Conserved Protein Domain Family
APC_basic

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pfam05956: APC_basic 
APC basic domain
This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Statistics
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PSSM-Id: 428690
Aligned: 11 rows
Threshold Bit Score: 289.469
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015220786 2017 VVFRGRTVIYMPNpKKETNssqKPPLKKTSPKT--------ETPV-KNPNLAQQRSRSLHRLGRANDSTELSLPKRSSTP 2087
XP_008122667 1928 VVFRGRTVIYMPKvSKESQ---VQSPRCTPKKTgpi--tktESPL-KNGNLNQQRSRSLHRPGKISEIADLSLPKRSATP 2001
EDL31570     1757 TMLRGRTVIYSAGpASRTQskgISGPCTTPKKTgtsgttqpETVT-KAPSPEQQRSRSLHRPGKISELAALRHPPRSATP 1835
XP_006050589 1816 AVLRGHTVIYMPTpATRAQprgAPGSRIVARKMgapspvqpAAPT-KAPNPGQQRSRSLHRPGKISELATLSPPQRSATP 1894
XP_012904217 1784 AVLRGRTVIYVPSpAPRAQpkgHPGTHVAPRKMgppspaqpGAPA-KTPSPGQQRSRSLHRPGKSSELAALSPPQRSATP 1862
P25054       2223 SISRGRTMIHIPG-VRNSSsstSPVSKKGPPL---------KTPAsKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQ 2291 human
XP_014351222 1935 mVSRGRTMIHIPG-VRNSSpstSPVSNKTPPK---------NTPS-KSPSSNQISSNS-PRGFKGSGKSDPNPVGRQTGA 2002
XP_007240270 1960 VVFRGRTVIYTP--KKETTlsqRPPPKKVTPK---------DAP--KNPNLAQHRSRSLHRLGRPNDSTQLSLPKRSSTP 2026
XP_011472584 1954 VVLRGRTVIYTP--KKETApsqRPPPRKVSTKT--------DAP--KNPNLAQHRSKSLHRLGHPQD-TELSLPKRSYTP 2020 Japanese medaka
XP_022536604 2175 VVSRGRTMTHVPG-VRSSSpstSPIPKKPPAR---------GQVA-KPPSQGPNSVNS-PRSIKPPSKTDPSPARESPAT 2242 Mexican tetra
XP_005999939 1983 VVFRGRTVIYMPk--------eSASPRSTPKKTak-----nDAFP-QNSNQLQQRSRSLHRLEKSTELADLSLQKRSATP 2048 coelacanth
XP_015220786 2088 PARIPKSTSSGSSQNSTPSRQPQKKLTSPSQSSKQIPKKDVK------------------------------------PT 2131
XP_008122667 2002 PARMTKAPSSGSSRTSTPSQPNQKKLTSPSQPQASSRGSGKAdls------------------------------sssPG 2051
EDL31570     1836 PARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGS-------------------------------------- 1877
XP_006050589 1895 PARLAKTPSSSSSQTSPASQPLPRRSPPAAQPAGPLPGPRAS-------------------------------------- 1936
XP_012904217 1863 PARLAKAPSSGSSPASPASQAPTRRLPTGTQAAGPLPGPGAA-------------------------------------- 1904
P25054       2292 IGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRngi------------------------------sppNK 2341 human
XP_014351222 2003 QGGSSKGTSRSGSRDSTPSRPAQQPLSRPMQSPGRSSISPGRngi------------------------------nppNK 2052
XP_007240270 2027 PARIPKSSSSGSSQSSTPCRQPYKKITSPTQTVKQSPKVASSa-----------------------------------PS 2071
XP_011472584 2021 PPRIPKSSSSGS----------------------------GSsqsstpskqsqkkitsptqtnkaiekksttspsgssvs 2072 Japanese medaka
XP_022536604 2243 PGGSSKASSRSGSRDSTPSRPPQQSLTRPMQSPGRNSVSPGRngl------------------------------tppNK 2292 Mexican tetra
XP_005999939 2049 PARISKGPSSGSSRNSTPSRQPQKKLTSPSQINKQLTGPGTRsng----------------------------------- 2093 coelacanth
XP_015220786 2132 NSPTDKKTSPAaspsPK--------SpahKKTQKSPVRIPFMQTPSR-QPMASRTISPLVTNQPSpg---iSRQNTQLKR 2199
XP_008122667 2052 ANPKPVQKSPA----SK--------Q---NKTQKSPVRIPFMQKPAK-KTILMRNTMPVLEEQVGrgtgrdPRPKSNVKG 2115
EDL31570     1878 ----LVPKSPArallAK--------Q---HKTQKSPVRIPFMQRPAR------RVPPPLARPSPEp----gSRGRAGAEG 1932
XP_006050589 1937 ----PVPKTQArallAK--------Q---HKTQKSPVRIPFMQRPAR------RGPPPLARAAPEp----gPRGRVGAEG 1991
XP_012904217 1905 ----LVPQTPTrallSK--------Q---HKTQKSPVRIPFMQRPAR------RGPPALARAAPEp----gPRGRAAAEG 1959
P25054       2342 LSQLPRTSSPStastKS--------SgsgKMSYTSPGRQMSQQNLTK-QTGLSKNASSI------------PRSESASKG 2400 human
XP_014351222 2053 LSQLPRTSSPSpgstKS--------SgsgRMAYTSPGRHLGQQPPSK-QTNLPKSASGI------------PRSESASKG 2111
XP_007240270 2072 SPPEKKGCVSPpnqnPK--------SppdSKTQKSPVRIPFMQNPTR----QSRAISPLVTNQPTst--nrPNSGTQITG 2137
XP_011472584 2073 spPERKGRSPVvnknEK--------Sp-pPKTQKSPVRIPFMHTSTK----QPRPLSPLVTNHTV------NRQISQVNG 2133 Japanese medaka
XP_022536604 2293 LSQIPRTVSPSaa-sKP--------AgsgRMTYASPGRQLSQHTPSKqQSGLPRSTSGI------------PRSESASKV 2351 Mexican tetra
XP_005999939 2094 -sipEKKCNPAvsttTKsdnkspgpK---NKTQKSPVRIPFMQTPTKkVIPQRNNSSPLINQF--------NRQKQNLNG 2161 coelacanth
XP_015220786 2200 t-------LPANRLDLVRMSSTRSSSSE-SDRA---GFLRQLTFIKESPS-LLRQRSEIPSS-RS------VPT-SKCAS 2259
XP_008122667 2116 t-------LQSSRLNLVRVSSARSVSGE-SDRS---GFLRQLTFIKESSTlLMRHRTKLSSS-SAprasspCSSlSQGAS 2183
EDL31570     1933 tp-----gARGSRLGLVRMASARSSGSEsSDRS---GFRRQLTFIKESPGlLRRRRSELSSA-DS------TAStSQAAS 1997
XP_006050589 1992 gs-----aARGGRLGLVRMASARSSGSEsSDRS---GFRRQLTFIKESPGlMRRRRSELSAP-EA------TNPtTQAAS 2056
XP_012904217 1960 sp-----gARGGRLGLVRVASARSSGSEsSDRS---GFRRQLTFIKESPGlLRRRRLELSTP-EA------ARPaSQGGS 2024
P25054       2401 lnqmnngnGANKKVELSRMSSTKSSGSE-SDRSerpVLVRQSTFIKEAPSpTLRRKLEESASfES------LSPsSRPAS 2473 human
XP_014351222 2112 lnhs-ansGSGKKVELSRMSSTKSSGSE-SDRSerpVLVRQSTFIKEAPSpTLRRKLEESASfES------LSPsSRPAS 2183
XP_007240270 2138 rr-----iLPANRLDLVRMTAAHSRSGE-TDRN---GFLRQLTFIKESAN-VSRQ--DIPGS-RS------VPT-SKHGS 2197
XP_011472584 2134 kr-----mAPVNKFDLVRMTSVHSNGSE-SDRS---GFLRQLTFIKESKT-ALRR--D-SCP-RN------MPG-SQNGS 2192 Japanese medaka
XP_022536604 2352 lnqs-gasGPPKKAELSRMSSTKSSGSE-SDRSekpGLVRQSTFIKEAPSpTLKRKLEESASfES------LSP----SS 2419 Mexican tetra
XP_005999939 2162 k------nLQPTRLDLVRMSSARSSGSE-SDKS---GFLRQLTFIKESSShILRQRSEISSS-ES------LSSlSRCAS 2224 coelacanth
XP_015220786 2260 PRKMR-------PGAPAAFLCSSRCQELKgvGQGPRE---------------------TQdegqgqga-----qrqraal 2306
XP_008122667 2184 PRRGR-------LGLPTVFLCSSRCDDLK--AEKPLG---------------------ASqrp---------------vi 2218
EDL31570     1998 PRRGR-------PALPAVFLCSSRCDELRvsPRQPLA---------------------A--------------------- 2028
XP_006050589 2057 PCRGR-------PALPAVFLCSSRCDELRvgSRQAPA---------------------P--------------------- 2087
XP_012904217 2025 PRRSQ-------PALPAVFLCSSRCDELRaaPRQAPV---------------------P--------------------- 2055
P25054       2474 PTRSQaqtpvlsPSLPDMSLSTHSSVQAGgwRKLPPN---------------------LS-------------------- 2512 human
XP_014351222 2184 PTRSQiqtpvlsPSLPDMLVSAHSPHQINswRKSPHN---------------------HN-------------------- 2222
XP_007240270 2198 PRRAR-------PGAPAVFLCSSRCQELKptAQGPRR---------------------LQglqgqrngqeqgilkqnmtl 2249
XP_011472584 2193 PRRAV-------PGAPAVFLCSSRCQELKatVQAPKRvqvkdppqtwqdqkptqglqkQTst-----------------l 2248 Japanese medaka
XP_022536604 2420 PSQSQtpv--ssPSLPDMSLSL--PYQGSgwKKSPQS---------------------QN-------------------- 2454 Mexican tetra
XP_005999939 2225 PRKSK-------SDIPAVFLCSSRCQELK--VAKPVM---------------------PNhnv---------------tl 2259 coelacanth
XP_015220786 2307 SRASSsdrglSGVRPARRTSSESPCRAPQ-KNISga-----wqRERDTFKRHSSSPHINILKRATSRSSIL 2371
XP_008122667 2219 PRGTP-----VGTKPPRRTSSESPSRLPV-KTNN---------LPPEPFKRYSSSPQINVTKRTASLASTV 2274
EDL31570     2029 -QRSPqakpgLAPRAPRRTSSESPSRLPV-RASP---------GRPETVKRYASLPHISVSRRSDSAVSVP 2088
XP_006050589 2088 -QRAHtarprPSERQPRRTSSESPSRLPV-RTPA---------AXPETVKRYASLPHISVARRPDATSPEP 2147
XP_012904217 2056 -QRAPaarpsPSERPARRPSSESPSRLPV-RTPT---------APPEAVKRYASLPHISVARRPDGAAPGA 2115
P25054       2513 PTIEYndgrpAKRHDIARSHSESPSRLPInRSGT---------WKREHSKHSSSLPRVSTWRRTGSSSSIL 2574 human
XP_014351222 2223 PPLEPgdgrvMRRHDITRSHSESPSRLPVnRSGT---------WKREHSKHSSSLPRVSTWRRTGSSSSIL 2284
XP_007240270 2250 SRANStdrdlTVRRPARRTSSESPCRIPQ-RNIPepk---preKKDDTFKRYSSSPSINVLSRVTSRSSLR 2316
XP_011472584 2249 SRATSserdlT-KRAARRTSSESPCRMAE-RNGPartsggkkqQDKDTFKRHASSPSINILSRVTSRSSLR 2317 Japanese medaka
XP_022536604 2455 -SSENgdgksIRRQDISRSHSESPSRLPInRAGT---------WKREHSKHSSSLPRVGTWKRTGSSSSIL 2515 Mexican tetra
XP_005999939 2260 SKTTTs----SDRKHPKRTSSESPSRPPV-KNNP---------MQREILKRHSSFPHINMRKRTNSPSVFS 2316 coelacanth
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