Conserved Protein Domain Family
PTRF_SDPR
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pfam15237: PTRF_SDPR (this model, PSSM-Id:405834 is obsolete and has been replaced by 464578)
PTRF/SDPR family
This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway. PRKCDBP appears to act as an immune potentiator. PTRF is involved in caveolae formation and function. SDPR is involved in the targetting of protein kinase Calpha to caveolae.
Links
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Statistics
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PSSM-Id: 405834
Aligned: 26 rows
Threshold Bit Score: 264.247
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004080775  68 QVNGVLVLSLLDKIIGAVDQIQQTQSGLETRQQEMERSVISIQGELTKLTKSHSTTSNSVNKMMEKVRKVSVNVKTVRAT 147 Japanese medaka
XP_004747756  27 QDAALTIVTVLDKVATIVDSVQASQKRLEERHREMENAIKSVQIDLLKLSQSHSNTGYVINKLFEKTRKVSAHIKDVKAR 106 domestic ferret
XP_006010362  26 QVNIMTIMSLLDKVAEIVDSVQASQRRIEERHTEIENSIKTIQIDILKLAKDHNTTGSTVNKLLEKTRKVSSNVKDVRAR 105 coelacanth
XP_006634597  27 pISTLTILSLLERVAGIIDNVQACQQRMEERQLELENNIKTIQIDVLKLAKDHSITGNTVEKLLEKTRKVSSNVKDVRQR 106 spotted gar
NP_001008579  13 epSAMNIFSLLERVSGIIDNVQACQQRMEERQLELENTVKTIQADVVKLTKEHTATSGTVEKLLEKTRKVSCHIKDVRVR 92  zebrafish
A1L260        18 pVSALSILSLLERVSTIIDGVQASQQRMEERQQQLEGSVSAVQSELLKLARDHGATATTVDKLLQKARRVSTHVKEVRSR 97  zebrafish
XP_005812677  27 pISALTILSLLERVAGIIDNVQSCQQRMEERQLELENNIKTIQGDVLKLAKDHSDTSGTVEKLLQKTRKVSANVKEVRTR 106 southern platyfish
XP_012398157  27 QDAALTIVTVLDKVATIIDSVQESQKRIEERHRTMENTIKSVQIDMLKLSQAHNNTGYMVNKLFEKTRKVSAHVKEIKAR 106 Tasmanian devil
XP_002935326  27 hDAALTIVTVLDKVATIVDTVQASQKRIEERHREMEDAIKTIQIELLKLAQAHSNTSYTVNKLLEKTRKVSSNVKDVKSR 106 tropical clawed...
XP_005041886  28 QDAAYTIVTVLDKVANIVDSVQASQKRIEEKHREMENAIKTIQIDILKLAQAHGNTGFTVNKLLQKTRKVSSTMKEVRAR 107 collared flycat...

XP_004080775 148 LEKQGGQIKKLESNEAELLKRRNFKVMIYQDETKLPSKLSISKsmrtsesVTGsrGGSMLELKEAMEEPGEeagegeked 227 Japanese medaka
XP_004747756 107 VERQQVHVKKVESKQEEIMKKNKFRVVIFQEEIRCPTSLSIVKd------R------SLTENQETEEDVFDp-------- 166 domestic ferret
XP_006010362 106 VDKQSARVKKVETTQEELLRKNRFRVVIYQGETEVPCAS-VSKf------PKD--CAV-SGGQEENLDNETg-------- 167 coelacanth
XP_006634597 107 VEKQNIRVKKVEATQEELLMRNKFRVVIYQGETEIPSVA-VTKt------PKG--APG-VS--TVEPDTYDa-------- 166 spotted gar
NP_001008579  93 VEKQNVRVKKVEETQVELLNKNKFRVVIYQGDNEVPAVAGPKAs------PKGa-MGGDAA---ADPDAPEa-------- 154 zebrafish
A1L260        98 VEKQNVRVKKVETTQDELLTRNKFRVVIYQGEKEVPSVA-VTKt------PK---GAG-LAELEVEPDEYDi-------- 158 zebrafish
XP_005812677 107 VEKQNIRVKKVETTQDELLTRNKFRVVIYQGETEVPSVA-VTKs------PK---GLG-LEGLDIEPDAYDi-------- 167 southern platyfish
XP_012398157 107 VEKHSLNVKKVETKQEEILRKNKFRVVIFQEEVPCPTSLSVVKe--------------KSLLEDTQEDEFCl-------- 164 Tasmanian devil
XP_002935326 107 VDKQSDQVQKVESKQEEMLRKNKFRVVIFQEDIECPTKLTVAKe---------------SALDGNLRDNLYt-------- 163 tropical clawed...
XP_005041886 108 VERQSTSVRKVEAKQQEMLRKNKFRVVIYQEETECPSSLSVIKe---------------MTAGETIEDDFFp-------- 164 collared flycat...

XP_004080775 228 kpHVDLSSDEEglEIEEVIEESRAERIKRSSLQRVQTLKTVFSrekmdrtraktkenlektrqktkdniektkqktkenl 307 Japanese medaka
XP_004747756 167 --pIDLSSDEEy-YVEE----SRSARLRKSGKERIDNIKKAFSkenm--------------------------------- 206 domestic ferret
XP_006010362 168 -pPADLSSDEEy-MVVEEQETA-AARLKKSGLKRIDTIKKAFTkeni--------------------------------- 211 coelacanth
XP_006634597 167 --pADLSSDEEy-MVVEEADSSTAARLKKSGMRRIESIKKAFTkenm--------------------------------- 210 spotted gar
NP_001008579 155 -pLPD--SDEEy-MVVEEADSSTAAKLKKTGLKRIESLKQTFSrenm--------------------------------- 197 zebrafish
A1L260       159 --pADLSSDEEy-MVVEDAESSRGARLKQSGLKGIENIKAAFSkenm--------------------------------- 202 zebrafish
XP_005812677 168 --pADLSSDEEy-LRDEEPDPSRAARLKKSMVKSTETLKAAFSkenm--------------------------------- 211 southern platyfish
XP_012398157 165 --pDDLSSDEEy-EIEE----SRAAQFKKSGKKQIDNIKKAFSkenm--------------------------------- 204 Tasmanian devil
XP_002935326 164 --pDDLSSDEEy-CVQE----SRTSRLKKSGMKRIDNIKMAFSkenm--------------------------------- 203 tropical clawed...
XP_005041886 165 --pDDLSSDEEy-YIEE----SKATKFKKSGMRRIDDIKKAFSreni--------------------------------- 204 collared flycat...

XP_004080775 308 ektrqktkdniektkqktkenlektR------------------HNIEKKMGKLGTRMsVNPERKqkmk----------- 358 Japanese medaka
XP_004747756 207 ----------------------qktR------------------QNFDKKVNRIRTRI-VTPERRerlrqsg-------- 237 domestic ferret
XP_006010362 212 ----------------------qktR------------------QNIGQKMNRISTRI-VPPERRekirqs--------- 241 coelacanth
XP_006634597 211 ----------------------tktK------------------QNLGTKVNQISTRI-VTPERRekir----------- 238 spotted gar
NP_001008579 198 ----------------------tktK------------------ENLGTKVNKLGERI-VTAERRekir----------- 225 zebrafish
A1L260       203 ----------------------nktRektrenlsktkeslsktgQTLGTKFNTLGEKI-VPPEQRe-------------- 245 zebrafish
XP_005812677 212 ----------------------sktK------------------DNLGTKIHNLGEKV-MPPERRekmq----------- 239 southern platyfish
XP_012398157 205 ----------------------qktR------------------QNFDKKVDRIRTRI-VTPERRerirqsgerlrqsge 243 Tasmanian devil
XP_002935326 204 ----------------------qktK------------------QNFGNKVNRIRTRI-VTPERRerir----------- 231 tropical clawed...
XP_005041886 205 ----------------------qktR------------------QNFGKKVNRLQTRI-VTPERRerir----------- 232 collared flycat...

XP_004080775 359 -----------tssDKMKKAFtpdhvvyarSKTAMYKVPP 387 Japanese medaka
XP_004747756 238 -------erlrqsgERLKQSGe-------rFKKSISNAAP 263 domestic ferret
XP_006010362 242 ---------gektgERLRQSGe-------rLKQSITKAAP 265 coelacanth
XP_006634597 239 -----------qsgERIKHSGe-------rLKESISKAAP 260 spotted gar
NP_001008579 226 -----------qsgERLKQSGe-------rFKETITKTVP 247 zebrafish
A1L260       246 ---------------kIKQSSe-------rLKENIAKKAP 263 zebrafish
XP_005812677 240 -----------qagERLKQSGe-------rLKENIAKKAP 261 southern platyfish
XP_012398157 244 rlrqsgeklrqssgERLKQSGe-------rFKKTISKATP 276 Tasmanian devil
XP_002935326 232 -----------qsgERLKKSGe-------rFKQSIVKAAP 253 tropical clawed frog
XP_005041886 233 -----------qsgERLRQSGm-------rIKKSISQAAP 254 collared flycatcher
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