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Conserved domains on  [gi|194377876|dbj|BAG63301|]
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unnamed protein product [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
72-400 4.08e-114

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 339.19  E-value: 4.08e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  72 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 151
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 152 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 231
Cdd:COG2319  152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 232 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 311
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 312 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 391
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                 ....*....
gi 194377876 392 KDNTCRIWR 400
Cdd:COG2319  392 ADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
72-400 4.08e-114

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 339.19  E-value: 4.08e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  72 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 151
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 152 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 231
Cdd:COG2319  152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 232 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 311
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 312 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 391
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                 ....*....
gi 194377876 392 KDNTCRIWR 400
Cdd:COG2319  392 ADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-400 3.36e-93

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 281.53  E-value: 3.36e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 111 ELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 190
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 191 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 270
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 271 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 350
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 194377876 351 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 400
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 83-287 4.12e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 73.97  E-value: 4.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  83 VALNKSGSCFITGSYDRTCKLWDSAS----GEELN----TLEGhRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC 154
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELAS-RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 155 YHTFRGHTAEIVCLSFNPQS-TLVATGSMDTTAKLWDIQNGEEVYTLRGhSAEIISLSF-NTSGDRIITGSFDHTVVVWD 232
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYD 646

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194377876 233 ADTGR-KVNILIGHCAEISSASFnWDCSLILTGSMDKTCKLWDAT------NGKCVATLTGH 287
Cdd:PLN00181 647 LRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-358 9.38e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 9.38e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194377876   319 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 358
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
152-190 3.47e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 3.47e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194377876  152 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 190
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
72-400 4.08e-114

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 339.19  E-value: 4.08e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  72 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 151
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 152 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 231
Cdd:COG2319  152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 232 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 311
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 312 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 391
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                 ....*....
gi 194377876 392 KDNTCRIWR 400
Cdd:COG2319  392 ADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
72-400 1.47e-104

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 314.54  E-value: 1.47e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  72 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCKLWSVET 151
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 152 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 231
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 232 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 311
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 312 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 391
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349


                 ....*....
gi 194377876 392 KDNTCRIWR 400
Cdd:COG2319  350 DDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
72-361 1.87e-103

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 311.85  E-value: 1.87e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  72 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 151
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 152 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 231
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 232 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 311
Cdd:COG2319  274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 194377876 312 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 361
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-400 3.36e-93

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 281.53  E-value: 3.36e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 111 ELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 190
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 191 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 270
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 271 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 350
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 194377876 351 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 400
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 69-358 8.84e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 272.67  E-value: 8.84e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  69 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCKLWS 148
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 149 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 228
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 229 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASA 308
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 194377876 309 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 358
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
94-399 1.26e-89

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 276.41  E-value: 1.26e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  94 TGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 173
Cdd:COG2319   11 AASADLALALLAAALGALLLLLLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 174 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 253
Cdd:COG2319   90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 254 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEI 333
Cdd:COG2319  170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194377876 334 SKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 399
Cdd:COG2319  250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
71-319 2.64e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.53  E-value: 2.64e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  71 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCKLWSVE 150
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGKLLASGSADGTVRLWDLA 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 151 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 230
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 231 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 310
Cdd:COG2319  315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                 ....*....
gi 194377876 311 TARIFSAAT 319
Cdd:COG2319  395 TVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
132-400 2.68e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 236.73  E-value: 2.68e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 132 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLS 211
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 212 FNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 291
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 292 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGH 371
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                        250       260
                 ....*....|....*....|....*....
gi 194377876 372 TDEIFSCAFNYKGNIVITGSKDNTCRIWR 400
Cdd:COG2319  246 SGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
39-277 2.99e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 215.93  E-value: 2.99e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  39 LLTASRTEQVKLLiqrlqeklgqnSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGH 118
Cdd:COG2319  177 LASGSDDGTVRLW-----------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 119 RNVVYAIAFnNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 198
Cdd:COG2319  246 SGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194377876 199 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 277
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
169-399 3.47e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.13  E-value: 3.47e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 169 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 248
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 249 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEG 328
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194377876 329 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 399
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 66-232 3.72e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 3.72e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  66 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDSASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCK 145
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIK 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 146 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFD 225
Cdd:cd00200  203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*..
gi 194377876 226 HTVVVWD 232
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
211-400 9.46e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 9.46e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 211 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 290
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 291 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG 370
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 194377876 371 HTDEIFSCAFNYKGNIVITGSKDNTCRIWR 400
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 83-287 4.12e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 73.97  E-value: 4.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  83 VALNKSGSCFITGSYDRTCKLWDSAS----GEELN----TLEGhRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC 154
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELAS-RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 155 YHTFRGHTAEIVCLSFNPQS-TLVATGSMDTTAKLWDIQNGEEVYTLRGhSAEIISLSF-NTSGDRIITGSFDHTVVVWD 232
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYD 646

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194377876 233 ADTGR-KVNILIGHCAEISSASFnWDCSLILTGSMDKTCKLWDAT------NGKCVATLTGH 287
Cdd:PLN00181 647 LRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
PTZ00421 PTZ00421
coronin; Provisional
 160-287 3.44e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 64.53  E-value: 3.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 160 GHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDI------QN-GEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVV 230
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltQNiSDPIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNV 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194377876 231 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGH 287
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
PTZ00421 PTZ00421
coronin; Provisional
 245-398 8.60e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 63.37  E-value: 8.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 245 HCAEISSASFNWDCSLILT----------GSMDKTCKLWDATNGKCVAT---LTGHDDEILDSCFD-YTGKLIATASADG 310
Cdd:PTZ00421  19 HFLNVTPSTALWDCSNTIAcndrfiavpwQQLGSTAVLKHTDYGKLASNppiLLGQEGPIIDVAFNpFDPQKLFTASEDG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 311 TarIF------SAATRKC---IAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAF 380
Cdd:PTZ00421  99 T--IMgwgipeEGLTQNIsdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEW 176

                        170
                 ....*....|....*...
gi 194377876 381 NYKGNIVITGSKDNTCRI 398
Cdd:PTZ00421 177 NLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 319-358 9.38e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 9.38e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194377876   319 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 358
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-190 1.46e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194377876   151 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 190
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 161-394 2.91e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 161 HTAEIVC-LSFNPQSTLVATGSMDTTAKLWD----IQNGEEVY----TLRGHSaEIISLSFNTS-GDRIITGSFDHTVVV 230
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRS-KLSGICWNSYiKSQVASSNFEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 231 WDADTGRKVNILIGH-----CAEISSAsfnwDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEildSCFDY---TGKL 302
Cdd:PLN00181 560 WDVARSQLVTEMKEHekrvwSIDYSSA----DPTLLASGSDDGSVKLWSINQGVSIGTIKTKANI---CCVQFpseSGRS 632

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 303 IATASADGTARIFSAATRKC-IAKLEGHEGEISKISFnPQGNHLLTGSSDKTARIWDAQTGQC------LQVLEGHTDEI 375
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVK 711

                        250
                 ....*....|....*....
gi 194377876 376 FSCAFNYKGNIVITGSKDN 394
Cdd:PLN00181 712 NFVGLSVSDGYIATGSETN 730
WD40 pfam00400
WD domain, G-beta repeat;
152-190 3.47e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 3.47e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194377876  152 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 190
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 361-399 3.80e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 3.80e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 194377876   361 TGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 399
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
320-358 1.05e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.05e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194377876  320 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 358
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
362-399 1.41e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 1.41e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 194377876  362 GQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 399
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-232 4.07e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 4.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194377876   193 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 232
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 79-233 1.50e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  79 PLTNVALNK-SGSCFITGSYDRTCKLWD-SASGEELNT------LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE 150
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 151 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAE-------------IISLSFNTSGD 217
Cdd:PTZ00421 157 RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwakrkdlIITLGCSKSQQ 236

                        170
                 ....*....|....*.
gi 194377876 218 RiitgsfdhTVVVWDA 233
Cdd:PTZ00421 237 R--------QIMLWDT 244
WD40 pfam00400
WD domain, G-beta repeat;
194-232 1.58e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.58e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194377876  194 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 232
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 200-335 2.61e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 200 LRGHSAEIISLSFNTSGD-RIITGSFDHTVVVWDADT-GRKVNI------LIGHCAEISSASFNWDCSLIL-TGSMDKTC 270
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPqKLFTASEDGTIMGWGIPEeGLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLaSAGADMVV 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194377876 271 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK 335
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQ 215
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 277-316 4.67e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 4.67e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194377876   277 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 316
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-148 6.51e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 194377876   108 SGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWS 148
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-274 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194377876   235 TGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 274
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
278-316 2.39e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.39e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194377876  278 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 316
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
109-148 2.64e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.64e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 194377876  109 GEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWS 148
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
236-274 3.30e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194377876  236 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 274
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 277-396 4.86e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.06  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  277 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGtarifsaatrKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 356
Cdd:pfam20426  81 GAQCFATLQTPSENFLISCGNWENSFQVISLNDG----------RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194377876  357 WDAQTGQCLQ-----------------------VLEGHTDEIFSCAFNYKGNIVITGSKDNTC 396
Cdd:pfam20426 151 WEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIITCLYVSVELDIVISGSKDGTC 213
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 135-270 4.86e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.06  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  135 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIqngeevytLRGHSAEIISLSFNT 214
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV--------LRGRSSEKRSRNTQT 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194377876  215 SGDRIitgsfDHTVVvwdadtGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 270
Cdd:pfam20426 169 EFPRK-----DHVIA------ETPFHILCGHDDIITCLYVSVELDIVISGSKDGTC 213
PTZ00420 PTZ00420
coronin; Provisional
 115-217 4.95e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 4.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 115 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV--------ETGKCYHTFRGHTAEIVCLSFNPQST-LVATGSMDTT 185
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYyIMCSSGFDSF 149

                         90       100       110
                 ....*....|....*....|....*....|..
gi 194377876 186 AKLWDIQNGEEVYTLRgHSAEIISLSFNTSGD 217
Cdd:PTZ00420 150 VNIWDIENEKRAFQIN-MPKKLSSLKWNIKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-105 5.95e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.95e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194377876    66 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD 105
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
71-105 2.06e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 194377876   71 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD 105
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 302-375 5.43e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876  302 LIATASADGT--------ARIFSAAtrkciakLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 373
Cdd:pfam12894   9 LIALATEDGElllhrlnwQRVWTLS-------PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81


                  ..
gi 194377876  374 EI 375
Cdd:pfam12894  82 LI 83
PTZ00420 PTZ00420
coronin; Provisional
 197-279 1.55e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 197 VYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWD-ADTGRKVN-------ILIGHCAEISSASFNWDCSLILTGS-M 266
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSEILaSGSEDLTIRVWEiPHNDESVKeikdpqcILKGHKKKISIIDWNPMNYYIMCSSgF 146

                         90
                 ....*....|...
gi 194377876 267 DKTCKLWDATNGK 279
Cdd:PTZ00420 147 DSFVNIWDIENEK 159
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 276-339 3.09e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 3.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194377876  276 TNGKCV--ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 339
Cdd:pfam12894  24 LNWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 145-213 3.09e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 3.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194377876  145 KLWSVETGKcyhtfrgHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN 213
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 221-371 5.87e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.72  E-value: 5.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 221 TGSFDHTvvvwdaDTGRKVN---ILIGHCAEISSASFN-WDCSLILTGSMDKTCKLWD-ATNG------KCVATLTGHDD 289
Cdd:PTZ00421  53 TAVLKHT------DYGKLASnppILLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGWGiPEEGltqnisDPIVHLQGHTK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876 290 EILDSCFDYTGK-LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL 368
Cdd:PTZ00421 127 KVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSV 206


                 ...
gi 194377876 369 EGH 371
Cdd:PTZ00421 207 EAH 209
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 79-201 6.80e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.13  E-value: 6.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377876   79 PLT-NVALnkSGSCFIT-----GSYDRTCKLWDSA-------SGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCK 145
Cdd:pfam20426  73 PLAeNVEL--GAQCFATlqtpsENFLISCGNWENSfqvislnDGRMVQSIRQHKDVVSCVAVT-SDGSILATGSYDTTVM 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194377876  146 LWSVETGKC-----------------------YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 201
Cdd:pfam20426 150 VWEVLRGRSsekrsrntqtefprkdhviaetpFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIR 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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