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Conserved domains on  [gi|46090757|dbj|BAD13516|]
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kruppel-like zinc finger protein isoform 2, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-81 2.35e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 99.20  E-value: 2.35e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46090757      8 LSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNLVSLGEdnvrpeacicsGICLPDLSvtSMLEQKRDPWT 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF-----------QVPKPDLI--SQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-674 1.66e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 280 QKPYNNKECGKVFSHHAYLAQHRKIHTGEKPYKCS--ECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKVFRHKSSLTTH 357
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 358 QTVHTGE-RPYKCNECGKGFSRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHRKIHTGGRRYKCNECGKAFRTCS 436
Cdd:COG5048 111 SSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 437 DLTAHLLIHtgekpYECIDCGKvFRHKSSLTYHCRIHTGEKPYKCNECGKVFSQNSNLQRHRKIHTGEKLYKCNECGKVF 516
Cdd:COG5048 191 NVSTSIPSS-----SENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 517 RQNSHLAQHRDIHTGE-------KPYSCNECGKVFRRNSHLVRHRN--VHTGE--KPYSCNE--CGKVFSRNSHLARHRN 583
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 584 IHTGEKPHSC--NECGKVFSRNSH-----LARHRKIHTGEKLYKC--NECSKVFSRNSRLAQHRNIHTGVKPYSCN--EC 652
Cdd:COG5048 345 LHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                       410       420
                ....*....|....*....|..
gi 46090757 653 GKVFSKNSILVQHCSIHTREKP 674
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 7.03e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   241 NFAQHQRIHTGEKPYKYNECGKVFNQ 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
83-414 8.06e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 8.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757  83 QSEVKIINNPDGRECIKGVNTEKSSKLGSSAGNKSLKNQHGLTLQLHLTEWQPFQAVRNIYGCKHVEKSISDNSSVSPVQ 162
Cdd:COG5048 130 PSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSY 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 163 ISFFSVKTHIFNNYRNDFLFSTLLPQEQKV--------------HIREKPYGCNEHGKVFRVSSSLTNRQVIHIADKT-- 226
Cdd:COG5048 210 SIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspsslsssdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlp 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 227 YKCSDCGEIFSSNSNFAQHQR--IHTGE--KPY--KYNECGKVFNQNSHLAQHQKIHTGQKPYNNK--ECGKVFSH--HA 296
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFscPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllNN 369

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 297 YLAQHRKIHTGEKPYKCSECGKAFSVCSSLTahlvihtgekpydckecgkvfRHKSSLTTHQTVHTGERPYKCNECGKGF 376
Cdd:COG5048 370 EPPQSLQQYKDLKNDKKSETLSNSCIRNFKR---------------------DSNLSLHIITHLSFRPYNCKNPPCSKSF 428

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 46090757 377 SRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHR 414
Cdd:COG5048 429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-81 2.35e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 99.20  E-value: 2.35e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46090757      8 LSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNLVSLGEdnvrpeacicsGICLPDLSvtSMLEQKRDPWT 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF-----------QVPKPDLI--SQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 2.93e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 2.93e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 46090757     8 LSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNLVSLG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 1.40e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.91  E-value: 1.40e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 46090757   8 LSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNLVSL 47
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-674 1.66e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 280 QKPYNNKECGKVFSHHAYLAQHRKIHTGEKPYKCS--ECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKVFRHKSSLTTH 357
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 358 QTVHTGE-RPYKCNECGKGFSRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHRKIHTGGRRYKCNECGKAFRTCS 436
Cdd:COG5048 111 SSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 437 DLTAHLLIHtgekpYECIDCGKvFRHKSSLTYHCRIHTGEKPYKCNECGKVFSQNSNLQRHRKIHTGEKLYKCNECGKVF 516
Cdd:COG5048 191 NVSTSIPSS-----SENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 517 RQNSHLAQHRDIHTGE-------KPYSCNECGKVFRRNSHLVRHRN--VHTGE--KPYSCNE--CGKVFSRNSHLARHRN 583
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 584 IHTGEKPHSC--NECGKVFSRNSH-----LARHRKIHTGEKLYKC--NECSKVFSRNSRLAQHRNIHTGVKPYSCN--EC 652
Cdd:COG5048 345 LHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                       410       420
                ....*....|....*....|..
gi 46090757 653 GKVFSKNSILVQHCSIHTREKP 674
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
465-490 4.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 46090757   465 SLTYHCRIHTGEKPYKCNECGKVFSQ 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 7.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   241 NFAQHQRIHTGEKPYKYNECGKVFNQ 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
83-414 8.06e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 8.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757  83 QSEVKIINNPDGRECIKGVNTEKSSKLGSSAGNKSLKNQHGLTLQLHLTEWQPFQAVRNIYGCKHVEKSISDNSSVSPVQ 162
Cdd:COG5048 130 PSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSY 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 163 ISFFSVKTHIFNNYRNDFLFSTLLPQEQKV--------------HIREKPYGCNEHGKVFRVSSSLTNRQVIHIADKT-- 226
Cdd:COG5048 210 SIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspsslsssdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlp 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 227 YKCSDCGEIFSSNSNFAQHQR--IHTGE--KPY--KYNECGKVFNQNSHLAQHQKIHTGQKPYNNK--ECGKVFSH--HA 296
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFscPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllNN 369

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 297 YLAQHRKIHTGEKPYKCSECGKAFSVCSSLTahlvihtgekpydckecgkvfRHKSSLTTHQTVHTGERPYKCNECGKGF 376
Cdd:COG5048 370 EPPQSLQQYKDLKNDKKSETLSNSCIRNFKR---------------------DSNLSLHIITHLSFRPYNCKNPPCSKSF 428

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 46090757 377 SRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHR 414
Cdd:COG5048 429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-81 2.35e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 99.20  E-value: 2.35e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46090757      8 LSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNLVSLGEdnvrpeacicsGICLPDLSvtSMLEQKRDPWT 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF-----------QVPKPDLI--SQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 2.93e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 2.93e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 46090757     8 LSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNLVSLG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 1.40e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.91  E-value: 1.40e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 46090757   8 LSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNLVSL 47
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-674 1.66e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 280 QKPYNNKECGKVFSHHAYLAQHRKIHTGEKPYKCS--ECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKVFRHKSSLTTH 357
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 358 QTVHTGE-RPYKCNECGKGFSRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHRKIHTGGRRYKCNECGKAFRTCS 436
Cdd:COG5048 111 SSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 437 DLTAHLLIHtgekpYECIDCGKvFRHKSSLTYHCRIHTGEKPYKCNECGKVFSQNSNLQRHRKIHTGEKLYKCNECGKVF 516
Cdd:COG5048 191 NVSTSIPSS-----SENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 517 RQNSHLAQHRDIHTGE-------KPYSCNECGKVFRRNSHLVRHRN--VHTGE--KPYSCNE--CGKVFSRNSHLARHRN 583
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 584 IHTGEKPHSC--NECGKVFSRNSH-----LARHRKIHTGEKLYKC--NECSKVFSRNSRLAQHRNIHTGVKPYSCN--EC 652
Cdd:COG5048 345 LHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                       410       420
                ....*....|....*....|..
gi 46090757 653 GKVFSKNSILVQHCSIHTREKP 674
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-609 1.49e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 211 SSSLTNRQVIHIADKTYKCSDCGEIFSSNSNFAQHQRIHTGEKPY--KYNECGKVFNQNSHLAQHQKIHTGQKPY-NNKE 287
Cdd:COG5048  18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDlNSKS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 288 CGKVFSHHAYLAQHRKIHTGEKPYKCSECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKVFRH----------------- 350
Cdd:COG5048  98 LPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpansls 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 351 -----KSSLTTHQTVHTGERPYKCNECGKGFSRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHRKIHTGGRRYKC 425
Cdd:COG5048 178 kdpssNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 426 NECGKAFRTCSDLTAHLLIHTGE-------KPYECIDCGKVFRHKSSLTYH--CRIHTGE--KPYKCNE--CGKVFSQNS 492
Cdd:COG5048 258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRND 337

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 493 NLQRHRKIHTGEKLYKC--NECGKVFRQNSH-----LAQHRDIHTGEKPYSC--NECGKVFRRNSHLVRHRNVHTGEKPY 563
Cdd:COG5048 338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 46090757 564 SCN--ECGKVFSRNSHLARHRNIHTGEKPHSCNECGKvFSRNSHLARH 609
Cdd:COG5048 418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
465-490 4.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 46090757   465 SLTYHCRIHTGEKPYKCNECGKVFSQ 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-321 5.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.00e-04
                          10        20
                  ....*....|....*....|....*
gi 46090757   297 YLAQHRKIHTGEKPYKCSECGKAFS 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 437-499 9.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 437 DLTAHLLIHTGEKPYEC--IDCGKVFRHKSSLTYHcRIH--------------------TGEKPYKCNECGKVFSQNSNL 494
Cdd:COG5189 336 DTPSRMLKVKDGKPYKCpvEGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGL 414


                ....*
gi 46090757 495 QRHRK 499
Cdd:COG5189 415 KYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-518 9.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 46090757   493 NLQRHRKIHTGEKLYKCNECGKVFRQ 518
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 479-501 1.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|...
gi 46090757   479 YKCNECGKVFSQNSNLQRHRKIH 501
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-404 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|...
gi 46090757   382 LARHRKVHTGEKPYKCNECGKVF 404
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
577-602 2.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   577 HLARHRNIHTGEKPHSCNECGKVFSR 602
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
605-630 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   605 HLARHRKIHTGEKLYKCNECSKVFSR 630
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 563-585 4.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.36e-03
                          10        20
                  ....*....|....*....|...
gi 46090757   563 YSCNECGKVFSRNSHLARHRNIH 585
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 535-557 5.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.20e-03
                          10        20
                  ....*....|....*....|...
gi 46090757   535 YSCNECGKVFRRNSHLVRHRNVH 557
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
549-574 5.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   549 HLVRHRNVHTGEKPYSCNECGKVFSR 574
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
521-546 6.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   521 HLAQHRDIHTGEKPYSCNECGKVFRR 546
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 7.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   241 NFAQHQRIHTGEKPYKYNECGKVFNQ 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
83-414 8.06e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 8.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757  83 QSEVKIINNPDGRECIKGVNTEKSSKLGSSAGNKSLKNQHGLTLQLHLTEWQPFQAVRNIYGCKHVEKSISDNSSVSPVQ 162
Cdd:COG5048 130 PSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSY 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 163 ISFFSVKTHIFNNYRNDFLFSTLLPQEQKV--------------HIREKPYGCNEHGKVFRVSSSLTNRQVIHIADKT-- 226
Cdd:COG5048 210 SIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspsslsssdsSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlp 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 227 YKCSDCGEIFSSNSNFAQHQR--IHTGE--KPY--KYNECGKVFNQNSHLAQHQKIHTGQKPYNNK--ECGKVFSH--HA 296
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFscPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllNN 369

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 297 YLAQHRKIHTGEKPYKCSECGKAFSVCSSLTahlvihtgekpydckecgkvfRHKSSLTTHQTVHTGERPYKCNECGKGF 376
Cdd:COG5048 370 EPPQSLQQYKDLKNDKKSETLSNSCIRNFKR---------------------DSNLSLHIITHLSFRPYNCKNPPCSKSF 428

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 46090757 377 SRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHR 414
Cdd:COG5048 429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 475-554 9.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 9.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46090757 475 GEKPYKCN--ECGKVFSQNSNLQRHRKiHtgeklykcNECGKVFRQNSHLAQHRDIHTGEKPYSCNECGKVFRRNSHLVR 552
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 46090757 553 HR 554
Cdd:COG5189 417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-434 9.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 46090757   409 RLARHRKIHTGGRRYKCNECGKAFRT 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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