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Conserved domains on  [gi|34850469|dbj|BAC87833|]
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KRAP [Mus musculus]

Protein Classification

KRAP_IP3R_bind and SSFA2_C domain-containing protein( domain architecture ID 10631616)

KRAP_IP3R_bind and SSFA2_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 861-1029 3.77e-97

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


:

Pssm-ID: 464281  Cd Length: 171  Bit Score: 307.23  E-value: 3.77e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    861 TLSAHSVPNISGAACSAF-SPFGCPYSHRHAAHPYRACSVNPPSAIEMQLRRVLHDIRSSLQNLSQYPMTRGPDL-AAAP 938
Cdd:pfam14723    1 TWSTHSVPNLSGAPCGAFySPFSCPYSPRHQGPPHRGHSRNPPSTTEMQLRRVLHDIRNSVQNLSQYPVLRGPDLsTASG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    939 YSTQNSSVLPLYENTFQELQVVRRSLNLFRTQMMDLELAMLRQQTVVYPHMTEEDRYEVDQLQGLRNSVRMELQDLEMQL 1018
Cdd:pfam14723   81 YNTQRSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELELQL 160

                          170
                   ....*....|.
gi 34850469   1019 EERLLGLDEQL 1029
Cdd:pfam14723  161 EDRLLALEEQL 171
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 146-299 2.87e-67

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


:

Pssm-ID: 464280  Cd Length: 145  Bit Score: 222.98  E-value: 2.87e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    146 HQKGRSMNSTGSGKSsgTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFARGIDIKVFLSAQMQRM 225
Cdd:pfam14722    1 LSRGTSFNSSHSTAS--TPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34850469    226 EVENPNyaLTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSmssvtSTKEVADSPPPLTRSNTANRLMKTLS 299
Cdd:pfam14722   79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQAEEK-----SVGSEPQSPSVSETKEHRRRMGKLLS 145
 
Name Accession Description Interval E-value
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 861-1029 3.77e-97

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 307.23  E-value: 3.77e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    861 TLSAHSVPNISGAACSAF-SPFGCPYSHRHAAHPYRACSVNPPSAIEMQLRRVLHDIRSSLQNLSQYPMTRGPDL-AAAP 938
Cdd:pfam14723    1 TWSTHSVPNLSGAPCGAFySPFSCPYSPRHQGPPHRGHSRNPPSTTEMQLRRVLHDIRNSVQNLSQYPVLRGPDLsTASG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    939 YSTQNSSVLPLYENTFQELQVVRRSLNLFRTQMMDLELAMLRQQTVVYPHMTEEDRYEVDQLQGLRNSVRMELQDLEMQL 1018
Cdd:pfam14723   81 YNTQRSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELELQL 160

                          170
                   ....*....|.
gi 34850469   1019 EERLLGLDEQL 1029
Cdd:pfam14723  161 EDRLLALEEQL 171
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 146-299 2.87e-67

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 222.98  E-value: 2.87e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    146 HQKGRSMNSTGSGKSsgTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFARGIDIKVFLSAQMQRM 225
Cdd:pfam14722    1 LSRGTSFNSSHSTAS--TPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34850469    226 EVENPNyaLTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSmssvtSTKEVADSPPPLTRSNTANRLMKTLS 299
Cdd:pfam14722   79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQAEEK-----SVGSEPQSPSVSETKEHRRRMGKLLS 145
 
Name Accession Description Interval E-value
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 861-1029 3.77e-97

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 307.23  E-value: 3.77e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    861 TLSAHSVPNISGAACSAF-SPFGCPYSHRHAAHPYRACSVNPPSAIEMQLRRVLHDIRSSLQNLSQYPMTRGPDL-AAAP 938
Cdd:pfam14723    1 TWSTHSVPNLSGAPCGAFySPFSCPYSPRHQGPPHRGHSRNPPSTTEMQLRRVLHDIRNSVQNLSQYPVLRGPDLsTASG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    939 YSTQNSSVLPLYENTFQELQVVRRSLNLFRTQMMDLELAMLRQQTVVYPHMTEEDRYEVDQLQGLRNSVRMELQDLEMQL 1018
Cdd:pfam14723   81 YNTQRSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELELQL 160

                          170
                   ....*....|.
gi 34850469   1019 EERLLGLDEQL 1029
Cdd:pfam14723  161 EDRLLALEEQL 171
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 146-299 2.87e-67

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 222.98  E-value: 2.87e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34850469    146 HQKGRSMNSTGSGKSsgTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFARGIDIKVFLSAQMQRM 225
Cdd:pfam14722    1 LSRGTSFNSSHSTAS--TPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34850469    226 EVENPNyaLTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSmssvtSTKEVADSPPPLTRSNTANRLMKTLS 299
Cdd:pfam14722   79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQAEEK-----SVGSEPQSPSVSETKEHRRRMGKLLS 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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