Conserved Protein Domain Family
Fox-1_C
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pfam12414: Fox-1_C 
Calcitonin gene-related peptide regulator C terminal
This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with pfam00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.
Links
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Statistics
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PSSM-Id: 463568
Aligned: 8 rows
Threshold Bit Score: 72.2791
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008111765 239 VASIPYPMMAp-----AALAYRGA-LRGRGRAtIYNPIRAAPAPSPVPAYGS---------------------------- 284
4_pfamImport   1 LTGFPYPTAG------AAVAYRGAhLRGRGRA-VYNTFRAAPPPPPIPTYGA---------------------------- 45 
XP_005001479 208 VTGFPYPTTG------TAVAYRGAhLRGRGRA-VYNTFRAAPPPPPIPTYGAaleqtlvkmpvpwaglapcplppqqtpe 280
XP_017729906 202 MPGFPYPAAT------AAAAYRGAhLRGRGRT-VYNTFRAAAPPPPIPAYGG---------------------------- 246
Q642J5       228 VPGFPYPAATa-----AAAAYRGAhLRGRGRT-VYNTFRAAAPPPHIPAYGG---------------------------- 273 zebrafish
XP_015456234 239 VPGFPYPTAAaaaaatTAATFRGAhLRGRGRP-VYGAVRAAVPQPAIPAYPG---------------------------- 289 Mexican tetra
KAE8611161   219 VPGFPYPTAAaa--atTAAAFRGAhLRGRGRT-VYGAVR-AVPPTAIPTYPG---------------------------- 266 tropical clawed...
XP_028841179 249 VPGFPYPTAAaaa-asTAAAFRGAhLRGRGRP-VYSAVRAAVPQPAIPAYPG---------------------------- 298 denticle herring

XP_008111765 285 -------------------VLYPDGL-YG-SD-IY-GYpAAYRVAQT----PAAAaa------taAAAYSDGYGRVYtTA 331
4_pfamImport  46 -------------------ILYLDNIaYK-NN-IAgGY-AAYRYAQP----AAAA----------ATAYSDSYGRVYtAA 89 
XP_005001479 281 payptspafpplscpfasrVVYQDGF-YG-AE-IYgGY-AAYRYTQP----AAAAa--------aAAAYSDSYGRVYaAA 344
XP_017729906 247 -------------------VVYQEPV-YG-NKlLQgGY-AAYRYAQP----TPAT----------AAAYSDRNQFVFvAA 290
Q642J5       274 -------------------VVYQDGF-YG-AD-IYgGY-TAYRYTQP----ATAT----------AAAYSDSYGRVY-AA 315 zebrafish
XP_015456234 290 -------------------VVYQDGF-YGpAD-LYgGY-AAYRYAQP----TAVAgptaaaaaaaAAAYSDSYGRVY-TA 342 Mexican tetra
KAE8611161   267 -------------------VLYQDGF-YG-TE-LYgGY-AAYRYTQP----ATAAt--------aATAAAa-------AA 304 tropical clawed...
XP_028841179 299 -------------------VVYQDGF-YG-AAdLYgGY-AAYRYAQPaavtGATAaaa-----aaAAAYSDSYGRVY-TT 350 denticle herring

XP_008111765 332 EPY 334
4_pfamImport  90 DPY 92 
XP_005001479 345 DPY 347
XP_017729906 291 DEI 293
Q642J5       316 DPY 318 zebrafish
XP_015456234 343 DPY 345 Mexican tetra
KAE8611161   305 AAY 307 tropical clawed frog
XP_028841179 351 DPY 353 denticle herring
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