTVRFWNFSKPdSLLETVEHHTEFTCGLDFSlQSPTQVADCSWDETIKIYDPA 317
Cdd:cd00200 155 QDGTIKLWDLRTG-KCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
6-230 3.39e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 3.39e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731    6 GGAARMLRTPGRHGYAAEFSPylPGR-LACATAQhygiagcGTLLILDPDeAGLRLFRSFDWNDGLFDVTWSENNEHvLI 84
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSP--DGKlLASGSAD-------GTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRL-LA 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   85 TCSGDGSLQLWDTAKAAgPLQVYKEHAQEVYSVDWSqtRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWS 164
Cdd:COG2319 263 SGSADGTVRLWDLATGE-LLRTLTGHSGGVNSVAFS--PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4505731  165 PHiPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWcKYNENLLVTGAVDCSLRGWDLRN 230
Cdd:COG2319 340 PD-GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF-SPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 116-273 1.38e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.57  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   116 SVDWSQTRGEQlVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKaAGVRIVIP 195
Cdd:PLN00181 537 GICWNSYIKSQ-VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSIN-QGVSIGTI 614

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4505731   196 AHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFspFHASVLASCSYDFTVRFWNFS 273
Cdd:PLN00181 615 KTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 209-321 6.88e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.82  E-value: 6.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   209 YNENLLVTGAVDCSLRGWDL------RNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSlLETV 282
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA-VEVI 164

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 4505731   283 EHHTEFTCGLDFSLQSpTQVADCSWDETIKIYDPACLTI 321
Cdd:PTZ00421 165 KCHSDQITSLEWNLDG-SLLCTTSKDKKLNIIDPRDGTI 202
PTZ00421 PTZ00421
coronin; Provisional
 70-235 6.43e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 6.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731    70 LFDVTWSENNEHVLITCSGDGSLQLWD------TAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSwDQTVKLWDPT 143
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGA-DMVVNVWDVE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   144 VGKSLCTFRGHESIIYSTIWSphIPGC-FASASGDQTLRIWDVKAAGVRIVIPAHQ-AEILSCDWCKyNENLLVTGAVDC 221
Cdd:PTZ00421 157 RGKAVEVIKCHSDQITSLEWN--LDGSlLCTTSKDKKLNIIDPRDGTIVSSVEAHAsAKSQRCLWAK-RKDLIITLGCSK 233

                        170
                 ....*....|....*...
gi 4505731   222 S----LRGWDLRNVRQPV 235
Cdd:PTZ00421 234 SqqrqIMLWDTRKMASPY 251
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-141 4.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4505731     103 PLQVYKEHAQEVYSVDWSQTrgEQLVVSGSWDQTVKLWD 141
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
103-141 6.33e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 6.33e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4505731    103 PLQVYKEHAQEVYSVDWSQTrgEQLVVSGSWDQTVKLWD 141
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-184 9.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 9.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4505731     145 GKSLCTFRGHESIIYSTIWSPHIPgCFASASGDQTLRIWD 184
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 232-271 1.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.78e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4505731     232 RQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWN 271
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 234-276 1.92e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 1.92e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 4505731   234 PVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPD 276
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHND 108
WD40 pfam00400
WD domain, G-beta repeat;
232-271 1.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4505731    232 RQPVFELLGHTYAIRRVKFSPFHaSVLASCSYDFTVRFWN 271
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
145-184 1.28e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4505731    145 GKSLCTFRGHESIIYSTIWSPHiPGCFASASGDQTLRIWD 184
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 151-238 3.97e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.78  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505731   151 FRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRI--------VIPAHQAEILSCDWCKYNENLLVTGAVDCS 222
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVkeikdpqcILKGHKKKISIIDWNPMNYYIMCSSGFDSF 149

                         90
                 ....*....|....*.
gi 4505731   223 LRGWDLRNVRQpVFEL 238
Cdd:PTZ00420 150 VNIWDIENEKR-AFQI 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH