Conserved Protein Domain Family
Prominin

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pfam05478: Prominin 
Prominin
The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.
Statistics
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PSSM-Id: 461660
Aligned: 27 rows
Threshold Bit Score: 799.147
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAQB:GK12310-PA  105 TTHEQQGQVHWPPVEFTPYKSKANYTK--DTWSSSTAMSPIYNFTHFLYDSILTYepALPPGYIVIKDKdtlalgpkveq 182 
EDO38922              20 FTAAKAANTVNGSKINWDIPKEEEWKSniNLKFDDRGLQPWYDLSVSFINTV-LN--KDPYEIMREVIS----------- 85  
XP_002046099          57 TAHEKLGQLHFSTAEFTEYKSKANYTK--EPKYSTKAMDPVYNFTRYFFGFILPDeaAIPPGYVVVKDGnylalgpkven 134 
XP_002046100          53 TTHEQLGQQHYPSADLTVYKSKIRYTI--ELNRTSWNIKPAFNLSQFFFDHTITDtpSLPRGYLAVKNGdtlvmgpkvvd 130 
XP_002025591          92 TTHEQVGQVHFPKPIYTKFNGFFNYSR--DLSSTTKAVNPIYNFTHFIFGTVMTDepALPPGYIMVQQEkvlvlgknver 169 
EDW32791              39 TTHEQLGQDHWPSVEYSPYLGFGNYSL--DLTSSQKALSPVNTLTHFALRLFLSD---LPPGYVTTTANnklvlgpkvwk 113 
EDW31944             101 TTHEQLGQDHWPSAEYSPYRGFGRYSR--ELASPRKALSPINTITHFILRSFLSD---LPPGYVTSTDNnklalgpkvwk 175 
WGS:AADE:GA20556-PA   95 TTHEQMGELHWAPVDYTPYKPTVNYTR--PPTAPTTAMNPIFNFTHKLYDSIISDepALPPGYIVMQ-Gdslalgpkfhn 171 
FlyBase:CG7740-PF     76 TTHEQLGQPHWPPVQYTVYRPTTNYTK--APPPPTSAMNPIFNFTHFLYDKVLYRdePIPEGYIVVKNSdtlslgpkvee 153 
KPU78240             103 TTHEQLGQPHYAPVEYSAYTPTSNYTE--EPGPPTSAMNSVYNFTHFLYDKIIYRnqPIPDGYIIIKNGdtlalgpkveq 180 
WGS:AAQB:GK12310-PA  183 NDWAALLAE--------YWL-ILAWVFFLLILIILIPFIAVCYCCfC-CCRRCRQGCpPCTSKQDARRRCCCGILLLLLI 252 
EDO38922              86 -ENKPLTEDpvnrfvtgYALgVVICAGIGVLFMLIMPIVGFCFCC-CrCCNNCGGEMsQKDLPGNACKRSVFGVILSIIT 163 
XP_002046099         135 NDWRDLLTQ--------YWM-VLIAVVILAILAVIMPIIAVCYCCfC-CCRRCKEGCpPCDSQKDARRRCCCGLLLLLLI 204 
XP_002046100         131 NDWSDLLGQ--------YFL-LILWVIILVVLIILIPFLAVCYCCfC-CCRRCKRGCgPCDEANDKRRALICAVILALLL 200 
XP_002025591         170 NEWSLLMSR--------YWL-VLFFVIFLLAAIIVIPFIAVCYCCfC-CCLRCKQGCiRCMAATDRRRRMCCGICLFLLI 239 
EDW32791             114 NDWAALLAQ--------YWF-LLVVVISLLFCIIIIPFIGVCYCCfC-CCLRCKQN----KRSNEFRRRCLCSVCLALLV 179 
EDW31944             176 NDWAALLAQ--------YWF-LVVVVIILLVCIIIIPFIGVCYCCfC-CCLRCKQH----KISESFRRRRLYGVCLGLLV 241 
WGS:AADE:GA20556-PA  172 ADFRDLIAR--------YWL-VLLFILFLCVIIVVMPFVAVCYCClC-CCRRCRQGCpPCTSKQDAQRRLWCGVCLLILI 241 
FlyBase:CG7740-PF    154 NDWRDLLAH--------YWM-VLIWVVILVVLIIVIPFIAVCYCCfC-CCRRCRQGCpPCTSKQDAQRRFCCGICLLILI 223 
KPU78240             181 NDWRDLLRH--------YWL-LFIIVFVLLLLIIIVPFIAVCYCCfC-CCRRCRQGCpPCTTKQDAQRRFCCGICLLLLI 250 
WGS:AAQB:GK12310-PA  253 IGLIFGIIIAFATNRMLNQGFEDTTTTIRRGSEDTCTFLRDVSNHIYHLFVYnYEEVETHLIDSLNNAH--KHIFLDLAD 330 
EDO38922             164 LLMFAGVLLMFVCNDNMSHSVGNSKSTIDGIVNEAVGFVNKTFNEFDNVVDKdFKTAVDQLSYDISDAGvkEHLGDPLLA 243 
XP_002046099         205 IGILFGVIIAFATNRLLDRGLEETTTTMRRGSQDTCTYLKDVSDHIHHLLVNnYGEMDKHLSDILTNAH--THIFLDLMD 282 
XP_002046100         201 VFILLGAIIGYTSNRGLDRGLAETASTVRRGNEDTCRFLEDVNAHIHHIFVYnYEELEAHLTDMLNNAH--HHIFLDLAD 278 
XP_002025591         240 IGLIFGLLIAFVTNKFLHRGLQESMVTMRRSSEDTCTFLRNVADHIHHLLVFnFQELEMHLIEQINDAH--NHIFLDLAD 317 
EDW32791             180 IGLMLGLFIMFIANKFVDRGLEDSNMTMKRASRDTCTFLKDVADHIYHLLVYnYQELEAHLEDQLNNAH--DHIFLDLGD 257 
EDW31944             242 VSLMFCLLIMFFANKFLDRGLADSNMTMKRAGQDHCTFLKEVADHIYHLMVYnYQELEAHLDEQLSTAS--NHIFLDLGD 319 
WGS:AADE:GA20556-PA  242 VGLIFGIVIAFVTNRLLDRGFDQATVTMKRGSDDICLFLKDVADHVHHLMVYnYEEMQTHISDELSSAH--KHIFLDLAD 319 
FlyBase:CG7740-PF    224 IGLIFGIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLKDVADHVHHLMMYnYEEMETHVLDQLTHAH--RHIFLDLSD 301 
KPU78240             251 IGLIFGIIIALVTNRMLDDGFAETTDTMQRGGQDTCTFLKDVSDHMYHLMVYnYEEFETHVTDQLNQAH--KHILLDLAD 328 
WGS:AAQB:GK12310-PA  331 TSESS---ALSELERILDNMPEALALMRQVDKLEKDLRFYGSQLRDGVRGLKRDINYNVANLCNt----QQCQNFLETSN 403 
EDO38922             244 VLESAilkPIEAVATLSQNTKAMENQLVVIVNNTNDLKKMGTTLSSGLQVARDNLTDILND-CKntsdpSICGDINTNE- 321 
XP_002046099         283 ASEAN---AVYDLKRILENMEEAQKLIKEVDKLEKDLRFYGTQLRDGVRGVKRDVNYACAVLCGn----RECLHFLKKTE 355 
XP_002046100         279 TSESN---AIEHLDRIFDNMKEARALMKQVVALDKDLRFYSTQLRDGVRGAKRDVNYACSNLISn----NKCKQFLRNSE 351 
XP_002025591         318 ASDSN---ALIELERILDSMPLAHPKMKQLEYLEKELRFYMSNLRDSIRGLKRDMTYTVTHYCGnt--kERCYKTMAEKS 392 
EDW32791             258 TSEST---ALAEMERILNNMPKALKIMLQVEALEKDIRFFGSQFRDGMRGQKRDLSYAAYALCHl----EKCYKFNHDMG 330 
EDW31944             320 TSESN---ALIEMERILANMPRALMIMSQVDDLEKDIRLFGSQLRDGLRGQKRDLSYAAYALCHl----PKCYKFNHDMG 392 
WGS:AADE:GA20556-PA  320 TSEST---SLGELERILHNMPEARQLMEQVAKMETDLRFYGAQLRDGLRGMKRDINFAVANLCTt----QECQTFLSSSS 392 
FlyBase:CG7740-PF    302 TSESN---SLAEMERVLENMPEALELMRQVEKMEKDLRFYGSQLRDGVRGIKRDVNFAVANLCQl----QMCQKFLISSN 374 
KPU78240             329 TSESN---SLAELERILDNMPEALQLMREVEKLETDLRFYGAQLRDGVRGIKRDINFAVANLCQl----QACQKFLITSN 401 
WGS:AAQB:GK12310-PA  404 IelIDTSKCIhfDQIPNTTVYVENMAEIIQENYAIIPKMAIERLQTVNEKVRMVMSHVVPPLIRDVQAGKEIFQTQATNI 483 
EDO38922             322 ---LKQDANF--SAVDNVQSQLDNIREVSELDFEKAAKEGLQTVRDIPITMINKTSGPRNDIIKMIANATTQVKKILTDG 396 
XP_002046099         356 IefLDNSKCLqfDQLPDTTYYSKAIEYIIAKNSGKTTKEVIDRLQYVGKRIKAGIDPLIPPIIRDIHNGQEQFRTQANNI 435 
XP_002046100         352 LefVDTSSCLhlDNMPNTTLFLEGIEQIIKDDVAIIPKKALERFQDIASKIETAMNQVIPPLLHDINQGREKFRIQAANI 431 
XP_002025591         393 VlyMDTSTCLhlDELPNTTVYVEAVEMIIKKRYNLIPKLALVRFNKVREKIKEQMELVGPPLKRTIATGHSIFDDRALKI 472 
EDW32791             331 VvtYDVSKCLhlDLIPNTTIFVEAMKQIIEDKLYQIPIRGMARLKKVKDIILKQMKLVLPPIFRSLTRSRIMFLNEAIEI 410 
EDW31944             393 IttYDVSKCLhfDLIPNSTVFVEGMKKIIMDKTYLIPLSGLARLKNIKDLIVKHMALAFPPVFKSLAGARLMLLDEATGI 472 
WGS:AADE:GA20556-PA  393 IelIDTSKCLhfDTIPNATLYLEGLNIVVKENYIKIPTDGLTRMENVSLKVKEQLNSVTPSMIRDLNGGRDTFRSHARRI 472 
FlyBase:CG7740-PF    375 IehIDSSQCLhfDNLPNTKEFVEGMENIVASEYYAIPQRGLSRLKKVSDKVKTQLSFVVPPMMRDLTKGRTIFREHATNV 454 
KPU78240             402 IeyIDTSECLhfDKMPNTSSYVKGMEDIVNGNYHLIPQAALARMQKINGKVMEHMTNIIPPITQNLGKGRATFRDTATEL 481 
WGS:AAQB:GK12310-PA  484 -RNIIDAVLSDIHlNTLRSTKSFDDVYEKFGEDRSLVSVIVCMLILLILFVLI-IALLCGCFGRRRSGYG-DDCCSKATG 560 
EDO38922             397 rKTVDDGVLQQLK-NIQSDSNYYTDLVKQYDKYRWYAGVGAACSIIVTHCCDDgAGLMCGICGYDKDATPsTRGSVSNMG 475 
XP_002046099         436 -RSMIDAAISDIHlNTVRSTKAFEDVYDKYGADRSIINVIVCSVLLIILLFLI-IALICGCCGRRRRGYR-DDCCSKGTG 512 
XP_002046100         432 -HRTIESVISDIHmRTLRSTESFEDVYEKFGKSRSYINALVCIFLLVIVILMA-VGLICGCTR------------SKPTG 497 
XP_002025591         473 -RNMIDAIISDIHlNTMRSTKTFDDVYEKFGTDRRTINIICITLIFIIIVFLF-TSLVCGVGGYSRTHPGpSGFCSKGMA 550 
EDW32791             411 -RDLIDSMISDIHlNTLRTARTFDDVYEKFGEDRRTINIVIFLLIFIIIVILI-SALVCGFLGPNRTMPGpPRVFSKGMA 488 
EDW31944             473 -RDLIDSMINDIHlNTLRTSRMFDDIHDKFGADRRAINIVICILIFIIIVILI-SALVCGCLGPSRTKPGpSGVFSKGMA 550 
WGS:AADE:GA20556-PA  473 -RNQVDAVLSQIHlKTSRSSRSFDDVYDKFGNNRSVISVIVCLLMIMILGILI-VSLLCGCFGRRKTGYR-DDCCSKATA 549 
FlyBase:CG7740-PF    455 -RNIVEGVLSDIHiKTLHSTKSFEDVYERFGHDRNVVSLIVCLLILLVLFILI-FALLCGCFGRRRTGYG-DECCSKSTG 531 
KPU78240             482 -RNKVDAVISDIHlKTVRSSKSFDDIYERFGPDRSVMSLIACMLILLILFILV-VALLCGCFGRRRTGYG-DDCCSKATG 558 
WGS:AAQB:GK12310-PA  561 ATCLLLAILLIFCVFSFITLVGLLYFMIGLVTYQGGCAPWrdqDQNALF-RQIDSV-------IDLNRYLpketn--rdn 630 
EDO38922             476 GNCLMAAVGFAFIFSWFFMLVTTICFLIGSPLQRIVCEPI---QSNTIWkEVIDNPasyktgeLPLSGILg--------- 543 
XP_002046099         513 ASCLLLAMLLIFCVFSIVVLVGLFYFVVGLATYQGACAPLrdqESNALF-RQLNSI-------IDLNQYLpkse----lk 580 
XP_002046100         498 ATCLLMGIILIFAVFSFLVLIGLFYFMVGLVTYQGACAPLrdlDKNALF-RELDAV-------IDLNRIIrardegrtse 569 
XP_002025591         551 ASCLLIAIILIFCVFSFITMVGVFYFMIGLVTYEGACAPTtqdEKYELF-RQLDAV-------IDMNRYLrptn----pg 618 
EDW32791             489 ASCLFIAIIMIFCVFSFITLVGLFYLIIGLITYTSACAPLkndQN--IF-RYLDPV-------IDINRYMsgst-----e 553 
EDW31944             551 ASCLLLAIILIFCVFSFITLVGLFYLMIGLITYTSACAPLkdgQN--IL-RHVDPV-------IDLNRYMsgr------- 613 
WGS:AADE:GA20556-PA  550 ANCLFLAILLIFCMISFITLMGLVYFMIGLVTYQGACAPLrdvDKNGLF-RQLDSM-------VDLNRYLpradd---ae 618 
FlyBase:CG7740-PF    532 ATCLLLAILLIFCVFSFIALVGLFYFMLGMVTYQGACAPLrdqENNTLF-RQLDAS-------IDLNHYLppse-----s 598 
KPU78240             559 ASCLLFAILLIFCVFSFLTLIGLFYFIVGFVAYQGACAPLrdqENNAFF-RQLDST-------INLNDYApav------- 623 
WGS:AAQB:GK12310-PA  631 deLVVPPFRMSSAIKACEANQSIFDMLRTNKIYDINDISRISVMTsheSDDSDHGPIFNEDLSTVVLLTAEERNRLNKLR 710 
EDO38922             544 -gNKSVSIKAGEVLSNCRQNMPAYKALKIESLFNISEQFDIKRLLg--ETIDKELDNLKVNLTDQKILNNDSRQSLKKLN 620 
XP_002046099         581 seTPLPPLRISNAIRACQADQSIFKLLQENDLYDIDDLVRFKVIS-----ETPSVPISLANLDNFTILTEKDKRDLAELR 655 
XP_002046100         570 veETGEELHMSKAIKACNQNQSIFDLLKHNNIYRVEDLTSISIMSe-sKEEDKKESIFEEDLSTVYLLTSDERIKLEKAH 648 
XP_002025591         619 deWVMPPLHMSEAVRSCRANESIFQLLRTNNIYDINDLANIILLP----DIPEEAPVFTEDLTKLEILTESEKILLNKVR 694 
EDW32791             554 vrEPFSTLPVSEAIRACNANESVFQLLRAKNIYDIKKLLNLEVFV----DGFEDPPLFTGDLSNVELILEKEKLLLTDMR 629 
EDW31944             614 sgDTQPTLPVSDAIRACNANESIFDLLRAKKIYDINNLLNKEIFV----EDFEDPPVFTGDLTTLKLILEEEKVHLNKMR 689 
WGS:AADE:GA20556-PA  619 plKAAPPLRMSNALKMCEANQSVFDMLRANRLYDINELKRIKVMSs--EEDSDSTKIFDEDMSKTELLTKEEFGKLEAMR 696 
FlyBase:CG7740-PF    599 nkEVVQPLKMSSAIKACHANQTIFDMMRQHNIYDINDLTRIKVMSh-sQENTDSIKVFDEDLSTVVLLTKEERDELKTAG 677 
KPU78240             624 gdDDRPPMRMSGTIKACHANQTIFNVLRDHHVYDIRELARVKVLTe-pDDDSDSSKFFDEDLSNTVLLTDAERKDLNTVK 702 
WGS:AAQB:GK12310-PA  711 NGNLSTYHSSLYMEYLCKEFTPMDLRSLAQS-IDSMYNSLeyp-------------------tyaWAKIQFYNAVYSMRA 770 
EDO38922             621 ESGVDDINFDSFLNQTRKGITKSNLTIFAAQ-LDELAKNFsragddqsggpatnsilkyivclfkELGNRTEEIAKDLRD 699 
XP_002046099         656 GSNLSSYHSKVFTDVMCTQLTPVDLPTMANQ-LKELRASLwsqw-----------------giydWARTSLYNEAYNLQR 717 
XP_002046100         649 TGNLSGYHSVLYVENMCQALTP-SLPTISAA-LRKLQDDLyynsrw--------------dsytrYGRIALLNEAYHFDM 712 
XP_002025591         695 NSNLSTYHSMLYDQNLCLKLSNNDLEVLANVlLEDLATDEavl--------------------kiDGRVHSILHKYSALA 754 
EDW32791             630 EGNLSEYHSSLYSEHLCTKFIHTDFSIIKSK-SMAFVYEIntky-----------------lkgwSGVIAYYLAAVDLIR 691 
EDW31944             690 AGNLSEYHSILYSEHLCTKFTHTDYSILKTK-TRAFAYEIntry-----------------lkgfPACLAYFLASSDLAK 751 
WGS:AADE:GA20556-PA  697 QGGAANYHSELF-KDLCSEFTPVNLNALGEK-MYALSNSLesp-------------------tfgWARVSFWNEGLNAKS 755 
FlyBase:CG7740-PF    678 ESKLAKYHSSLYMPSLCTQFTPMNLNALSEQ-LYKLSNDLeyp-------------------aygWAKVSFWNEGLNTKA 737 
KPU78240             703 ETNLSAYHSAMYLMNLCNQFTPMNLNALAEQ-MYKLSNDLeyp-------------------tygWAKVSFWNEGLNTKA 762 
WGS:AAQB:GK12310-PA  771 FHDNFVIKLSGIVDKMRENLKKIDElilyENHDFNSSITILVAAVLRSEHFIQTRGKEYINLLGSNLTVELTEQIEDYVN 850 
EDO38922             700 LDKNTAQQMRTKADDIEKNVNDLKA----IGGDLSNAAVNALNEAEKAEQYLYYSAGPDIATTVAKFAARVLGWGYQFTD 775 
XP_002046099         718 YHDEFVEKIKSIISKMTEKLLKIDElilyNGNAFGESIKKLHESTERSEVFLRANGEQYVSGLRANLTSYIKEQVVQYIE 797 
XP_002046100         713 YNYEWTDKILKIMGKMKQKLLKIDDlilyENRNFTNSITVLANAVIRAENFLKGRGSHFINSLGQNLTDVVNEQVDEFIR 792 
XP_002025591         755 YHKTFYLPVQRGIKKALKVVKEIDTlilyLNHDFGNSIEILLTAVINAENFVRKRGAEYVNNLGYNLTSAINEQVEEYIN 834 
EDW32791             692 YGNYFLDPLTSAVKKLLEKVKEIDKlilyDNNNFGDSFKILMDAVERSENFIRNKGNDYINHLANNLSTSVNLQIQEYVE 771 
EDW31944             752 YDKYLVVPLTNAVNKALQKVNEIDSlilyDNNNFGNSIGVLMDAVQRSEDFIRYKGNNYINNLAHNLSISVNLQLQEYIE 831 
WGS:AADE:GA20556-PA  756 YYQNFIPKLTTIVEKMKSNMKRIDElilyENRDFNNSIRLLLKAVRESQNFIQTKGTRYINELGKNLTSTISNMIDEYIS 835 
FlyBase:CG7740-PF    738 FYRNFVPKLTSLVEKMKANLKKIDElisyENHDFTNTIKILTATAINSEQFIQTRGKDYINALGGNLTNSIDQMIDDYID 817 
KPU78240             763 FHRNFVPKLNSIVEKMRHNLMKIDElilyENQDFATTIKILTETAIASEKFIKTRGNDYINTIIDNMTESIHENYDKYVD 842 
WGS:AAQB:GK12310-PA  851 MVITESNDNVGHCAPLSYIYYRGVDLICHRLVDPINGFWVGVLLCSLLFIPILFVAHRLMCLYK 914 
EDO38922             776 HVLNLVENNIGKCKPLTNIFDGTVMYMCNDLLYPFNGFWLSMGFCLFFFIPSIIFSVKLAKHYR 839 
XP_002046099         798 MVVDKCHGNVGKCAPLAQVYNRSVDLICHRLVDPMNGFWVGVLLCGVLFLPVLFVAHRLLCLYK 861 
XP_002046100         793 GIMDECSRKVGRCAPLSYIYYRGVDLVCYRLVDPINGFWMGILPAALLLLPLLYVAHKLMCLWK 856 
XP_002025591         835 MVITEANNKVGLCQPLAYIYYEGVYFVCSRLVDPINGFWLGLLLCSILLLPTLVVCHRLMCLYL 898 
EDW32791             772 RVIREAENNVGHCKPLAYIYHQGASLICERLVDPINAFWLATIFCCMLLLPVLLVAHCLMCLYS 835 
EDW31944             832 RVISEVNKNVGHCKPLAYIYSQSAYLICERLVDPINAFAMATLLCCMFLLPVLPVAHRLMCMYL 895 
WGS:AADE:GA20556-PA  836 MVIDESNENVGRCEPLAYIYHQGVDLVCRSMVDPINGYWVGVLLCALLFLPILYVSHRLMCLYK 899 
FlyBase:CG7740-PF    818 MIIKEANESVGHCAPLSYIYYRGVDLICHRIVDPINGFWVGILLCALLFLPILFVAHRLMCLYK 881 
KPU78240             843 MVINDAEYNVGHCAPLAYIYYRGVDHICHRIVDPINGFWVGILLCALLLLPILFVAHKLMCLYK 906 
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