7KBU,1SRA


Conserved Protein Domain Family
SPARC_Ca_bdg
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pfam10591: SPARC_Ca_bdg 
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Secreted protein acidic and rich in cysteine Ca binding region
The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.
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Statistics
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PSSM-Id: 463162
Aligned: 21 rows
Threshold Bit Score: 117.058
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7KBU_A        83 PTCTDFEVIQFPLRMRDWLKNILMQLYEANSEHagylnekqrnkvkkiyldekrllagDHPIDLLLRDFKKNYHMYVYPV 162
BAF56044     149 GSCSAEDLREYPERMTNWFIKSLALIRNRPEEH-------------------------GGLSQKEKETLQQEWSQSTHAI 203
P36377       148 PACLDTELTEFPLRMRDWLKNVLITLYERDEDNnlltekqklkvk-nihenekrleagDHTVELLARDFEKNYNMYIFPV 226 chicken
XP_021251992 525 PHCTDYEVDQFPLRMRDWLKNILMQYYERDQDTsgfltekqrnkvkkiylnekrlmsgEHPVELLLHDFEKNYHMYVYPV 604
CAP39116     139 DECTEEHMAQFPERMADWLFQVMKELKKRRELHk------------------------LEWEELLSEAENDDEKKHVYPV 194
XP_002023777 166 RICDGEDLKEFPRRMRDWLFNVMRDLAERDELT-------------------------EHYMQMELEAETNNSRRWSNAA 220
Q1HPY3       182 PDCTESEMSDFPRRMRDWLFNIMRDMAERRELT-------------------------PHYLKMEREAESNLTRRWANAA 236 domestic silkworm
Q16II0       178 PDCSENDLADFPRRMRDWLFNVMRDLAVRNELP-------------------------EAYMELEQEAESNLTKRWTNAA 232 yellow fever mo...
CAG06250      29 GCTDSELHSLAARLKDWFRVLHLDANRDLKSSD-------------------------NFDSTTGHFDTSILPICKDSLG 83 
NP_001027592 214 QPCGEHELSEYPTRMRSWIKNIYLQMYDEAEDMgglnekqrfhgrklvanrdrlqtyeEHHIDLMSREFQKFYPLYKYPI 293

7KBU_A       163 HWQFSELDQHpMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGH 219
BAF56044     204 FWKFDRLDKNpSDHYLDFAELEGLRAPIVLFEPCTKPFLQACDVDNDTLISAVEFGR 260
P36377       227 HWQFGQLDQHpIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLDFDKYIALEEWAS 283 chicken
XP_021251992 605 HWQFYQLDQHpVDRSLTHSELASLRASLVPMEHCITRFFQECDGDQDKLITLKEWCH 661
CAP39116     195 IWKFCELDTKpHDKSVSHHELIPITAPVIPMESCIKPFLEGCDANNDGNISIKEWGK 251
XP_002023777 221 VWKWCDLDGD-TDRSVSRHELFPIRAPLVSLEHCIAPFLESCDSNNDHRITLIEWGA 276
Q1HPY3       237 IWKWCDLDAQtNDRFVSRHELFPIRAPLMALEHCIAPFLDRCDADDDHRVTLAEWGK 293 domestic silkworm
Q16II0       233 IWKWCDLDGHpNDNSVSRHELFPIRAPLMTLEHCIAPFLETCDPNGDHRITLQEWGK 289 yellow fever mosquito
CAG06250      84 WMFNKLDINF-DLLLDQSELSALYLD--KYEMCMKPLFNSCDSFKDGKLSNNEWCYC 137
NP_001027592 294 HWKFGILDVNpTDKYLSKRELEPMRAPLVPLEHCTDTFFSTADANKDHLISLYEWAE 350
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