Conserved Protein Domain Family
TB2_DP1_HVA22
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pfam03134: TB2_DP1_HVA22 (this model, PSSM-Id:427159 is obsolete and has been replaced by 460820)
TB2/DP1, HVA22 family
This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.
Links
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Statistics
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PSSM-Id: 427159
Aligned: 315 rows
Threshold Bit Score: 38.2549
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008189637         73 PAVATISLtV-SPpMSRkyervsaatEAlNeKFTYWMTFTAILILESLCrPVLR----LLPLYQMCRTWFFIWCFAPIrD 147 pea aphid
XP_011274407         12 PLISTFKS-LkTNdINLi--------KS---WLIYWIVFGSLTILEFQFyNLILk---YLPFYSIIKLYLSIWLILPN-T 75  Wickerha...
WGS:AFBI:EDEG_00410  60 PLKETLTC-LkQVkPRA---------SElRhLLIFWLLFGVLTALDAYS-SWLVg---LIPFFYTFKLVFLLWAGPLK-F 124 Edhazard...
EOB14563             58 PLKETLLV-LkQVnPSK---------DEmKhLLIFWLVFGILTGLDSYS-SCIVr---FIPLFYTMKFVFLLYIGPYK-F 122 Nosema b...
EEQ82753             58 PLRETLLV-LkQVnPNK---------EEiRhLLIFWLVFGILTSLDAYS-RFIVs---FIPMFYTLKFFLLLYIGPFR-F 122 Nosema c...
Q8STK5               58 PLQETLVI-LrQVnPKK---------DEaKhMLVFWMVFGILTSLDAYS-GAIIs---FIPLWYTMKFFFLLWAGPLK-F 122 Encephal...
1_pfamImport          1 PILQAFKI-LkKPtNKK---------LT-Q-SVHYWSVYGSFLIIDWFLtTFFIt--cFIPFYDFFVLVFTIGMAVPQ-L 65 
A0CDJ7               14 PLIQSFKV-L-KNkDKE---------GQqT-LLKYWCINWMISLLDIVL-EIVLn--dLL--VDIVLVSLAIGLIYNN-F 75  Parameci...
9_pfamImport          1 PAYYSLKF-L-KKrNQQ---------QIsN-ILKFWCVNSVWTIFEVLV-PLVVd--qWF--FFVTNVIFYVALTFPE-Y 62 
XP_002903661        422 PAYVTIGV-L-GE-KRT---------RRyEwWIAY---FSVAVTVDYLI-TAIGreigWIPLFYHVKLLVMMWLQFPY-F 484 Phytopht...

XP_008189637        148 NGSAYIYDAII-R---PQ 161 pea aphid
XP_011274407         76 KGYEFIYFNYI-D---EY 89  Wickerhamomyces ciferrii
WGS:AFBI:EDEG_00410 125 NASEVLYDKLIsKipeDY 142 Edhazardia aedis USNM 41457
EOB14563            123 RGGRWLYDNLLcQipeEW 140 Nosema bombycis CQ1
EEQ82753            123 KGTKIIYDSLIsKvpeKW 140 Nosema ceranae BRL01
Q8STK5              123 RGGIIIYDNILaRipeKW 140 Encephalitozoon cuniculi GB-M1
1_pfamImport         66 GVAPMLYTKFL-A---PA 79 
A0CDJ7               76 KFSAAIFNNSI-Q---PF 89  Paramecium tetraurelia
9_pfamImport         63 KRAGQIFDLTI-S---KL 76 
XP_002903661        485 QGAERIFNACF-S---SV 498 Phytophthora infestans T30-4
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