NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|60360176|dbj|BAD90307|]
View 

mKIAA4168 protein, partial [Mus musculus]

Protein Classification

chondroitin N-acetylgalactosaminyltransferase family protein( domain architecture ID 10418577)

chondroitin N-acetylgalactosaminyltransferase family protein such as chondroitin sulfate synthase 1, which has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity

EC:  2.4.1.-
Gene Ontology:  GO:0008376
PubMed:  11788602|9445404|12691742|10521532

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CHGN pfam05679
Chondroitin N-acetylgalactosaminyltransferase;
333-869 0e+00

Chondroitin N-acetylgalactosaminyltransferase;


:

Pssm-ID: 461712 [Multi-domain]  Cd Length: 500  Bit Score: 756.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   333 HIGECLREMYTTHEDVEVGRCVRRFGGTQCVWSYEMQQLFHENYEHNRKGYIQDLHNSKIHAAITLHPNKRPAYQYRLHN 412
Cdd:pfam05679   1 HLDWCLKNLYSTHEDVELGRCIQKFAGIPCTWSYEGQRYFYFNYSSGKKGFIGNLKSKEFHSAITLHPVKDPADMYRLHK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   413 YMLSRKISELRYRTIQLHRESALMSKLSNSEVSKEDQQLGRTPSFNHfqPRERNEVMEWEFLTGKLLYSAAENQPpRQSI 492
Cdd:pfam05679  81 YFLSLELQKLRQEIIKLQREIKNMSELLPEGIDSLSWPLGIPPPLNR--PKSRFDVLRWDYFTETHLYSADDGQP-RRRL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   493 NSILRSALDDTVLQVMEMINENAKSRGRLIDFKEIQYGYRRVDPMHGVEYILDLLLLYKRHKGRklTVPVRRHAYLQQPF 572
Cdd:pfam05679 158 DGADKEDLDDVINTAMEEINRNYRPRGRVLEFKQLLNGYRRFDPLRGMEYILDLLLEYKKYRGR--TVPVRRRVYLQRPF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   573 SKPFFREVEELDvnrlvesinsgtqsfsvisnslkilsslqeakdigghNEKKVHILVPLVGRYDIFLRFMENFESTCLI 652
Cdd:pfam05679 236 SKVEIIPMPYVT-------------------------------------ESTRVHIILPLSGRYETFERFLENYERVCLE 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   653 PKQNV-KLVIILFSRDAGQE--SIKHIELIQEYQSRYPSAEMMLIPMKGEFSRGLGLEMASSQFDNDTLLLFCDVDLIFR 729
Cdd:pfam05679 279 TGENVvLLLVVLYDPDEGQNdvFAEIKELIEELEKKYPKAKIPWISVKGEFSRGKALDLGAKKFPPDSLLFFCDVDMVFT 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   730 GDFLQRCRDNTVQGQQVYYPIIFSQYDPKVTHMRNPPTEGD--FVFSKETGFWRDYGYGITCIYKSDLLGAGGFDTSIQG 807
Cdd:pfam05679 359 PEFLNRCRMNTIQGKQVYFPIVFSQYDPEVVYYDKPVPTSDdnFDISKDTGHWRRYGFGIVCFYKSDYMAVGGFRTSIQG 438

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 60360176   808 WGLEDVDLYNKVILSGLRPFRSQEVGVVHIFHPVHCDPNLDPKQYKMCLGSKASTFASTMQL 869
Cdd:pfam05679 439 WGLEDVDLYDKFVKSGLHVFRAVEPGLVHRYHPRHCDPRLSEKQYHMCLGSKAEGLASRTQL 500
Galactosyl_T super family cl21608
Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose: ...
 173-403 1.25e-14

Galactosyltransferase; This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.


The actual alignment was detected with superfamily member pfam02434:

Pssm-ID: 473923  Cd Length: 248  Bit Score: 74.66  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   173 GDFLYVGVMTAQKYLGSRALAAQRTWARFIPGRVEFFSsqQSPSAALgqPPPPLPVIALPGVDDSYPPQKKSFMM-IKYm 251
Cdd:pfam02434   3 LDDIFIAVKTTKKFHKTRLPLLLKTWISRAKHQTYIFT--DGEDEGL--PTRTGGHLINTNCSAGHCRKALSCKMaVEY- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   252 hDHYL-DKYEWFMRADDDVYIKGDKLEEFLRSLNSSKPLYLGQT---GLGNTEELGKLGLEPGENFCMGGPGMIFSREVL 327
Cdd:pfam02434  78 -DRFLeSGKKWFCHVDDDNYVNVPRLVRLLSCYNHTQDVYLGKPslyRPIEATERVKGNRKVGFWFATGGAGFCISRGLA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   328 RRMVPHIGEClrEMYTT------HEDVEVGRCVRRFGGTQCVWSyemqQLFHENYEHnrkgyIQDLHNSKIHAAITL--- 398
Cdd:pfam02434 157 LKMSPWASGG--RFMSTsekirlPDDCTLGYIIENLLGVPLTHS----PLFHSHLEN-----LQDLPPETLHEQVTLsyg 225


                  ....*.
gi 60360176   399 -HPNKR 403
Cdd:pfam02434 226 kFWNKR 231
PRK14959 super family cl33044
DNA polymerase III subunits gamma and tau; Provisional
 9-181 7.94e-09

DNA polymerase III subunits gamma and tau; Provisional


The actual alignment was detected with superfamily member PRK14959:

Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 59.31  E-value: 7.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    9 RRPWVSVALGLVLGFTAASWLIAPRVAELSEKRRRGSSLCSYYGRSATGPRADAQQLLPQP-QSRPrleQSPPPA----- 82
Cdd:PRK14959 340 RRVLTSLEPAMALELLLLNLAMLPRLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTPgTQGP---QGTAPAagmtp 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   83 SHELPGPQQPEAAPGgPSFrssPWQQPAPLPQRRrGHTPEGATALPGAPAAKGEPEEEDGGAADPrkggrpgSSHngsGD 162
Cdd:PRK14959 417 SSAAPATPAPSAAPS-PRV---PWDDAPPAPPRS-GIPPRPAPRMPEASPVPGAPDSVASASDAP-------PTL---GD 481

                        170
                 ....*....|....*....
gi 60360176  163 GGAAAPTSGPGDFLYVGVM 181
Cdd:PRK14959 482 PSDTAEHTPSGPRTWDGFL 500
 
Name Accession Description Interval E-value
CHGN pfam05679
Chondroitin N-acetylgalactosaminyltransferase;
333-869 0e+00

Chondroitin N-acetylgalactosaminyltransferase;


Pssm-ID: 461712 [Multi-domain]  Cd Length: 500  Bit Score: 756.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   333 HIGECLREMYTTHEDVEVGRCVRRFGGTQCVWSYEMQQLFHENYEHNRKGYIQDLHNSKIHAAITLHPNKRPAYQYRLHN 412
Cdd:pfam05679   1 HLDWCLKNLYSTHEDVELGRCIQKFAGIPCTWSYEGQRYFYFNYSSGKKGFIGNLKSKEFHSAITLHPVKDPADMYRLHK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   413 YMLSRKISELRYRTIQLHRESALMSKLSNSEVSKEDQQLGRTPSFNHfqPRERNEVMEWEFLTGKLLYSAAENQPpRQSI 492
Cdd:pfam05679  81 YFLSLELQKLRQEIIKLQREIKNMSELLPEGIDSLSWPLGIPPPLNR--PKSRFDVLRWDYFTETHLYSADDGQP-RRRL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   493 NSILRSALDDTVLQVMEMINENAKSRGRLIDFKEIQYGYRRVDPMHGVEYILDLLLLYKRHKGRklTVPVRRHAYLQQPF 572
Cdd:pfam05679 158 DGADKEDLDDVINTAMEEINRNYRPRGRVLEFKQLLNGYRRFDPLRGMEYILDLLLEYKKYRGR--TVPVRRRVYLQRPF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   573 SKPFFREVEELDvnrlvesinsgtqsfsvisnslkilsslqeakdigghNEKKVHILVPLVGRYDIFLRFMENFESTCLI 652
Cdd:pfam05679 236 SKVEIIPMPYVT-------------------------------------ESTRVHIILPLSGRYETFERFLENYERVCLE 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   653 PKQNV-KLVIILFSRDAGQE--SIKHIELIQEYQSRYPSAEMMLIPMKGEFSRGLGLEMASSQFDNDTLLLFCDVDLIFR 729
Cdd:pfam05679 279 TGENVvLLLVVLYDPDEGQNdvFAEIKELIEELEKKYPKAKIPWISVKGEFSRGKALDLGAKKFPPDSLLFFCDVDMVFT 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   730 GDFLQRCRDNTVQGQQVYYPIIFSQYDPKVTHMRNPPTEGD--FVFSKETGFWRDYGYGITCIYKSDLLGAGGFDTSIQG 807
Cdd:pfam05679 359 PEFLNRCRMNTIQGKQVYFPIVFSQYDPEVVYYDKPVPTSDdnFDISKDTGHWRRYGFGIVCFYKSDYMAVGGFRTSIQG 438

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 60360176   808 WGLEDVDLYNKVILSGLRPFRSQEVGVVHIFHPVHCDPNLDPKQYKMCLGSKASTFASTMQL 869
Cdd:pfam05679 439 WGLEDVDLYDKFVKSGLHVFRAVEPGLVHRYHPRHCDPRLSEKQYHMCLGSKAEGLASRTQL 500
Fringe pfam02434
Fringe-like; The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls ...
 173-403 1.25e-14

Fringe-like; The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands. FNG is localized to the Golgi apparatus (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homolog, lunatic fringe, has been implicated in a variety of functions.


Pssm-ID: 367085  Cd Length: 248  Bit Score: 74.66  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   173 GDFLYVGVMTAQKYLGSRALAAQRTWARFIPGRVEFFSsqQSPSAALgqPPPPLPVIALPGVDDSYPPQKKSFMM-IKYm 251
Cdd:pfam02434   3 LDDIFIAVKTTKKFHKTRLPLLLKTWISRAKHQTYIFT--DGEDEGL--PTRTGGHLINTNCSAGHCRKALSCKMaVEY- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   252 hDHYL-DKYEWFMRADDDVYIKGDKLEEFLRSLNSSKPLYLGQT---GLGNTEELGKLGLEPGENFCMGGPGMIFSREVL 327
Cdd:pfam02434  78 -DRFLeSGKKWFCHVDDDNYVNVPRLVRLLSCYNHTQDVYLGKPslyRPIEATERVKGNRKVGFWFATGGAGFCISRGLA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   328 RRMVPHIGEClrEMYTT------HEDVEVGRCVRRFGGTQCVWSyemqQLFHENYEHnrkgyIQDLHNSKIHAAITL--- 398
Cdd:pfam02434 157 LKMSPWASGG--RFMSTsekirlPDDCTLGYIIENLLGVPLTHS----PLFHSHLEN-----LQDLPPETLHEQVTLsyg 225


                  ....*.
gi 60360176   399 -HPNKR 403
Cdd:pfam02434 226 kFWNKR 231
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 9-181 7.94e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 59.31  E-value: 7.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    9 RRPWVSVALGLVLGFTAASWLIAPRVAELSEKRRRGSSLCSYYGRSATGPRADAQQLLPQP-QSRPrleQSPPPA----- 82
Cdd:PRK14959 340 RRVLTSLEPAMALELLLLNLAMLPRLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTPgTQGP---QGTAPAagmtp 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   83 SHELPGPQQPEAAPGgPSFrssPWQQPAPLPQRRrGHTPEGATALPGAPAAKGEPEEEDGGAADPrkggrpgSSHngsGD 162
Cdd:PRK14959 417 SSAAPATPAPSAAPS-PRV---PWDDAPPAPPRS-GIPPRPAPRMPEASPVPGAPDSVASASDAP-------PTL---GD 481

                        170
                 ....*....|....*....
gi 60360176  163 GGAAAPTSGPGDFLYVGVM 181
Cdd:PRK14959 482 PSDTAEHTPSGPRTWDGFL 500
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 58-241 1.17e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 45.82  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  58 PRADAQQLLPQPQSRPRLEQSPPPAS----HELPGPQQPE----AAPGGPSFRSSPWQQPAPLPQ-----RRRGHTPEGA 124
Cdd:COG5180 266 RAAIGDTPAAEPPGLPVLEAGSEPQSdapeAETARPIDVKgvasAPPATRPVRPPGGARDPGTPRpgqptERPAGVPEAA 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176 125 TALPGAPAAKGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAAAPTSGPGDFLYVGVMTAQKYLGSRALAAQRTWARFIpg 204
Cdd:COG5180 346 SDAGQPPSAYPPAEEAVPGKPLEQGAPRPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETA-- 423

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 60360176 205 rveffsSQQSPSAALGQPPPPLPViALPGVDDSYPPQ 241
Cdd:COG5180 424 ------SLGGAAGGAGQGPKADFV-PGDAESVSGPAG 453
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 677-839 3.02e-04

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 42.56  E-value: 3.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176 677 ELIQEYQSRYPsaemmlIPMK-------GeF----SRGLGLEMASSQFdndtlLLFCDVDLIFRGDFLQRCRDNT----- 740
Cdd:cd06420  42 ELIEEFKSQFP------IPIKhvwqedeG-FrkakIRNKAIAAAKGDY-----LIFIDGDCIPHPDFIADHIELAepgvf 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176 741 VQGQQVYYPIIFSQYDPKVTHMrnpptegdfvfsketGFWrdygygitciyKSDLLGAGGFDTSIQGWGLEDVDLYNKVI 820
Cdd:cd06420 110 LSGSRVLLNEKLTERGIRGCNM---------------SFW-----------KKDLLAVNGFDEEFTGWGGEDSELVARLL 163

                       170
                ....*....|....*....
gi 60360176 821 LSGLRPFRSQEVGVVhiFH 839
Cdd:cd06420 164 NSGIKFRKLKFAAIV--FH 180
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 74-208 1.20e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 42.30  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   74 RLEQSPPPASHELPGPQQPEAAPGGPSfrsspwqqpaplpqrrrghtPEGATALPGAPAAKGEPEEEDGGAADPRKGGRP 153
Cdd:NF041121  14 QMGRAAAPPSPEGPAPTAASQPATPPP--------------------PAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPP 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 60360176  154 GSSHNGSgdggaaaPTSGPGDFLYVGVMTAQKYLGSRALA-AQRTWARFIPGRVEF 208
Cdd:NF041121  74 PPPPPGP-------AGAAPGAALPVRVPAPPALPNPLELArALRPLKRRVPSPRRV 122
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 64-153 3.92e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 39.25  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    64 QLLPQPQSRPRLEQSPPPAshelpGPQQPEAAPGGPSFRSSPWQQ-PAPLPQRRRGHTPEGATALPGAPAAKGEPEEEDG 142
Cdd:pfam15240  53 GFPPQPPASDDPPGPPPPG-----GPQQPPPQGGKQKPQGPPPQGgPRPPPGKPQGPPPQGGNQQQGPPPPGKPQGPPPQ 127

                          90
                  ....*....|.
gi 60360176   143 GAADPRKGGRP 153
Cdd:pfam15240 128 GGGPPPQGGNQ 138
 
Name Accession Description Interval E-value
CHGN pfam05679
Chondroitin N-acetylgalactosaminyltransferase;
333-869 0e+00

Chondroitin N-acetylgalactosaminyltransferase;


Pssm-ID: 461712 [Multi-domain]  Cd Length: 500  Bit Score: 756.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   333 HIGECLREMYTTHEDVEVGRCVRRFGGTQCVWSYEMQQLFHENYEHNRKGYIQDLHNSKIHAAITLHPNKRPAYQYRLHN 412
Cdd:pfam05679   1 HLDWCLKNLYSTHEDVELGRCIQKFAGIPCTWSYEGQRYFYFNYSSGKKGFIGNLKSKEFHSAITLHPVKDPADMYRLHK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   413 YMLSRKISELRYRTIQLHRESALMSKLSNSEVSKEDQQLGRTPSFNHfqPRERNEVMEWEFLTGKLLYSAAENQPpRQSI 492
Cdd:pfam05679  81 YFLSLELQKLRQEIIKLQREIKNMSELLPEGIDSLSWPLGIPPPLNR--PKSRFDVLRWDYFTETHLYSADDGQP-RRRL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   493 NSILRSALDDTVLQVMEMINENAKSRGRLIDFKEIQYGYRRVDPMHGVEYILDLLLLYKRHKGRklTVPVRRHAYLQQPF 572
Cdd:pfam05679 158 DGADKEDLDDVINTAMEEINRNYRPRGRVLEFKQLLNGYRRFDPLRGMEYILDLLLEYKKYRGR--TVPVRRRVYLQRPF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   573 SKPFFREVEELDvnrlvesinsgtqsfsvisnslkilsslqeakdigghNEKKVHILVPLVGRYDIFLRFMENFESTCLI 652
Cdd:pfam05679 236 SKVEIIPMPYVT-------------------------------------ESTRVHIILPLSGRYETFERFLENYERVCLE 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   653 PKQNV-KLVIILFSRDAGQE--SIKHIELIQEYQSRYPSAEMMLIPMKGEFSRGLGLEMASSQFDNDTLLLFCDVDLIFR 729
Cdd:pfam05679 279 TGENVvLLLVVLYDPDEGQNdvFAEIKELIEELEKKYPKAKIPWISVKGEFSRGKALDLGAKKFPPDSLLFFCDVDMVFT 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   730 GDFLQRCRDNTVQGQQVYYPIIFSQYDPKVTHMRNPPTEGD--FVFSKETGFWRDYGYGITCIYKSDLLGAGGFDTSIQG 807
Cdd:pfam05679 359 PEFLNRCRMNTIQGKQVYFPIVFSQYDPEVVYYDKPVPTSDdnFDISKDTGHWRRYGFGIVCFYKSDYMAVGGFRTSIQG 438

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 60360176   808 WGLEDVDLYNKVILSGLRPFRSQEVGVVHIFHPVHCDPNLDPKQYKMCLGSKASTFASTMQL 869
Cdd:pfam05679 439 WGLEDVDLYDKFVKSGLHVFRAVEPGLVHRYHPRHCDPRLSEKQYHMCLGSKAEGLASRTQL 500
Fringe pfam02434
Fringe-like; The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls ...
 173-403 1.25e-14

Fringe-like; The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands. FNG is localized to the Golgi apparatus (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homolog, lunatic fringe, has been implicated in a variety of functions.


Pssm-ID: 367085  Cd Length: 248  Bit Score: 74.66  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   173 GDFLYVGVMTAQKYLGSRALAAQRTWARFIPGRVEFFSsqQSPSAALgqPPPPLPVIALPGVDDSYPPQKKSFMM-IKYm 251
Cdd:pfam02434   3 LDDIFIAVKTTKKFHKTRLPLLLKTWISRAKHQTYIFT--DGEDEGL--PTRTGGHLINTNCSAGHCRKALSCKMaVEY- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   252 hDHYL-DKYEWFMRADDDVYIKGDKLEEFLRSLNSSKPLYLGQT---GLGNTEELGKLGLEPGENFCMGGPGMIFSREVL 327
Cdd:pfam02434  78 -DRFLeSGKKWFCHVDDDNYVNVPRLVRLLSCYNHTQDVYLGKPslyRPIEATERVKGNRKVGFWFATGGAGFCISRGLA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   328 RRMVPHIGEClrEMYTT------HEDVEVGRCVRRFGGTQCVWSyemqQLFHENYEHnrkgyIQDLHNSKIHAAITL--- 398
Cdd:pfam02434 157 LKMSPWASGG--RFMSTsekirlPDDCTLGYIIENLLGVPLTHS----PLFHSHLEN-----LQDLPPETLHEQVTLsyg 225


                  ....*.
gi 60360176   399 -HPNKR 403
Cdd:pfam02434 226 kFWNKR 231
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 9-181 7.94e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 59.31  E-value: 7.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    9 RRPWVSVALGLVLGFTAASWLIAPRVAELSEKRRRGSSLCSYYGRSATGPRADAQQLLPQP-QSRPrleQSPPPA----- 82
Cdd:PRK14959 340 RRVLTSLEPAMALELLLLNLAMLPRLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTPgTQGP---QGTAPAagmtp 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   83 SHELPGPQQPEAAPGgPSFrssPWQQPAPLPQRRrGHTPEGATALPGAPAAKGEPEEEDGGAADPrkggrpgSSHngsGD 162
Cdd:PRK14959 417 SSAAPATPAPSAAPS-PRV---PWDDAPPAPPRS-GIPPRPAPRMPEASPVPGAPDSVASASDAP-------PTL---GD 481

                        170
                 ....*....|....*....
gi 60360176  163 GGAAAPTSGPGDFLYVGVM 181
Cdd:PRK14959 482 PSDTAEHTPSGPRTWDGFL 500
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 52-241 9.33e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 59.23  E-value: 9.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   52 GRSATGPRADAQQLLPQPQSRPrlEQSPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAPLPQRRRGHTPEGATALPGAP 131
Cdd:PRK07764 594 AAGGEGPPAPASSGPPEEAARP--AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPA 671

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  132 AAKGEPEEEDGGAADPrkGGRPGSSHNGSGDGGAAAPTSGPgdflyvgvmtAQKYLGSRALAAQRTWArfipgrveffSS 211
Cdd:PRK07764 672 KAGGAAPAAPPPAPAP--AAPAAPAGAAPAQPAPAPAATPP----------AGQADDPAAQPPQAAQG----------AS 729

                        170       180       190
                 ....*....|....*....|....*....|
gi 60360176  212 QQSPSAALGQPPPPLPVIALPGVDDSYPPQ 241
Cdd:PRK07764 730 APSPAADDPVPLPPEPDDPPDPAGAPAQPP 759
PHA03247 PHA03247
large tegument protein UL36; Provisional
 67-227 5.37e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 5.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    67 PQPQSRPRLeqsPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAPlPQRRRGHTPEGATALPGAPAAKGEPEEEDGGAAD 146
Cdd:PHA03247 2551 PPPPLPPAA---PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAP-PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   147 PRKGGRPGSSHNGSGDGGAAAPTSGPGDFLYVGVMTAQKYLGSRALAA------QRTWARFIPGRVeffssqqSPSAALG 220
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqassppQRPRRRAARPTV-------GSLTSLA 2699


                  ....*..
gi 60360176   221 QPPPPLP 227
Cdd:PHA03247 2700 DPPPPPP 2706
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 52-240 6.62e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.25  E-value: 6.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    52 GRSATGPRADAQQLLPQPqSRPRLEQSPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAPLPQRRRGHT----------- 120
Cdd:PHA03307  160 AAVASDAASSRQAALPLS-SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSaaddagasssd 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   121 ------------PEGATALPGaPAAKGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAAAPTSGPGDflyvgvmtaqkylG 188
Cdd:PHA03307  239 ssssessgcgwgPENECPLPR-PAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSP-------------G 304

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 60360176   189 SRALAAQRTWARFIPGrveffSSQQSPSAALGQPPPPLPVIALPGVDDSYPP 240
Cdd:PHA03307  305 SGPAPSSPRASSSSSS-----SRESSSSSTSSSSESSRGAAVSPGPSPSRSP 351
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 55-148 8.35e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 53.07  E-value: 8.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   55 ATGPRADAQQLLPQPQSRPRLEQSPPPASHELPGPQQPEAAPGG-PSFRSSPWQQPAPLPQRRRGHTPEGATALPGAPAA 133
Cdd:PRK07764 417 PAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAaPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA 496

                         90
                 ....*....|....*..
gi 60360176  134 KGEPEEEDGG--AADPR 148
Cdd:PRK07764 497 PAAPAAPAGAddAATLR 513
Glyco_transf_7C pfam02709
N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of ...
 780-840 2.87e-06

N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 460659 [Multi-domain]  Cd Length: 78  Bit Score: 45.68  E-value: 2.87e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 60360176   780 WRDYGYGITCIYKSDLLGAGGFDTSIQGWGLEDVDLYNKVILSGLRPFR-SQEVG-VVHIFHP 840
Cdd:pfam02709  16 YKTYFGGVLALSREDFERINGFSNGFWGWGGEDDDLYNRLLLAGLEIERpPGDIGrYYMLYHK 78
PHA03378 PHA03378
EBNA-3B; Provisional
 51-172 4.18e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.84  E-value: 4.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   51 YGRSATGPRAdaqqLLPqPQSRPRLEQSPPPAshelPGPQQPEAAPGGPSFRSSPWQQPAPLPQRrrghTPEGATALPGA 130
Cdd:PHA03378 674 YQPSPTGANT----MLP-IQWAPGTMQPPPRA----PTPMRPPAAPPGRAQRPAAATGRARPPAA----APGRARPPAAA 740

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 60360176  131 PAAKGEPEEEDGGAADPRkgGRPGSSHNGSGDGGAAAPTSGP 172
Cdd:PHA03378 741 PGRARPPAAAPGRARPPA--AAPGRARPPAAAPGAPTPQPPP 780
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 52-239 4.25e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.75  E-value: 4.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   52 GRSATGPRADAQQLlpqpqsrPRLEQSPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAPLPQRRRghTPEGATALPGAP 131
Cdd:PRK07764 365 PSASDDERGLLARL-------ERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAP--APAAAPQPAPAP 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  132 AAKGEPEeedGGAADPRKGGRPGSSHngsGDGGAAAPTSGPGdflyvgvmtaqkylgsralAAQRTWARFIPGRVEFFSS 211
Cdd:PRK07764 436 APAPAPP---SPAGNAPAGGAPSPPP---AAAPSAQPAPAPA-------------------AAPEPTAAPAPAPPAAPAP 490

                        170       180
                 ....*....|....*....|....*...
gi 60360176  212 QQSPSAAlGQPPPPLPVIALPGVDDSYP 239
Cdd:PRK07764 491 AAAPAAP-AAPAAPAGADDAATLRERWP 517
PHA03378 PHA03378
EBNA-3B; Provisional
 32-173 3.16e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.75  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   32 PRVAELSEKRRRGSSLCSYYGRSATG---PRADAQQLLPQPQSRPRLEQSPPPASHELPGPQQPEAAP-------GGPSF 101
Cdd:PHA03378 707 PAAPPGRAQRPAAATGRARPPAAAPGrarPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPtpqpppqAPPAP 786

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 60360176  102 RSSPWQQPAPLPQRRRGHTPEgATALPGAPAAKGEPEE-EDGGAADPRKGGRPGSSHNGSGDGGAAA-PTSGPG 173
Cdd:PHA03378 787 QQRPRGAPTPQPPPQAGPTSM-QLMPRAAPGQQGPTKQiLRQLLTGGVKRGRPSLKKPAALERQAAAgPTPSPG 859
PHA03247 PHA03247
large tegument protein UL36; Provisional
 53-240 3.21e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 3.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    53 RSATGPRADAQQLLPQPqsrPRLEQSPPPASHELPGPQQPEAAPGgpsfrSSPWQQPAPLPQrrrghTPEGATALPGAPA 132
Cdd:PHA03247 2689 RPTVGSLTSLADPPPPP---PTPEPAPHALVSATPLPPGPAAARQ-----ASPALPAAPAPP-----AVPAGPATPGGPA 2755

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   133 AKGEPEEEDGGAADPRKGGRPGsshngsgdGGAAAPTSGPGDFLYVGVMTAQKYLGSRALAAQrtwarfIPGRVEFFSSQ 212
Cdd:PHA03247 2756 RPARPPTTAGPPAPAPPAAPAA--------GPPRRLTRPAVASLSESRESLPSPWDPADPPAA------VLAPAAALPPA 2821

                         170       180
                  ....*....|....*....|....*...
gi 60360176   213 QSPSAALgqPPPPLPVIALPGVDDSYPP 240
Cdd:PHA03247 2822 ASPAGPL--PPPTSAQPTAPPPPPGPPP 2847
PHA03247 PHA03247
large tegument protein UL36; Provisional
 41-150 3.43e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    41 RRRGSSLcSYYGRSATGPRADAQQLL-PQPQSRPRLEQSPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAPLPQRRrgh 119
Cdd:PHA03247 2863 RRRPPSR-SPAAKPAAPARPPVRRLArPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR--- 2938

                          90       100       110
                  ....*....|....*....|....*....|.
gi 60360176   120 tPEGATALPGAPAAKGEPEeedGGAADPRKG 150
Cdd:PHA03247 2939 -PQPPLAPTTDPAGAGEPS---GAVPQPWLG 2965
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 32-230 4.44e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 4.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    32 PRVAELSEKRRRGSSLCSYYGRSATGPRADAQQLLPQPQSRPRLEQSPPPASHELPGPqQPEAAPGGPSFRSSPWQQPAP 111
Cdd:PHA03307  225 GRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRP-GPASSSSSPRERSPSPSPSSP 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   112 lpqrrrgHTPEGATALPGAPAAKGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAAAPTSGPGDFlyVGVMTAQKYLGSRA 191
Cdd:PHA03307  304 -------GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPA--DPSSPRKRPRPSRA 374

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 60360176   192 LAAQRTWARFIPGR------VEFFSSQQSPSAALGQPPPPLPVIA 230
Cdd:PHA03307  375 PSSPAASAGRPTRRraraavAGRARRRDATGRFPAGRPRPSPLDA 419
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 30-166 4.82e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 4.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   30 IAPRVAELsEKRRRGSSLCSYYGRSATGPR-ADAQQLLPQPQSRPRLEQSPPPASHELPGPQ-QPEAAPGGPSFRSSPWQ 107
Cdd:PRK07764 374 LLARLERL-ERRLGVAGGAGAPAAAAPSAAaAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPApAPAPAPPSPAGNAPAGG 452

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 60360176  108 QPAPLPQRRRGHTPEGATALPGAPAAKGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAA 166
Cdd:PRK07764 453 APSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 54-174 5.12e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 5.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   54 SATGPRADAQQLLPQPQSRPRLEQSPPPASHELPGPQQPEAAPGGPSfRSSPWQQPAPLPQRRRGHTPEGATALPGAPAA 133
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATP-PAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 60360176  134 KGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAAAPTSGPGD 174
Cdd:PRK07764 742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 22-174 1.06e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   22 GFTAASWLIAPRVAELSEKRRRGSSLCSYYGRSATGPRADAQQLL---PQPQSRPRLEQSPPPASHELPGPQQPEAAPGG 98
Cdd:PRK07764 635 APAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAappPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQA 714

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 60360176   99 PSfrssPWQQPAPLPQRRRGHTPEGATALPGAPaakgEPEEEDGGAADPRKGGRPGsshnGSGDGGAAAPTSGPGD 174
Cdd:PRK07764 715 DD----PAAQPPQAAQGASAPSPAADDPVPLPP----EPDDPPDPAGAPAQPPPPP----APAPAAAPAAAPPPSP 778
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 58-241 1.17e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 45.82  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  58 PRADAQQLLPQPQSRPRLEQSPPPAS----HELPGPQQPE----AAPGGPSFRSSPWQQPAPLPQ-----RRRGHTPEGA 124
Cdd:COG5180 266 RAAIGDTPAAEPPGLPVLEAGSEPQSdapeAETARPIDVKgvasAPPATRPVRPPGGARDPGTPRpgqptERPAGVPEAA 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176 125 TALPGAPAAKGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAAAPTSGPGDFLYVGVMTAQKYLGSRALAAQRTWARFIpg 204
Cdd:COG5180 346 SDAGQPPSAYPPAEEAVPGKPLEQGAPRPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETA-- 423

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 60360176 205 rveffsSQQSPSAALGQPPPPLPViALPGVDDSYPPQ 241
Cdd:COG5180 424 ------SLGGAAGGAGQGPKADFV-PGDAESVSGPAG 453
dnaA PRK14086
chromosomal replication initiator protein DnaA;
31-174 2.00e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 45.20  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   31 APRVAELSEKRRRGSSLCSYYGRSATGPRADAQQLLPQ--------PQSRPRLEQSPPPASHELPGPQQ-----PEAAPG 97
Cdd:PRK14086 101 HARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQlptarpayPAYQQRPEPGAWPRAADDYGWQQqrlgfPPRAPY 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   98 GPS---------FRSSPWQQPAPLPQRRR-GHTPEGATALPG---------APAAKGEPEEEDGGAADPRKGGRPGSSHN 158
Cdd:PRK14086 181 ASPasyapeqerDREPYDAGRPEYDQRRRdYDHPRPDWDRPRrdrtdrpepPPGAGHVHRGGPGPPERDDAPVVPIRPSA 260

                        170
                 ....*....|....*.
gi 60360176  159 GSGDGGAAAPTSGPGD 174
Cdd:PRK14086 261 PGPLAAQPAPAPGPGE 276
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 57-234 2.09e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    57 GPRADAQQL--LPQPQSRPRLEQSPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAP----LPQRRRGHTPEGATALPGA 130
Cdd:PHA03307   76 GTEAPANESrsTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPdlseMLRPVGSPGPPPAASPPAA 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   131 PAAKGEPEE---EDGGAADP--------RKGGRPGSSHNGSGDGGAAAPTSGPgdflyVGVMTAQKYLGSRALAAQRTWA 199
Cdd:PHA03307  156 GASPAAVASdaaSSRQAALPlsspeetaRAPSSPPAEPPPSTPPAAASPRPPR-----RSSPISASASSPAPAPGRSAAD 230

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 60360176   200 RFIPGRVEFFSSQQSPSAALGQ---PPPPLPVIALPGV 234
Cdd:PHA03307  231 DAGASSSDSSSSESSGCGWGPEnecPLPRPAPITLPTR 268
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1-240 2.16e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    1 AATMAVRSRRPWVSVALGLVLGFTAASWLIAPRVAELSEKRRRGSSLCSYYGRSATGPRADAQQLLPQPQSRPRLE---- 76
Cdd:PRK07003 402 VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSAsapa 481

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   77 -QSPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAPLPQRRRGHTPEGATALPGAPAAkGEPEEEDGGAADP----RKGG 151
Cdd:PRK07003 482 sDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAA-AAPAARAGGAAAAldvlRNAG 560

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  152 RPGSSHNGSGDGGAAAPTSGPGdflyvgvmTAQKYLGSR-ALAAQRTWARFIPGRVEFFSSQQSPSAA-LGQPPPP---- 225
Cdd:PRK07003 561 MRVSSDRGARAAAAAKPAAAPA--------AAPKPAAPRvAVQVPTPRARAATGDAPPNGAARAEQAAeSRGAPPPwedi 632

                        250       260
                 ....*....|....*....|...
gi 60360176  226 -----LPVIA---LPGVDDSYPP 240
Cdd:PRK07003 633 ppddyVPLSAdegFGGPDDGFVP 655
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 677-839 3.02e-04

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 42.56  E-value: 3.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176 677 ELIQEYQSRYPsaemmlIPMK-------GeF----SRGLGLEMASSQFdndtlLLFCDVDLIFRGDFLQRCRDNT----- 740
Cdd:cd06420  42 ELIEEFKSQFP------IPIKhvwqedeG-FrkakIRNKAIAAAKGDY-----LIFIDGDCIPHPDFIADHIELAepgvf 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176 741 VQGQQVYYPIIFSQYDPKVTHMrnpptegdfvfsketGFWrdygygitciyKSDLLGAGGFDTSIQGWGLEDVDLYNKVI 820
Cdd:cd06420 110 LSGSRVLLNEKLTERGIRGCNM---------------SFW-----------KKDLLAVNGFDEEFTGWGGEDSELVARLL 163

                       170
                ....*....|....*....
gi 60360176 821 LSGLRPFRSQEVGVVhiFH 839
Cdd:cd06420 164 NSGIKFRKLKFAAIV--FH 180
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
52-240 4.10e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   52 GRSATGPRADAQQLLPQPQSRPRLEQSPPPASHELPGPQQPEAAPGGPSFRSSPWQ-QPAPLP----QRRRGHTPEGATA 126
Cdd:PRK12323 370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARrSPAPEAlaaaRQASARGPGGAPA 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  127 LPGAPAAKGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAAAPTSG---PGDFLYVGVMTAQKYLGSRALAAQRTWARFIP 203
Cdd:PRK12323 450 PAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdppPWEELPPEFASPAPAQPDAAPAGWVAESIPDP 529

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 60360176  204 GRVEFFSSQQSPSAALGQPPPPLPVIALPGVDDSYPP 240
Cdd:PRK12323 530 ATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP 566
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-174 5.18e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176     1 AATMAVRS----------------RRPWVSVAlglvlGFTAASWLIAP---RVAELSEKRRRGSSLCSYYGRSATGPRAD 61
Cdd:PHA03307  718 ERVAAVRAvslvartvaplvryspRRARARAS-----AWDITDALFSNpslVPAKLAEALALLEPAEPQRGAGSSPPVRA 792

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    62 AQqLLPQPQSRPRLEQSPPPASHELPGPQQPEAAPGGPSFRSSPWQQPAPLPQRRRGHTPEGATALPGAPAAKGEPEEED 141
Cdd:PHA03307  793 EA-AFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSESSKSKPAAAGGRARGKNGR 871

                         170       180       190
                  ....*....|....*....|....*....|...
gi 60360176   142 GGAADPRKGGRPGSSHNGSGDgGAAAPTSGPGD 174
Cdd:PHA03307  872 RRPRPPEPRARPGAAAPPKAA-AAAPPAGAPAP 903
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 67-216 5.76e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.56  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   67 PQPQSRPRLEQSPPPASHELPGPQ---QPEAAPgGPSFRSSPWQQPAPLPQRRRGHTPEGATALPGAPAAKgePEEEDGG 143
Cdd:PHA03269  54 PDPAVAPTSAASRKPDLAQAPTPAaseKFDPAP-APHQAASRAPDPAVAPQLAAAPKPDAAEAFTSAAQAH--EAPADAG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  144 AADPRKGGRPgsshngsgdggAAAPTSGPGDFLYVGVM--TAQKYLGSRALAAQRT-----WARFIPGRVEFFSSQQSPS 216
Cdd:PHA03269 131 TSAASKKPDP-----------AAHTQHSPPPFAYTRSMehIACTHGGIQFIPYFHKfilpcYLQIFTGQGAAFKQHELPK 199
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
54-162 1.01e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   54 SATGPRADAQQLLPQPQSRPRLEQSPP-PAShelPGPQQPEAAPGGPSFRSSPWQQPAPLPQRRRGHTPEGATALPGAPA 132
Cdd:PRK12323 478 AAPARAAPAAAPAPADDDPPPWEELPPeFAS---PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAA 554

                         90       100       110
                 ....*....|....*....|....*....|
gi 60360176  133 AKGEPEEedggAADPRKGGRPGSSHNGSGD 162
Cdd:PRK12323 555 AATEPVV----APRPPRASASGLPDMFDGD 580
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
87-239 1.12e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   87 PGPQQPEAAPggPSFRSSPWQQPAPLPQRRRGHTPEGAT--ALPGAPAAKGEPEEEDGGAADPRKGGR----PGSSHNGS 160
Cdd:PRK12323 365 PGQSGGGAGP--ATAAAAPVAQPAPAAAAPAAAAPAPAAppAAPAAAPAAAAAARAVAAAPARRSPAPealaAARQASAR 442

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176  161 GDGGAAAPTSGPGDFLYVGVMTAQKYLGSRALAAQRTWARFIPGRVeffssqqsPSAALGQPPP--PLPV-IALPGVDDS 237
Cdd:PRK12323 443 GPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA--------PAPADDDPPPweELPPeFASPAPAQP 514


                 ..
gi 60360176  238 YP 239
Cdd:PRK12323 515 DA 516
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 74-208 1.20e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 42.30  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   74 RLEQSPPPASHELPGPQQPEAAPGGPSfrsspwqqpaplpqrrrghtPEGATALPGAPAAKGEPEEEDGGAADPRKGGRP 153
Cdd:NF041121  14 QMGRAAAPPSPEGPAPTAASQPATPPP--------------------PAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPP 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 60360176  154 GSSHNGSgdggaaaPTSGPGDFLYVGVMTAQKYLGSRALA-AQRTWARFIPGRVEF 208
Cdd:NF041121  74 PPPPPGP-------AGAAPGAALPVRVPAPPALPNPLELArALRPLKRRVPSPRRV 122
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 34-240 2.03e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    34 VAELSEKRRRGSSLCSYYGRSATGPRADAqqlLPQPQSRPRLEQSPPPASHELPGPQQP----EAAPGGPSfRSSPWQQP 109
Cdd:PHA03307   76 GTEAPANESRSTPTWSLSTLAPASPAREG---SPTPPGPSSPDPPPPTPPPASPPPSPApdlsEMLRPVGS-PGPPPAAS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   110 APLPQRRRGHTPEGATALPGA--PAAKGE--------PEEEDGGAADPRKG----GRPGSSHNGSGDGGAAAPTSGPGDF 175
Cdd:PHA03307  152 PPAAGASPAAVASDAASSRQAalPLSSPEetarapssPPAEPPPSTPPAAAsprpPRRSSPISASASSPAPAPGRSAADD 231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 60360176   176 LYVGVMTAQKYLGSRALAAQRTWA-RFIPGRVEFFSSQQSPSAALGQPPPPLPVIALPGVDDSYPP 240
Cdd:PHA03307  232 AGASSSDSSSSESSGCGWGPENECpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPS 297
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 52-148 2.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   52 GRSATGPRADAQQLLPQPQSRPRlEQSPPPASHELPGPQQPEaaPGGPSFRSSPWQQPAPlPQRRRGHTPEGATALPGAP 131
Cdd:PRK07764 704 APAATPPAGQADDPAAQPPQAAQ-GASAPSPAADDPVPLPPE--PDDPPDPAGAPAQPPP-PPAPAPAAAPAAAPPPSPP 779

                         90
                 ....*....|....*..
gi 60360176  132 AAKGEPEEEDGGAADPR 148
Cdd:PRK07764 780 SEEEEMAEDDAPSMDDE 796
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 64-153 3.92e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 39.25  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    64 QLLPQPQSRPRLEQSPPPAshelpGPQQPEAAPGGPSFRSSPWQQ-PAPLPQRRRGHTPEGATALPGAPAAKGEPEEEDG 142
Cdd:pfam15240  53 GFPPQPPASDDPPGPPPPG-----GPQQPPPQGGKQKPQGPPPQGgPRPPPGKPQGPPPQGGNQQQGPPPPGKPQGPPPQ 127

                          90
                  ....*....|.
gi 60360176   143 GAADPRKGGRP 153
Cdd:pfam15240 128 GGGPPPQGGNQ 138
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 58-152 4.09e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.88  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   58 PRADAQQLLPQPQSRPRLEQSPPPASHELPGPQQPEAAPGGpsfRSSPWQQPAPLPQRRRGHTPEgatalPGAPAAKGEP 137
Cdd:PRK14965 363 PGAPVSELLDRLEALERGAPAPPSAAWGAPTPAAPAAPPPA---AAPPVPPAAPARPAAARPAPA-----PAPPAAAAPP 434

                         90
                 ....*....|....*
gi 60360176  138 EEEDGGAADPRKGGR 152
Cdd:PRK14965 435 ARSADPAAAASAGDR 449
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 57-171 4.51e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 38.87  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    57 GPRADAQQLLPQPQSRPRLEQSPPPASHELP-------GPQQPEAAPGGPSFRSSPWQQ-PAPLPQRRRGHTPEGATALP 128
Cdd:pfam15240  34 EEEGQSQQGGQGPQGPPPGGFPPQPPASDDPpgppppgGPQQPPPQGGKQKPQGPPPQGgPRPPPGKPQGPPPQGGNQQQ 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 60360176   129 GAP---AAKGEPEEEDGGAADPRKGGRPGSSHNGSGDGGAAAPTSG 171
Cdd:pfam15240 114 GPPppgKPQGPPPQGGGPPPQGGNQQGPPPPPPGNPQGPPQRPPQP 159
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 79-244 4.73e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176    79 PPPASHELPGPqqPEAAPGGPSFRSSPWQQPAPLP-QRRRGHTPEGATALPGAPAAKGEPEEEDGGAADPRKGG--RPGS 155
Cdd:PHA03307   65 FEPPTGPPPGP--GTEAPANESRSTPTWSLSTLAPaSPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEmlRPVG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176   156 SHNGSGDGGAAAPTSGPGDflyVGVMTAQKYLGSRALAAQRTWARFIPGRVEFFSSQQSPSAALGQPPPPLPVIALPGVD 235
Cdd:PHA03307  143 SPGPPPAASPPAAGASPAA---VASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219


                  ....*....
gi 60360176   236 DSYPPQKKS 244
Cdd:PHA03307  220 PAPAPGRSA 228
GINS_A_psf1 cd11710
Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric ...
 367-444 6.67e-03

Alpha-helical domain of GINS complex protein Psf1; Psf1 is a component of the GINS tetrameric protein complex. Psf1 is mainly expressed in highly proliferative tissues, such as blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Loss of Psf1 causes embryonic lethality. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologs are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3.


Pssm-ID: 212548  Cd Length: 129  Bit Score: 37.62  E-value: 6.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60360176 367 EMQQLFHENYEHNRKGYIQDLHNS-----KIHAAITLHpNKRP--AYQY-RLhnymlsRKISELRYRTIQlHRESALMSK 438
Cdd:cd11710  33 EIRDLYEENQALLEEAQEEEEDPGlipglLVRHLSILR-NKRCllAYLYeRL------DRIRELRWENGS-VLPEDIKEN 104


                ....*.
gi 60360176 439 LSNSEV 444
Cdd:cd11710 105 LSPAEK 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH