Fxn protein [Mus musculus]
frataxin family protein( domain architecture ID 2077)
frataxin family protein promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways; similar to Trachipleistophora hominis frataxin
List of domain hits
Name | Accession | Description | Interval | E-value | ||
Frataxin super family | cl00238 | Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ... |
20-83 | 1.09e-39 | ||
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet. The actual alignment was detected with superfamily member TIGR03422: Pssm-ID: 469678 Cd Length: 97 Bit Score: 126.97 E-value: 1.09e-39
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Name | Accession | Description | Interval | E-value | ||
mito_frataxin | TIGR03422 | frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ... |
20-83 | 1.09e-39 | ||
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately. Pssm-ID: 132463 Cd Length: 97 Bit Score: 126.97 E-value: 1.09e-39
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Frataxin_Cyay | pfam01491 | Frataxin-like domain; This family contains proteins that have a domain related to the globular ... |
20-89 | 1.31e-38 | ||
Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport. Pssm-ID: 460230 Cd Length: 106 Bit Score: 124.56 E-value: 1.31e-38
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Frataxin | cd00503 | Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ... |
20-91 | 5.99e-33 | ||
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet. Pssm-ID: 238280 Cd Length: 105 Bit Score: 110.05 E-value: 5.99e-33
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CyaY | COG1965 | Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ... |
18-93 | 1.11e-16 | ||
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 441568 Cd Length: 106 Bit Score: 68.67 E-value: 1.11e-16
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cyaY | PRK00446 | frataxin-like protein; Provisional |
18-92 | 2.49e-10 | ||
frataxin-like protein; Provisional Pssm-ID: 234765 Cd Length: 105 Bit Score: 52.58 E-value: 2.49e-10
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Name | Accession | Description | Interval | E-value | ||
mito_frataxin | TIGR03422 | frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ... |
20-83 | 1.09e-39 | ||
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately. Pssm-ID: 132463 Cd Length: 97 Bit Score: 126.97 E-value: 1.09e-39
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Frataxin_Cyay | pfam01491 | Frataxin-like domain; This family contains proteins that have a domain related to the globular ... |
20-89 | 1.31e-38 | ||
Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport. Pssm-ID: 460230 Cd Length: 106 Bit Score: 124.56 E-value: 1.31e-38
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Frataxin | cd00503 | Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ... |
20-91 | 5.99e-33 | ||
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet. Pssm-ID: 238280 Cd Length: 105 Bit Score: 110.05 E-value: 5.99e-33
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FeS_CyaY | TIGR03421 | iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ... |
18-91 | 3.59e-26 | ||
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other] Pssm-ID: 274572 Cd Length: 102 Bit Score: 93.04 E-value: 3.59e-26
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CyaY | COG1965 | Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ... |
18-93 | 1.11e-16 | ||
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis Pssm-ID: 441568 Cd Length: 106 Bit Score: 68.67 E-value: 1.11e-16
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cyaY | PRK00446 | frataxin-like protein; Provisional |
18-92 | 2.49e-10 | ||
frataxin-like protein; Provisional Pssm-ID: 234765 Cd Length: 105 Bit Score: 52.58 E-value: 2.49e-10
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cyaY | PRK01379 | iron donor protein CyaY; |
20-81 | 1.53e-09 | ||
iron donor protein CyaY; Pssm-ID: 134546 Cd Length: 103 Bit Score: 50.70 E-value: 1.53e-09
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Blast search parameters | ||||
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