Conserved Protein Domain Family
DUF3544
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pfam12064: DUF3544 
Protein kinase C-binding protein 1
This is a domain found predominantly in eukaryotes and associated with pfam00628 pfam01753 pfam00439 pfam00855. Family members include protein kinase C-binding protein 1 (also known as ZMYND8) which acts as a transcriptional corepressor of the H3K4 demethylase JARID1D. ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) binds acetylated damaged chromatin, including actively transcribed regions, as a means of recruiting the nucleosome remodeling and histone deacetylation (NuRD) chromatin remodeling complex for transcriptional repression and DNA double-strand break (DSB) repair by homologous recombination (HR).
Links
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Statistics
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PSSM-Id: 463452
Aligned: 10 rows
Threshold Bit Score: 239.04
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_022538483  473 RRISMTDIPRSPMSTNSSAHTGSDGEQEGGEKSQAKVP--LPHQTGGEESLESTaspaap----rpgpaGSAVDSPKPFH 546 
XP_014324866  448 QRHPLGDGQRSPMSTNSSAHGGSDGEQETADRTQTKSA--NSQSSAGEESTDCT---------------GNSLDSSKPPH 510 
AAG34905       46 RRISLSDMPRSPMSTNSSVHTGSDVEQD-AEK---KAT--SSHFSASEESMDFLdkstaspastktgqaGSLSGSPKPFS 119 
XP_013130445  428 RRVSMTDMPRSPMSTNSSVHTGSDGEQD-VEKGN-RNP--ALHYSTGEESMDCTaspvsg----kmgpgGSVSGSPKPF- 498 
XP_022533321  350 RRISMTDMPRSPMSTNSSVHTGSDLEQDASERGT-KLQ--SSHCSAGEDSMDCTaspa----------sqkTTGSPKPV- 415 
XP_005162002  422 CRISVTDMPRSPMSTNSSVHTGSDLEQD--ERGA-KMS--SSHCSAGEDSMDCTaspa----------slkTSGSPKPL- 485 
XP_692886     445 RRISMTDMPRSPMSTNSSAHTGSDGEQETAEKGHAKAA--LPHYSTGEESQDCTaspa-------ssraGSTLESPKPFH 515 
XP_028431898  423 RRLPLNEMPRSPMSTNSSAHTGSDGEHDTADKSQTKAP--NSQYSTGEESMDCTgispaspahprpcpaGSSLDSPKPFH 500  yellow perch
CAF96847      285 RRLPLTDIPRSPTSTNSSAHTGSDGEQETADKSQTKVPvtNNQYSTGEESMDSTaspahp----rpgpaGSSLDSPKAFH 360  spotted green...
XP_011473674  422 RQPPVSDVPCSPVSTNSSAHTGSDGEQEAADKSQAKAT--AGQCSTEEESMDCTg---------------NSLDSPKTMN 484  Japanese medaka

XP_022538483  547 ST--TPSTPiKQEKTPTTGSILNLNLDRSKAEMDLKELSETVqqqqqQQQQGPQASLTSPKRQIRSRFQLNLDKTIESCK 624 
XP_014324866  511 SQ--TPDTS-KQEKAPQTGSILNLNLDRSKAEMDLKELSETV-----QQKQGAAPALTSPKRQIKSRFQLNLDKTIESCK 582 
AAG34905      120 PQlsAPITT-KTDKTSTTGSILNLNLDRSKAEMDLKELSESV------QQQSTPVPLISPKRQIRSRFQLNLDKTIESCK 192 
XP_013130445  499 ----NPGLVpKQERTAGTGGILNLNLDRVKAEMDLKELSETVqq--qQQQQGVPAPPSTPKRPIRS-----LDKTIESCK 567 
XP_022533321  416 ----LPAPL-KQERTQTTGSILNLNLDRIKAEMDLKELSESVqq--qQQQQGASVVLTSPKKPTRS-----LDKTIESCK 483 
XP_005162002  486 ----LTTPV-KQERSSGTGGILNLNLDRVKAEMDLKELSEAVqqqqqQQQQGASVLLTSPKKPTRS-----LDKTIESCK 555 
XP_692886     516 SP--APNTPvKQEKTPTTGSILNLNLDRSKAEMDLKELSESV-----QQQQGAQPSLTSPKRQIRSRFQLNLDKTIESCK 588 
XP_028431898  501 SQ--APGVP-KQEKTPPTGSILNLNLDRSKAEMDLKELSETV-----QQKQGATPVLTSPKRQIKSRFQLNLDKTIESCK 572  yellow perch
CAF96847      361 GR--PAGMS-KQEKAPPTGSILNLNLDRSKAEMDLKELSETV-----QQKQGATPVLTSPKRQIKSRFQLNLDKTIESCK 432  spotted green...
XP_011473674  485 SQ--APGIT-KQERPPQTGSILNLNLDRSKAEMDLKELSETV-----QQKQGATVALTSPKRQIKSRFQLNLDKTIESCK 556  Japanese medaka

XP_022538483  625 AQLGIDEISEDVYKGVEHSDSEDSDKSDSSDSEYASDDEQKPKSSQESSADD 676 
XP_014324866  583 AQLGIDEISVDVYKGVEHSDSEDSDKSDSSESEYATDEESKSKPGQDSAAKR 634 
AAG34905      193 AQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDK 244 
XP_013130445  568 AQLGIDEISEDAYKDVDHSDSEDSEKSDSSDSEYLSDEEHKPKSSAQEDKDK 619 
XP_022533321  484 AQLGIQEISDDVYRGVDHSDSDDSDKSDSSDSEYASEEEHGPKESNQDNGAH 535 
XP_005162002  556 AQLGINEISDDMCGGVEHSDSEDSDKCDSSDSEEMSDDEQKPKNTNHNNSVH 607 
XP_692886     589 AQLGIDEISEDVYKGVEHSDSEESDKSDSSDSEYGSEDEQKSKNGQNNKTTA 640 
XP_028431898  573 AQLGIDEISVDVYKGVEHSDSEDSDKSDSSDSEYASDEEQKTKDGRDAAPND 624  yellow perch
CAF96847      433 AQLGIDEISVDAYKGVEHSDSEDSEKSDSSDSEDSSDVEQKAKNNQDAASAS 484  spotted green pufferfish
XP_011473674  557 AQLGIDEISVDAYKGVEHSDSEDTDKSDSSESDSASDEEQNTKGDQDTANDK 608  Japanese medaka
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