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Conserved domains on  [gi|148667388|gb|EDK99804|]
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nucleolar protein 1, isoform CRA_a [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nop2p super family cl33194
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 297-569 7.25e-115

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


The actual alignment was detected with superfamily member TIGR00446:

Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 348.69  E-value: 7.25e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  297 LRTNTLKTRRRDLAQALINRGVNLDPLGKWSKsgLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDM 376
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYF--FEVKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  377 CCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNT--IHYDGRQFPKVVGGFDRVLLDAPCSGTGVISK 454
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTivINADGRKFGAYLLKFDAILLDAPCSGEGVIRK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  455 DPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTgldFGQEG 533
Cdd:TIGR00446 159 DPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEII---KGDEF 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 148667388  534 FTRFQARrfhPTLRSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:TIGR00446 232 FGINIGK---GEVKGALRVFPQNYDCEGFFVAKLRK 264
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 575-792 6.41e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 6.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  575 PQPHA-----GNSAAATPTEPDLKDQVTPKSENGSQPTKKARGA-VKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEP-S 647
Cdd:PHA03247 2631 PSPAAnepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPeP 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  648 VPDAQVSTRP----SQSAGNADVNSKRKRSEKLKQRGPKwKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDC 723
Cdd:PHA03247 2711 APHALVSATPlppgPAAARQASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTA------GPPAPAPPAAPAAGPPRRL 2783

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148667388  724 AP----SLGEAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKrrksmTKGNSQPLLS 792
Cdd:PHA03247 2784 TRpavaSLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-----PPGPPPPSLP 2851
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 297-569 7.25e-115

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 348.69  E-value: 7.25e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  297 LRTNTLKTRRRDLAQALINRGVNLDPLGKWSKsgLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDM 376
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYF--FEVKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  377 CCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNT--IHYDGRQFPKVVGGFDRVLLDAPCSGTGVISK 454
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTivINADGRKFGAYLLKFDAILLDAPCSGEGVIRK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  455 DPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTgldFGQEG 533
Cdd:TIGR00446 159 DPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEII---KGDEF 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 148667388  534 FTRFQARrfhPTLRSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:TIGR00446 232 FGINIGK---GEVKGALRVFPQNYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 222-569 2.02e-105

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 330.82  E-value: 2.02e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 222 QRVHKRIQDIV-GVLRDFGAQREEgrsrAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTN 300
Cdd:COG0144  107 EAVGPGAAGLVnAVLRRVLREREA----LLAAADPVERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVN 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 301 TLKTRRRDLAQALINRGVNLDPlGKWSKSGLVVyDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAP 380
Cdd:COG0144  183 TLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EGPGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAP 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 381 GGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTN--TIHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPA 457
Cdd:COG0144  261 GGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNveVVVADARELLEWLPGkFDRVLLDAPCSGTGTLRRHPD 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 458 VKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGLDFGQEGFTR 536
Cdd:COG0144  341 IKWRRTPEDIAELAALQRELLDAAARLL----KPGGRLVYSTCSLLPEENEEVVEAFLARHpDFELVPLAELLPGLALTD 416

                        330       340       350
                 ....*....|....*....|....*....|...
gi 148667388 537 fqarrfhptlRSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:COG0144  417 ----------GGYLRLLPHRHGTDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 362-568 3.21e-100

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 308.20  E-value: 3.21e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  362 VMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTI--HYDGRQFPKVVGG--F 437
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIilNGDGRQPDQWLGGvlF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  438 DRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKK 517
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 148667388  518 R-NVRLVPT------GLDFGQEgftrfqarrfhptlrSTRRFYPHTHNMDGFFIAKFK 568
Cdd:pfam01189 157 HpDVELVPTplfepvGLAIGEQ---------------PTLRLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
223-569 8.80e-84

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 273.98  E-value: 8.80e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 223 RVHKRIQDIV-GVLRDFgaQREEGRSRAEyLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNT 301
Cdd:PRK14902 109 RGHKGIAKFVnGVLRNI--LREGLPDIDE-IKDPVKRLSIKYSHPVWLVKRWIDQYGEEKAEKILESLNEPPKASIRVNT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 302 LKTRRRDLAQALINRGVNLDPlGKWSKSGLVVydSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPG 381
Cdd:PRK14902 186 LKISVEELIEKLEEEGYEVEE-SLLSPEALVI--EKGNIAGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPG 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 382 GKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTN--TIHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPAV 458
Cdd:PRK14902 263 GKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNieTKALDARKVHEKFAEkFDKILVDAPCSGLGVIRRKPDI 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 459 KTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKrnvrlvptGLDFGQEGFTRFQ 538
Cdd:PRK14902 343 KYNKTKEDIESLQEIQLEILESVAQYL----KKGGILVYSTCTIEKEENEEVIEAFLEE--------HPEFELVPLQHEK 410

                        330       340       350
                 ....*....|....*....|....*....|..
gi 148667388 539 A-RRFHPTLRSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:PRK14902 411 PdELVYEVKDGYLQILPNDYGTDGFFIAKLRK 442
PHA03247 PHA03247
large tegument protein UL36; Provisional
 575-792 6.41e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 6.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  575 PQPHA-----GNSAAATPTEPDLKDQVTPKSENGSQPTKKARGA-VKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEP-S 647
Cdd:PHA03247 2631 PSPAAnepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPeP 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  648 VPDAQVSTRP----SQSAGNADVNSKRKRSEKLKQRGPKwKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDC 723
Cdd:PHA03247 2711 APHALVSATPlppgPAAARQASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTA------GPPAPAPPAAPAAGPPRRL 2783

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148667388  724 AP----SLGEAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKrrksmTKGNSQPLLS 792
Cdd:PHA03247 2784 TRpavaSLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-----PPGPPPPSLP 2851
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 372-498 1.36e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.65  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 372 RILDMCCAPGGKTSYIAQLMKntGVILANDANADRLKSVVGNLHRLGVTNT--IHYDGRQFPKV-VGGFDRVLLDAPCsg 448
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAALLADNVevLKGDAEELPPEaDESFDVIISDPPL-- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 148667388 449 tgviskdpavktnkdekdiqrcaHLQKELLLSAIDSVNAASKTGGYLVYC 498
Cdd:cd02440   77 -----------------------HHLVEDLARFLEEARRLLKPGGVLVLT 103
P120R pfam08062
P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 ...
 607-628 8.92e-04

P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 is found in three copies.


Pssm-ID: 285324  Cd Length: 22  Bit Score: 37.08  E-value: 8.92e-04
                          10        20
                  ....*....|....*....|..
gi 148667388  607 TKKARGAVKAKQQLLRQPHSKK 628
Cdd:pfam08062   1 AGKAKGAEKRKQQLLKQPHPKK 22
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 297-569 7.25e-115

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 348.69  E-value: 7.25e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  297 LRTNTLKTRRRDLAQALINRGVNLDPLGKWSKsgLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDM 376
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYF--FEVKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  377 CCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNT--IHYDGRQFPKVVGGFDRVLLDAPCSGTGVISK 454
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTivINADGRKFGAYLLKFDAILLDAPCSGEGVIRK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  455 DPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTgldFGQEG 533
Cdd:TIGR00446 159 DPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEII---KGDEF 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 148667388  534 FTRFQARrfhPTLRSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:TIGR00446 232 FGINIGK---GEVKGALRVFPQNYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 222-569 2.02e-105

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 330.82  E-value: 2.02e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 222 QRVHKRIQDIV-GVLRDFGAQREEgrsrAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTN 300
Cdd:COG0144  107 EAVGPGAAGLVnAVLRRVLREREA----LLAAADPVERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVN 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 301 TLKTRRRDLAQALINRGVNLDPlGKWSKSGLVVyDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAP 380
Cdd:COG0144  183 TLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EGPGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAP 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 381 GGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTN--TIHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPA 457
Cdd:COG0144  261 GGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNveVVVADARELLEWLPGkFDRVLLDAPCSGTGTLRRHPD 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 458 VKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGLDFGQEGFTR 536
Cdd:COG0144  341 IKWRRTPEDIAELAALQRELLDAAARLL----KPGGRLVYSTCSLLPEENEEVVEAFLARHpDFELVPLAELLPGLALTD 416

                        330       340       350
                 ....*....|....*....|....*....|...
gi 148667388 537 fqarrfhptlRSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:COG0144  417 ----------GGYLRLLPHRHGTDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 362-568 3.21e-100

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 308.20  E-value: 3.21e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  362 VMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTI--HYDGRQFPKVVGG--F 437
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIilNGDGRQPDQWLGGvlF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  438 DRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKK 517
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 148667388  518 R-NVRLVPT------GLDFGQEgftrfqarrfhptlrSTRRFYPHTHNMDGFFIAKFK 568
Cdd:pfam01189 157 HpDVELVPTplfepvGLAIGEQ---------------PTLRLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
223-569 8.80e-84

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 273.98  E-value: 8.80e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 223 RVHKRIQDIV-GVLRDFgaQREEGRSRAEyLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNT 301
Cdd:PRK14902 109 RGHKGIAKFVnGVLRNI--LREGLPDIDE-IKDPVKRLSIKYSHPVWLVKRWIDQYGEEKAEKILESLNEPPKASIRVNT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 302 LKTRRRDLAQALINRGVNLDPlGKWSKSGLVVydSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPG 381
Cdd:PRK14902 186 LKISVEELIEKLEEEGYEVEE-SLLSPEALVI--EKGNIAGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPG 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 382 GKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTN--TIHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPAV 458
Cdd:PRK14902 263 GKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNieTKALDARKVHEKFAEkFDKILVDAPCSGLGVIRRKPDI 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 459 KTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKrnvrlvptGLDFGQEGFTRFQ 538
Cdd:PRK14902 343 KYNKTKEDIESLQEIQLEILESVAQYL----KKGGILVYSTCTIEKEENEEVIEAFLEE--------HPEFELVPLQHEK 410

                        330       340       350
                 ....*....|....*....|....*....|..
gi 148667388 539 A-RRFHPTLRSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:PRK14902 411 PdELVYEVKDGYLQILPNDYGTDGFFIAKLRK 442
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 284-578 6.91e-58

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 204.76  E-value: 6.91e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 284 EFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPLgKWSKSGLVV---YDSSVPIGATPEYLAGHYMLQGASSML 360
Cdd:PRK11933  24 DFIAACQRPLRRSIRVNTLKISVADFLQLMAPYGWTLTPI-PWCEEGFWIerdDEDALPLGNTAEHLSGLFYIQEASSML 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 361 PVMAL-APQEH-ERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTI--HYDGRQFpkvvGG 436
Cdd:PRK11933 103 PVAALfADDNApQRVLDMAAAPGSKTTQIAALMNNQGAIVANEYSASRVKVLHANISRCGVSNVAltHFDGRVF----GA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 437 -----FDRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDsvnaASKTGGYLVYCTCSITVEENEWVV 511
Cdd:PRK11933 179 alpetFDAILLDAPCSGEGTVRKDPDALKNWSPESNLEIAATQRELIESAFH----ALKPGGTLVYSTCTLNREENQAVC 254

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148667388 512 DYaLKKR---NVRLVPTGLDFGQ-------EGFtrfqarrFHptlrstrrFYPHTHNMDGFFIAKFKKFSNSIPQPH 578
Cdd:PRK11933 255 LW-LKETypdAVEFEPLGDLFPGaekalteEGF-------LH--------VFPQIYDSEGFFVARLRKTASVPRLPA 315
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 225-569 6.86e-55

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 195.47  E-value: 6.86e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  225 HKRIQDIV-GVLRDFgaQREEGRSRAEYLSrlqkdLATYYSYGDFLLSKLMELFPLSELiEFLEANEVPRPITLRTNTLK 303
Cdd:TIGR00563 103 RKGLKGLVnGVLRRF--QREQEELLAEFNA-----LDARYLHPEWLVKRLQKAYPGQWQ-SICEANNQRPPMWLRINRTK 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  304 TRRRDLAQALINRGVNLDPLGKWSKSglVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGK 383
Cdd:TIGR00563 175 HSRDEWLALLAEAGMKGFPHDLAPDA--VRLETPAAVHALPGFEEGWVTVQDASAQWVATWLAPQNEETILDACAAPGGK 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  384 TSYIAQLMKNtGVILANDANADRLKSVVGNLHRLGVTNTIHY-DGRQ----FPKVVGGFDRVLLDAPCSGTGVISKDPAV 458
Cdd:TIGR00563 253 TTHILELAPQ-AQVVALDIHEHRLKRVYENLKRLGLTIKAETkDGDGrgpsQWAENEQFDRILLDAPCSATGVIRRHPDI 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  459 KTNKDEKDIQRCAHLQKELLlsaiDSVNAASKTGGYLVYCTCSITVEENEWVVDyalkkrnvrlvptglDFGQEGFTR-F 537
Cdd:TIGR00563 332 KWLRKPRDIAELAELQSEIL----DAIWPLLKTGGTLVYATCSVLPEENSEQIK---------------AFLQEHPDFpF 392

                         330       340       350
                  ....*....|....*....|....*....|...
gi 148667388  538 QARRFHPTLRSTR-RFYPHTHNMDGFFIAKFKK 569
Cdd:TIGR00563 393 EKTGTPEQVRDGGlQILPHAEEGDGFFYAKLIK 425
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
 233-569 1.11e-54

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 194.76  E-value: 1.11e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 233 GVLRDFGAQREEGRSrAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEA-NEVPrPITLRTNTLKTRRRDLAQ 311
Cdd:PRK14901 118 GILRQYLRAREAGDP-LPLPEDPIERLAILHSFPDWLVKLWLEWLGLEEAEQLCKWfNQPP-SLDLRINPLRTSLEEVQA 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 312 ALINRGVNLDPLGKwSKSGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLM 391
Cdd:PRK14901 196 ALAEAGITATPIPG-LPQGLRLTGNPGSIRQLPGYEEGWWTVQDRSAQLVAPLLDPQPGEVILDACAAPGGKTTHIAELM 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 392 KNTGVILANDANADRLKSVVGNLHRLGvTNTIHY---DGRQF----PKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDE 464
Cdd:PRK14901 275 GDQGEIWAVDRSASRLKKLQENAQRLG-LKSIKIlaaDSRNLlelkPQWRGYFDRILLDAPCSGLGTLHRHPDARWRQTP 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 465 KDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDyalkkrnvrlvptgldfgqegftRFQARrfHP 544
Cdd:PRK14901 354 EKIQELAPLQAELLESLAPLL----KPGGTLVYATCTLHPAENEAQIE-----------------------QFLAR--HP 404

                        330       340
                 ....*....|....*....|....*...
gi 148667388 545 TLRS---TRRFYPHTHNMDGFFIAKFKK 569
Cdd:PRK14901 405 DWKLeppKQKIWPHRQDGDGFFMAVLRK 432
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
233-569 3.90e-53

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 190.40  E-value: 3.90e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 233 GVLRDFgaQREegrsRAEYLSRLQKDLATYYSYGDFLLSKLMELFPlSELIEFLEANEVPRPITLRTNTLKTRRRDLAQA 312
Cdd:PRK10901 117 AVLRRF--QRE----QEELLAELQADPVARYNHPSWLIKRLKKAYP-EQWQAILAANNQRPPMWLRVNRRHHSRDAYLAL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 313 LINRGVNLDPlGKWSKSGLVVyDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMK 392
Cdd:PRK10901 190 LAEAGIEAFP-HAVGPDAIRL-ETPVPVHQLPGFAEGWVSVQDAAAQLAATLLAPQNGERVLDACAAPGGKTAHILELAP 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 393 NTGVIlANDANADRLKSVVGNLHRLGVTNTIH----------YDGRQfpkvvggFDRVLLDAPCSGTGVISKDPAVKTNK 462
Cdd:PRK10901 268 QAQVV-ALDIDAQRLERVRENLQRLGLKATVIvgdardpaqwWDGQP-------FDRILLDAPCSATGVIRRHPDIKWLR 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 463 DEKDIQRCAHLQKELLlsaiDSVNAASKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGLDFGqegftrfqarr 541
Cdd:PRK10901 340 RPEDIAALAALQSEIL----DALWPLLKPGGTLLYATCSILPEENEQQIKAFLARHpDAELLDTGTPQQ----------- 404

                        330       340
                 ....*....|....*....|....*...
gi 148667388 542 fhptlrSTRRFYPHTHNMDGFFIAKFKK 569
Cdd:PRK10901 405 ------PGRQLLPGEEDGDGFFYALLIK 426
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
 220-517 2.96e-36

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 142.51  E-value: 2.96e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 220 DLQRVHK--RIQDIV-GVLRDFGAQRE------EGRSRAEYLSRLqkdlatyYSYGDFLLSKLMELFPLSELIEFLEANE 290
Cdd:PRK14904 104 KLARKYKgeHMAKLVnGVLRNISPETIsldewlKGMPEAERLSLL-------YSHPEWLLERWIARYGEERTEAMLSYNN 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 291 VPRPITLRTNTLKTRRRDLAQALINRGVnldplgKWSKSGLVVYDSSVPIGATPEYLA-GHYMLQGASSMLPVMALAPQE 369
Cdd:PRK14904 177 QAPLFGFRINRLKTTPEKFLAAPADASV------TFEKSGLPNFFLSKDFSLFEPFLKlGLVSVQNPTQALACLLLNPQP 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 370 HERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVT--NTIHYDGRQFPKvVGGFDRVLLDAPCS 447
Cdd:PRK14904 251 GSTVLDLCAAPGGKSTFMAELMQNRGQITAVDRYPQKLEKIRSHASALGITiiETIEGDARSFSP-EEQPDAILLDAPCT 329

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148667388 448 GTGVISKDPAVKTNKDEKDIQRCAHLQKELLlsaidsVNAAS--KTGGYLVYCTCSITVEENEWVVDYALKK 517
Cdd:PRK14904 330 GTGVLGRRAELRWKLTPEKLAELVGLQAELL------DHAASllKPGGVLVYATCSIEPEENELQIEAFLQR 395
PRK14903 PRK14903
16S rRNA methyltransferase B; Provisional
 257-525 3.18e-35

16S rRNA methyltransferase B; Provisional


Pssm-ID: 184896 [Multi-domain]  Cd Length: 431  Bit Score: 139.24  E-value: 3.18e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 257 KDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPlGKWSKSGLVVYDS 336
Cdd:PRK14903 126 KELHLKYSHPKWLVNYWRSFLPEEAVLRIMEWNQEPLPTMLRVNSLAITREEVIKILAEEGTEAVP-GKHSPFSLIVRKL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 337 SVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHR 416
Cdd:PRK14903 205 GVNMNDSRVIKDGLATVQGESSQIVPLLMELEPGLRVLDTCAAPGGKTTAIAELMKDQGKILAVDISREKIQLVEKHAKR 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 417 LGVT--NTIHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGG 493
Cdd:PRK14903 285 LKLSsiEIKIADAERLTEYVQDtFDRILVDAPCTSLGTARNHPEVLRRVNKEDFKKLSEIQLRIVSQAWKLL----EKGG 360

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148667388 494 YLVYCTCSITVEENEWVV-DYALKKRNVRLVPT 525
Cdd:PRK14903 361 ILLYSTCTVTKEENTEVVkRFVYEQKDAEVIDI 393
Methyltr_RsmF_N pfam17125
N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the ...
 284-358 1.27e-08

N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the RsmF methyl transferase. RsmF is a multi-site-specific methyltransferase that is responsible for the synthesis of three modifications on cytidines in 16S ribosomal RNA. The N-terminus is critical for stabilising the catalytic core of the enzyme.


Pssm-ID: 465356 [Multi-domain]  Cd Length: 88  Bit Score: 52.86  E-value: 1.27e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148667388  284 EFLEANEVPRPITLRTNTLKTRRRDLAQALinrGVNLDPLgKWSKSGLvVYDSSVPIGATPEYLAGHYMLQGASS 358
Cdd:pfam17125  19 AFLAAYDEPRPVGLRVNTLKISVEEFLKLS---PFELEPV-PWCEEGF-YLEERPRPGKHPYHHAGLYYIQEPSA 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
 575-792 6.41e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 6.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  575 PQPHA-----GNSAAATPTEPDLKDQVTPKSENGSQPTKKARGA-VKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEP-S 647
Cdd:PHA03247 2631 PSPAAnepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPeP 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  648 VPDAQVSTRP----SQSAGNADVNSKRKRSEKLKQRGPKwKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDC 723
Cdd:PHA03247 2711 APHALVSATPlppgPAAARQASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTA------GPPAPAPPAAPAAGPPRRL 2783

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148667388  724 AP----SLGEAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKrrksmTKGNSQPLLS 792
Cdd:PHA03247 2784 TRpavaSLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-----PPGPPPPSLP 2851
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 372-498 1.36e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.65  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 372 RILDMCCAPGGKTSYIAQLMKntGVILANDANADRLKSVVGNLHRLGVTNT--IHYDGRQFPKV-VGGFDRVLLDAPCsg 448
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAALLADNVevLKGDAEELPPEaDESFDVIISDPPL-- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 148667388 449 tgviskdpavktnkdekdiqrcaHLQKELLLSAIDSVNAASKTGGYLVYC 498
Cdd:cd02440   77 -----------------------HHLVEDLARFLEEARRLLKPGGVLVLT 103
P120R pfam08062
P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 ...
 607-628 8.92e-04

P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 is found in three copies.


Pssm-ID: 285324  Cd Length: 22  Bit Score: 37.08  E-value: 8.92e-04
                          10        20
                  ....*....|....*....|..
gi 148667388  607 TKKARGAVKAKQQLLRQPHSKK 628
Cdd:pfam08062   1 AGKAKGAEKRKQQLLKQPHPKK 22
PHA03247 PHA03247
large tegument protein UL36; Provisional
 577-774 2.35e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  577 PHAGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPfqklngiakgPGLSTEPSVPDAQVSTR 656
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP----------AAKPAAPARPPVRRLAR 2888

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  657 PSQSagnadvnsKRKRSEKLKQRGPKWKPSKEAAV-PKPSAPSRVEDSRTPPVPTPSEIRAAPRPKDCAPSLGEAKKKQK 735
Cdd:PHA03247 2889 PAVS--------RSTESFALPPDQPERPPQPQAPPpPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 148667388  736 GKQQLAQQPANGAAPlKEDAVSKGPSAPfvSPHSSTRPP 774
Cdd:PHA03247 2961 QPWLGALVPGRVAVP-RFRVPQPAPSRE--APASSTPPL 2996
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
575-778 3.89e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 575 PQPHAGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPFQKLNGIAKGPGlSTEPSVPDAQVS 654
Cdd:PRK12323 385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-PAPAAAPAAAAR 463

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388 655 TRPSQSAGNADVNSKRKRSEklkQRGPKWKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDCAPSLGEAkKKQ 734
Cdd:PRK12323 464 PAAAGPRPVAAAAAAAPARA---APAAAPAPADDDPPPWEELPP------EFASPAPAQPDAAPAGWVAESIPDPA-TAD 533

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 148667388 735 KGKQQLAQQPANGAAPLkedAVSKGPSAPFVSPhsstRPPPAKR 778
Cdd:PRK12323 534 PDDAFETLAPAPAAAPA---PRAAAATEPVVAP----RPPRASA 570
PHA03247 PHA03247
large tegument protein UL36; Provisional
 579-783 4.01e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  579 AGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPfqklngiAKGPGLSTEPS----VPDAQVS 654
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-------PPGPPPPSLPLggsvAPGGDVR 2863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  655 TR-PSQSAGNADVNSKRKRSEKLKQRGPKWKPSKEAAVPKPSAPSRVEDSRTPPVPTPS-EIRAAPRPKDCAPSLGEAKK 732
Cdd:PHA03247 2864 RRpPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQpPPPPQPQPPPPPPPRPQPPL 2943

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148667388  733 KQKGKQQLAQQPANGAAPLKEDAVSKGPSA---PFVSPHSSTRPPPAKRRKSMT 783
Cdd:PHA03247 2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAvprFRVPQPAPSREAPASSTPPLT 2997
PHA03247 PHA03247
large tegument protein UL36; Provisional
 640-777 9.41e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148667388  640 PGLSTEPSVPDAQVSTRPSQSAgnadVNSKRKRSEKLKQRGPKWKPSKEAAVPK-PSAPSRVEDSRTPPVPTPSeiraAP 718
Cdd:PHA03247 2560 PPAAPDRSVPPPRPAPRPSEPA----VTSRARRPDAPPQSARPRAPVDDRGDPRgPAPPSPLPPDTHAPDPPPP----SP 2631

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148667388  719 RPKDCAPSLGEAkKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAK 777
Cdd:PHA03247 2632 SPAANEPDPHPP-PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR 2689
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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