1PTR,3UGL,1PTQ,2ENZ,3UEJ,3UEY,3UFF,3UGD,4FKD


Conserved Protein Domain Family
C1_nPKC_theta-like_rpt2
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cd20837: C1_nPKC_theta-like_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins
PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410387
Aligned: 32 rows
Threshold Bit Score: 92.8849
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding siteDAG/PE binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:2ENZ; Homo sapiens PKC-theta binds two Zn2+ ions.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #            #  #             #  #    #  #       #
1PTR_A         1 HRFKVYNYMSPTFCDHCGSLLWGLvKQGLKCEDCGMNVHHKCREKVaNLC 50  house mouse
2ENZ_A        13 HRFKVYNYKSPTFCEHCGTLLWGLaRQGLKCDACGMNVHHRCQTKVaNLC 62  human
XP_012558584 241 HRFNPKNYLGPAFCDHCGSLLYGLfRQGLNCEACNTNVHFKCKAKVpNLC 290 Hydra vulgaris
RUS69785     257 HRFKINNYMSPTFCDHCGSMLFGLfRQGLKCEVCGINCHKKCRQFMpNLC 306 eastern emerald elysia
XP_002740313 236 HRFKVHNYMSPTFCDHCGTMLYGLfRQGVKCEVCAVNVHHKCKKLVpNLC 285 Saccoglossus kowalevskii
PIK52997     102 HRFKVNNYMSPTFCDHCGTMLYGLfRQGLKCEVCNFNVHHKCQKNVpHLC 151 Japanese sea cucumber
XP_021002147 236 HQFQVHTFKSPTFCNHCGSLLYGFrKQGFKCTQCNITCHQKCEKFMpNLC 285 common house spider
ESN91769      14 HRFVLNSFMSPTFCDHCGSMLFGLfKQGLKCEECGATCHKKCYKFVpNLC 63  Helobdella robusta
XP_013379149 235 HRFKVHNYMSPTFCDHCGSLLVGLfRQGLKCETCGTNCHKKCQKLIaNLC 284 Lingula anatina
P34722       238 HRFKTYNFKSPTFCDHCGSMLYGLfKQGLRCEVCNVACHHKCERLMsNLC 287 Caenorhabditis elegans

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