7JPK


Conserved Protein Domain Family
VGCC_alpha2

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pfam08473: VGCC_alpha2 
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Neuronal voltage-dependent calcium channel alpha 2acd
This eukaryotic domain has been found in the neuronal voltage-dependent calcium channel (VGCC) alpha 2a, 2c, and 2d subunits. It is also found in other calcium channel alpha-2 delta subunits to the C-terminus of a Cache domain (pfam02743).
Statistics
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PSSM-Id: 462488
Aligned: 13 rows
Threshold Bit Score: 597.824
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7JPK_F        646 YSETLKPDNFEESGYTFLAPRDYCSDLKP---SDNNTEFLLNFNEFIDRKTPNnpSCNTDLINRVLLDAGFTNELVQnYW 722 
XP_023180764  638 FESLLPNSFESEGHVFIAPREYCNDLELS---NNNTEFLLNFIALMEKVTPDSkqCDSLLLHNLILDTGIIRQLVDKvWK 714 
XP_002935678  631 YFESLLPNNFELEGRVFLAPRQYCKELEQ---SDNNTEFLENFISLMEKVTPDskHCDSFLLHNLILDTGITRDLADrVW 707 
XP_023205783  641 SESLLSDKFDEYGYTFIAPRMYCKDLKPPdkeTNNTEYLMDFNNYIDTKTPNNpmCNVELVNRLLLDAGITSDLIKI-WK 719 
XP_023808266  626 FSETLLVDKFDEYGYTFIAPRTYCKDMEPl-nKYTNTEFLVMFNDYIDRRTPNdpECNVELMNRLLLDAGITADLIK-IW 703 
XP_025755351  618 SESLMADKFDEYGYTLIAPRDYCKDLKPD---ANNTEFLKRFNDYIDRKTPNNpmCNVDLVNRLLLDAGITSDLIKI-WK 693 
XP_011605244  622 SMETLQLERFDEYGYTFISPREYCKELKL---SLNNTQFLLDFNQYIDRYTPN--ACNVSLVSRLILDAGLTAELVK-VW 695 
XP_028425876  618 FSESLMADKFDEYGYTFIAPRMYCKDLKPpdkNKNNTEFLIEFNNYIDTKTPNnpMCNVELVNRLLLDAGITSSLIK-YW 696  yellow perch
XP_020644540  598 DFEYLLPNSFESEGHVFIAPREYCKDLNL---SKNNTEFLENFIALMEKVTPDskQCDNFLLHNLILDTGITQQLVErVW 674  central beard...
XP_014341948  637 yFESLLPNSFESDGHVFIAPREYCKDLDL---SNNNTEFLENFIALMEKVTPDskQCNNFLLHNLILDTGITRQLAErVW 713  coelacanth
XP_015207700  650 VSESMQLENFNENGYTLIAPREYCKDLKP---SENRTQFLMDFNEFIDRKTPNnpTCNAMLVNRLLLDAGITSELVQ-HW 725  spotted gar
XP_029774431  593 YFEFLLPSSFESEGHVFIAPREYCKDLNA---SDNNTEFLKNFIELMEKVTPDskQCNNFLLHNLILDTGITQQLVErVW 669  meerkat
NP_001038425  625 FSESLQVDKFEEYGYTLIAPRDYCEDLKAq--NENMTQFLIDFNEYIDVKTPNdpQCNMDLMNRLLLDAGITAELVK-HW 701  zebrafish
7JPK_F        723 SKQKNiK-GVKARFVVTDGGITRVYPKEAGEN------WQ--ENPETYEDSFYKRSLDNDNYVFTAPYFNKSgPG-AYE- 791 
XP_023180764  715 NKDLNtYgFLAVFAATDGGITRVFPNKAAETW------EE--DPEPFNASYYRRSLDNKGYIFTAPYRSAGA-DLlNPE- 784 
XP_002935678  708 KDKDLlTyGLLAVFAATDGGITRVFPNKAADD------WI--EDLEPHNATYYRRSLDNKGYIFRAPYKESG-YRpSEL- 777 
XP_023205783  720 RNELQqG-VIARFVATDGGITRVFPKSAGLDW------KE--DAETYESSFYKRSLDNDVYIFTPTR----------CT- 779 
XP_023808266  704 KKSELpN-GVKAVFVATDGGITRVYPESAGME------WN--EEVETYESSFYKRSLENDLYIFTPKPYNKN-LSsSES- 772 
XP_025755351  694 ENDPInG-VMSRYVATEGGITRVYPTSNGLDW------TG--QAETYDLSFYKRSLDNDLYIFTPTVFQNSS-QY----- 758 
XP_011605244  696 SEQTM-D-GIVARFVATDGGVTRVYPRSVGED------WI--ENPETYESSFYKRTLDNDVYIFTAPSFNTE-NK-DSF- 762 
XP_028425876  697 KGTELqH-GVLARFVATDGGITRVYPKSAGLY------WK--EEAETYESSFYKRSLDNDLYVFTP------------Tp 755  yellow perch
XP_020644540  675 RDQDLnTySLLAVFVATDGGITRVFPNKAAED------WE--EDLEPFNASFYRRSLDNKGYMFKPPCREPS-YRgLEL- 744  central beard...
XP_014341948  714 KDRDLhTyGLLAVFAATDGGITRVFPNKSEKQqsshkrIVvlRAPHPAVAG-------SAGRALALGSKANN-YApFDA- 784  coelacanth
XP_015207700  726 KKQSLt--GVVARFVATDGGITRVYPKSAGED------WK--ESAETYEASFYKRSLDNDFYIFTAPYFNNS-GSgESG- 793  spotted gar
XP_029774431  670 RDQDLnTySLLAVFAATDGGITRVFPNKAAED------WT--ENPEPFNASFYRRSLDNHGYVFKPPHQDAL-LRpLEL- 739  meerkat
NP_001038425  702 NKNQLsD-RIKAKFVATDGGVTRVYPASAGSE------WT--GQAETYESSFYKRSLDNDLYVFTPLPFT------GNK- 765  zebrafish
7JPK_F        792 -------S----GIMVSKAVEIYIQGK---LLKPAVVGIKIDVNSWIENF----TKTSIRDPCAGPVCD--------CKR 845 
XP_023180764  785 -------NdtvgILVSTALDITIGGKT---VKPAVLGVKLDLEAWTDKFKil-aSNHTDSRQGSNTCGPnrgcemdcEAN 853 
XP_002935678  778 -------EnntvGILVSTAVELDIMGK---KLKPAVVGVKLDLESWVEKFkvlaSNQSERHPQGPHKCSpsascemdCDV 847 
XP_023205783  780 -------EsdndVLVSRAVNLEINNIT---LKPAVVGVKLDIDSWMESFI----NITYRMNCKDEICGC--------KKG 837 
XP_023808266  773 -------De---sILASKAVDLKIGEV---LLKPAVVGVKLDIKAWMNSL----MNTTTTINCKDEICG--------CRI 827 
XP_025755351  759 -------Eg--sVLVSKAVNLKIDDIT---LKPAVAGVQLDIDMWREIFS----NTSQRKSCKDELCGC--------TIG 814 
XP_011605244  763 -------Se--sGILVSKAVELTIDEV---TLKPAVVGVKLNVSFWMNSF----MNATLKLNCKDEICG--------CLR 818 
XP_028425876  756 yltkentSd--dSVLVSKAVNLNIDGIilkP--A-VVGVKLDISAWMASF----INITQKINCNDEICG--------CQR 818  yellow perch
XP_020644540  745 -------EnstvGILVSTPVELNFGDK---HLKPAVVGVKLDLEAWAEKFkvlaSNRTERDQLGTRRCDpstscemdCEA 814  central beard...
XP_014341948  785 -------MndtiGILVSTVVELNMNGK---TLKPAVVGVKLDLEAWVSKFkilaSNQT--DPSGPQKCEpsascemdCDA 852  coelacanth
XP_015207700  794 -------Fd--sGILVSRAVDLTIDGK---KMKPAVVGVKISIAEWMANF----TNATIRKGCNSEICG--------CEK 849  spotted gar
XP_029774431  740 -------EndtvGILVSTAVELSLGGR---TLRPAVVGVKLDLEAWAEKFk--vLASNRTHQDQPQKCGpsshcemdCEV 807  meerkat
NP_001038425  766 -------Te--eSVLVSRAMDLRIDEF---WLKPAVVGVKLDVQSWMESF----MNTTITPKCEGEICG--------CRR 821  zebrafish
7JPK_F        846 NSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPS 925 
XP_023180764  854 SDDLLCYLIDDGGFLIMSNQKDDWSEVGKFLGVVDPNLMYALYNNSFYKRKQSFDYQSVCELLQNSDTGAARRGVFVPTI 933 
XP_002935678  848 NDEELLCVLIDDGGFLVMSNQQDHWSQVGKFFSEVDPNLMSALYNNSFYTRKESYDYQSVCAPKTESNKGAAPRGIFVPT 927 
XP_023205783  838 DQYIDCVVLDDGGFMVMSNQEDYVNQIGCFFGIIDPDLMRTLVNSSLFTAKSTYDYQSLCEPKRESKAAAGLRSIYVPTI 917 
XP_023808266  828 NNAYIDCIVLDDGGFLVMSNQEEYIKEIGNFFGVIDPTIMRALVNDSLYTSKSTYDYQSLCDPKRTSKKAAGPRSVYVPT 907 
XP_025755351  815 DKNLNCYILDDGGFLVMTNQIDHFNEIGKFFGEIDPCIMRSLINSSLYTNKSTYNYQSLCDPKKEDKTSAGMRSVYVPTI 894 
XP_011605244  819 NDKHVDCVILDDGGFLLMSNQDEYISLIGQFFGEVDPVLMINLVNTSLYSFNKTYDYQSVCDPEKDSKAAAGPRSVYVPS 898 
XP_028425876  819 NDVYVDCVILDDGGFLVMSNRDEYIDQIGRFFGGIDPILMVNLVNSSLFTSKKTFDYQSLCDPEKESKAAAGLRSVYVPT 898  yellow perch
XP_020644540  815 NYKDLLCVLIDDGGFLVLSNQEDYWFQVGKFFSEVDAHLMSALYNNSFYTRKESYDFQSVCAPEAPSNTGGAPRGVYVPT 894  central beard...
XP_014341948  853 YNNDLLCVLIDDGGFLIMSNQREHWNQIGMFFSEVDANLMHALYNYSFFRKKESFDYQSVCTPKAESNTGAAPRGVFVPT 932  coelacanth
XP_015207700  850 NSKLVDCVILDDGGFLLMSNQDEYIDEIGWFFGEIDPILMTNLVNTSLYAFNKSYDYQSVCDPDRGPKAAAGLRSVFVPT 929  spotted gar
XP_029774431  808 NNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPT 887  meerkat
NP_001038425  822 NDEYLDCVLLDDGGFLVMANQDKYIDQIGEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLRSVYVPT 901  zebrafish
7JPK_F        926 IADILQIGWWATAAAWSILQQFLLSLTFPRLLEAADMEDDDFtAsMSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIF 1005
XP_023180764  934 ADFVNLAWWTSAAAWSLFQQLLYGLAYHSWFVTDEVEAEVIE-S-KERSCVMIQTQYYFSNLSNSYNILQDCGNCSRLIH 1011
XP_002935678  928 IADVLNLAWLTSAAAWSLFQHLLVSVIYGSWLQADDIAAENM-E-PREASCIMKQTQYYFGNINSTYSAVIDCGPCSRYF 1005
XP_023205783  918 ADILNLGWWATAAAWSIVQQLLVSITLPNVLDAAETDDQV-SdAmSKEVCITEQTQYFFENDETSFGGLFECANSTRQYL 996 
XP_023808266  908 IADILNLGWWATAAAWSVLQQLMVSITYPSFLDAVDVEDK-MpDsMTKEVCITEQTQYYFENKRSTFSGSVDCGNCSRLF 986 
XP_025755351  895 ADVLNLGWWATAAAWSIMQQLVVSITLPNFGEAATD---DAPdV-EKEVCIKEEYQYYFENDSLSFRGVIDTEKCSRLYH 970 
XP_011605244  899 IADLLSIGWWASSAAWSILQQLLVGLLFPNLLEAAEPADEEIpDaMFKESCITEQTQYFFDNEERSYSGVLDCGNCSRMY 978 
XP_028425876  899 IADILNLGWFATAAAWSILQQLLVSITFPNFLDAAEMDDE-MsDaMLKEVCITEQTQYYFENNDRSFRGTIDCENCTRLY 977  yellow perch
XP_020644540  895 MADFLNLAWWTSAAAWSLFQQFLYGLTYSSWFQTEDVTADSM-E-PKETSCIMKQTQYYFSTVDSIYNAMIDCGNCSRLF 972  central beard...
XP_014341948  933 IFDFLNLAWWTSAAAWSLLQQLMYGLAYNSWFRADDVTADGL-D-LRETSCIMKETQYFFSNTATSFNNMIDCGNCSRLF 1010 coelacanth
XP_015207700  930 IADILNIGWWASAAAWSIVQQLFVSFTFPNFLEAADTEEE-QtAaLSKESCITEQTQYYFDNNNKSFSGVLDCENCSRIY 1008 spotted gar
XP_029774431  888 IADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGNpE-ARESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLF 966  meerkat
NP_001038425  902 IADILNIGWWASAAAWSIMQQLFVSITFPNFLEAVDISDEs--EtPSKESCIKEQTQYFFDSNDTTFKGTVDCQNCSRQF 979  zebrafish
7JPK_F       1006 HVEKLMNTNLIFIMVEsKGTCP--CDTRLLIQAEQ-T--SDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCG 1074
XP_023180764 1012 AKRINNTNLLFVVAEK-LPCSSc-EIEDLSQDKEE-F--KEENPCEEMTTARYRKGPSTCFDSNAAENTSDCGR 1080
XP_002935678 1006 HAQRLSNTNLLFVVAE-KMICSq-CDSMKLDQAET-R--SEGPEQCDLVQMPRYRKGPHMCFDYNPMEDTSDCG 1074
XP_023205783  997 AEKVPNTNLVLIISDRqQGNSQscGLGPLVQDEKQ-S--AGPDPCEMALSPRYRKGPIVCFDKTEHEEDPDCGG 1067
XP_023808266  987 LAEKLPKTNLVFIIADaKGTCSs-CVSSKLIQEEQ-Q--SDGPNPCEMALSPRYRKGP-ACFDKNQPEKDADCG 1055
XP_025755351  971 AERLPKTNLVFIVAETeHGCEc--QEKILKQEEQE-S--QGPDPCQLASEPRFRKGPAACFDNNSHDEVMCRRS 1039
XP_011605244  979 RAEKLPNTNLVFLITDaKATCLs-CDPRPLRQAEQ-P--SEGPDPCELAQNPRYRKGPDVCFDNNENEDDSDCG 1048
XP_028425876  978 HAEKLPKTNLVFIIADaKLTCSs-Cdtkpli---qdeqqSNGPDPCEMAQNPRYRKGPAVCFDNNEHEKDPDCG 1047 yellow perch
XP_020644540  973 HAQRLASTNLLFVVAE-KPICSq-CESTKlLQAEIkAppGD-RNQCELVEKPRYRKGPHICFDYNATEDTSDCG 1043 central bearded dragon
XP_014341948 1011 HAQRLANTNLLFVVAD-KLMCNq-CDSMKLIQAKTr---SDGPPQCDLVENPRYRKGPDLCFDYNALEDTTDCG 1079 coelacanth
XP_015207700 1009 RAEKLPNTNLLFLIVDaKETCPc-SSTKPLIQAEQ-P--SKGPDPCDLVHNPRYRKGPEVCFDNDENEDYTDCG 1078 spotted gar
XP_029774431  967 HAQRLTNTNLLFVVAE-KPLCSq-CETGRLLQKET-HcpADGPEQCELVQRPRYRRGPHICFDYNATEDTSDCG 1037 meerkat
NP_001038425  980 IAEKLMKTNLVLIVADtEm-----CSQM-----------SPGPDPCLISQNPRYRKGPMECFDNNVNENNEPCG 1037 zebrafish
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