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Conserved domains on  [gi|62825131|gb|AAY16126|]
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truncated NADPH oxidase activator 1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-170 7.61e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 7.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  38 ARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHA----------- 106
Cdd:COG0457   8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAealnnlglalq 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62825131 107 -------AIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEG--SLNGLDSALDQVQRR 170
Cdd:COG0457  88 algryeeALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDadALYNLGIALEKLGRY 160
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-170 7.61e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 7.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  38 ARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHA----------- 106
Cdd:COG0457   8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAealnnlglalq 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62825131 107 -------AIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEG--SLNGLDSALDQVQRR 170
Cdd:COG0457  88 algryeeALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDadALYNLGIALEKLGRY 160
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-170 7.61e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 7.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  38 ARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHA----------- 106
Cdd:COG0457   8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAealnnlglalq 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62825131 107 -------AIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEG--SLNGLDSALDQVQRR 170
Cdd:COG0457  88 algryeeALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDadALYNLGIALEKLGRY 160
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
20-100 3.12e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 3.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  20 RGDWARALHLFSGvpAPPARLcfNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLAL 99
Cdd:COG4785  93 IADFDQALELDPD--LAEAYN--NRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKAL 168


                .
gi 62825131 100 E 100
Cdd:COG4785 169 E 169
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
6-148 1.48e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 1.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131   6 DLVRAWH-LGAQAVDRGDWARALHLFS-GVPAPP--ARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVA 81
Cdd:COG0457  74 DDAEALNnLGLALQALGRYEEALEDYDkALELDPddAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62825131  82 NFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREA 148
Cdd:COG0457 154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 15-154 2.27e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.45  E-value: 2.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  15 AQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSD 94
Cdd:COG3914  55 AAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAA 134

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62825131  95 FWLALE------------------QLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPE 154
Cdd:COG3914 135 LRRALAlnpdfaeaylnlgealrrLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPD 212
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
9-95 3.05e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.22  E-value: 3.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131   9 RAWHLGAQAVDRGDWARALHLFSGVPAPP--ARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLA 86
Cdd:COG4785  42 ADLALALAAAALAAAALAAERIDRALALPdlAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLG 121


                ....*....
gi 62825131  87 RFQEALSDF 95
Cdd:COG4785 122 DYDAALEDF 130
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 6-199 3.64e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 3.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131   6 DLVRAWH-LGAQAVDRGDWARALHLFS---GVPAPPARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVA 81
Cdd:COG3914 110 DNAEALFnLGNLLLALGRLEEALAALRralALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  82 NFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASS-------------LREA 148
Cdd:COG3914 190 LQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPfallylpdddpaeLLAL 269

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62825131 149 MSKWpeGSLNGLDSALDQVQRRGSLPPRQVPR-GEV---FRPH------RWHLKHLEPVDF 199
Cdd:COG3914 270 ARAW--AQLVAAAAAPELPPPPNPRDPDRKLRiGYVsadFRRHavgyllEPLLEHHDRSRF 328
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 38-154 3.04e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 3.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  38 ARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFwlaleqlrgHAAIDYTQlglrf 117
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLL---------HEALELDP----- 69

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 62825131 118 klQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPE 154
Cdd:COG4783  70 --DEPEARLNLGLALLKAGDYDEALALLEKALKLDPE 104
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
47-154 1.61e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 1.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  47 VHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALsDFWLALEQLRGHAaidytqlglrfklqawEVLH 126
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNA----------------EALL 63

                        90       100
                ....*....|....*....|....*...
gi 62825131 127 NVASAQCQLGLWTEAASSLREAMSKWPE 154
Cdd:COG3063  64 NLAELLLELGDYDEALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 2-153 2.14e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.02  E-value: 2.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131   2 ASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLTGDPEAALRAFDQAVTKDTCMAVGFFQRGVA 81
Cdd:COG5010  18 TKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALL 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62825131  82 NFQLARFQEALSDFWLALEQLRGHAaidytqlglrfklqawEVLHNVASAQCQLGLWTEAASSLREAMSKWP 153
Cdd:COG5010  98 YSRSGDKDEAKEYYEKALALSPDNP----------------NAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 12-154 2.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62825131  12 HLGAQAVDRGDWARALHLF---SGVPAPPARLCFNAGCVHLLTGDPEAALRAFDQAVTKD-TCMAvgffqrgvANFQLAR 87
Cdd:COG2956 115 LLAEIYEQEGDWEKAIEVLerlLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDpDCAR--------ALLLLAE 186

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62825131  88 FQEALSDFWLALEQLRGHAAIDYTQLglrfklqawEVLHNVASAQCQLGLWTEAASSLREAMSKWPE 154
Cdd:COG2956 187 LYLEQGDYEEAIAALERALEQDPDYL---------PALPRLAELYEKLGDPEEALELLRKALELDPS 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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