Conserved Protein Domain Family
zf-C3HC

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pfam07967: zf-C3HC 
C3HC zinc finger-like
This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.
Statistics
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PSSM-Id: 429759
Aligned: 22 rows
Threshold Bit Score: 114.008
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001385117 100 PFNADQLVARLKTFTALN-WhipslpscegVVSENTLNELKCARNGWKCvsFSlnn-ntKNHLLCTTCNQSLVLKfsegq 177
NP_001070846  65 aaNKEAFFNRVESYSCLK-W----------AGKPSVLSPLRCARYGWIN--VD------CDMLKCCSCQAFLCAS----- 120
Q5M8S7        63 STSKDAFFGRVESFSSLK-W----------AGKPSELCPLICAKYGWSN--IE------CDMLKCSSCNAYLCAS----- 118 tropical clawed...
Q3SZH2        72 sTSKEAFFSRVETYSSLK-W----------AGKPSELSPLVCAKYGWVT--VE------CDMLKCSSCQAFLCAT----- 127 cattle
Q9GYR0        48 YRDMETYHKIIKTYKAPT-W------------YGCAVSPRDLADYGWAC--VK------KDCVKCIECEQYLSTVl---- 102 Caenorhabditis ...
XP_002634353  47 IRDVEAYKKIIKTYKAPT-W------------FGCAVSPRDLADYGWEC--VK------KDCVKCVECEELLCTSl---- 101
XP_001485757 109 PYSRPQLLHRLASYTALN-Wslpe---salALKLWEVSELKCAQNGWRC--VSirnsnlKNHLVCDVCHHQLILRynevh 182
XP_001422026  49 PLSRADYFRRLRAFRDCVrWn---------FDKPSALQGPACAARGWTL--EA------RDLLRCETCEALLAYPg---- 107
Q5KC46       119 PFSALSLLSRLMTFQPYT-Ys---------PQHPLTLSPVRAAMKGWVN--EG------REGLKCDVCGARWGLGg---- 176 Cryptococcus ne...
O94506        40 PWSREEFLRRLLTYRSR--Wa---------YVNDPQIGEINCCLNGWLC--ES------NNILVCDVCRNKINLTalq-- 98  Schizosaccharom...
XP_001385117 178 qqkeysafdydflknsSIEASCNQLNNALHNKYLDQVVyEGHSPSCSWRNFETPlEGIYYPrpyLNKTnERLLRDYLKNL 257
NP_001070846 121 ----------------IQATLDFQKYKGRISEVRQQLQ-TQHEKFCSWPDFPCP-DRFWMVp--INEP-TVLLAAFLERY 179
Q5M8S7       119 ----------------LQPVLDFSKYKQRCVELQEALR-KAHEKFCFWPDSPCP-DYFWALm--VTEP-SSVLSDFVGRF 177 tropical clawed...
Q3SZH2       128 ----------------LQPAFDFDRYKERCAELKKALC-TAHEKFCFWPDSPSP-DRFGMLp--LDEP-TVLVSEFLDRF 186 cattle
Q9GYR0       103 ---------------pNICKVSFNVYNSSLQDIHEKMT-TAHRTTCKLRCGAPPfRIVEPTakeVMDGiQRRLSDSKKII 166 Caenorhabditis ...
XP_002634353 102 ---------------pNICKVSFNVYNSRLQEIHDQLS-SAHRTTCKLRTGAPPiRFTEPTskeIMSGiQSRLSDSKSIE 165
XP_001485757 183 -----------dsifdFDVEEVAQLNVNLARSYLKQITtKAHGTACPWQSLETPlQGVYYMrpfLKNTnETLLAEYRKAL 251
XP_001422026 108 ----------------NVDKLDEDARKDVNERVMKDLV-DTHERGCAWRETGCS-TSARGFp---AASaDETRADFASRV 166
Q5KC46       177 ----------------LEKVRDEAMKSNLGERLAKGFE-ERHEKNCAWRICASPgNLYEQLrhlVHPPiTSSLAPLAS-- 237 Cryptococcus ne...
O94506        99 -------------qvdAENDSLNELPEKTKERLEVSLK-EEHQDNCLWRLHKFPpDIYHLSv-------SAELVQVGRRF 157 Schizosaccharom...
XP_001385117 258 KNLM-----DNGMILNE 269
NP_001070846 180 KSACll--eQQLPAMKp 194
Q5M8S7       178 DNLChl--eIQLPSIKH 192 tropical clawed frog
Q3SZH2       187 QSLChl--dLQLPSLrp 201 cattle
Q9GYR0       167 DEDLk----ADIPSDVN 179 Caenorhabditis elegans
XP_002634353 166 DDDFv----VHIPSDVN 178
XP_001485757 252 SGLVrh--wRVLELQIS 266
XP_001422026 167 DAIArr--gGKLPMVVG 181
Q5KC46       238 -HLLle--cLALPSLRL 251 Cryptococcus neoformans
O94506       158 NSLStrlvsTHLPEEMT 174 Schizosaccharomyces pombe 972h-
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