6Y2D,1X4M


Conserved Protein Domain Family
KH-I_FUBP1_rpt2
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cd22481: KH-I_FUBP1_rpt2 
second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
FUBP1, also called FBP, or FUSE-binding protein 1, or DNA helicase V, or DH V, binds RNA and single-stranded DNA (ssDNA) and may act both as activator and repressor of transcription. It regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUBP1 contains four K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Links
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Statistics
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PSSM-Id: 411909
Aligned: 8 rows
Threshold Bit Score: 128.2
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ### #####  ##  ##    ####                                  
6Y2D_A         3 NAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDgpqntgaDKPLRITGDPYKVQQAKEMVLELI 73 
1X4M_A        14 NAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDgpqntgaDKPLRITGDPYKVQQAKEMVLELI 84  house mouse
NP_998309    174 MSVHEMMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDgpqntgaDKPLRISGDPFKVQQAKDMVMDLI 244 zebrafish
XP_007885441 174 TAVQEIMIPATKAGLVIGKGGETIKHLQERAGVKMVMIQDgpqptgtDKPLRITGDPYKVQQAKEMVMDLI 244 elephant shark
XP_005998990 178 GAVQEIMVPASKAGLVIGKGGETIKQLQERAGVKMVMIQEgpqntgaDKPLRITGDPYKVQQAKEMVLELI 248 coelacanth
Q96AE4       185 NAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDgpqntgaDKPLRITGDPYKVQQAKEMVLELI 255 human
NP_001006535 182 NAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDgpqntgaDKPLRITGDPYKVQQAKEMVLELI 252 chicken
AAN77161     173 NAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDgpqntgaDKPLRIAGDPYKVQQAKEMVLELI 243 African clawed frog

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