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Conserved domains on  [gi|124297779|gb|AAI31922|]
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Toll-like receptor 12 [Mus musculus]

Protein Classification

toll-like receptor( domain architecture ID 17353363)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
761-902 1.95e-16

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 76.98  E-value: 1.95e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779   761 FDVFVSHCRQDqgWVIEELLPALEGFLPaglGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLEL 840
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLR---GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124297779   841 RLATSLLLAAPSpPVLLLVFLEPISRHQLPGYHRLARLLRRgDYCLWPEEEERKsgFWTWLR 902
Cdd:smart00255  77 VAALENALEEGG-LRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQ--FWKKAL 134
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
56-482 3.69e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  56 SVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSLhltqllPGALRGLGQLQSLSFFDSPLRrSLflpP 135
Cdd:COG4886   60 LLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG------NEELSNLTNLESLDLSGNQLT-DL---P 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 136 DAFSDLISLQRLHISGpcldkkagirlppglqwlgvtlsciQDVGELAGMFPDLVQgsssrvswtLQKLDLSSNwklKMA 215
Cdd:COG4886  130 EELANLTNLKELDLSN-------------------------NQLTDLPEPLGNLTN---------LKSLDLSNN---QLT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 216 S-PGSLQGL-QVEILDLTRTPLDAVwlkGLGLQKLDvlyaqtataelaaeavahfELQGLIVKESKIGSISqEALASCHS 293
Cdd:COG4886  173 DlPEELGNLtNLKELDLSNNQITDL---PEPLGNLT-------------------NLEELDLSGNQLTDLP-EPLANLTN 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 294 LKTLGLSSTGLTKLPpgFLTAMPRLQRLELSGNQLQSavlcMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLL 373
Cdd:COG4886  230 LETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 374 RYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAP 453
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 124297779 454 AVLFLPMYLTSLELHIASGTTEHWTLSPA 482
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
439-625 5.87e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 439 NLHTLSLKLPALPAPAVLFLPMYLTSLELHIASGTTEHWTLSPAIFPSLETLTISGGGLKLKLGSQNASGVFPALQKLSL 518
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 519 LKNSLDAFCSqgtSNLFLWQLPKLQSLRVWGAGNSSRPCLITGLPSLRELKLASLQsITqprsvQLEELVGDLPQLQALV 598
Cdd:COG4886   95 LTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LT-----DLPEPLGNLTNLKSLD 165

                        170       180
                 ....*....|....*....|....*..
gi 124297779 599 LSSTGLKSLSaAAFQRLHSLQVLVLEY 625
Cdd:COG4886  166 LSNNQLTDLP-EELGNLTNLKELDLSN 191
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
761-902 1.95e-16

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 76.98  E-value: 1.95e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779   761 FDVFVSHCRQDqgWVIEELLPALEGFLPaglGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLEL 840
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLR---GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124297779   841 RLATSLLLAAPSpPVLLLVFLEPISRHQLPGYHRLARLLRRgDYCLWPEEEERKsgFWTWLR 902
Cdd:smart00255  77 VAALENALEEGG-LRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQ--FWKKAL 134
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 763-863 1.40e-12

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 65.03  E-value: 1.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  763 VFVSHCRQDQGWViEELLPALEGflpagLGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRL 842
Cdd:pfam13676   1 VFISYAGEDRAWA-EWLADALEA-----AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                          90       100
                  ....*....|....*....|.
gi 124297779  843 AtslLLAAPSPPVLLLVFLEP 863
Cdd:pfam13676  75 A---LADPEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-482 3.69e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  56 SVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSLhltqllPGALRGLGQLQSLSFFDSPLRrSLflpP 135
Cdd:COG4886   60 LLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG------NEELSNLTNLESLDLSGNQLT-DL---P 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 136 DAFSDLISLQRLHISGpcldkkagirlppglqwlgvtlsciQDVGELAGMFPDLVQgsssrvswtLQKLDLSSNwklKMA 215
Cdd:COG4886  130 EELANLTNLKELDLSN-------------------------NQLTDLPEPLGNLTN---------LKSLDLSNN---QLT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 216 S-PGSLQGL-QVEILDLTRTPLDAVwlkGLGLQKLDvlyaqtataelaaeavahfELQGLIVKESKIGSISqEALASCHS 293
Cdd:COG4886  173 DlPEELGNLtNLKELDLSNNQITDL---PEPLGNLT-------------------NLEELDLSGNQLTDLP-EPLANLTN 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 294 LKTLGLSSTGLTKLPpgFLTAMPRLQRLELSGNQLQSavlcMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLL 373
Cdd:COG4886  230 LETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 374 RYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAP 453
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 124297779 454 AVLFLPMYLTSLELHIASGTTEHWTLSPA 482
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR_8 pfam13855
Leucine rich repeat;
342-402 9.83e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 9.83e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124297779  342 SGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPL 402
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 281-548 4.20e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 4.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 281 GSISQEALASCHSLKTLGLSSTGLT-KLPPGFLtamPRLQRLELSGNQLQSAVlcMNETGDVSGLTTLDLSGNRLRILPP 359
Cdd:PLN00113 107 GPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSI---PNLETLDLSNNMLSGEI--PNDIGSFSSLKVLDLGGNVLVGKIP 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 360 AAFSCLPHLRELLLRYNQLLsleGYLFQELQQLETLKldgnpLLHLGKNWLAA--------LPALTTLSLLDTQIRMSPE 431
Cdd:PLN00113 182 NSLTNLTSLEFLTLASNQLV---GQIPRELGQMKSLK-----WIYLGYNNLSGeipyeiggLTSLNHLDLVYNNLTGPIP 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 432 PGFWGAKNLHTLSLKLPAL--PAPAVLFLPMYLTSLELHIASGTTEhwtlSPAIFPSLETLTIsggglkLKLGSQNASGV 509
Cdd:PLN00113 254 SSLGNLKNLQYLFLYQNKLsgPIPPSIFSLQKLISLDLSDNSLSGE----IPELVIQLQNLEI------LHLFSNNFTGK 323

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 124297779 510 FPAlqklsllknsldAFCSqgtsnlflwqLPKLQSLRVW 548
Cdd:PLN00113 324 IPV------------ALTS----------LPRLQVLQLW 340
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 286-423 8.01e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 8.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 286 EALASCHSLKTLGLSStgltklppgfltamprlQRLElSGNQLQSAVLCMNETGDvsGLTTLDLSGNRLRILPPaaFSCL 365
Cdd:cd21340   84 EGLENLTNLEELHIEN-----------------QRLP-PGEKLTFDPRSLAALSN--SLRVLNISGNNIDSLEP--LAPL 141

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 366 PHLRELLLRYNQLLSLE--GYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLD 423
Cdd:cd21340  142 RNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
439-625 5.87e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 439 NLHTLSLKLPALPAPAVLFLPMYLTSLELHIASGTTEHWTLSPAIFPSLETLTISGGGLKLKLGSQNASGVFPALQKLSL 518
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 519 LKNSLDAFCSqgtSNLFLWQLPKLQSLRVWGAGNSSRPCLITGLPSLRELKLASLQsITqprsvQLEELVGDLPQLQALV 598
Cdd:COG4886   95 LTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LT-----DLPEPLGNLTNLKSLD 165

                        170       180
                 ....*....|....*....|....*..
gi 124297779 599 LSSTGLKSLSaAAFQRLHSLQVLVLEY 625
Cdd:COG4886  166 LSNNQLTDLP-EELGNLTNLKELDLSN 191
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 364-625 1.41e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 364 CLPHLRELLLRynqllSLEGYLFQELQQLETLKLDGNPLLHLGKNWLA----ALPALTTLSLLDTQIRMSPE------PG 433
Cdd:cd00116    2 QLSLKGELLKT-----ERATELLPKLLCLQVLRLEGNTLGEEAAKALAsalrPQPSLKELCLSLNETGRIPRglqsllQG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 434 FWGAKNLHTLSLKLPALPAPAVLFLPMYLTSLELHIASgttehwtlspaifpsLETLTISGGGLKLKLGSqnASGVFPAL 513
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELK---------------LNNNGLGDRGLRLLAKG--LKDLPPAL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 514 QKLSLLKNSLDAFCSQGTSNLFLwQLPKLQSLRVwgAGNSSRPCLIT----GLPSLRELKLASLQS--ITQPRSVQLEEL 587
Cdd:cd00116  140 EKLVLGRNRLEGASCEALAKALR-ANRDLKELNL--ANNGIGDAGIRalaeGLKANCNLEVLDLNNngLTDEGASALAET 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 124297779 588 VGDLPQLQALVLSSTGLKSLSAAAF-----QRLHSLQVLVLEY 625
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSC 259
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
389-643 4.07e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 389 LQQLETLKLDGNPLLHLGKNWLAALP-----ALTTLSLLDTQIRMSPEPgfwgAKNLHTLSL---KLPALPApavlfLPM 460
Cdd:PRK15387 192 VQKMRACLNNGNAVLNVGESGLTTLPdclpaHITTLVIPDNNLTSLPAL----PPELRTLEVsgnQLTSLPV-----LPP 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 461 YLtsLELHIASGTTEHWtlsPAIFPSLETLTISGGGLklklgsQNASGVFPALQKLSLLKNSLDAfcsqgtsnlflwqLP 540
Cdd:PRK15387 263 GL--LELSIFSNPLTHL---PALPSGLCKLWIFGNQL------TSLPVLPPGLQELSVSDNQLAS-------------LP 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 541 KLQS--LRVWGAGN--SSRPCLITGLP--SLRELKLASLQSITQprsvQLEELVGDLPQLQALVLSSTGLKSLSAAAfQR 614
Cdd:PRK15387 319 ALPSelCKLWAYNNqlTSLPTLPSGLQelSVSDNQLASLPTLPS----ELYKLWAYNNRLTSLPALPSGLKELIVSG-NR 393

                        250       260
                 ....*....|....*....|....*....
gi 124297779 615 LHSLQVLVLEYeKDLMLQDSLREYSPQMP 643
Cdd:PRK15387 394 LTSLPVLPSEL-KELMVSGNRLTSLPMLP 421
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
761-902 1.95e-16

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 76.98  E-value: 1.95e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779   761 FDVFVSHCRQDqgWVIEELLPALEGFLPaglGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLEL 840
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLR---GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124297779   841 RLATSLLLAAPSpPVLLLVFLEPISRHQLPGYHRLARLLRRgDYCLWPEEEERKsgFWTWLR 902
Cdd:smart00255  77 VAALENALEEGG-LRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQ--FWKKAL 134
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 763-863 1.40e-12

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 65.03  E-value: 1.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  763 VFVSHCRQDQGWViEELLPALEGflpagLGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRL 842
Cdd:pfam13676   1 VFISYAGEDRAWA-EWLADALEA-----AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                          90       100
                  ....*....|....*....|.
gi 124297779  843 AtslLLAAPSPPVLLLVFLEP 863
Cdd:pfam13676  75 A---LADPEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-482 3.69e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  56 SVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSLhltqllPGALRGLGQLQSLSFFDSPLRrSLflpP 135
Cdd:COG4886   60 LLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG------NEELSNLTNLESLDLSGNQLT-DL---P 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 136 DAFSDLISLQRLHISGpcldkkagirlppglqwlgvtlsciQDVGELAGMFPDLVQgsssrvswtLQKLDLSSNwklKMA 215
Cdd:COG4886  130 EELANLTNLKELDLSN-------------------------NQLTDLPEPLGNLTN---------LKSLDLSNN---QLT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 216 S-PGSLQGL-QVEILDLTRTPLDAVwlkGLGLQKLDvlyaqtataelaaeavahfELQGLIVKESKIGSISqEALASCHS 293
Cdd:COG4886  173 DlPEELGNLtNLKELDLSNNQITDL---PEPLGNLT-------------------NLEELDLSGNQLTDLP-EPLANLTN 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 294 LKTLGLSSTGLTKLPpgFLTAMPRLQRLELSGNQLQSavlcMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLL 373
Cdd:COG4886  230 LETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 374 RYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAP 453
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 124297779 454 AVLFLPMYLTSLELHIASGTTEHWTLSPA 482
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR_8 pfam13855
Leucine rich repeat;
342-402 9.83e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 9.83e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124297779  342 SGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPL 402
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 761-881 2.55e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 56.99  E-value: 2.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  761 FDVFVS-HCRQDQGWVIEELLPALEGFlpaglGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLE 839
Cdd:pfam01582   1 YDVFLSfRGSDTREWFVSHLLKELKQK-----GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 124297779  840 lrLATSLLLAAPSPPVLLLVFLEPISRHQLPGYHRLARLLRR 881
Cdd:pfam01582  76 --LVKILECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKK 115
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 281-548 4.20e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 4.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 281 GSISQEALASCHSLKTLGLSSTGLT-KLPPGFLtamPRLQRLELSGNQLQSAVlcMNETGDVSGLTTLDLSGNRLRILPP 359
Cdd:PLN00113 107 GPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSI---PNLETLDLSNNMLSGEI--PNDIGSFSSLKVLDLGGNVLVGKIP 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 360 AAFSCLPHLRELLLRYNQLLsleGYLFQELQQLETLKldgnpLLHLGKNWLAA--------LPALTTLSLLDTQIRMSPE 431
Cdd:PLN00113 182 NSLTNLTSLEFLTLASNQLV---GQIPRELGQMKSLK-----WIYLGYNNLSGeipyeiggLTSLNHLDLVYNNLTGPIP 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 432 PGFWGAKNLHTLSLKLPAL--PAPAVLFLPMYLTSLELHIASGTTEhwtlSPAIFPSLETLTIsggglkLKLGSQNASGV 509
Cdd:PLN00113 254 SSLGNLKNLQYLFLYQNKLsgPIPPSIFSLQKLISLDLSDNSLSGE----IPELVIQLQNLEI------LHLFSNNFTGK 323

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 124297779 510 FPAlqklsllknsldAFCSqgtsnlflwqLPKLQSLRVW 548
Cdd:PLN00113 324 IPV------------ALTS----------LPRLQVLQLW 340
LRR_8 pfam13855
Leucine rich repeat;
316-378 8.06e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 8.06e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124297779  316 PRLQRLELSGNQLQSavLCMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQL 378
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
366-426 6.43e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.43e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124297779  366 PHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQI 426
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-625 7.84e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 7.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 268 FELQGLIVKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNqlqsavlcmNETGDVSGLTTL 347
Cdd:COG4886   48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 348 DLSGNRLRILPpAAFSCLPHLRELLLRYNQLLSLEGYLFQeLQQLETLKLDGNPLLHLGKnWLAALPALTTLSLLDTQIR 427
Cdd:COG4886  119 DLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 428 mspepgfwgaknlhtlslklpALPAPavlflpmyltslelhiasgttehwtlspaifpsletltisggglklklgsqnas 507
Cdd:COG4886  196 ---------------------DLPEP------------------------------------------------------ 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 508 gvfpalqklsllknsldafcsqgtsnlfLWQLPKLQSLRVWGAGNSSRPCLITGLPSLRELKLaslqsitqpRSVQLEEL 587
Cdd:COG4886  201 ----------------------------LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDL---------SNNQLTDL 243

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 124297779 588 --VGDLPQLQALVLSSTGLKSLSAAAfqRLHSLQVLVLEY 625
Cdd:COG4886  244 peLGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 286-423 8.01e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 8.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 286 EALASCHSLKTLGLSStgltklppgfltamprlQRLElSGNQLQSAVLCMNETGDvsGLTTLDLSGNRLRILPPaaFSCL 365
Cdd:cd21340   84 EGLENLTNLEELHIEN-----------------QRLP-PGEKLTFDPRSLAALSN--SLRVLNISGNNIDSLEP--LAPL 141

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 366 PHLRELLLRYNQLLSLE--GYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLD 423
Cdd:cd21340  142 RNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 297-378 9.86e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.43  E-value: 9.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 297 LGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVlcMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYN 376
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNI--PPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500


                 ..
gi 124297779 377 QL 378
Cdd:PLN03150 501 SL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 268-445 1.42e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 268 FELQGLIVKESKIGSIS---QEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVlcMNETGDVSGL 344
Cdd:PLN00113 281 FSLQKLISLDLSDNSLSgeiPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI--PKNLGKHNNL 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 345 TTLDLSGNRLRILPPAAFSCLPHLRELLLRYNqllSLEGYLFQEL---QQLETLKLDGNPLLHLGKNWLAALPALTTLSL 421
Cdd:PLN00113 359 TVLDLSTNNLTGEIPEGLCSSGNLFKLILFSN---SLEGEIPKSLgacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI 435

                        170       180
                 ....*....|....*....|....
gi 124297779 422 LDTQIRMSPEPGFWGAKNLHTLSL 445
Cdd:PLN00113 436 SNNNLQGRINSRKWDMPSLQMLSL 459
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 270-426 1.75e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 270 LQGLIVKESKIGSISQEALAS----CHSLKTLGLSSTGLTKlpPGF------LTAMPRLQRLELSGNQL--QSAVLCMNE 337
Cdd:COG5238  210 VTTLWLKRNPIGDEGAEILAEalkgNKSLTTLDLSNNQIGD--EGVialaeaLKNNTTVETLYLSGNQIgaEGAIALAKA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 338 TGDVSGLTTLDLSGNRLRilPPAAFSCLPHLR------ELLLRYNQLlSLEG--YLFQELQ---QLETLKLDGNPLLHLG 406
Cdd:COG5238  288 LQGNTTLTSLDLSVNRIG--DEGAIALAEGLQgnktlhTLNLAYNGI-GAQGaiALAKALQentTLHSLDLSDNQIGDEG 364

                        170       180
                 ....*....|....*....|....
gi 124297779 407 KNWLAALPA----LTTLSLLDTQI 426
Cdd:COG5238  365 AIALAKYLEgnttLRELNLGKNNI 388
LRR_9 pfam14580
Leucine-rich repeat;
346-430 2.71e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.52  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  346 TLDLSGNRLRILPpaAFSCLPHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGK-NWLAALPALTTLSLLDT 424
Cdd:pfam14580  46 TIDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDlDPLASLKKLTFLSLLRN 123


                  ....*.
gi 124297779  425 QIRMSP 430
Cdd:pfam14580 124 PVTNKP 129
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
344-523 4.69e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 344 LTTLDLSGNRLRILPPaafSCLPHLRELLLRYNQLLSLEGYLFQELQQLEtlkLDGNPLLHLGK-------------NWL 410
Cdd:PRK15370 201 ITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPErlpsalqsldlfhNKI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 411 AALP-----ALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAPavlfLPMYLTSLElhiaSGTTEHWTLSPAIFP 485
Cdd:PRK15370 275 SCLPenlpeELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPET----LPPGLKTLE----AGENALTSLPASLPP 346

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 124297779 486 SLETLTISGGGLKLKlgsqnASGVFPALQKLSLLKNSL 523
Cdd:PRK15370 347 ELQVLDVSKNQITVL-----PETLPPTITTLDVSRNAL 379
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 294-378 1.71e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 294 LKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVlcMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLL 373
Cdd:PLN00113 477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI--PDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDL 554


                 ....*
gi 124297779 374 RYNQL 378
Cdd:PLN00113 555 SQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
269-328 1.87e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  269 ELQGLIVKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQL 328
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 94-359 3.99e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779  94 LKVLALSLH-LTQLLPGALRGLGQLQSLSFFDSPLRRSLflpPDAFSDLISLQRLHISGPCLDKKagirLPPGLQWLGVT 172
Cdd:PLN00113 358 LTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGEI---PKSLGACRSLRRVRLQDNSFSGE----LPSEFTKLPLV 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 173 lsciqdvgelagMFPDL----VQGSSSRVSW---TLQKLDLSSNwKLKMASPGSLQGLQVEILDLTRTPLDAVWLKGLGl 245
Cdd:PLN00113 431 ------------YFLDIsnnnLQGRINSRKWdmpSLQMLSLARN-KFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLG- 496

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 246 qKLDvlyaqtataelaaeavahfELQGLIVKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSG 325
Cdd:PLN00113 497 -SLS-------------------ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 124297779 326 NQLQSAVlcMNETGDVSGLTTLDLSGNRLR-ILPP 359
Cdd:PLN00113 557 NQLSGEI--PKNLGNVESLVQVNISHNHLHgSLPS 589
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
439-625 5.87e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 439 NLHTLSLKLPALPAPAVLFLPMYLTSLELHIASGTTEHWTLSPAIFPSLETLTISGGGLKLKLGSQNASGVFPALQKLSL 518
Cdd:COG4886   15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 519 LKNSLDAFCSqgtSNLFLWQLPKLQSLRVWGAGNSSRPCLITGLPSLRELKLASLQsITqprsvQLEELVGDLPQLQALV 598
Cdd:COG4886   95 LTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LT-----DLPEPLGNLTNLKSLD 165

                        170       180
                 ....*....|....*....|....*..
gi 124297779 599 LSSTGLKSLSaAAFQRLHSLQVLVLEY 625
Cdd:COG4886  166 LSNNQLTDLP-EELGNLTNLKELDLSN 191
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 364-625 1.41e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 364 CLPHLRELLLRynqllSLEGYLFQELQQLETLKLDGNPLLHLGKNWLA----ALPALTTLSLLDTQIRMSPE------PG 433
Cdd:cd00116    2 QLSLKGELLKT-----ERATELLPKLLCLQVLRLEGNTLGEEAAKALAsalrPQPSLKELCLSLNETGRIPRglqsllQG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 434 FWGAKNLHTLSLKLPALPAPAVLFLPMYLTSLELHIASgttehwtlspaifpsLETLTISGGGLKLKLGSqnASGVFPAL 513
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELK---------------LNNNGLGDRGLRLLAKG--LKDLPPAL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 514 QKLSLLKNSLDAFCSQGTSNLFLwQLPKLQSLRVwgAGNSSRPCLIT----GLPSLRELKLASLQS--ITQPRSVQLEEL 587
Cdd:cd00116  140 EKLVLGRNRLEGASCEALAKALR-ANRDLKELNL--ANNGIGDAGIRalaeGLKANCNLEVLDLNNngLTDEGASALAET 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 124297779 588 VGDLPQLQALVLSSTGLKSLSAAAF-----QRLHSLQVLVLEY 625
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSC 259
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
389-643 4.07e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 389 LQQLETLKLDGNPLLHLGKNWLAALP-----ALTTLSLLDTQIRMSPEPgfwgAKNLHTLSL---KLPALPApavlfLPM 460
Cdd:PRK15387 192 VQKMRACLNNGNAVLNVGESGLTTLPdclpaHITTLVIPDNNLTSLPAL----PPELRTLEVsgnQLTSLPV-----LPP 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 461 YLtsLELHIASGTTEHWtlsPAIFPSLETLTISGGGLklklgsQNASGVFPALQKLSLLKNSLDAfcsqgtsnlflwqLP 540
Cdd:PRK15387 263 GL--LELSIFSNPLTHL---PALPSGLCKLWIFGNQL------TSLPVLPPGLQELSVSDNQLAS-------------LP 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124297779 541 KLQS--LRVWGAGN--SSRPCLITGLP--SLRELKLASLQSITQprsvQLEELVGDLPQLQALVLSSTGLKSLSAAAfQR 614
Cdd:PRK15387 319 ALPSelCKLWAYNNqlTSLPTLPSGLQelSVSDNQLASLPTLPS----ELYKLWAYNNRLTSLPALPSGLKELIVSG-NR 393

                        250       260
                 ....*....|....*....|....*....
gi 124297779 615 LHSLQVLVLEYeKDLMLQDSLREYSPQMP 643
Cdd:PRK15387 394 LTSLPVLPSEL-KELMVSGNRLTSLPMLP 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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