BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  10 IGIPFPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFggggggggGGGGGGGGRGGVGGHRN 89
Cdd:cd18327    1 IGIPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLF--------TGGGGGSGDLGAGGGQD 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 511649071  90 VCELDFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILG 144
Cdd:cd18327   73 VCELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 511649071  447 LKIHMRKHTGERPYACELCDARFLH 471
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  10 IGIPFPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFggggggggGGGGGGGGRGGVGGHRN 89
Cdd:cd18327    1 IGIPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLF--------TGGGGGSGDLGAGGGQD 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 511649071  90 VCELDFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILG 144
Cdd:cd18327   73 VCELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071    36 DLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGGGGgggggggrggvgghrNVCELDFVPPEVLSALLEFAYTATLTI 115
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------------SEIYLDDVSPEDFRALLNFLYTGKLDL 65

                           90       100
                   ....*....|....*....|....*...
gi 511649071   116 SSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:smart00225  66 PEENVEELLELADYLQIPGLVELCEEFL 93

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|...
gi 511649071  421 RHMRTHTGEKPFACHVCGVRFTR 443
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  10 IGIPFPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFggggggggGGGGGGGGRGGVGGHRN 89
Cdd:cd18327    1 IGIPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLF--------TGGGGGSGDLGAGGGQD 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 511649071  90 VCELDFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILG 144
Cdd:cd18327   73 VCELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  10 IGIPFPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFgggggggggggggggGRGGVGGHRN 89
Cdd:cd18328    1 IGIPFPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLF---------------TAGTLADQPY 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 511649071  90 VCELDFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18328   66 VYEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  14 FPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFggggggggggggggggrggvGGHRNVCEL 93
Cdd:cd18206    2 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF--------------------VDQKDVVHL 61

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 511649071  94 DFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQAC 139
Cdd:cd18206   62 DISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  16 QHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGGGGGGgggggrggvgghrnvCELDF 95
Cdd:cd18237    3 KLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSE---------------VELKD 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 511649071  96 VPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILGQ 145
Cdd:cd18237   68 AEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  34 LCDLTLVTQGLEYRTHRSVLAACSLYFRRLFgggggggggggggggGRGGVGGHRNVCELDFVPPEVLSALLEFAYTATL 113
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMF---------------SSGMKESSSSEIELDDVSPEAFEALLDYIYTGEL 65

                         90
                 ....*....|....*..
gi 511649071 114 TISSSNMREVLRASRVL 130
Cdd:cd18186   66 ELSEENVEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  17 HSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFgggggggggggggggGRGGVGGHRNVCELDFV 96
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELF---------------SSDSDGESILTVKLDGL 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 511649071  97 PPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18306   66 DPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  15 PQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFgggggggggggggggGRGGVGGHRNVCELD 94
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMF---------------TGDLSESRANRVTLQ 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 511649071  95 FVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILgQTEGHA 150
Cdd:cd18235   67 DVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFL-QSQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  15 PQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFggggggggggggggGGRGGVGGHRNVCELD 94
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLY--------------CQVQKTSDQATVTHLD 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 511649071  95 FVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18230   68 IVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  25 LNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGGGggggggggrggvgghRNVCELDFVPPEVLSAL 104
Cdd:cd18240    8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETE---------------KKVYKIPGVSPEMMELI 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 511649071 105 LEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILG 144
Cdd:cd18240   73 IEYAYTRTVPITAENVEELLPAADQFNIMGIVKACCDFLE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  15 PQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGGgggggggggrggvggHRNVCELD 94
Cdd:cd18250    2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRES---------------RADRVVLH 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 511649071  95 FVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILGQ 145
Cdd:cd18250   67 GVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQ 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  17 HSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFrrlfggggggggggggggggrggvgGHRNVCELD-- 94
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYF-------------------------HSRIVGQADae 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 511649071  95 ---FVPPEV----LSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18277   65 lniTLPEEVtvkgFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  17 HSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGggggggggggggrggvgghRNVCELD-- 94
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTE-------------------DNIVFLDqs 61

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 511649071  95 FVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQAC 139
Cdd:cd18217   62 QVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071   9 LIGIPFPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGggggggggggggrggvgghR 88
Cdd:cd18289    4 MLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNS-------------------K 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 511649071  89 NVCEL-DFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18289   65 SAFELpATVPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLM 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  14 FPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGggggggggggrggvgghRNVCEL 93
Cdd:cd18325    3 FPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDK-----------------RDIVHL 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 511649071  94 --DFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILGQTE 147
Cdd:cd18325   66 nsDIVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDKE 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  14 FPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGggggggggggrggvgghRNVCEL 93
Cdd:cd18194    3 FPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDK-----------------RDLVRL 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 511649071  94 --DFVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQAC 139
Cdd:cd18194   66 nsDIVTAPAFGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  16 QHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFgggggggggggggggGRGGVGGHRNVCELDF 95
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALF---------------AGGMSESSKDVVQIHG 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 511649071  96 VPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL-GQTE 147
Cdd:cd18256   67 VEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLkGQLH 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  15 PQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGGGGGGgggggrggvgghrnvCELD 94
Cdd:cd18339    2 PAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK---------------IEIK 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 511649071  95 FVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADILgQTEGH 149
Cdd:cd18339   67 DVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL-QSQLH 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  20 ELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFgggggggggggggGGGRGGVGGHRNVCELDFVPPE 99
Cdd:cd18201    7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLY-------------CFTNKESCDQTTVTHLDVVAVQ 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 511649071 100 VLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18201   74 GFSVILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  15 PQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFggggggggggggggggrggvgGHRNVCELD 94
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLV---------------------LHDNLIHLD 59

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 511649071  95 --FVPPEVLSALLEFAYTATL---TISSSNMREVLRASRVLEIGCVAQACADILGQ 145
Cdd:cd18216   60 qdMVSPTVFQQILDFIYTGKLldsLFEEPNLSEVLAAANYLQLPDLAALCRSKLKR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  20 ELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGGGGgggggggrggvgghRNVCELDF--VP 97
Cdd:cd18258    3 EMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGG--------------GEKLELTMsnIN 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 511649071  98 PEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18258   69 ADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFL 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  14 FPQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFggggggggggggggggrggvgGHRNVCEL 93
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLV---------------------LHDNLINL 59

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 511649071  94 --DFVPPEVLSALLEFAYTATLTISSS----NMREVLRASRVLEIGCVAQAC 139
Cdd:cd18334   60 dtDMVNPTVFRQILDFIYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  25 LNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFGGGGGGGGggggggggrggvgghRNVCELDFVPPEVLSAL 104
Cdd:cd18238    6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESK---------------QDSITIKDIDEEAVELL 70

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 511649071 105 LEFAYTATLTISSSNMREVLRASRVLEIGCVAQACAD 141
Cdd:cd18238   71 VDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 511649071  15 PQHSSELLRGLNEQRRRGLLCDLTLVTQGLEYRTHRSVLAACSLYFRRLFgggggggggggggggGRGGVGGHRNVCELD 94
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMF---------------GGHLKESRQAVVEIQ 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 511649071  95 FVPPEVLSALLEFAYTATLTISSSNMREVLRASRVLEIGCVAQACADIL 143
Cdd:cd18265   69 KVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFL 117