3MDG


Conserved Protein Domain Family
NUDIX_2
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pfam13869: NUDIX_2 (this model, PSSM-Id:404710 is obsolete and has been replaced by 433540)
Nucleotide hydrolase
Nudix hydrolases are found in all classes of organism and hydrolyze a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, di-nucleoside and diphospho-inositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity.
Links
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Statistics
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PSSM-Id: 404710
Aligned: 19 rows
Threshold Bit Score: 233.687
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3MDG_A                    35 RTINLYPL-TNYTFGTK----EPLYE-KD---SSVAARFQRMREEFDKIGM-RRTVEGVLIVHEHRLPHVLLLQ-L---G 100
EFC41954                   5 KVVDIYDY-TFIKWTKK----NPQVE-KD---KSVPERLKRLENNYLTHGM-KRTVEAAIAVNIHGHPHIMLLR-I---G 70  Nae...
Q55E68                     4 KTLTLYNFnTSYSFGKE----E-KKE-KE---QSLTSKLARLKDSYEKEGL-RKAVEGIIIIHDHGHPHILLLQ-D---N 69  Dic...
XP_001899572              24 SVIRLYPL-TNYSVQNN----DYEDP-PQ---IFDYKQSLKLRQQYENNGM-IRTVQGVLLGHQNSIIHVLLLK-NgvgQ 92  Bru...
WGS:AAFB:cds.EHI_077110A  57 PLLKIYPI-ENYQIDKK----EKLDKlKH---QTFGYQMDQLKISVEKNHVpRTSVYGVILVHKNNFPHLLVLQ-S---N 124 Ent...
Q4U960                    21 SEWDIYPQ-TMYKFEHN----STKVG-RGlifRLSDEILERRVKTYAVSGM-RITVCGVILSHRKGFPYVLLLK-R---D 89  The...
XP_001611850              16 PDWLVYPE-DSYSFRDD----SAPIG-QGllfRTPESLLCKRIRAYNQNGL-RITVYGLILCHRNGFPCILVLR-D---T 84  Bab...
XP_002140304              29 PTWLIYPL-ENYGIRVDdnpsENLME-DS---IANMNGFNKKVDSFLRDGI-GRSVAALILTHRYLCPHVVLLQ-S---D 98  Cry...
CAQ38053                  39 GEWLVYPQ-ANYEFNIV----EKLKS-KF---IMDTDKIKKRINAYNQDGI-RNSALAIILCHRYEYPHLLLLQnI---E 105 Pla...
XP_002508304              18 RAIHVYPV-SNYTFGSK----AAKAD-KD---ATVAEAMIRYKDKYEKEGM-RRTVEAILLVNQHDHPHVLLLQ-R---T 83  Mic...

3MDG_A                   101 TT----F-----FKLPGGELNPGEDE-VEGLKRLMTEILG--------------RQD--GV--------LQDWVIDDCIG 146
EFC41954                  71 NSqk-gF-----HKLPGGRCRRDETE-EECLKRKLTKRLA--------------PEDpnEI--------MPEWIVHGVVS 121 Nae...
Q55E68                    70 -N----Y-----FKLPGGKLKPGENE-IDGLIRKLTKKLS--------------PTGtpVS--------DAPWEIGDHVS 116 Dic...
XP_001899572              93 IQ----S-----SKLPEVTLYNSEDE-IDGMKRLMAEVMG--------------FKD--TA--------EAVCQIQHVAA 138 Bru...
WGS:AAFB:cds.EHI_077110A 125 LS----MdlkdeIHLVGGRLKIGEDDpVEGLKRKLRKKMS--------------ME----Y--------ITHYEIGELLG 174 Ent...
Q4U960                    90 LDk---S-----VGLLGGKCKSFENP-KEALSSKLARFIT--------------STK--HKhqlnikdtMENIHVGELLA 144 The...
XP_001611850              85 SG----N-----IGLLGGKCKSFENP-REVLKLKLARFVS--------------TSRk-GVhqlnvranVDTIIVGEFMG 139 Bab...
XP_002140304              99 LTs---E-----WMLPNCLYRAWENP-RTVLVSFLKSLFF--------------TDSnsTE--------NNTAEVGEYLG 147 Cry...
CAQ38053                 106 SQ----T-----YHLLSGKYKSWEKP-REVLKKKLQKYVNqirdmhfgtshfntEEK--ET--------EDPIEIGEFLG 165 Pla...
XP_002508304              84 MAgggvE-----YKLPGGRLRHGEGE-VAGLQRKLHNKLS--------------PSE--QSl------rIEHWECGDCVA 135 Mic...

3MDG_A                   147 NWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRF 222
EFC41954                 122 VWYRPNFENSFYPYLPAHITKPKERKLIYLVTIPE-CTIAYPRNYDFIPMPFFDLYENSKKFGSIISSLPQVISKF 196 Naegler...
Q55E68                   117 TWWRPNFEPSLFPYIPSHITKPKECKKLFVVTLPEKCKFAVSNNLSLIAVSLYEIYNNSQRYGAVISSIPALISRY 192 Dictyos...
XP_001899572             139 KWWRPNFEESIYPYIPSHITKPKEMIKVFVVELPKQTTFTIAKNNALIAAPVFEIYNNISNYGHIIASLPHVLGRF 214 Brugia ...
WGS:AAFB:cds.EHI_077110A 175 TFYRIEYDKNLYPYIPVHVSQVKEIINIYMIHLVEKCDFKIFDTDKLSSIPLFALHNNFEKYNITLCSIPTLVSRY 250 Entamoe...
Q4U960                   145 DFWRCDFNTEPLPYLPLHTNRPKEKISLYQVILPENCKISVPKGYNLKFVPLYDFYN--AEFGLSLASLPHLLSRF 218 Theiler...
XP_001611850             140 EFWRAEYDSDVLPYLPLHINRPREKILIYQVTLREQCSFIAPGDMHIEPMALHEFYC--AEQSVAISALPHLLTRF 213 Babesia...
XP_002140304             148 SWWRTEFNYSPLPYLPPHSTRPKELIRIYQVLLPPKVLFKLPKYHVLKSLPLFDLDPNI--FGIACGGIPQLISRF 221 Cryptos...
CAQ38053                 166 EWWKTQFNSVYLPYLPAHITRPKEYIRLYQVTLTSRCIFHLPPGFTLKALPLFDLST----CGVAIGGLTSVLSRF 237 Plasmod...
XP_002508304             136 RWFRPAFEPNYYPYLPAHVTKPKESRTVYIAQLPERCKFCVPKNLKLLAVPLFEMYANEAKYGAVAASVPYLISRF 211 Micromo...
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