Conserved Protein Domain Family
RING-HC_CHFR
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cd16503: RING-HC_CHFR 
RING finger, HC subclass, found in checkpoint with forkhead and RING finger domains protein (CHFR)
CHFR, also known as RING finger protein 196 (RNF196), is a checkpoint protein that delays entry into mitosis in response to stress. It functions as an E3 ubiquitin ligase that ubiquitinates and degrades its target proteins, such as Aurora-A, Plk1, Kif22, and PARP-1, which are critical for proper mitotic transitions. It also plays an important role in cell cycle progression and tumor suppression, and is negatively regulated by SUMOylation-mediated proteasomal ubiquitylation. Moreover, CHFR is involved in the early stage of the DNA damage response, which mediates the crosstalk between ubiquitination and poly-ADP-ribosylation. CHFR contains a fork head associated (FHA) domain and a C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438166
Aligned: 19 rows
Threshold Bit Score: 83.9555
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #            # #  #  #                #  #           
Q96EP1       300 ETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSs------LCPTCRCPVERICKNH 353 human
EOB02347     310 ETLTCIICQELLHDCVSLQPCMHTFCAACYSGWMERSs------LCPTCRCPVERICKNH 363 mallard
EAL67780     400 ENLICGICQDIIYKCLTLIPCMHNFCVCCYGDWRANSm------DCPQCRQSVKSAQKNH 453 Dictyostelium discoideum AX4
ELR14310     232 DNMVCGICQELLYKCVALFPCMHNFCACCYSEWRERGn-----sQCPQCRTHVQGLSKNH 286 Acanthamoeba castellanii str. Neff
KJE96122     173 QNLQCGICMEILHDCVSVVPCLHDFCGACYSDWMEKKs------DCPTCRAKVTSISRNH 226 Capsaspora owczarzaki ATCC 30864
CAK77621     152 EDMHCPICDDLIFQCVSLVPCLHNFCGACFSDWMAKSk------TCPSCRKDVQSVNKNS 205 Paramecium tetraurelia strain d4-2
XP_031027615 189 EILTCGICQDLLFQAVSAVPCLHNFCGACFSAWIDKCkpm--apECPNCRTQCKLVKKNH 246 Synchytrium microbalum
NP_175188    134 EHAKCSICLNIWHDVVTAAPCLHNFCNGCFSEWMRRSeekhkhvLCPQCRTTVQYVGKNH 193 thale cress
XP_001451111 146 DELICTICNDYLFEAVTTNPCNHHFCGACLSTWLEKQlh----nDCPNCRVSIKSIMIAR 201 Paramecium tetraurelia strain d4-2
XP_001433660 178 DELQCTICNDYLFEAVAANPCNHHFCGSCLSNWFKKQt-----yECPNCRAKLTGVMQAR 232 Paramecium tetraurelia strain d4-2

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