Conserved Protein Domain Family
BicD

?
pfam09730: BicD (this model, PSSM-Id:430782 is obsolete and has been replaced by 462863)
Microtubule-associated protein Bicaudal-D
BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta pfam05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells.
Statistics
?
PSSM-Id: 430782
Aligned: 6 rows
Threshold Bit Score: 938.897
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q921C5        83 GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKEINQNVEIQRGR 162 house mouse
3_pfamImport   1 GQAYSTHRKVAADGESREESLILESASKEALYQQKLLELQNELRQAKASFSSVQAENERLASIVLDMRENSELAELQRGQ 80 
1_pfamImport   1 GQAYTNHRKVAADGESREESLIQESACKEAYYEQRVLELQNDLRQARNLVANAQSENDRQNALSQEIKDHSQMVELQRNQ 80 
XP_006507087  74 GQSFSIHRKVAEDGETREETLLQESASKEAYYLNKILEMQNELKQSRAVVTNVQAENERLSAVVQELKENNEMVELQRIR 153 house mouse
AAI34922      81 ADSVSSHKRAAADGESREERLLQESANKEAEMDIRMDELQAELKQARVMLNNTSAENERLVSLSTQMKKECECLEVEKTR 160 zebrafish
2_pfamImport   1 -DSVSSQKRAAADGECREECLLQETASKEAAMATRIEEVQAELKQTRLALSNTHAEIDRLAVFSTQLKKECECLEAEKGH 79 
Q921C5       163 LRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEE 242 house mouse
3_pfamImport  81 LRDDIREYKVREARLLQDCSELEEENISLQKQVSVLRQNQVEFEGLKHEIRRFEEDSQCLQSQLEEAVRLREIAERQLTE 160
1_pfamImport  81 LRDDIKEYKLLEARLLQDYTELEEENITLQKQVSVLKQSQVEFEGLKHEIRRLEEDTQFLNSQLEDAIRLKEIAERQLGE 160
XP_006507087 154 MKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEE 233 house mouse
AAI34922     161 MREEMKEYKTREAQQLQDNSELEEENISLQKQVSVLKENQVEFESVKLELTHKDEELELMRAQLEEAGRLREIAEHQLDE 240 zebrafish
2_pfamImport  80 MRDEMKEYKVRELRLLQDNAELEEENTSLQKQESVLKENQVEFEGIKLELTQKNEEQEELRGQLDEAARLREIAEKQLDE 159
Q921C5       243 ALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDD-TVTAEPNNDaEALvNGFEHSg--LVKSSLdn-k 318 house mouse
3_pfamImport 161 ALETIKTEREQKATLRKELSHYMTIGGSVYGGSFSISIDNLKLHEDpSANTEPDND-DLI-RGFENGl--LKVSEG---- 232
1_pfamImport 161 ALETIKTERELKASLRKELSHYMNIGDALYNSPLSISLDGLKFSEE--AATEPNND-EAL-LGYENGftkLANAINydnc 236
XP_006507087 234 ALETLKNEREQKNNLRKELSQYINLSD----SHISISVDGLKFAED---GSEPNND-DKM-NGHIHGp--LGKLNGdy-r 301 house mouse
AAI34922     241 ALEALKEEREQKNSLRREVAA-LTLNPFDSISHLEIQL---NDSRDgEKDREEGEEdEEM-DSGYNNskgMErn-----r 310 zebrafish
2_pfamImport 160 ALEALKEEREQKNSLRRELSA-LTLNPFDSVGNLELHLDQLDDSREeGRGGEREGEgEDQ-DSGFNNg-gSKNNGLlh-r 235
Q921C5       319 tSTPRKDGLA--PPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENL 396 house mouse
3_pfamImport 233 -GEDKKGEAF--KPAPSLVDDLLSELNICEIQKLKQQLMQVEREKVVLISSLQESQKQLEQAYGTVSEQKETVNRLTENL 309
1_pfamImport 237 vSTP-KKELF--PPAPSLVDDLLSELNISEIQKLKQQLMQMEREKVNLLTTLQDSQKQLEQANGALSEHQDKVNRLTENL 313
XP_006507087 302 tPTTRKGESL--HP----VSDLFSELNISEIQKLKQQLIQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHV 375 house mouse
AAI34922     311 cSTPRNSEVFlrPQAPGLVSDLLSELHLSDSQKLKQQLIQVEREKATLSSTVHELQQQLVQSKDAFSEQQEKMDQLTQHL 390 zebrafish
2_pfamImport 236 fSTPRSSDVFlrAPASGLVSDLLSELQFSDSQKLKQQLLQTEREKTSLVDKVEELQMQLVMSKQALSQQEDKVGSLTQQL 315
Q921C5       397 SALRRLQAGKERQTSLDNEKDRDSHED---GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEK 473 house mouse
3_pfamImport 310 SAMRKLQASKERQSALDSEKDRDSHDD---GDYYELDINGPEILQCKYTVAMSEAGELRQELKTLRAKYEKCRNQYEEEQ 386
1_pfamImport 314 NAIRKLQASKERQSALDNEKERDSHED---GDYYEVDINGPEILECKYKVAVSEAGELKEELKTLKAEYQACQSRYEDDR 390
XP_006507087 376 NAMRGLQNSKEIKAELDCEKGRNSAEE---AHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTEEK 452 house mouse
AAI34922     391 ENLQNMITKRSAEDGNRMSSSPTSQDPengINYYEVDTKSTEVLECRMQAANEELARLHVKLKDAEKRYKTLEERCKLEK 470 zebrafish
2_pfamImport 316 EAVKG-----GQQDADDSGDQKSENAT----LEYEVDTKSKEVLEARMRSASEELLKLRDELTQAGARYNTLEQRYKQEK 386
Q921C5       474 GRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNR 553 house mouse
3_pfamImport 387 TRLERDVQELRSKLQTLERISHLDKAEMARLEKELRLVSEAAGESLGSLNVAQDELISFSEELANLYNHVCMCNNETPNR 466
1_pfamImport 391 ARLENDVTTLGEKLASLEKTSHVDREEKNKLETELRKLRDVAGESQGSLSVAQDELVTFSEELATLYNHVCMCNNETPNR 470
XP_006507087 453 TKYESKIQMYDEQVTNLEKTSKESGEKMAHMEKELQKMTGIANENHNTLNTAQDELVTFSEELAQLYHHVCLCNNETPNR 532 house mouse
AAI34922     471 QRWRGEAQDLADQIRQCITASRQDQERIGQLEREIGATRKVATDSEGHLSAAQEELLAFSEDLANLYHHVCVSNNLTPSR 550 zebrafish
2_pfamImport 387 DRWRAEAQDLADKIRQCIKSSKQDQERIGELEKEIGATRKVASDSEGHLSVAQEELLAFSEELSILYHHICVCNNLTPKR 466
Q921C5       554 VMLDYYREGQGKAGr---TSPEGRGRRSPVLLPKGL-------LATEVgradggtgDNSPSPSSSLP-SPL--------- 613 house mouse
3_pfamImport 467 VMLDYYKQGKAIIK----KGQEGKEPPSSILLTNGM-------IETEV--------KNSPSGNSSVTlAPT--------- 518
1_pfamImport 471 VMLDFYKEGKGGR-----SSPEGRGRRSPILLTKGL--------FPEPgkt--dlsDRAPSPVSSLP-SPV--------- 525
XP_006507087 533 VMLDYYRQSRVTRSgslkGPDDPRGLLSPRLSRRGVsspvesrTSSEPvskentetSKEPSPTKTPTiSPVitappsspv 612 house mouse
AAI34922     551 VTLDYYREGAQAVRt--qNHQLPHHYRGSLRRQRRS---------GEVldpnstgsGDAPSNCGSCPgSPT--------- 610 zebrafish
2_pfamImport 467 VTLDYYRDGARASAr--kSHVYPQHLRKPRADDVFAskasvlqFMGEMdta--gtgSESP----NCPgSPI--------- 529
Q921C5       614 ---SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA----SQELGPAVDKDKEALMEEILKLKSLLSTKREQI 686 house mouse
3_pfamImport 519 ---SDHRPEPMNIYNLVAIIRDQIRHLQQAVDRTTELSRQRLA----NLELSSVADKDKEACMEEILKLKSLLSTKREQI 591
1_pfamImport 526 ---SDHRREPMNIYNLVAIIRDQIKHLQLAVDRTTELSRQRVA----SLELGTVADKDKEACMEEILKLKSLLSTKREQI 598
XP_006507087 613 ldtSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA----ARELAPMIDKDKEALMEEILKLKSLLSTKREQI 688 house mouse
AAI34922     611 ---LDFR-DPTNVRNLVAVIRCQIKHLQVAVD----LCRQRSLlsspAAGGSTESDRDTEALIEEVLKLKSLLSTKREQI 682 zebrafish
2_pfamImport 530 ---LDFR-DPSNVRNLVAVIRCQIKHLRVAVD----LCRQRGAvpysGLSSSEESERDAESLLEEVLKLKSLLSTKREQI 601
Q921C5       687 TTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAA 766 house mouse
3_pfamImport 592 ATLRAVLKANKQTAEVALANLKSKYDSEKAMVKETMMKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDDMQRQLAA 671
1_pfamImport 599 ATLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKGLKEDAATFSSLRAMFATRCDEYVMQLEEMQRQLTA 678
XP_006507087 689 ATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAA 768 house mouse
AAI34922     683 ATLRTVLKANKQTAELALTNLKTKYETEKSMVTETMMKLRNELKALKEDAATFSSLRVMFASRCDQYVTQLDEMQRQLAA 762 zebrafish
2_pfamImport 602 ATLRTVLKANKQTAELALSNLKTKYETEKSIVSETMMKLRNELKALKEDAATFSSLRVMFASRCDQYVTQLDEMQRQLAA 681
Q921C5       767 AEDEKKTLNSLLRMAIQQKLALTQRLELLEL 797 house mouse
3_pfamImport 672 AEDEKKTLNSLLRMAIQQKLALTQRLEDLEF 702
1_pfamImport 679 AEDEKKTLNSLLRMAIQQKLALTQRLEDLEF 709
XP_006507087 769 AEDEKKTLNTLLRMAIQQKLALTQRLEDLEF 799 house mouse
AAI34922     763 AEDEKKTLNSLLRMAIQQKLALTQRLEDLEA 793 zebrafish
2_pfamImport 682 AEDEKKTLNSLLRMAIQQKLALTQRLEDLE- 711
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap