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Conserved domains on  [gi|28175349|gb|AAH43477|]
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Tle4 protein, partial [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-178 1.18e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 1.18e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGE 80
Cdd:COG2319 138 GSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHV-TKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDIS 158
Cdd:COG2319 218 LLASGSADGTVRLWDLaTGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFS 297

                       170       180
                ....*....|....*....|
gi 28175349 159 VDDKYIVTGSGDKKATVYEV 178
Cdd:COG2319 298 PDGKLLASGSDDGTVRLWDL 317
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-178 1.18e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 1.18e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGE 80
Cdd:COG2319 138 GSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHV-TKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDIS 158
Cdd:COG2319 218 LLASGSADGTVRLWDLaTGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFS 297

                       170       180
                ....*....|....*....|
gi 28175349 159 VDDKYIVTGSGDKKATVYEV 178
Cdd:COG2319 298 PDGKLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-136 2.50e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 2.50e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGE 80
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGY 232

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28175349  81 WLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWR 136
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGEcVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 5-176 9.54e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 9.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349    5 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 82
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   83 AVGMENSNVEVLHVTKPdkyQLHL-----HESCVLSLKFAHCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 154
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709

                        170       180
                 ....*....|....*....|....*.
gi 28175349  155 ----CDISVDDKYIVTGSGDKKATVY 176
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-54 3.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 3.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 28175349     15 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 54
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
17-54 3.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 3.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 28175349    17 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 54
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-178 1.18e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 1.18e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGE 80
Cdd:COG2319 138 GSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHV-TKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDIS 158
Cdd:COG2319 218 LLASGSADGTVRLWDLaTGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFS 297

                       170       180
                ....*....|....*....|
gi 28175349 159 VDDKYIVTGSGDKKATVYEV 178
Cdd:COG2319 298 PDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
2-178 1.45e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.45e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGE 80
Cdd:COG2319 222 GSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGK 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKE-SSSVLSCDIS 158
Cdd:COG2319 302 LLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFS 381

                       170       180
                ....*....|....*....|
gi 28175349 159 VDDKYIVTGSGDKKATVYEV 178
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
2-178 5.07e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 5.07e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGE 80
Cdd:COG2319  96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGK 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHVTKPDKYQ-LHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSK-ESSSVLSCDIS 158
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFS 255

                       170       180
                ....*....|....*....|
gi 28175349 159 VDDKYIVTGSGDKKATVYEV 178
Cdd:COG2319 256 PDGRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
2-138 5.05e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 5.05e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGE 80
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK 343

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28175349  81 WLAVGMENSNVEVLHV-TKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTP 138
Cdd:COG2319 344 TLASGSDDGTVRLWDLaTGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-136 2.50e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 2.50e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGE 80
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGY 232

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28175349  81 WLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWR 136
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGEcVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-178 3.67e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 3.67e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ-QHDFTSQIFSLGYCPTGE 80
Cdd:cd00200  27 GSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRtLTGHTSYVSSVAFSPDGR 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKwFVSTGK-DNLLNAWRTPYGASIFQ-SKESSSVLSCDI 157
Cdd:cd00200 107 ILSSSSRDKTIKVWDVETGKcLTTLRGHTDWVNSVAFSPDGT-FVASSSqDGTIKLWDLRTGKCVATlTGHTGEVNSVAF 185

                       170       180
                ....*....|....*....|.
gi 28175349 158 SVDDKYIVTGSGDKKATVYEV 178
Cdd:cd00200 186 SPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-177 7.90e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 7.90e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGE 80
Cdd:cd00200 111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGE 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDIS 158
Cdd:cd00200 191 KLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTlSGHTNSVTSLAWS 270

                       170
                ....*....|....*....
gi 28175349 159 VDDKYIVTGSGDKKATVYE 177
Cdd:cd00200 271 PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-178 1.65e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.65e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  18 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMENSNVEVL 94
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  95 HVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDK 171
Cdd:cd00200  79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157


                ....*..
gi 28175349 172 KATVYEV 178
Cdd:cd00200 158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
2-178 5.41e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 5.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   2 ASGDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGE 80
Cdd:COG2319  54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGK 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349  81 WLAVGMENSNVEVLHV-TKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDIS 158
Cdd:COG2319 134 TLASGSADGTVRLWDLaTGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFS 213

                       170       180
                ....*....|....*....|
gi 28175349 159 VDDKYIVTGSGDKKATVYEV 178
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDL 233
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 5-176 9.54e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 9.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349    5 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 82
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28175349   83 AVGMENSNVEVLHVTKPdkyQLHL-----HESCVLSLKFAHCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 154
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709

                        170       180
                 ....*....|....*....|....*.
gi 28175349  155 ----CDISVDDKYIVTGSGDKKATVY 176
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 15-54 3.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 3.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 28175349     15 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 54
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
17-54 3.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 3.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 28175349    17 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 54
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 18-59 4.80e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 36.59  E-value: 4.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 28175349    18 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGR 59
Cdd:pfam20426 116 MVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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