Conserved Protein Domain Family
PIGO_PIGG

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pfam19316: PIGO_PIGG 
GPI ethanolamine phosphate transferase membrane region
This entry corresponds to the transmembrane region of the GPI ethanolamine phosphate transferase enzymes. The family includes the PIGO and PIGG proteins from human. These proteins are involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis.
Statistics
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PSSM-Id: 437148
Aligned: 65 rows
Threshold Bit Score: 445.878
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KJX99502     446 ASSYNIPFMATGMALTTVILLLSLLSLpASIfsrsP-TT--PA-TSF-FGLTTLLYTIMMFASSYVEEEQQFWYWLTPAW 520 
OJJ96307     379 AGNMQVCLLHYGIAIAVIALLLAWVTC-KSI----P-PP--SK-NFLvLNLFQLGHGITLLFPVLVEKEHLFWFWGSTVW 449 
OCT50539     434 ASNYDLVNMQIGIGLSTVAFTLCLPHFlKGV----V-QA--GFdGAF-LVLVMLSYAVTMFASSYVEEEHQFWYWTLAGY 505 
XP_007723141 432 ASKYDLGSMQIGIGLSVLALALCLPNFvQGV----Q-RC--GVeGFI-LCFIMLIYAFTMFASSYVEEEHQFWYWILGAW 503 
XP_007729818 432 ASNYDLRSMQVGIGLGVLALTLCLPSFtQGL----R-AG--GFeGVA-LVSIMALYAITMFASSYVEEEHQFWYWALGAY 503 
XP_009161071 432 ASNYDLASMRLGIGLGLIALSLCLPNFiNGI----Q-KYsyGNeSFA-LLLIMALYAVTMFASSYVEEEHQFWYWILGAW 505 
Q4WDM5       397 ASKYNTTRLYLGLFVAALAVLLSFFPAyGLG----SkYS--YA-VTF-LMLIIISYGGMMFASSYVEEEQQFWYWVVTAW 468  Aspergillus fu...
OJJ69254     437 ASDYDLRNLLLGLALIFLVVLLPLPTTyALL----SkSG--HS-GAF-FALSILSYGGMMFASSYVEEEQQFWNWIFTAW 508 
OJJ04600     438 ASNYDLGYLSLGICIASFAVVFSLPSAyRVL----SkYR--HP-GLF-LVASVLLYGAMMFASSYVEEEQQFWYWIFTGW 509 
CEL01568     434 ASNYDLRYLCLAICIAGLAILLLLPTSyEAL----RrYQ--QP-GLF-LVASIFSYGAMMFASSYVEEEQQFWYWSFTGW 505 
KJX99502     521 VLLLS-ISALP-Rt-tSa---SSr-tK-------VaAAAVAVLAVHRLMVRWNQTGQKHSGAEDIVHTLFPLHHNFMWML 586 
OJJ96307     450 MGWVI-LTTGC-S---S----YR---V-------S-LGNCTPLFLHMLSQRWNIHDRDAAEKVYSIQSLFQRRPLCLWFL 509 
OCT50539     506 LVILY-CKDSRfEvagNtsgpRAl-lG-------SaTGTALAIILFGVARRWRQTGQKYAGEADIISEVVAPNGWMLWSL 576 
XP_007723141 504 LIVLY-CKDSRyTfhgEs--tMA-----------GpMSTALVYVLFGVIRRWRQTGQKYAGDPDLLSDVVTPNPWILWVL 569 
XP_007729818 504 LIILY-FKGGRyAispEs--aVT-----------GsTQPALAYMLFGLVRRWRQTGQKYAGDPDILSEVVTPNPSLLWVL 569 
XP_009161071 506 LIILC-CKDGRyAappAn--eSArsgG-------SsIQTALAFLLFGVVRRWRQTGQKYAGGPDLLSELVTPYPWLLWTL 575 
Q4WDM5       469 TVYLH-IKSLR-Pw-hGsk-dTR---------------------------RWNQTGQKFAAEPDIARDFFPRHQNILWAL 517  Aspergillus fu...
OJJ69254     509 VFYLHvRSSIL-Pl-cS-------------------YGALALLLSHRVLRRWNQTGQKFATEPDIARTFLPSHRLILWFL 567 
OJJ04600     510 VFYLH-ARSFRtEr-vTpdveNDk-aSrvmanvfTaAGSVALGVSHRLLRRWNQTGQKFAAEPDIAREYFPSHQSSLWVL 586 
CEL01568     506 AFYLH-VRSCQfRr-gTspagSQr-iShs---llRiYGAAALTICHRILRRWNQTGQKFATEPDIARTYFPNHQGALWAL 579 
KJX99502     587 ILLSYAVTGWGMMRTT-Fa-DlLPA-----EVEALVAVMAVVPAIVFKLNFTQADAPELVGELAEGLRs-WTG-QWSLLV 657 
OJJ96307     510 IAVTLLHTSYIFTVHP-R--AnVTRgaqekPLLVLAHRAILLTIFLFKFASAARAGPGLIDRAPEWLQgiILE-QLPLTR 585 
OCT50539     577 VMLTYAVLSRNLSRRTgVwmG-SPQ-------MGVLPALVSISAFLFKIAFTAADAPELLDSFPILNPlvRFVsAYPLVS 648 
XP_007723141 570 VVITYAVPSRNLSRKAaVwmG-AKQ-------MGLLPVLVTLSAFFFKIAFTAADAPELLQTFPIFKPlvSFVsHYPLVS 641 
XP_007729818 570 VVLTYALLSTNLSRRAvTwtG-ARQ-------MGLLPALVSTSAFLFKIAFTAADAPELLQAFPIFGPlvSFVsRYPLVN 641 
XP_009161071 576 VVLTYVQLTVNLSQKTsTwvN-VRQ-------MGLLPVLVSISAFLFKIAFTAADAPELLQDFPLFDAlvGFVsRYPLVN 647 
Q4WDM5       518 IILTYFDTCMHLCLNS----H-SSN------IWRSAAILTTIAAFFFKLVFVASDSPELLYESLLSPIqkSLE-EMPLVP 585  Aspergillus fu...
OJJ69254     568 VISTYANTCRHLLAHR----P-LSK------LWQLYCVALALGAFFLKLSYVASDSPELLPEALLVLWkrEFD-GASTVL 635 
OJJ04600     587 VGITYTGVYSQLMNNF----S-PSW------MSRFFCLSVTATSFMFKLVFAESESPELLNGTVFRDIanLLS-GISLVI 654 
CEL01568     580 VMVAYADIYLYLIQSS----S-PSP------LWYLTCLVVTVVAFTYKLAFAAIESPELITEFVPSRIatALK-GVPLVL 647 
KJX99502     658 QAQFV-------------------FLVLGGVGVGSVVLAVASARaRKSL---Gg-EGGGdglpslaerLHYPLTLFLMTQ 714 
OJJ96307     586 MAQFI-------------------FVSLAIGGGYVVLRSCAQEAsLKSV---DatELPP---------LLEVLNLYLFMQ 634 
OCT50539     649 LARVV-------------------FVGLIHLLGCAIYYETPWKG--AEH---L----GKfl-----taFQDVLSLFLITQ 695 
XP_007723141 642 LAKIV-------------------FLGLAQILACAVYYEAPWKS--TQH---L----QSll-----taFQDVLSVFLITQ 688 
XP_007729818 642 LARVV-------------------FLGLAHLLACAVYYEKPWKS--ARQ---L----QSfl-----taFQDVLSIFLITQ 688 
XP_009161071 648 LARVV-------------------FIGLAHLLLCAIYYETPWKS--ARH---L----ASfl-----tvFQDVLSIFLATQ 694 
Q4WDM5       586 PARLSkavnipiflmfrlqaiildFLKMSAIEVTLTSLLSQNMT-FFAF---G--GSNAi-------------------- 639  Aspergillus fu...
OJJ69254     636 FTRLVv-------------------VGILSLVPFSM-CTCNNLQ-R-LV-------PSTv--------FHEALTLFLVTQ 678 
OJJ04600     655 YARAT-------------------MVGIAILLLLTA-SNGIKEF-CMDVlmeT--VSSGi-------vAHEALTLFLLTQ 704 
CEL01568     648 YARLV-------------------MFGILILWAIGA-KFRRKG------------ASPGt-------vAHEALTLFLVTQ 688 
KJX99502     715 TRAPNVPLFLGMEVQRRALgyllspRRptTDtpptpaaadghtTRVLEVATTTLLLTHTTFFATGGSNSISSIDLSNAYN 794 
OJJ96307     635 TIPGNIPLLLIYRIQLKWIv-----SSa-AN------------LSAFQVCFSIVLFTHSAFFAFGNANTIAALRYTEGFN 696 
OCT50539     696 TRTVYVPLFLFFNAQLWLLr-----RR--RC------------HSITEAATLALLFQYASFFAFGGTNSISTIDLSNAYN 756 
XP_007723141 689 SRTVYIPVFLFFNLQLSLLr-----RG--RR------------YSIGEITILGLLFQYATFFAMGGTNSIATVDLSNAYN 749 
XP_007729818 689 SRTVYIPLYLFFNLQLYLLr-----RG--RR------------YSVGELGILALLFQYASFFAMGGTNSIATIDLSNAYN 749 
XP_009161071 695 SRTVYIPLYLLFNLQLSLLr-----RG--RR------------YSTGEVTILSLLFQYLSFFAMGGTNSIATIDLSNAYN 755 
Q4WDM5       640 ----------------------------------------------------------------------SSVDLSNAYN 649  Aspergillus fu...
OJJ69254     679 TRATNIPIFLILRAHANIL------AT--MK------------LPALELAITSLIMQYMTFFAFGGSNSIATVDLSNAYN 738 
OJJ04600     705 SRVTNIPIFSILRLQLKVL------AS--MG------------LTSVETTITTLLMQYLTFFAFGGSNAISSVDLSNAYN 764 
CEL01568     689 SRVPNIPMFLALRLQLQIL------AS--FN------------LTSVEITVTSLFMQYVTFFAFGGSNAISSIDLSNAYN 748 
KJX99502     795 GVSDYNVAAVGGLLFVGNWAGGVWWCSAAVLLLnaagRKsgrdvavaaqEekggrdwvrRErEreaeetkravssppssh 874 
OJJ96307     697 GLQAHHWLLSPVHTFCSNYAGPIWWSGNGLRLL----VA----------Tg--------QG-E----------------- 736 
OCT50539     757 GVSGYNVGAVGILTFVSNWAGPIWWAFGTCQLFs--tAQl---------G---------TD-N----------------- 798 
XP_007723141 750 GVSGYNIVAVGVLTFVSNWAAPVWWAFAVCQLIs--iGDl---------N---------NG-G----------------- 791 
XP_007729818 750 GVSGYNVVAVGILTFVSNWAAPIWWAFAVCQLFs--vVDl---------S---------NG-G----------------- 791 
XP_009161071 756 GVSGYNVVAVGVLTFVSNWAASIWWAFAVCQLLv--dPEg--------lN---------NG-H----------------- 798 
Q4WDM5       650 GIGSYSVVLVGVLTFISNWAGPIWWASAARLLYs---NP----------T---------FA-E----------------- 689  Aspergillus fu...
OJJ69254     739 GIGTYNVVLVGILTFMSNWAGPIWWVSAARVLRl---SQ----------A---------RH-E----------------- 778 
OJJ04600     765 GIGNYNIIFVGILTYVGNWAGPIWWVSATKLLRa---GQ----------T---------WD-E----------------- 804 
CEL01568     749 GVGNYNIILVGILTYVGNWAGPIWWVSASKLLRs---RR----------P---------WD-E----------------- 788 
KJX99502     875 sssanhrtaaeaetAGGkgG-WQLYLSLQTTFIACSLLGVMASCTALRTHLFIWTVFSPKFLYAMAWSGGWHLGVNVMVG 953 
OJJ96307     737 --------------RSGr-SdLFEHLGLRTVFVAYGLVGAMGACYLLREETVVWTVMAPKFLYTVLWTVPFHLLFNMAMP 801 
OCT50539     799 ---------------YS----F--LSTALATFACIHTLSVMVACMVLREHLFIWTVFSTKYLYTAAWVMGQHIFVNVLAI 857 
XP_007723141 792 ---------------YS----F--LLTTLATFAGVHALAVMVACTFLREHLFIWTVFSPKYLYTAAWVVCQHTIINSLGV 850 
XP_007729818 792 ---------------YS----F--LLTALATFSCVHALAVMVACTFLREHLFIWTVFSPKYLYTAAWVVGQHTIINTMGL 850 
XP_009161071 799 ---------------SG----F--LLMSLSTFACVHTIAVMVACTVLREHLFIWTVFSPKYLYTAAWIVGQHIVINSISV 857 
Q4WDM5       690 ---------------RY------GQRTLLTFHAATSLMSVMAACTMLRTHLFIWTVFSPKYLYTLAWTILNHMFINLPAT 748  Aspergillus fu...
OJJ69254     779 ---------------RE------SHMAVLTFHMAVTLMSVMAACTILRSHLFIWTVFSPKYLYAMAWTIFNHLAVNLLGE 837 
OJJ04600     805 ---------------MQ------THISLLTFHTATTLVSVMAACTALRTHLFIWTVFSPKYLYTMSWAIIHHLAVSLLSE 863 
CEL01568     789 ---------------RQ------SHIPLLSFCVACTLLSVMVACTVLRTHLFIWTVFSPKYLYTISWAIIHHFAVNLLWE 847 
KJX99502     954 gLAGWLSGW 962 
OJJ96307     802 -IVLWVGGR 809 
OCT50539     858 gTLLWRGSE 866 
XP_007723141 851 gTLLWQIGT 859 
XP_007729818 851 gMLLWQGDR 859 
XP_009161071 858 gALLWHSST 866 
Q4WDM5       749 aNVSQVLNW 757  Aspergillus fumigatus Af293
OJJ69254     838 tLHFISTRQ 846 
OJJ04600     864 vSQLFSAIT 872 
CEL01568     848 iDLFFADAS 856 
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