Conserved Protein Domain Family
KH-I_PCBP3_rpt2
?
cd22519: KH-I_PCBP3_rpt2 
second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
PCBP3, also called alpha-CP3, or PCBP3-overlapping transcript, or PCBP3-overlapping transcript 1, or heterogeneous nuclear ribonucleoprotein E3, or hnRNP E3, is a single-stranded nucleic acid binding protein that binds preferentially to oligo dC. It can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences. PCBP3 contains three K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Links
?
Statistics
?
PSSM-Id: 411947
Aligned: 6 rows
Threshold Bit Score: 142.618
Created: 14-Aug-2020
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
 
putative DNAGXXG motif
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens PCBP2 (2AXY) binds telomeric DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #    ## #####  #   #       ####    #   #                           
P57721       125 TSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPP 203 human
XP_014344426  93 TSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPP 171 coelacanth
XP_007888857 122 TSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTISGMPDAIIQCVKQICVVMLEVEY 200 elephant shark
XP_025008184  93 TSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLEVQS 171 chicken
NP_001086212  93 TSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPP 171 African clawed frog
NP_001018567  95 TSKPPVTLRLVVPASQCGSLIGKGGSKIKEMRESTGAQVQVAGDMLPNSTERAVTISGTPEAIIQCVKQICVVMLESPP 173 Danio rerio

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap