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?cl21496: 2OG-FeII_Oxy Superfamily (this model, PSSM-Id:419693 is obsolete and has been replaced by 473886)
2OG-Fe(II) oxygenase superfamily This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalyzing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",