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Conserved domains on  [gi|29468292|gb|AAO85488|]
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proline rich, vinculin and TIR domain containing protein-B [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RHIM pfam12721
RIP homotypic interaction motif; RIP proteins are receptor-interacting serine ...
 511-530 3.76e-06

RIP homotypic interaction motif; RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.


:

Pssm-ID: 463679  Cd Length: 21  Bit Score: 43.49  E-value: 3.76e-06
                          10        20
                  ....*....|....*....|
gi 29468292   511 QPLIIHHAQMVQLGLNNHMW 530
Cdd:pfam12721   1 PPVIINNCSGVQIGNNNHMS 20
TIR_2 super family cl48220
TIR domain; This is a family of Toll-like receptors.
 258-351 7.60e-04

TIR domain; This is a family of Toll-like receptors.


The actual alignment was detected with superfamily member pfam13676:

Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 39.61  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29468292   258 FVILHARADEHIALRVREKLEALGVPdgaTFCEDFQVPGRGEL-SCLQDAIDHSAFIILLLTSNFdcrLSLHQVNQAMMS 336
Cdd:pfam13676   1 VFISYAGEDRAWAEWLADALEAAGYR---VWLDRWDIRPGDDWvEEIEEAIENSDRVLVVLSPNY---LESPWCRAEWEA 74

                          90
                  ....*....|....*
gi 29468292   337 NLTRQGSPDCVIPFL 351
Cdd:pfam13676  75 ALADPEGRKRLIPVR 89
 
Name Accession Description Interval E-value
RHIM pfam12721
RIP homotypic interaction motif; RIP proteins are receptor-interacting serine ...
 511-530 3.76e-06

RIP homotypic interaction motif; RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.


Pssm-ID: 463679  Cd Length: 21  Bit Score: 43.49  E-value: 3.76e-06
                          10        20
                  ....*....|....*....|
gi 29468292   511 QPLIIHHAQMVQLGLNNHMW 530
Cdd:pfam12721   1 PPVIINNCSGVQIGNNNHMS 20
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 258-351 7.60e-04

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 39.61  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29468292   258 FVILHARADEHIALRVREKLEALGVPdgaTFCEDFQVPGRGEL-SCLQDAIDHSAFIILLLTSNFdcrLSLHQVNQAMMS 336
Cdd:pfam13676   1 VFISYAGEDRAWAEWLADALEAAGYR---VWLDRWDIRPGDDWvEEIEEAIENSDRVLVVLSPNY---LESPWCRAEWEA 74

                          90
                  ....*....|....*
gi 29468292   337 NLTRQGSPDCVIPFL 351
Cdd:pfam13676  75 ALADPEGRKRLIPVR 89
TIR smart00255
Toll - interleukin 1 - resistance;
260-388 8.94e-04

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 39.61  E-value: 8.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29468292    260 ILHARAD---EHIALRVREKLEALGVpdgaTFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNF-DCRLSLHQVnQAMM 335
Cdd:smart00255   6 ISYSGKEdvrNEFLSHLLEKLRGYGL----CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYaESEWCLDEL-VAAL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29468292    336 SNLTRQGSpDCVIP-FL-PLESSPAQLSSDTASLL--SGLVRLDEHSQIFARKVANT 388
Cdd:smart00255  81 ENALEEGG-LRVIPiFYeVIPSDVRKQPGKFRKVFkkNYLKWPEDEKEQFWKKALYA 136
 
Name Accession Description Interval E-value
RHIM pfam12721
RIP homotypic interaction motif; RIP proteins are receptor-interacting serine ...
 511-530 3.76e-06

RIP homotypic interaction motif; RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.


Pssm-ID: 463679  Cd Length: 21  Bit Score: 43.49  E-value: 3.76e-06
                          10        20
                  ....*....|....*....|
gi 29468292   511 QPLIIHHAQMVQLGLNNHMW 530
Cdd:pfam12721   1 PPVIINNCSGVQIGNNNHMS 20
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 258-351 7.60e-04

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 39.61  E-value: 7.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29468292   258 FVILHARADEHIALRVREKLEALGVPdgaTFCEDFQVPGRGEL-SCLQDAIDHSAFIILLLTSNFdcrLSLHQVNQAMMS 336
Cdd:pfam13676   1 VFISYAGEDRAWAEWLADALEAAGYR---VWLDRWDIRPGDDWvEEIEEAIENSDRVLVVLSPNY---LESPWCRAEWEA 74

                          90
                  ....*....|....*
gi 29468292   337 NLTRQGSPDCVIPFL 351
Cdd:pfam13676  75 ALADPEGRKRLIPVR 89
TIR smart00255
Toll - interleukin 1 - resistance;
260-388 8.94e-04

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 39.61  E-value: 8.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29468292    260 ILHARAD---EHIALRVREKLEALGVpdgaTFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNF-DCRLSLHQVnQAMM 335
Cdd:smart00255   6 ISYSGKEdvrNEFLSHLLEKLRGYGL----CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYaESEWCLDEL-VAAL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29468292    336 SNLTRQGSpDCVIP-FL-PLESSPAQLSSDTASLL--SGLVRLDEHSQIFARKVANT 388
Cdd:smart00255  81 ENALEEGG-LRVIPiFYeVIPSDVRKQPGKFRKVFkkNYLKWPEDEKEQFWKKALYA 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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