Conserved Protein Domain Family
MUN

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pfam06292: MUN 
MUN domain
This entry corresponds to the MUN domain found in Munc13 proteins. These constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. Structural studies have defined MHD1 and MHD2 to be part of the larger MUN domain which forms an elongated structure composed of any pairs of alpha helices.
Statistics
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PSSM-Id: 461870
Aligned: 24 rows
Threshold Bit Score: 334.756
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDS43288      712 QVlrECIRACMKATYEClSDNVqalyggnfqndsahtsalssSE---KSSAESQS-----------------------Di 765 
EDO45421      697 NEirKCLQKAALVNYTRvSAYAq------------------iEG---ISVRKKSSsrphpcycsifkfrilhkentgkRk 755 
XP_002606817  667 AVikSCMEKAALINYTRiSEYAr------------------iEVpanKPVGDQDSlssvs-------------ttdmqGe 715 
XP_013132045  795 KLvqRCLEQAAQINYSQlIEYAk------------------iKV----------------------------------Dh 822 
9_pfamImport    1 NLvrRCLQEAARLNYSQlLQYAh------------------iKG----STIKERRpl----------------------r 36  
XP_027960680  802 KVvrKCLEKAALINYTRlTEYAk------------------iEE--------TMN-----------------------Q- 831  Steller sea lion
XP_017947783  791 KIvrKCLENAALINYTRlTEYAk------------------iE----------ES-----------------------Mn 819  tropical claw...
XP_031143558  857 GVirKCLEQAAQLNYERiKEYAt------------------iEV----EKGQKDQkdp-----------------envGr 897  pikeperch
XP_021332919  801 AVirKCLEQAAQINYQRiTDYAr------------------vEV----EKTLKDQkdp-----------------envAn 841  zebrafish
XP_018668523  809 AVikHCLEEAALVNYTRvSEYAk------------------vDA----AQKDSNKt----------------------Kp 844  vase tunicate
CDS43288      766 dPVlGVR--------SLSYWHKLISLMVSVIEDDRK-HYAPVL----------N---QFPQDINLGDLSAEMMWNLLAED 823 
EDO45421      756 dAP-PDK--------RLDDIMHLAELCIDLLQQNEE-HHA-------------E---ALAWVADLMAEHQEIFWSLFSVD 809 
XP_002606817  716 eVP-TKK--------RLDDVIRLAELCIDVLQQNDE-HYA-------------E---AFAWFSDLLAEHKEIFWSLFQVD 769 
XP_013132045  823 qAP-PEK--------RLEDMMRLGELCIEVLQQNEE-HHS-------------E---AFSCWPELMAEHAEKFLSLYRAD 876 
9_pfamImport   37 lRT-SER--------RLEEVLRLGELCLDVLQQNQEhHHANPAaanpl-lwrlQ---AFSWWPELMTEHAETFLSLYRAN 103 
XP_027960680  832 -AP-PAR--------KLEEVLHLAELCIEVLQQNEE-HHAEGR----------E---AFAWWPDLLAEHAEKFWALFTVD 887  Steller sea lion
XP_017947783  820 qEY-ASK--------KLEDVINLAELCIEVLQQNEE-HHSE----------------AFSWWPDLLAEHAEIFWALFSVD 873  tropical claw...
XP_031143558  898 lVT-PAK--------KLEETIRLAELVIEVLQQNQE-HHAEAAvtssgdqsgkE---AFAWWTDLMVEHAENFLALYAID 964  pikeperch
XP_021332919  842 lAT-PAK--------KLEHVIRLAELVIEVLHQNQD-HHAEAAvtst---gdqSgkeAFAWWSDLMVEHAENFLSLYGVD 908  zebrafish
XP_018668523  845 eQG-ETKslneassrRLEVIIHLAELCIDVLQQNEE-HHFEGR----------E---AFAWFSDLMTEHSEIFWSLFAVD 909  vase tunicate
CDS43288      824 ISVGLTQHyeavlrrltdttptittssrqkrstavatveqtgeqitttrlskakiKTSDYLNlcFRIKWFYNTYVR--PS 901 
EDO45421      810 MDAALAVQ-----------------------------------------------LPDTWDS--FQLFQLLNDYLSnePS 840 
XP_002606817  770 MDSALEVQ-----------------------------------------------PPDSWDS--FPLFQLLNDYLRqdEN 800 
XP_013132045  877 MEAALQVQ-----------------------------------------------SIDSWNS--FPLFQLFNNFLRtdPH 907 
9_pfamImport  104 MDAALQAQ-----------------------------------------------PIDSWNS--FPLFQLLNNFLRsdAH 134 
XP_027960680  888 MDTALEAQ-----------------------------------------------PQDSWDS--FPLFQLLNNFLRndTL 918  Steller sea lion
XP_017947783  874 MNSALESQ-----------------------------------------------PQDSWES--FPLFQLLNNFLRndSL 904  tropical claw...
XP_031143558  965 MDAALEIQ-----------------------------------------------SPESWDS--FPLFQLLNDFLRtdYH 995  pikeperch
XP_021332919  909 MDAALEIQ-----------------------------------------------SPESWDS--FPLFQLLNDFLRtdYH 939  zebrafish
XP_018668523  910 MDTVIEKQ-----------------------------------------------PPDTWNS--FPLFQLLNDYLIndHT 940  vase tunicate
CDS43288      902 RRnrkeddPEYPKWFEPLVMLWLSENDEVSENYLRNAYERDK----RDgFQRS-------------SEHALY-------- 956 
EDO45421      841 LQrgk-fhLHLRETFAPLVIRYIDLMESSIAQSVHKDFAKETwiav---------------------------------- 885 
XP_002606817  801 LTggk-fhSHLRETFAPMVVRYVDLMESSIAQSIHKGFERETwlpqgvnlglpev------------------------- 854 
XP_013132045  908 LCngm-fhKHLQDLYIPLVVRYIDLMELAIAQSIHRGFQKETwqpl---------------------------------- 952 
9_pfamImport  135 LSggs-fhRHLQDVFVPLVVRYIDLMESSIAQSLHRGFQQETweplKPlsgvmvklrlkqintlfnyssilp-------m 206 
XP_027960680  919 LCngk-fhKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETwqpvKN-IANS-------------LPNVALpkvpslpl 983  Steller sea lion
XP_017947783  905 LCngk-fhKHVQECFMPLVIRYIDLMESSIAQSIHKGFEQETwqpvKS-ITNN-------------LPTVTLpkvpsltl 969  tropical claw...
XP_031143558  996 LCngk-fhKHLQDLYAPLVVRYVDLMESSIAQSIHKGFERESwepvKSltsnlpnvnlpnvnlqipkvpnlpvpvaglsv 1074 pikeperch
XP_021332919  940 LCngk-fhKHLQDLYAPLVVRYVDLMESSIAQSIHRGFERESwepvKSltsnlpnvnlpnvnlqipkvpnlpvpvaglsv 1018 zebrafish
XP_018668523  941 LRdgr-fhCHLRDTFAPLVIRYTDLMESSIAQSIHHGFGKDGwsss---------------------------------- 985  vase tunicate
CDS43288      957 -----------------------SNSVVDVFTQLNQCFDVIRKLECPDRDVEANYMHRFAQTVEKVLLAYSESVQLDFAQ 1013
EDO45421      886 --------------------gegCNSSEELFWKLGALQQFISDLNWPDEVMEAHLIKRLKLMSADMVESCIKRTKERLDK 945 
XP_002606817  855 -----------pvdipmlgasngCETSEDVLWKLEALQNFIKDLHWPEEEFGNHLEQRLKLMACDMIESAIQRTQKSFEN 923 
XP_013132045  953 --------------------nngSATSEDLFWKLNTLQMFVMDLHWPEPEFAKHLEQRLKLMASDMMEACVKRTKSAFDA 1012
9_pfamImport  207 plphppsfslslirstvwpeangSATSEDLFWKLDALQMFLADLRWPEPDFAKHLEQRLKLMAGDMVDACVRRTRAAFDV 286 
XP_027960680  984 nlpqipsfstpswmaslyestngSATSEDLFWKLDALQMFVFDLHWPEQEFAHHLEQRLKLMASDMIEACVKRTRTAFEV 1063 Steller sea lion
XP_017947783  970 nlpqipsfsapswmaslydstngSTTSEDLFWKLDALQVFVQDLHWPEAEFANHLEQRLKLMASDMIEACVKRTRAAFEL 1049 tropical claw...
XP_031143558 1075 nlpqmpsfstpswmaaiydsdngSGTSEDLFWKLDALQTFIRDLHWPEEEFAKHLESRIQLMSSNMIENCVKRTRMAFES 1154 pikeperch
XP_021332919 1019 nlpqmpsfstpswmaaiydsdngSGTSEDLFWKLDALQTFIRDLHWPEEEFAKHLDNRMKLMSSDMIETSVKRTRGAFES 1098 zebrafish
XP_018668523  986 -------------------nsgkNTIANDVLWKLDALQSFVRELHWPDAIFACHIEHRLKLMASDMIQSVVSRTVQRFNV 1046 vase tunicate
CDS43288     1014 FKSD---------ARTACILINNTQQLRVQLEkvYEAMe-GEDfNLHEETRKQLTKLQVCLKNAVDLLVFAFAGEFEEDI 1083
EDO45421      946 WLSTtkfstdyviPSTVFVMMNVITQAKKQSQ--ILCA---RE-ESESEQHRYHSDVYEVLTGSQKDVAERIAEKLNSVL 1019
XP_002606817  924 RLKRgrdspdfrmAVEACTMINVVFDAKKKST--QLCF---YK-SPDGQRHNYHTKIDDFLEKVYNEMISTLVAKMVTVV 997 
XP_013132045 1013 KMQKvckstdsllPVSVCTMFNVLIDAKNQCS--KLCVldSEQ-EIDRQWQQYHSKIDVLIDEALKNIITSLVSKFAAVL 1089
9_pfamImport  287 RLQKvggssdwrlPPSVCTMFNVLMDARRRSS--KLCV---LD-P--GQEQLYHSRIDVLIEETISDMISCLVTKFSTVL 358 
XP_027960680 1064 KLQKaskttdlriPASVCTMFNVLVDAKKQST--KLCA---LD-G--GQEQQYHSKIDDLIDNAVKEIISLLVSKFVSVL 1135 Steller sea lion
XP_017947783 1050 KLQRtnkstdfriSASVCTMFNVLVDAKKQCA--KLCV---LD-S--GQEQQYHSKIDDLIEETVKEIISLLVSKFISVL 1121 tropical claw...
XP_031143558 1155 KLTKsskstdfriSPPLCTMFNVMVDAKDQSA--KLCA---ME-M--GQEKQYHTQIDELIEESVKDMIQLLVAKFVAIL 1226 pikeperch
XP_021332919 1099 KLTKssrstdfriPLSLCTMFNVMVDAKDQSA--KLCA---ME-M--GQEKQYHSQIDELIEESVKDMIALLVAKFVAIL 1170 zebrafish
XP_018668523 1047 ILAScrvsvdfmvTSQICSLINVALECRKQSV--KICAs-GHD-A-SGTQHLYHVEVDEVLESAFSQMEGQIVDKFTKVL 1121 vase tunicate
CDS43288     1084 QRSVLEMGRllqgckettsgggsaegmeADCENCLRPLMDY--------------------FELVLSAQASSCEKTVLKR 1143
EDO45421     1020 NALLHKLAR-------------------YDHGSLLSSVFALknp--------------gneMELNFTRFVKTNLSRVMKE 1066
XP_002606817  998 ESVLAKLAR-------------------YDEGTLFSSFMNFgaslrqkaqnitgketpgleLADSYMYFVRINQDILRDK 1058
XP_013132045 1090 NGVLSKLSR-------------------YDEGTFFSSVLSFtkp--------------rvdLADTYISFVRQNQDILRHG 1136
9_pfamImport  359 HGLLSKLSR-------------------YDEGTLFSSILSFtteaakqmp---avpnpgsdLADAYIGFVRQNQDVLRAG 416 
XP_027960680 1136 EGVLSKLSR-------------------YDEGTFFSSILSFtvkaaakyv---dvpkpgmdLADTYIMFVRQNQDILREK 1193 Steller sea lion
XP_017947783 1122 ESVLSKLTK-------------------YDEGTLFSSILSFtvkaaskyv---evpkpgldLADTYITFVRQNQDILREK 1179 tropical claw...
XP_031143558 1227 ESVLAKISR-------------------YDEGTLFSSFLSFtvkaaskyv---dvpkpgmdVADGYVTFVRHSQDILRDK 1284 pikeperch
XP_021332919 1171 ESVLAKISR-------------------YDEGTLFSSFLSFtvkaaskyv---evpkpgmdVADGYVTFVRHSQDILRDK 1228 zebrafish
XP_018668523 1122 ESVLVKLSR-------------------YDEGSFTASLFTLtkp--------------gmeLANNFIYFIRANQDVLRES 1168 vase tunicate
CDS43288     1144 LLKELWritmenteklvvlpgvsdtkqalptvlvgpkgtasakliggaqsllshvgqnvsaakilqdfageslvgsrglt 1223
EDO45421     1067 LSEERL-------------------------------------------------------------------------- 1072
XP_002606817 1059 VNDELW-------------------------------------------------------------------------- 1064
XP_013132045 1137 VSDELY-------------------------------------------------------------------------- 1142
9_pfamImport  417 VGEELL-------------------------------------------------------------------------- 422 
XP_027960680 1194 INEEMY-------------------------------------------------------------------------- 1199 Steller sea lion
XP_017947783 1180 VNEEVY-------------------------------------------------------------------------- 1185 tropical claw...
XP_031143558 1285 VNEEVY-------------------------------------------------------------------------- 1290 pikeperch
XP_021332919 1229 VNEEVY-------------------------------------------------------------------------- 1234 zebrafish
XP_018668523 1169 ICDELF-------------------------------------------------------------------------- 1174 vase tunicate
CDS43288     1224 pyqcevltncLETVQVYFHAGGRGLKRSFLQSSPELHNLQQALALYSQTTDTLLKDY 1280
EDO45421     1073 ----------KKYIVKKWYTSMVMRICEWLSHRMSDSLHEYQLKTLLPITKEIPVLF 1119
XP_002606817 1065 ----------TLKAFEQWYVAAMNIIADWLKERQDIQLHIYQLITLMRMSKKMFRDF 1111
XP_013132045 1143 ----------IETVFDQWYTDSMKAICVWLTDRLDLQLHMYQLKTLIKIVKKTYHDF 1189
9_pfamImport  423 ----------LQRLFDRWFGASMEAVCVWLTDRLDLQLHSFQLRTLISVVKSTSRDL 469 
XP_027960680 1200 ----------IEKLFDQWYSSSMKVICVWLADRLDLQLHIYQLKTLIKIVKKTYRDF 1246 Steller sea lion
XP_017947783 1186 ----------IDKFFDQWYSSSIKVICVWLADRLDLQLHVYQLKTIIKIVKKTYRDF 1232 tropical clawed frog
XP_031143558 1291 ----------IERLFDQWYTATMNLLGTWLTERMDQQLHVYQLKILIRITKKKYRDF 1337 pikeperch
XP_021332919 1235 ----------IERLFDQWYTATMNLLATWLTERMDQQLHVYQLKILIRIVKKKYRDF 1281 zebrafish
XP_018668523 1175 ----------VEALFSNWYETSVKLLATWLTERSELQLNIYQLKTLIKLFKKFYHDF 1221 vase tunicate
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