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Conserved domains on  [gi|7634779|gb|AAF65181|]
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HDCMA39P, partial [Homo sapiens]

Protein Classification

Got1/Sft2-like family vesicle transport protein( domain architecture ID 6026)

Got1/Sft2-like family vesicle transport protein such as Homo sapiens vesicle transport protein GOT1A, which may be involved in fusion of ER-derived transport vesicles with the Golgi complex

Gene Ontology:  GO:0015031|GO:0006888
PubMed:  10406798

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Got1 super family cl02130
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 48-164 2.25e-13

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


The actual alignment was detected with superfamily member COG5120:

Pssm-ID: 470475  Cd Length: 129  Bit Score: 63.65  E-value: 2.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7634779   48 LTDTQKIGMGLTGFGVFFLFFGMILFFDKALLATGNVLFVAGLAFVIGLERTFRFFFQKHKMKATGFFLGGVFVVLIGWP 127
Cdd:COG5120   3 LMNLQKSGVVVTSIGFLFFLVGIFLFFDRALLILGNLLMIIGIFLIAGSRKSMFFFLRPEKIQGSVIFAMGVLLLLYRFP 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 7634779  128 LIGMIFEIYGFFLLFRGFFPVVVGFIRRVPVLGSLLN 164
Cdd:COG5120  83 MFGFLLETLGLFLLFRDFIPTIRTFLRTLPLIGPYID 119
 
Name Accession Description Interval E-value
GOT1 COG5120
Membrane protein involved in Golgi transport [Intracellular trafficking and secretion];
48-164 2.25e-13

Membrane protein involved in Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227450  Cd Length: 129  Bit Score: 63.65  E-value: 2.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7634779   48 LTDTQKIGMGLTGFGVFFLFFGMILFFDKALLATGNVLFVAGLAFVIGLERTFRFFFQKHKMKATGFFLGGVFVVLIGWP 127
Cdd:COG5120   3 LMNLQKSGVVVTSIGFLFFLVGIFLFFDRALLILGNLLMIIGIFLIAGSRKSMFFFLRPEKIQGSVIFAMGVLLLLYRFP 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 7634779  128 LIGMIFEIYGFFLLFRGFFPVVVGFIRRVPVLGSLLN 164
Cdd:COG5120  83 MFGFLLETLGLFLLFRDFIPTIRTFLRTLPLIGPYID 119
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 78-136 3.13e-05

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 41.32  E-value: 3.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 7634779     78 LLATGNVLFVAGLAFVIGLERTFRFFFQKHKMKATGFFLGGVFVVLIgwplIGMIFEIY 136
Cdd:pfam04178  33 LYTLGNILFLGSTGFLIGPKKQLKHMFSKERLPFTIAYLGSLLLTLY----FALILKSY 87
 
Name Accession Description Interval E-value
GOT1 COG5120
Membrane protein involved in Golgi transport [Intracellular trafficking and secretion];
48-164 2.25e-13

Membrane protein involved in Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227450  Cd Length: 129  Bit Score: 63.65  E-value: 2.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7634779   48 LTDTQKIGMGLTGFGVFFLFFGMILFFDKALLATGNVLFVAGLAFVIGLERTFRFFFQKHKMKATGFFLGGVFVVLIGWP 127
Cdd:COG5120   3 LMNLQKSGVVVTSIGFLFFLVGIFLFFDRALLILGNLLMIIGIFLIAGSRKSMFFFLRPEKIQGSVIFAMGVLLLLYRFP 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 7634779  128 LIGMIFEIYGFFLLFRGFFPVVVGFIRRVPVLGSLLN 164
Cdd:COG5120  83 MFGFLLETLGLFLLFRDFIPTIRTFLRTLPLIGPYID 119
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
 78-136 3.13e-05

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 41.32  E-value: 3.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 7634779     78 LLATGNVLFVAGLAFVIGLERTFRFFFQKHKMKATGFFLGGVFVVLIgwplIGMIFEIY 136
Cdd:pfam04178  33 LYTLGNILFLGSTGFLIGPKKQLKHMFSKERLPFTIAYLGSLLLTLY----FALILKSY 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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