Conserved Protein Domain Family
CECR6_TMEM121
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pfam14997: CECR6_TMEM121 (this model, PSSM-Id:405656 is obsolete and has been replaced by 464432)
CECR6/TMEM121 family
This family includes Cat eye syndrome critical region protein 6, a protein which has been identified in a screen for candidate genes for the developmental disorder Cat Eye Syndrome (CES). It also includes the TMEM121 transmembrane proteins. The function of this family is unknown.
Links
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Statistics
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PSSM-Id: 405656
Aligned: 14 rows
Threshold Bit Score: 181.326
Created: 22-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7RFR8        59 AFSAIkggtCWLLY-VYSIAIKVIFMYFFAfSDNdileNTRTDY-YNKSIVFILLSLStLIYTALSVKSYKQLYPDEnti 136 Plasmodium yoel...
XP_001636436  82 AFAYL----AWFVY-CLHLVPQIATLFRLK-ANE----LDEKTMvFGPNMLKMCLCIT-PVLFLFLIFAHHDARPYS--- 147 starlet sea ane...
EDO33715     101 PYAFI----AWFAYtAITLVPEIVVIFKNF-ADE----LEDVKI-LGQNVLKVALCIT-PMLFLLLVNSHHNTKQSA--- 166 starlet sea ane...
EFO87068     189 KYACF----AWGVY-ALVLIFKIGTCFRLFyEDIpptpLDNNDKlFDDFLFKAGLSLS-VLIFLFIFESHHYTPLVS--- 259 Caenorhabditis ...
EEB19155     119 PLIYV----SWAFY-VVLLLSKIAVIFTSEiPEH----LNTKNV-AGPQLLKVGIALS-GVIFLILVEGHNWSEPGS--- 184 human body louse
EFX84980     106 PLCYL----AWICY-ATCLVTKVAFIFKSEiINT----LKPQDI-FGPQLLKFTISSS-TIVFILLVAAHHDSEKDS--- 171 common water flea
CAF96745     177 TYAYL----AWLIY-VISCTPKVVLILETSiLD-----LITLKVpFGLTGFKVVVLLSvPLLFCLISAIVE--DPNG--- 241 spotted green p...
XP_005164731 167 TFAYL----AWLIY-VIASTPKVVLVLETSiLD-----LIALKVpFGVTGFKITMLLCaPLLYCLINSIIE--DPNG--- 231 zebrafish
NP_001138269  73 GYAMI----LWFLY-IFVLEIKLYFVFQNCkADR----K-SLET-VARKALTLLLSICvPGLYLVLVALDSMEYVRTf-- 139 zebrafish
EFB24297      73 GYAMT----LWFLY-VFVLEIKLYFIFQNYkAAR----RGAADP-VARKALTLLLSVCvPGLFLLLVALDRMEYVRTf-- 140 giant panda

Q7RFR8       137 sNEKIFHKDLILHVVIDLFDIFELLFTLLRLPHiiestnFWIKIIGGVLISFSVYLngySFPIISIVAEKNSKN--LDLG 214 Plasmodium yoel...
XP_001636436 148 -KRKLYLEKICGSVTLDLFDSVEMLEYLFDKEH------LNLGIEISILVFACVNI---FLPSLALYELKHNKFheSGQV 217 starlet sea ane...
EDO33715     167 --RKWYIDKLTGGVTLDLMDSIDILEILFLKDAiv---dLPVALENIIIAFACINF---FLPTLALLELSVNKF--DGQV 236 starlet sea ane...
EFO87068     260 -VRQVYISYLVAAICLDLIDNIYFLDLLWQAskd--kwnLELWLEWTILVVACINF---FMPTFALAKLRYAKV---PRF 330 Caenorhabditis ...
EEB19155     185 -PRYLYVSSICTKTGIEILDSVSFLSILLSDSGnnlpdtLTPTFISGIVAIAGVNF---LLPVLILYKLSLGEH--HNKR 258 human body louse
EFX84980     172 -QRALAIKSMCTNTAFELLDSVAFLSILIIKEShl---aVTYDFENFVLVFACINF---FLPTIALYQYSLSDF--GQLE 242 common water flea
CAF96745     242 -PSRHRSQSCFLSTCLDLLDAFTLVEMMLRGEi------pTVYLKYAVMSVYWVTL---AVPVVWLYELTVSEL------ 305 spotted green p...
XP_005164731 232 -ATRFHSQGCFVSTCLDILDSFILVEVLLKNEi------pNVYLRYTVISVYFIAL---GVPVVWLYELTASEM------ 295 zebrafish
NP_001138269 140 -RRKEDMRGRLFWVALDLLDLLDMQANLWEPQRt----gLPIWAEGLMFFYCYILLl--ILPCVSLSEISVQGD------ 206 zebrafish
EFB24297     141 -RKREDLRGRLFWVALDLLDLLDMQANLWEPPRt----gLPLWAEGLTFFYCYMLLl--VLPCVALSEVSMQGE------ 207 giant panda

Q7RFR8       215 DIYFCKKH-SAVIGIILIDIPFMILRFylLVF-------YFSNIHFQPLLIKNICFIPIKCITIKRC 273 Plasmodium yoelii yoelii
XP_001636436 218 SPVSFKII-YVCGFLLFVNVPFLVIRL--ILW-------HSFNLDISVLLAKNALGVILGLIEIFEF 274 starlet sea anemone
EDO33715     237 RSVSFQIL-YSLSYIGLVNVPFWIIRV--YIW-------WVFSQDVSVFIAKNIIMTVIYSMDIYES 293 starlet sea anemone
EFO87068     331 L-LVSEKL-WAFLYVLLVNGPFLGLRI--YLYivlevqqHGKKYDPSLFGVKNIAMIYIALRELWTR 393 Caenorhabditis remanei
EEB19155     259 LPVPLTVL-HNLLHVFSVDMPYFAIRL--LLW-------VRHNHNTSIFIMKNAFGMLMAVRNIYPD 315 human body louse
EFX84980     243 KPLDLNGV-YHLSHMSLVNVPYLAVRV--YLW-------SGYGSDISLFVMKNVIGILWHLKDIVPD 299 common water flea
CAF96745     306 ---GCRRLcFRFLSALLVNAPLLVIRC--LLV-------FVHNANVSAFLFKNVFFSACQLLELLEQ 360 spotted green pufferfish
XP_005164731 296 ---NCRWVwARFFTGVLLNAPLLVVRC--FLV-------FVYKTPVSVFMFKNIFFLGCKCLELVEQ 350 zebrafish
NP_001138269 207 HISPQKMMlYPLLSLVTINIVTILIRGvnMVL-------FQDSRVSTIFVGKNVVAIATKACTFLEY 266 zebrafish
EFB24297     208 HIAPQKMMlYPVLSLATVNVVAVLARAanMAL-------FRDSRVSAIFVGKNVVALATKACTFLEY 267 giant panda
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