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Conserved domains on  [gi|47218085|emb|CAG09957|]
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unnamed protein product, partial [Tetraodon nigroviridis]

Protein Classification

Int_alpha and Integrin_alpha2 domain-containing protein( domain architecture ID 12192626)

protein containing domains FG-GAP, Int_alpha, and Integrin_alpha2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 443-904 5.17e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 488.75  E-value: 5.17e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    443 RPVISIRRDVKVSPQEVDLTVKTCGDS----ICVAVDACFTYTANPAsYNPKLTVGFSVESDVERRKqGLPSRLAFLNRS 518
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTgtpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    519 lsdaEHQLNGTLELRSRKQEACIRILGTLKENIRDKLRSIPIEVSTEILdtRRSKPKNSLPPLMPILDASQPSKDVVMVN 598
Cdd:pfam08441   79 ----QPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    599 FLKEgCGSDHVCQSNLRMEYKLLYKENNQDVYspvptednipvfhLTyQRKDLAVQVTVSNEkGDDAYEAKLLTTFPTAL 678
Cdd:pfam08441  153 FLKD-CGEDNVCVPDLQLSAKFDSRESDEPLL-------------LG-DDNDLALEITVTNL-GEDAYEAELYVTLPPGL 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    679 SYSGVRfsPPPAEKQIICTAGQNGS--QADCELGNPFKRDSQVTFYIILSTKKMPLDTTEVDLDLQLQTTSVQH-NISPV 755
Cdd:pfam08441  217 DYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPV 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    756 KAKAKILIEFPLSVSGEARPNLVsFGGLVRGESAMK--TEEEVGSLVRFTFRINNLWKSPA-KASLHIHWPKTNKDGKWL 832
Cdd:pfam08441  295 SLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTVsGASLEISWPYELSNGKWL 373

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47218085    833 LYLVGIssSGPQEVLCSPLSEVNPLKLTQESDVSRPKREIGERKPVAKASLLPSKNK------LLSCGRGSRCVVLEC 904
Cdd:pfam08441  374 LYLLDV--QGQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKAtqtasvLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 348-400 1.24e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 60.47  E-value: 1.24e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47218085     348 SMFGLAVENIGDVNQDSFEDLAVGAPCDEDGA--GSVFIYHGSKQGVKTSPAQIL 400
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 289-327 8.72e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 8.72e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47218085    289 FGYDVAVVDLDSDGWQDIVVGAPQFYVKDrdvGGAVYVY 327
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 226-272 1.43e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 47218085     226 ANSYLGFSLDSGHRLSSSLGLTVVAGAPRANHS---GAVLLLRKKSDSTS 272
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSSGGGN 50
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 443-904 5.17e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 488.75  E-value: 5.17e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    443 RPVISIRRDVKVSPQEVDLTVKTCGDS----ICVAVDACFTYTANPAsYNPKLTVGFSVESDVERRKqGLPSRLAFLNRS 518
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTgtpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    519 lsdaEHQLNGTLELRSRKQEACIRILGTLKENIRDKLRSIPIEVSTEILdtRRSKPKNSLPPLMPILDASQPSKDVVMVN 598
Cdd:pfam08441   79 ----QPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    599 FLKEgCGSDHVCQSNLRMEYKLLYKENNQDVYspvptednipvfhLTyQRKDLAVQVTVSNEkGDDAYEAKLLTTFPTAL 678
Cdd:pfam08441  153 FLKD-CGEDNVCVPDLQLSAKFDSRESDEPLL-------------LG-DDNDLALEITVTNL-GEDAYEAELYVTLPPGL 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    679 SYSGVRfsPPPAEKQIICTAGQNGS--QADCELGNPFKRDSQVTFYIILSTKKMPLDTTEVDLDLQLQTTSVQH-NISPV 755
Cdd:pfam08441  217 DYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPV 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    756 KAKAKILIEFPLSVSGEARPNLVsFGGLVRGESAMK--TEEEVGSLVRFTFRINNLWKSPA-KASLHIHWPKTNKDGKWL 832
Cdd:pfam08441  295 SLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTVsGASLEISWPYELSNGKWL 373

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47218085    833 LYLVGIssSGPQEVLCSPLSEVNPLKLTQESDVSRPKREIGERKPVAKASLLPSKNK------LLSCGRGSRCVVLEC 904
Cdd:pfam08441  374 LYLLDV--QGQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKAtqtasvLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 348-400 1.24e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 60.47  E-value: 1.24e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47218085     348 SMFGLAVENIGDVNQDSFEDLAVGAPCDEDGA--GSVFIYHGSKQGVKTSPAQIL 400
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 289-327 8.72e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 8.72e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47218085    289 FGYDVAVVDLDSDGWQDIVVGAPQFYVKDrdvGGAVYVY 327
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 287-332 8.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 52.76  E-value: 8.17e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 47218085     287 SSFGYDVA-VVDLDSDGWQDIVVGAPQFYvkDRDVGGAVYVYMNQEG 332
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSG 47
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 350-385 9.60e-04

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 37.49  E-value: 9.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47218085    350 FGLAVEnIGDVNQDSFEDLAVGAP-CDEDGAGSVFIY 385
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPgEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 226-272 1.43e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 47218085     226 ANSYLGFSLDSGHRLSSSLGLTVVAGAPRANHS---GAVLLLRKKSDSTS 272
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSSGGGN 50
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 443-904 5.17e-163

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 488.75  E-value: 5.17e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    443 RPVISIRRDVKVSPQEVDLTVKTCGDS----ICVAVDACFTYTANPAsYNPKLTVGFSVESDVERRKqGLPSRLAFLNRS 518
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTgtpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    519 lsdaEHQLNGTLELRSRKQEACIRILGTLKENIRDKLRSIPIEVSTEILdtRRSKPKNSLPPLMPILDASQPSKDVVMVN 598
Cdd:pfam08441   79 ----QPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR--VDPRAPSDLPGLKPILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    599 FLKEgCGSDHVCQSNLRMEYKLLYKENNQDVYspvptednipvfhLTyQRKDLAVQVTVSNEkGDDAYEAKLLTTFPTAL 678
Cdd:pfam08441  153 FLKD-CGEDNVCVPDLQLSAKFDSRESDEPLL-------------LG-DDNDLALEITVTNL-GEDAYEAELYVTLPPGL 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    679 SYSGVRfsPPPAEKQIICTAGQNGS--QADCELGNPFKRDSQVTFYIILSTKKMPLDTTEVDLDLQLQTTSVQH-NISPV 755
Cdd:pfam08441  217 DYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPV 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47218085    756 KAKAKILIEFPLSVSGEARPNLVsFGGLVRGESAMK--TEEEVGSLVRFTFRINNLWKSPA-KASLHIHWPKTNKDGKWL 832
Cdd:pfam08441  295 SLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTVsGASLEISWPYELSNGKWL 373

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47218085    833 LYLVGIssSGPQEVLCSPLSEVNPLKLTQESDVSRPKREIGERKPVAKASLLPSKNK------LLSCGRGSRCVVLEC 904
Cdd:pfam08441  374 LYLLDV--QGQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKAtqtasvLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 348-400 1.24e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 60.47  E-value: 1.24e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 47218085     348 SMFGLAVENIGDVNQDSFEDLAVGAPCDEDGA--GSVFIYHGSKQGVKTSPAQIL 400
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 289-327 8.72e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 8.72e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 47218085    289 FGYDVAVVDLDSDGWQDIVVGAPQFYVKDrdvGGAVYVY 327
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 287-332 8.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 52.76  E-value: 8.17e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 47218085     287 SSFGYDVA-VVDLDSDGWQDIVVGAPQFYvkDRDVGGAVYVYMNQEG 332
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSG 47
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 297-370 2.75e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.60  E-value: 2.75e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47218085    297 DLDSDGWQDIVVGAPqfyvkdrdvgGAVYVY-MNQEGHWDGVTPVRLHGNKHSMfGLAVeniGDVNQDSFEDLAV 370
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYlNNGDGTFTFITSVSLGGGGGGL-SVAV---GDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 350-385 9.60e-04

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 37.49  E-value: 9.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47218085    350 FGLAVEnIGDVNQDSFEDLAVGAP-CDEDGAGSVFIY 385
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPgEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 226-272 1.43e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 47218085     226 ANSYLGFSLDSGHRLSSSLGLTVVAGAPRANHS---GAVLLLRKKSDSTS 272
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSSGGGN 50
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 258-308 6.65e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 36.05  E-value: 6.65e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 47218085    258 SGAVLLLRKKSDSTSRLVEEHIFYGPGLASSfgydVAVVDLDSDGWQDIVV 308
Cdd:pfam13517   15 DGGLRLYLNNGDGTFTFITSVSLGGGGGGLS----VAVGDLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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