pfam17968: Tlr3_TMD (this model, PSSM-Id:407816 is obsolete and has been replaced by 465595)
Toll-like receptor 3 trans-membrane domain
Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.
Jiyao W et al.(2023). "The conserved domain database in 2023.",