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Conserved domains on  [gi|190889102|gb|ACE96098|]
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tryptophan hydroxylase 2, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Biopterin_H super family cl46671
Biopterin-dependent aromatic amino acid hydroxylase; This family includes ...
 1-45 3.39e-32

Biopterin-dependent aromatic amino acid hydroxylase; This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.


The actual alignment was detected with superfamily member pfam00351:

Pssm-ID: 459776  Cd Length: 331  Bit Score: 111.86  E-value: 3.39e-32
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190889102    1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:pfam00351 119 RTGFTLRPVAGLLSARDFLAGLAFRVFHCTQYIRHHSSPMYTPEP 163
 
Name Accession Description Interval E-value
Biopterin_H pfam00351
Biopterin-dependent aromatic amino acid hydroxylase; This family includes ...
 1-45 3.39e-32

Biopterin-dependent aromatic amino acid hydroxylase; This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.


Pssm-ID: 459776  Cd Length: 331  Bit Score: 111.86  E-value: 3.39e-32
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190889102    1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:pfam00351 119 RTGFTLRPVAGLLSARDFLAGLAFRVFHCTQYIRHHSSPMYTPEP 163
eu_TrpOH cd03346
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino ...
 1-45 4.06e-30

Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tyrosine hydroxylase (TyrOH). TrpOH oxidizes L-tryptophan to 5-hydroxy-L-tryptophan, the rate-limiting step in the biosynthesis of serotonin (5-hydroxytryptamine), a widely distributed hormone and neurotransmitter.


Pssm-ID: 239462  Cd Length: 287  Bit Score: 105.27  E-value: 4.06e-30
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 190889102   1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:cd03346  119 RTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPFYTPEP 163
Trp_5_monoox TIGR01270
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a ...
 1-45 8.36e-29

tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. [Energy metabolism, Amino acids and amines]


Pssm-ID: 130337 [Multi-domain]  Cd Length: 464  Bit Score: 104.55  E-value: 8.36e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190889102    1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:TIGR01270 248 KTGFRLRPVAGYLSARDFLSGLAFRVFHCTQYVRHSADPFYTPEP 292
PhhA COG3186
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];
3-45 5.97e-13

Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];


Pssm-ID: 442419  Cd Length: 279  Bit Score: 59.82  E-value: 5.97e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 190889102   3 GFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:COG3186   82 GWRVVAVPGLIPPDAFFELLANRRFPVATFIRTPEEIDYLPEP 124
phhA PRK11913
phenylalanine 4-monooxygenase; Reviewed
 2-45 2.01e-12

phenylalanine 4-monooxygenase; Reviewed


Pssm-ID: 237020  Cd Length: 275  Bit Score: 58.34  E-value: 2.01e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 190889102   2 SGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:PRK11913  82 TGWQVVPVPGLIPFDVFFELLANRRFPVATFIRRPEELDYLQEP 125
 
Name Accession Description Interval E-value
Biopterin_H pfam00351
Biopterin-dependent aromatic amino acid hydroxylase; This family includes ...
 1-45 3.39e-32

Biopterin-dependent aromatic amino acid hydroxylase; This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.


Pssm-ID: 459776  Cd Length: 331  Bit Score: 111.86  E-value: 3.39e-32
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190889102    1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:pfam00351 119 RTGFTLRPVAGLLSARDFLAGLAFRVFHCTQYIRHHSSPMYTPEP 163
eu_TrpOH cd03346
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino ...
 1-45 4.06e-30

Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tyrosine hydroxylase (TyrOH). TrpOH oxidizes L-tryptophan to 5-hydroxy-L-tryptophan, the rate-limiting step in the biosynthesis of serotonin (5-hydroxytryptamine), a widely distributed hormone and neurotransmitter.


Pssm-ID: 239462  Cd Length: 287  Bit Score: 105.27  E-value: 4.06e-30
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 190889102   1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:cd03346  119 RTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPFYTPEP 163
Trp_5_monoox TIGR01270
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a ...
 1-45 8.36e-29

tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. [Energy metabolism, Amino acids and amines]


Pssm-ID: 130337 [Multi-domain]  Cd Length: 464  Bit Score: 104.55  E-value: 8.36e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190889102    1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:TIGR01270 248 KTGFRLRPVAGYLSARDFLSGLAFRVFHCTQYVRHSADPFYTPEP 292
eu_PheOH cd03347
Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent ...
 2-45 1.28e-24

Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic phenylalanine-4-hydroxylase (pro_PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan hydroxylase (TrpOH). PheOH catalyzes the first and rate-limiting step in the metabolism of the amino acid L-phenylalanine (L-Phe), the hydroxylation of L-Phe to L-tyrosine (L-Tyr). It uses (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as the physiological electron donor. The catalytic activity of the tetrameric enzyme is tightly regulated by the binding of L-Phe and BH4 as well as by phosphorylation. Mutations in the human enzyme are linked to a severe variant of phenylketonuria.


Pssm-ID: 239463  Cd Length: 306  Bit Score: 91.35  E-value: 1.28e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 190889102   2 SGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:cd03347  120 TGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPEP 163
Phe4hydrox_tetr TIGR01268
phenylalanine-4-hydroxylase, tetrameric form; This model describes the larger, tetrameric form ...
 2-45 1.38e-24

phenylalanine-4-hydroxylase, tetrameric form; This model describes the larger, tetrameric form of phenylalanine-4-hydroxylase, as found in metazoans. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. It is closely related to metazoan tyrosine 3-monooxygenase and tryptophan 5-monoxygenase, and more distantly to monomeric phenylalanine-4-hydroxylases of some Gram-negative bacteria. The member of this family from Drosophila has been described as having both phenylalanine-4-hydroxylase and tryptophan 5-monoxygenase activity (. However, a Drosophila member of the tryptophan 5-monoxygenase clade has subsequently been discovered.


Pssm-ID: 130335 [Multi-domain]  Cd Length: 436  Bit Score: 92.59  E-value: 1.38e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 190889102    2 SGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:TIGR01268 222 TGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSKPMYTPEP 265
arom_aa_hydroxylase cd00361
Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent ...
 1-45 4.02e-24

Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan hydroxylase (TrpOH). PheOH converts L-phenylalanine to L-tyrosine, an important step in phenylalanine catabolism and neurotransmitter biosynthesis, and is linked to a severe variant of phenylketonuria in humans. TyrOH and TrpOH are involved in the biosynthesis of catecholamine and serotonin, respectively. The eukaryotic enzymes are all homotetramers.


Pssm-ID: 238215  Cd Length: 221  Bit Score: 88.38  E-value: 4.02e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 190889102   1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:cd00361   59 LTGWTLVPVAGLISPRDFFALLAFRVFPVTQYIRHPEEPDYTPEP 103
eu_TyrOH cd03345
Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino ...
 1-45 2.58e-22

Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tryptophan hydroxylase (TrpOH). TyrOH catalyzes the conversion of tyrosine to L-dihydroxyphenylalanine (L-DOPA), the rate-limiting step in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.


Pssm-ID: 239461  Cd Length: 298  Bit Score: 85.18  E-value: 2.58e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 190889102   1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:cd03345  118 RTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEP 162
Tyr_3_monoox TIGR01269
tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member ...
 1-45 4.61e-22

tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria.


Pssm-ID: 130336 [Multi-domain]  Cd Length: 457  Bit Score: 85.75  E-value: 4.61e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190889102    1 RSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:TIGR01269 242 TTGFRLRPVAGLLSARDFLASLAFRVFQCTQYIRHHSSPMHTPEP 286
PhhA COG3186
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];
3-45 5.97e-13

Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];


Pssm-ID: 442419  Cd Length: 279  Bit Score: 59.82  E-value: 5.97e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 190889102   3 GFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:COG3186   82 GWRVVAVPGLIPPDAFFELLANRRFPVATFIRTPEEIDYLPEP 124
phhA PRK11913
phenylalanine 4-monooxygenase; Reviewed
 2-45 2.01e-12

phenylalanine 4-monooxygenase; Reviewed


Pssm-ID: 237020  Cd Length: 275  Bit Score: 58.34  E-value: 2.01e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 190889102   2 SGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEP 45
Cdd:PRK11913  82 TGWQVVPVPGLIPFDVFFELLANRRFPVATFIRRPEELDYLQEP 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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