Conserved Protein Domain Family
TMEM138
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pfam14935: TMEM138 (this model, PSSM-Id:405603 is obsolete and has been replaced by 434328)
Transmembrane protein 138
This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.
Links
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Statistics
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PSSM-Id: 405603
Aligned: 22 rows
Threshold Bit Score: 103.851
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q29PL3                       40 SIFFFVTQDALIIVEYLLFTLALHSTCVYQVGASHIILRNCKLFLGSITIYFLLSASQHFWIVYQSRLSAGENQnqeWPL 119 ...
CAP21918                     36 LLLIYILQDTLLIMSSLVLFVSFTATFVFQLGLIHIVLVQFLPTIIMSIFYTFVSIGYHYTSLSSTWEDQTVNI---FLE 112 ...
XP_008182455                 39 SILLFVLQDIGQLVAIAVLLITFFQTNIFQAGFIVLLFNEFRSTIITGVGYFILTLFVQVWTLTNRFKGQVYFY---WPD 115 ...
XP_011402877                 40 lsVVYALQDFFLVLSFILTFLIFFNTFTFTSGLITILLKKFSWSLCTGVAYLLVTIAYQIWSLNNRWNNRWV-----WSA 114 ...
1_pfamImport                  1 LFVVFIVQDAFLLMAVTCLCFSLFRTNVFKAGFVELLLYGFKGTIIFAALYIILTVSLQTFLLLLRWEQPIDYN---WPG 77 
XP_001869684                 40 IIFLFLAQDVCLILSFTAIIFSLYSTYVYQAGMAHLLYEKFRVPLLVAMMYFILCISLHTWQVVDHHKSPYLFQ---WPK 116 ...
WGS:AAAB:ENSANGP00000030664  40 VIFLFIAQDVCLMLSFTAFVFSLYSTYVYQAGMANLLYEKFRTPLLISMTYFFLSIALHLWQVLGHSNEPYQFQ---WPK 116 ...
OWR45793                     38 LLVLFIFQDLFLILSITMMLMTFFSTYLFQAGLVEVLIRKFRAAGSVIVSYLAASVLLHTAWLMQKWSDPES-V---STP 113 ...
XP_002425851                 38 QLVAFIFQDVFIVISLTVTLIGFFSTYVFQAGLVELLFDRFRLAILISVFYFIITIILHAWLLTIRWNNPNNFN---WTD 114 ...
EFN66129                     40 LLVLYVIQDFCLIAALTLLLVNFFSTYIFQAGLIQLLYTRFRITLILCIIYMILSISLHTWHITIHWSSPLKHY---WTK 116 ...

Q29PL3                      120 -GLYALAVIHRIMSVFYYYSSKSTALTMADPRYKeEHLDWIAEQ 162 Drosophila pseudoobscura
CAP21918                    113 tHLLIFFIFHKVISCIFYSFYKRTALQISDPKYN-SDSTWLREL 155 Caenorhabditis briggsae
XP_008182455                116 -GLYVFFVLHKFTSCLHYYLYKRTALCISDPKFY-TD-EWINHr 156 pea aphid
XP_011402877                115 -GLQFMYVLHKMVALFYYYIYKRGLYRLSDPKLYlPNSNWVSDr 157 Amphimedon queenslandica
1_pfamImport                 78 -LLSALYIIQRFFAVLFYYFYKRSSLRLSDHRFY--DEEWVKHT 118
XP_001869684                117 -ALTALFIIQRLFSPLYYYLYKRSALKMSDPRFY-ENLDWITSa 158 southern house mosquito
WGS:AAAB:ENSANGP00000030664 117 -ALTALFIIHRLFSPIYYYLYKKSALKMSDPRFY-ENLDWIASQ 158 Anopheles gambiae str. PEST
OWR45793                    114 -FLIVLFTFQRCLSPWYYFFYKRAALRVSDPRFY-EDIDWISQQ 155 Danaus plexippus plexippus
XP_002425851                115 -GLTIFFSCQRMFSPIYYYSTKRAMLRISDPRFY-QSLDWISRh 156 human body louse
EFN66129                    117 -GFHILYSIHRTVAVLYYYFYKRASLRIGDPRFY-KGSIWVQKQ 158 Florida carpenter ant
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