4L59,4FL6,1WJS


Conserved Protein Domain Family
MBT_L3MBTL3_rpt1
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cd20132: MBT_L3MBTL3_rpt1 
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first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
Links
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Statistics
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PSSM-Id: 439122
Aligned: 8 rows
Threshold Bit Score: 223.26
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Structure:4FL6; Homo sapiens L3MBTL3 binds UNC1215, a potent and selective chemical probe for methyllysine; contacts at 4A.
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  • Structure:4L59; Homo sapiens L3MBTL3 binds UNC2533 through its first MBT repeat; contacts as 4A.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #  # #               #  #   #                                 
4L59_A        32 YNKNGFKVGMKLEGVDPEHqsVYCVLTVAEVCGYRIKLHFDGYSdCYDFWVNAdALDIHPVGWCEKtGHKLHPPKGYKEe 111 human
4FL6_A        32 YNKNGFKVGMKLEGVDPEHqsVYCVLTVAEVCGYRIKLHFDGYSdCYDFWVNAdALDIHPVGWCEKtGHKLHPPKGYKEe 111 human
1WJS_A         9 YNKNGFKVGMKLEGVDPEHqsVYCVLTVAEVCGYRIKLHFDGYSdCYDFWVNAdALDIHPVGWCEKtGHKLHPPKGYKEe 88  human
NP_001232893 229 QCKNGFRVGMRLEGIDPEHpsMYCVLTIAEVSGHRIRLHFDHFSdCYDFWVNSnSPDIHPVGWCEKtGHKLHPPKGMKDe 308 zebrafish
Q96JM7       259 YNKNGFKVGMKLEGVDPEHqsVYCVLTVAEVCGYRIKLHFDGYSdCYDFWVNAdALDIHPVGWCEKtGHKLHPPKGYKEe 338 human
XP_014353940 240 HNKNGFKVGMKFEGVDPEHpsMYCVLTVAEVCGYRMRLHFDKYSdGYDFWVNVdSPDIHPVGWCEKtGHKLHPPKGMKEd 319 coelacanth
XP_007897437 250 QSKNGFKVGLKLEGVDPEHpsMYCALTVAEVCGYRIRLHFDRYSdCYDFWVNVdSPDIHPVGWCEKtGHKLHPPKGFKEd 329 elephant shark
POI28471       6 YNKNGFKVGMKLEGVDPEHqsIYCVLTVAEVCGYRIRLHFDGYPdCYDFWVNAdSSDIHPVGWCEKtGHKLHPPKGYKEe 85  Chinese bamboo-...

Feature 1                             
4L59_A       112 eFNWQTYLKTCKAQAAPKSLF 132 human
4FL6_A       112 eFNWQTYLKTCKAQAAPKSLF 132 human
1WJS_A        89 eFNWQTYLKTCKAQAAPKSLF 109 human
NP_001232893 309 eFSWSSYIKLNKIQTAPKALF 329 zebrafish
Q96JM7       339 eFNWQTYLKTCKAQAAPKSLF 359 human
XP_014353940 320 eFNWPSYLKMCKAQAANKSLF 340 coelacanth
XP_007897437 330 eFNWHLYMKMCKAQAAPKSLF 350 elephant shark
POI28471      86 eFNWPSYLKACKAQAAPKSLF 106 Chinese bamboo-partridge

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