Conserved Protein Domain Family
Fuz_longin_3
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pfam19038: Fuz_longin_3 (this model, PSSM-Id:408808 is obsolete and has been replaced by 465955)
Third Longin domain of FUZ, MON1 and HPS1
This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.
Links
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Statistics
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PSSM-Id: 408808
Aligned: 38 rows
Threshold Bit Score: 38.7693
Created: 28-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDV26624     321 EIWHFLYKSKTYGQFVSPKCR----------PPYNTVEEQTRLQELYKYLHHRMHAs-------------------aKPL 371 Trichoplax adha...
XP_011442063 285 NTLGFLLINKETNRCLCSISPtfng--ghpdETLSPSQRKEVLMSFYKRMVGTFFSsvvpgse-------sgpsefsHQA 355 Pacific oyster
XP_013398686 285 SILGFILINRESHRCLCTVEPmeeds-srqgKTMSIYRRREILRAFYKSVVRTIFTppqsdmdste-tadtlhtrlkHKA 362 Lingula anatina
Q2HZX7       287 GILGLLLINRDMNKSLYTVQAhpmeemqktdLKLTLEQRRSALRSFYTLAMSRYFPseradgkntlpseesfqsgfsHSA 366 tropical clawed...
Q9BT04       295 DILGLLLLHLELKRCLFTVEPlg-------dKEPSPEQRRRLLRNFYTLVTSTHFPpepgppek-----tedevyqaQLP 362 human
Q3UYI6       295 DILGLLLLHLELRRCLFTMEPsk-------dKEPSPEQRRRLLRNFYTLVATTHFPpepgpaek-----qedtvypaQMP 362 house mouse
1_pfamImport   1 ETLGFLLTNYKAQKFILGKNMqy------akNRVSGSHRLDILRTFYHQAVETYILsseseyns------sgdnwkfVGA 68 
2_pfamImport   1 AILGFLLVNYKIGKFVLSGNAqh------skNHVSGTHRLDTIRTFYHHAVETFLLpvddnsekee--epnksahqfKGA 72 
CRL02569     279 SVIGFLLINSRLKKYFISKNIqq-------vVGKRSSHRMDILRAFFHKSVYTEDFgal---------------sepVKV 336 Clunio marinus
EFX89267     288 NVLSYLVVNTEKRRSLSSLSPhsts--gdahSHLTAVRKRDILRTFYKTIVGTMINlpsatqs--------dsedasHDS 357 common water flea

EDV26624     372 KLVYRLRS------QEALLGWISETFELYAVFNPLVSKTVAIGNVKRLMAIIKQEE 421 Trichoplax adhaerens
XP_011442063 356 MESYITTE------THKCYAMMSGPHQLFMVYGEVIPTYAMRSITQKTLSLLTKDR 405 Pacific oyster
XP_013398686 363 LETYIVSE------THKCFAMNTNPYELYVLYSIHIPTYALRSTTTKLLSSLIKEK 412 Lingula anatina
Q2HZX7       367 HQCYTISS------SCKCYGMKTELHLLFLLLKPEVPTFSMRSIANKTIAAFTKDF 416 tropical clawed frog
Q9BT04       363 RACYLVLGteepgtGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTPLL 418 human
Q3UYI6       363 RACYLVLGpg---mGWQLVAVQLGLRLLLLLLSPHTPTHGLRSLATRTLQALTPLL 415 house mouse
1_pfamImport  69 KETYLCSE------YHKCYAVKDGDHILCILCTSTVPTHTVRMICQKMLKALLIDK 118
2_pfamImport  73 KETYWCSE------YHKCHALKETDHIFCVLYTSTVPTHTMRLITQKTLKILLADK 122
CRL02569     337 PEQYYTSD------YHKCHALIKDECILCVLFVSAVPTHTMKFISEDLLVKLLSEK 386 Clunio marinus
EFX89267     358 KEVFMNFE------YYSLHALISEMYLILVLYPSGLHNHYLRSITRSTLKILTHEK 407 common water flea
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