Conserved Protein Domain Family
CH_LRCH1
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cd21270: CH_LRCH1 
calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1
Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.
Links
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Statistics
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PSSM-Id: 409119
Aligned: 6 rows
Threshold Bit Score: 213.947
Created: 9-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative actin
Feature 1:putative actin binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens filamin-A binds F-actin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   #                                                      # ##  ## #       
Q9Y2L9       578 EEKELVEQLRESIEMRLKVsLHEDLGAALMDGVVLCHLVNHIRPRSVaSIHVPSPAVPKLSMAKCRRNVENFLEACRKLG 657 human
XP_007889949 609 EEREHIEQLRENIETRLKVdLPEETGAALMDGVVLCHLVNHIRPRSVvSIHVPSPAVPKLSMAKCRRNVENFLEACRKMG 688 elephant shark
EOA97538     513 EERELVEQLRENIETRLKIcLPEDLGSALMDGVVLCHLVNHVRPRSVaSIHVPSPAVPKLSMAKCRRNVENFLDACRKLG 592 mallard
KAA0715774   605 EELELTEQLRESIESRLKVnLPEDLGSSLMDGVVLCHLVNHIRPRSVaSIHVPSPAVPKLSMAKCRRNVENFLDACRKMG 684 Triplophysa tib...
XP_018121085 670 EERAGTEQLRKNIESRLKLsLPHDLGAALMDGVVLCHLANHVRPRSVqSIHVPSPAVPKLSMAKCRRNVENFLEACRKIG 749 African clawed ...
XP_014344689 652 EDLELMEQLRKNIETRLKVsLPSDLGAALTDGVVLCHLANHVRPRSVpSIHVPSPAVPKLTMAKCRRNVENFLEACRRIG 731 coelacanth

Feature 1          #########    # ## ##  ##  #   
Q9Y2L9       658 VPEADLCSPCDILqLDFRHIRKTVDTLLALGE 689 human
XP_007889949 689 VPEADLCSPYDILqSDVCGIQKTVGALLAHGE 720 elephant shark
EOA97538     593 IPEADLCSPYDILqSDIRHIRKTVDTLLALGE 624 mallard
KAA0715774   685 VPESSLCSAYDVLqCNLRPVWAMVGALLMLES 716 Triplophysa tibetana
XP_018121085 750 VPQDKVCLPSDILqLNLCSIKGTLECLLSFGE 781 African clawed frog
XP_014344689 732 VSQDSLCSPSEVLqLNPLGIMRTVETLLSCPG 763 coelacanth

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